Effects of lipid composition on photothermal optical coherence tomography signals.

abstract：:The advantages of using a telecentric imaging system in digital holographic microscopy (DHM) to study biological specimens are highlighted. To this end, the performances of nontelecentric DHM and telecentric DHM are evaluated from the quantitative phase imaging (QPI) point of view. The evaluated stability of the micro...

journal_title：Journal of biomedical optics

authors： Doblas A,Sánchez-Ortiga E,Martínez-Corral M,Saavedra G,Garcia-Sucerquia J

更新日期：2014-04-01 00:00:00

abstract：:Quantitative and qualitative evaluations of structure and composition are important in monitoring development of engineered vascular tissue both in vitro and in vivo. Destructive techniques are an obstacle for performing time-lapse analyses from a single sample or animal. This study demonstrates the ability of time-re...

journal_title：Journal of biomedical optics

authors： Fatakdawala H,Griffiths LG,Humphrey S,Marcu L

更新日期：2014-08-01 00:00:00

abstract：:Frequency domain optical coherence tomography (FD-OCT), based on an all-reflective high-speed InGaAs spectrometer, operating in the 1050 nm wavelength region for retinal diagnostics, enables high-speed, volumetric imaging of retinal pathologies with greater penetration into choroidal tissue is compared to conventional...

journal_title：Journal of biomedical optics

authors： Povazay B,Hermann B,Unterhuber A,Hofer B,Sattmann H,Zeiler F,Morgan JE,Falkner-Radler C,Glittenberg C,Blinder S,Drexler W

更新日期：2007-07-01 00:00:00

abstract：:The cyclic peptide, cyclopentapeptide cyclo(lys-Arg-Gly-Asp-phe) (c(KRGDf)), which is known to target alpha(v)beta3 integrin, is dual-labeled with a radiotracer, (111)indium, for gamma scintigraphy as well as with a near-infrared dye, IRDye800, for continuous-wave (cw) imaging of alpha(v)beta3 positive human M21 melan...

journal_title：Journal of biomedical optics

authors： Houston JP,Ke S,Wang W,Li C,Sevick-Muraca EM

更新日期：2005-09-01 00:00:00

abstract：:For a long time, the antioxidative status in cattle has been discussed as an indicator for stress conditions resulting from disease or exertion. Until now, invasive approaches have been necessary to obtain blood samples or biopsy materials and gain insights into the antioxidative status of cattle. Due to these efforts...

journal_title：Journal of biomedical optics

authors： Klein J,Darvin ME,Müller KE,Lademann J

更新日期：2012-10-01 00:00:00

abstract：:The measurement of changes in blood volume in tissue is important for monitoring the effects of a wide range of therapeutic interventions, from radiation therapy to skin-flap transplants. Many systems available for purchase are either expensive or difficult to use, limiting their utility in the clinical setting. A low...

journal_title：Journal of biomedical optics

authors： Glennie DL,Hayward JE,McKee DE,Farrell TJ

更新日期：2014-01-01 00:00:00

abstract：:The study presents comparison of near-infrared light propagation and near-infrared backscattered radiation power, as simulated with numerical modeling and measured live in a patient in clinical conditions with the use of the near-infrared transillumination-backscattering sounding (NIR-TBSS) technique. A unique chance ...

journal_title：Journal of biomedical optics

authors： Frydrychowski AF,Pluciński J

更新日期：2007-07-01 00:00:00

abstract：:Discrimination of benign and malignant melanocytic lesions is a major issue in clinical dermatology. Assessment of the thickness of melanoma is critical for prognosis and treatment selection. We aimed to evaluate a novel optical computed tomography (optical-CT) system as a tool for three-dimensional (3-D) imaging of m...

journal_title：Journal of biomedical optics

authors： Kokolakis A,Zacharakis G,Krasagakis K,Lasithiotakis K,Favicchio R,Spiliopoulos G,Giannikaki E,Ripoll J,Tosca A

更新日期：2012-06-01 00:00:00

abstract：:A highly efficient method based on Maxwell's theory was developed, which enables the calculation of the scanning of a focused beam through scattering media. Maxwell's equations were numerically solved in two dimensions using finite difference time domain simulations. The modeling of the focused beam was achieved by ap...

journal_title：Journal of biomedical optics

authors： Elmaklizi A,Schäfer J,Kienle A

更新日期：2014-07-01 00:00:00

abstract：:An approach to an established technique that is potentially applicable for a more comprehensive understanding of the electrical properties of red blood cells (RBCs) is presented. Using a high-intensity gradient laser trap, RBCs can be singly trapped and consequentially ionized. The subsequent dynamics of the ionized c...

journal_title：Journal of biomedical optics

authors： Kelley M,Cooper J,Devito D,Mushi R,Aguinaga MDP,Erenso DB

更新日期：2018-05-01 00:00:00

abstract：:We demonstrate dynamic in vivo imaging using a low-cost portable pulsed laser diode (PLD)-based photoacoustic tomography system. The system takes advantage of an 803-nm PLD having high-repetition rate ∼7000  Hz combined with a fast-scanning single-element ultrasound transducer leading to a 5 s cross-sectional imaging....

journal_title：Journal of biomedical optics

authors： Upputuri PK,Pramanik M

更新日期：2017-09-01 00:00:00

abstract：:Spatially resolved spectroscopy (SRS) allows the estimation of absolute tissue oxygen saturation, the ratio of oxygenated to total hemoglobin concentration, which may facilitate the comparison of results among patients. Eighty-two premature infants were included over two years. The cerebral tissue oxygenation index (c...

journal_title：Journal of biomedical optics

authors： Sorensen LC,Leung TS,Greisen G

更新日期：2008-11-01 00:00:00

abstract：:We present systematic characterization of a photoacoustic imaging system optimized for rapid, high-resolution tomographic imaging of small animals. The system is based on a 128-element ultrasonic transducer array with a 5-MHz center frequency and 80% bandwidth shaped to a quarter circle of 25 mm radius. A 16-channel d...

journal_title：Journal of biomedical optics

authors： Gamelin J,Aguirre A,Maurudis A,Huang F,Castillo D,Wang LV,Zhu Q

更新日期：2008-03-01 00:00:00

abstract：:The scattering of polarized light from a two layer scattering medium is investigated using Monte Carlo simulations. First order and normalized second order moments are used to analyze the spatial properties of the emerging light in different polarization states. Linearly and circularly polarized illumination is used t...

journal_title：Journal of biomedical optics

authors： Stockford IM,Morgan SP,Chang PC,Walker JG

更新日期：2002-07-01 00:00:00

abstract：:An integrated miniature multi-modal microscope (4M device) for microendoscopy was built and tested. Imaging performance is evaluated and imaging results are presented for both fluorescence and reflectance samples. Images of biological samples show successful imaging of both thin layers of fixed cells prepared on a sli...

journal_title：Journal of biomedical optics

authors： Rogers JD,Landau S,Tkaczyk TS,Descour MR,Rahman MS,Richards-Kortum R,Kärkäinen AH,Christenson T

更新日期：2008-09-01 00:00:00

abstract：:Doxorubicin is a commonly used chemotherapeutic employed to treat multiple human cancers, including numerous sarcomas and carcinomas. Furthermore, doxorubicin possesses strong fluorescent properties that make it an ideal reagent for modeling drug delivery by examining its distribution in cells and tissues. However, wh...

journal_title：Journal of biomedical optics

authors： Carlson M,Watson AL,Anderson L,Largaespada DA,Provenzano PP

更新日期：2017-11-01 00:00:00

abstract：:Alcohol testing is an expanding area of interest due to the impacts of alcohol abuse that extend well beyond drunk driving. However, existing approaches such as blood and urine assays are hampered in some testing environments by biohazard risks. A noninvasive, in vivo spectroscopic technique offers a promising alterna...

journal_title：Journal of biomedical optics

authors： Ridder TD,Ver Steeg BJ,Laaksonen BD

更新日期：2009-09-01 00:00:00

abstract：:We investigate optoelectronic properties of integrated structures comprising semiconductor light-emitting materials for optical probes of microscopic biological systems. Compound semiconductors are nearly ideal light emitters for probing cells and other microorganisms because of their spectral match to the transparenc...

journal_title：Journal of biomedical optics

authors： Gourley PL,Copeland RG,Cox JD,Hendricks JK,McDonald AE,Peterson SL,Sasaki DY

更新日期：2002-10-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) in tumor cells was found to play an important role in maintaining the malignant phenotype. Using laser scanning confocal fluorescence microscopy (LSCFM) in a recent work, we reported a variable fluorescence intensity of ethidium bromide (EB) in mitochondria nucleoids of living carcinoma cells...

journal_title：Journal of biomedical optics

authors： Villa AM,Fusi P,Pastori V,Amicarelli G,Pozzi C,Adlerstein D,Doglia SM

更新日期：2012-04-01 00:00:00

abstract：:In the last 25 years, optical coherence tomography (OCT) has advanced to be one of the most innovative and most successful translational optical imaging techniques, achieving substantial economic impact as well as clinical acceptance. This is largely owing to the resolution improvements by a factor of 10 to the submic...

journal_title：Journal of biomedical optics

authors： Drexler W,Liu M,Kumar A,Kamali T,Unterhuber A,Leitgeb RA

更新日期：2014-01-01 00:00:00

abstract：:Quantitative spectroscopy has recently been extended from a contact-probe to wide-area spectroscopic imaging to enable mapping of optical properties across a wide area of tissue. We train quantitative spectroscopic imaging (QSI) to identify cervical high-grade squamous intraepithelial lesions (HSILs) in 34 subjects un...

journal_title：Journal of biomedical optics

authors： Lau C,Mirkovic J,Yu CC,O'Donoghue GP,Galindo L,Dasari R,de las Morenas A,Feld M,Stier E

更新日期：2013-07-01 00:00:00

abstract：:Second-harmonic generation (SHG) imaging can help reveal interactions between collagen fibers and cancer cells. Quantitative analysis of SHG images of collagen fibers is challenged by the heterogeneity of collagen structures and low signal-to-noise ratio often found while imaging collagen in tissue. The role of collag...

journal_title：Journal of biomedical optics

authors： Bredfeldt JS,Liu Y,Pehlke CA,Conklin MW,Szulczewski JM,Inman DR,Keely PJ,Nowak RD,Mackie TR,Eliceiri KW

更新日期：2014-01-01 00:00:00

abstract：:The feasibility of spatial frequency domain imaging (SFDI) for breast surgical margin assessment was evaluated in tissue-simulating phantoms and in fully intact lumpectomy specimens at the time of surgery. Phantom data was evaluated according to contrast-detail resolution, quantitative accuracy and model-data goodness...

journal_title：Journal of biomedical optics

authors： Laughney AM,Krishnaswamy V,Rice TB,Cuccia DJ,Barth RJ,Tromberg BJ,Paulsen KD,Pogue BW,Wells WA

更新日期：2013-03-01 00:00:00

abstract：:Previous studies have shown the ability of many lymphatic vessels to contract phasically to pump lymph. Every lymphangion can act like a heart with pacemaker sites that initiate the phasic contractions. The contractile wave propagates along the vessel to synchronize the contraction. However, determining the location o...

journal_title：Journal of biomedical optics

authors： Akl TJ,Nepiyushchikh ZV,Gashev AA,Zawieja DC,Cot GL

更新日期：2011-02-01 00:00:00

abstract：:We present a novel Fourier-domain angle-resolved low-coherence interferometry (a /LCI) fiber probe designed for in vivo clinical application in gastrointestinal endoscopy. The a/LCI technique measures the depth-resolved angular scattering distribution to determine the size distribution and optical density of cell nucl...

journal_title：Journal of biomedical optics

authors： Zhu Y,Terry NG,Woosley JT,Shaheen NJ,Wax A

更新日期：2011-01-01 00:00:00

abstract：:Fluorescence Talbot microscope is a scalable field-of-view (FOV) imaging platform, which takes advantage of the phase sensitivity of the self-image of a periodic structure. Such a system can maintain the microscopic resolution and extend the FOV for the whole slide (15  mm×15  mm) scanning. Previously reported Talbot ...

journal_title：Journal of biomedical optics

authors： Sun Y,Pang S

更新日期：2016-08-01 00:00:00

abstract：:The absorption coefficient mu(a), scattering coefficient mu(s), and anisotropy factor g of diluted and undiluted human blood (hematocrit 0.84 and 42.1%) are determined under flow conditions in the wavelength range 250 to 1100 nm, covering the absorption bands of hemoglobin. These values are obtained by high precision ...

journal_title：Journal of biomedical optics

authors： Friebel M,Roggan A,Müller G,Meinke M

更新日期：2006-05-01 00:00:00

abstract：:Fourier domain (FD) techniques have increasingly gained attention in optical coherence tomography (OCT). This is primarily due to their demonstrated sensitivity of two to three orders of magnitude over conventional time-domain techniques. FDOCT images are subject to two primary sources of artifacts. First, a complex c...

journal_title：Journal of biomedical optics

authors： Davis AM,Choma MA,Izatt JA

更新日期：2005-11-01 00:00:00

abstract：:As the most abundant cell type in the central nervous system, astrocyte has been one of main research topics in neuroscience. Although various tools have been developed, at present, there is no tool that allows noninvasive activation of astrocyte in vivo without genetic or pharmacological perturbation. Here we report ...

journal_title：Journal of biomedical optics

authors： Choi M,Yoon J,Ku T,Choi K,Choi C

更新日期：2011-07-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder that leads to a decline in cognitive and intellectual abilities and an irreversible mental deterioration. Based on multidisciplinary AD research, the most universally accepted hypotheses on AD pathogenesis are the intracerebral aggregate formation of beta-amyloi...

journal_title：Journal of biomedical optics

authors： Kim CB,Choi YY,Song WK,Song KB

更新日期：2014-05-01 00:00:00