Diagnostic performance of receptor-specific surgical specimen staining correlates with receptor expression level.

abstract：:The optical activity of glucose molecules is important for diagnosing and monitoring blood glucose of diabetes. In order to accurately detect the diabetes at an early stage, there is an urgent need to develop innovative detection methods. By use of Mueller matrix decomposition (MMD), we have studied the optical activi...

journal_title：Journal of biomedical optics

authors： Sun P,Ma Y,Liu W,Yang Q,Jia Q

更新日期：2014-04-01 00:00:00

abstract：:Pedicle screw (PS) fixation has been widely used for spine diseases. Scientists and clinicians employ several approaches to navigate PS during operation. We have demonstrated the feasibility of monitoring the reduced scattering coefficient (μ's) on the trajectory of PS using near-infrared spectroscopy (NIRS). To perfo...

journal_title：Journal of biomedical optics

authors： Liu Y,Wang Y,Qian Z,Zhao J,Cao X,Li W

更新日期：2014-01-01 00:00:00

abstract：:Intracellular oxygen concentration is of primary importance in determining numerous physiological and pathological processes in biological systems. In this paper, we describe the application of the oxygen sensing indicator, ruthenium dibipyridine 4-(1"-pyrenyl)-2,2'-bipyridine chloride [Ru(bpy-pyr)(bpy)(2)], for molec...

journal_title：Journal of biomedical optics

authors： Ji J,Rosenzweig N,Jones I,Rosenzweig Z

更新日期：2002-07-01 00:00:00

abstract：:Real-time medical imaging systems such as reflectance confocal microscopes and optical coherence microscopes are being tested in multiple-patient and multiple-center clinical trials. The modulation transfer function (MTF) of these systems at any given time influences the image information content and can affect the in...

journal_title：Journal of biomedical optics

authors： Wang Z,Glazowski CE,Zavislan JM

更新日期：2007-09-01 00:00:00

abstract：:Several studies demonstrated that the cyclic adenosine monophosphate (cAMP), an important second messenger, is involved in the mechanism of low-level laser irradiation (LLLI) treatment. However, most of these studies obtained the cAMP level in cell culture extracts or supernatant. In this study, the cAMP level in livi...

journal_title：Journal of biomedical optics

authors： Huang Y,Zheng L,Yang H,Chen J,Wang Y,Li H,Xie S,Zeng H

更新日期：2015-05-01 00:00:00

abstract：:We have built an all-solid-state camera that is directly modulated at the pixel level for frequency-domain fluorescence lifetime imaging microscopy (FLIM) measurements. This novel camera eliminates the need for an image intensifier through the use of an application-specific charge coupled device design in a frequency-...

journal_title：Journal of biomedical optics

authors： Zhao Q,Schelen B,Schouten R,van den Oever R,Leenen R,van Kuijk H,Peters I,Polderdijk F,Bosiers J,Raspe M,Jalink K,Geert Sander de Jong J,van Geest B,Stoop K,Young IT

更新日期：2012-12-01 00:00:00

abstract：:Serum Raman spectroscopy (RS) has previously shown potential in oral cancer diagnosis and recurrence prediction. To evaluate the potential of serum RS in oral cancer screening, premalignant and cancer-specific detection was explored in the present study using 328 subjects belonging to healthy controls, premalignant, d...

journal_title：Journal of biomedical optics

authors： Sahu AK,Dhoot S,Singh A,Sawant SS,Nandakumar N,Talathi-Desai S,Garud M,Pagare S,Srivastava S,Nair S,Chaturvedi P,Murali Krishna C

更新日期：2015-11-01 00:00:00

abstract：:We demonstrate the ex vivo imaging of an oral cancerous sample with a swept-source optical coherence tomography (SS-OCT) system. With the axial resolution of 8 microm in free space and system sensitivity of 108 dB, we can well distinguish the normal and abnormal tissue portions in a sample. In particular, we analyze t...

journal_title：Journal of biomedical optics

authors： Tsai MT,Lee HC,Lu CW,Wang YM,Lee CK,Yang CC,Chiang CP

更新日期：2008-07-01 00:00:00

abstract：:Model-based light scattering spectroscopy (LSS) seemed a promising technique for in-vivo diagnosis of dysplasia in multiple organs. In the studies, the residual spectrum, the difference between the observed and modeled diffuse reflectance spectra, was attributed to single elastic light scattering from epithelial nucle...

journal_title：Journal of biomedical optics

authors： Lau C,Sćepanović O,Mirkovic J,McGee S,Yu CC,Fulghum S,Wallace M,Tunnell J,Bechtel K,Feld M

更新日期：2009-03-01 00:00:00

abstract：:Cancer is the main cause of canine morbidity and mortality. The existing evaluation of tumors requires an experienced veterinarian and usually includes invasive procedures (e.g., fine-needle aspiration) that can be unpleasant for the dog and the owner. We investigate visible and near-infrared diffuse reflectance spect...

journal_title：Journal of biomedical optics

authors： Cugmas B,Plavec T,Bregar M,Naglič P,Pernuš F,Likar B,Bürmen M

更新日期：2015-03-01 00:00:00

abstract：:Clinical imaging techniques for the anterior segment of the eye provide excellent anatomical information, but molecular imaging techniques are lacking. Molecular photoacoustic imaging is one option to address this need, but implementation requires use of contrast agents to distinguish molecular targets from background...

journal_title：Journal of biomedical optics

authors： Kubelick KP,Snider EJ,Ethier CR,Emelianov S

更新日期：2019-05-01 00:00:00

abstract：:We present Monte Carlo modeling studies to provide a quantitative understanding of contrast observed in spatially resolved reflectance spectra of normal and highly dysplastic cervical tissue. Simulations have been carried out to analyze the sensitivity of spectral measurements to a range of changes in epithelial and s...

journal_title：Journal of biomedical optics

authors： Arifler D,MacAulay C,Follen M,Richards-Kortum R

更新日期：2006-11-01 00:00:00

abstract：:The effect of silica/gold nanoshells and titanium dioxide nanoparticles on the optical properties of skin is studied. By implementing in vivo measurements and Monte Carlo simulations, we analyze the efficiency of using these nanoparticles as contrasting agents for optical coherence tomography (OCT) imaging of skin. In...

journal_title：Journal of biomedical optics

authors： Kirillin M,Shirmanova M,Sirotkina M,Bugrova M,Khlebtsov B,Zagaynova E

更新日期：2009-03-01 00:00:00

abstract：:UV-induced collagen cross-linking is a promising treatment for keratoconus that stiffens corneal tissue and prevents further degeneration. Since keratoconus is generally localized, the efficacy of collagen cross-linking (CXL) treatments could be improved by stiffening only the weakened parts of the cornea. Here, we de...

journal_title：Journal of biomedical optics

authors： Singh M,Li J,Vantipalli S,Han Z,Larin KV,Twa MD

更新日期：2017-09-01 00:00:00

abstract：:A method is proposed for determining the glucose concentration on the human fingertip by extracting two optical parameters, namely the optical rotation angle and the depolarization index, using a Mueller optical coherence tomography technique and a genetic algorithm. The feasibility of the proposed method is demonstra...

journal_title：Journal of biomedical optics

authors： Chen TL,Lo YL,Liao CC,Phan QH

更新日期：2018-04-01 00:00:00

abstract：:Blood pulse wave velocity (PWV) is an important physiological parameter that characterizes vascular stiffness. In this letter, we present electrocardiogram-synchronized, photoacoustic microscopy for noninvasive quantification of the PWV in the peripheral vessels of living mice. Interestingly, blood pulse wave-induced ...

journal_title：Journal of biomedical optics

authors： Yeh C,Hu S,Maslov K,Wang LV

更新日期：2012-07-01 00:00:00

abstract：:We present a study using a method able to assess tissue oxygenation, taking into account the absorption and the level of scattering in myocardial tissue using a calibrated fiber optic probe. With this method, interindividual comparisons of oxygenation can be made despite varying tissue optical properties during corona...

journal_title：Journal of biomedical optics

authors： Häggblad E,Lindbergh T,Karlsson MG,Casimir-Ahn H,Salerud EG,Strömberg T

更新日期：2008-09-01 00:00:00

abstract：:We introduce the application of functional data analysis (fDA) on functional near-infrared spectroscopy (fNIRS) signals for the development of an accurate and clinically practical assessment method of pain perception. We used the cold pressor test to induce different levels of pain in healthy subjects while the fNIRS ...

journal_title：Journal of biomedical optics

authors： Pourshoghi A,Zakeri I,Pourrezaei K

更新日期：2016-10-01 00:00:00

abstract：:The nEUROPt protocol is one of two new protocols developed within the European project nEUROPt to characterize the performances of time-domain systems for optical imaging of the brain. It was applied in joint measurement campaigns to compare the various instruments and to assess the impact of technical improvements. T...

journal_title：Journal of biomedical optics

authors： Wabnitz H,Jelzow A,Mazurenka M,Steinkellner O,Macdonald R,Milej D,Żołek N,Kacprzak M,Sawosz P,Maniewski R,Liebert A,Magazov S,Hebden J,Martelli F,Di Ninni P,Zaccanti G,Torricelli A,Contini D,Re R,Zucchelli L,Spine

更新日期：2014-08-01 00:00:00

abstract：:Functional near-infrared spectroscopy (fNIRS), acquired simultaneously with electroencephalography (EEG), allows the investigation of hemodynamic brain responses to epileptic activity. Because the presumed epileptogenic focus is patient-specific, an appropriate source/detector (SD) montage has to be reconfigured for e...

journal_title：Journal of biomedical optics

authors： Machado A,Marcotte O,Lina JM,Kobayashi E,Grova C

更新日期：2014-02-01 00:00:00

abstract：:There are several pathologies whose study and diagnosis is impaired by a relatively small number of documented cases. A practical approach to overcome this obstacle and advance the research in this area consists in employing computer simulations to perform controlled in silico experiments. The results of these experim...

journal_title：Journal of biomedical optics

authors： Baranoski GV,Chen TF,Kimmel BW,Miranda E,Yim D

更新日期：2012-09-01 00:00:00

abstract：:We compared light-induced fluorescence (LIF) to nominal injected drug dose for predicting the depth of necrosis response to photodynamic therapy (PDT) in a murine tumor model. Mice were implanted with radiation-induced fibrosarcoma (RIF) and were injected with 0, 5, or 10 mg/kg Photofrin. 630-nm light (30 J/cm(2), 75 ...

journal_title：Journal of biomedical optics

authors： Cheung R,Solonenko M,Busch TM,Del Piero F,Putt ME,Hahn SM,Yodh AG

更新日期：2003-04-01 00:00:00

abstract：:Quantitative polarized light microscopy (qPLM) is a popular tool for the investigation of birefringent architectures in biological tissues. Collagen, the most abundant protein in mammals, is such a birefringent material. Interpretation of results of qPLM in terms of collagen network architecture and anisotropy is chal...

journal_title：Journal of biomedical optics

authors： van Turnhout MC,Kranenbarg S,van Leeuwen JL

更新日期：2009-09-01 00:00:00

abstract：:Colorectal surgery is the standard treatment for patients with colorectal cancer. To overcome two of the main challenges, the circumferential resection margin and postoperative complications, real-time tissue assessment could be of great benefit during surgery. In this ex vivo study, diffuse reflectance spectroscopy (...

journal_title：Journal of biomedical optics

authors： Baltussen EJM,Snaebjornsson P,de Koning SGB,Sterenborg HJCM,Aalbers AGJ,Kok N,Beets GL,Hendriks BHW,Kuhlmann KFD,Ruers TJM

更新日期：2017-10-01 00:00:00

abstract：:Fourier transform infrared (FTIR) microspectroscopy has been used to estimate the spatial proteoglycan (PG) and collagen contents in articular cartilage (AC). However, it is not clear whether the results of FTIR analyses are consistent between different species. Our aim was to clarify how three different FTIR PG param...

journal_title：Journal of biomedical optics

authors： Rieppo L,Närhi T,Helminen HJ,Jurvelin JS,Saarakkala S,Rieppo J

更新日期：2013-09-01 00:00:00

abstract：:Different colors of visible light penetrate to varying depths in tissue due to the wavelength dependence of tissue optical absorption and elastic scattering. We exploit this to map the contour of the closest surface of a buried fluorescent object. This uses a novel algorithm based on the diffusion theory description o...

journal_title：Journal of biomedical optics

authors： Kim A,Roy M,Dadani FN,Wilson BC

更新日期：2010-11-01 00:00:00

abstract：:Diffuse optical imaging is an effective technique for noninvasive functional brain imaging. However, the measurements respond to systemic hemodynamic fluctuations caused by the cardiac cycle, respiration, and blood pressure, which may obscure or overwhelm the desired stimulus-evoked response. Previous work on this pro...

journal_title：Journal of biomedical optics

authors： Zhang Y,Brooks DH,Franceschini MA,Boas DA

更新日期：2005-01-01 00:00:00

abstract：:The earliest steps of breast cancer begin with aberrations in mammary ductal structure. Techniques that enable an investigator to image in situ and then analyze the same tissue using biochemical tools facilitates identification of genetic networks and signaling pathways active in the imaged structure. Cellular confoca...

journal_title：Journal of biomedical optics

authors： Parrish A,Halama E,Tilli MT,Freedman M,Furth PA

更新日期：2005-09-01 00:00:00

abstract：:A new imaging approach, structured light scatteroscopy (SLS), is demonstrated, which offers rapid wide-field imaging of microscopic morphological variations in bulk tissue surfaces. Elastic scattering of light offers exquisite sensitivity to ultrastructural changes at multiple size scales ranging from nanometers to mi...

journal_title：Journal of biomedical optics

authors： Krishnaswamy V,Elliott JT,McClatchy DM 3rd,Barth RJ Jr,Wells WA,Pogue BW,Paulsen KD

更新日期：2014-01-01 00:00:00

abstract：:The development of methods that allow microscale studies of complex biomaterials based on their molecular composition is of great interest to a wide range of research fields. We show that stimulated Raman scattering (SRS) microscopy is an excellent analytical tool to study distributions of different biomolecules in mu...

journal_title：Journal of biomedical optics

authors： Roeffaers MB,Zhang X,Freudiger CW,Saar BG,van Ruijven M,van Dalen G,Xiao C,Xie XS

更新日期：2010-11-01 00:00:00