Application of functional data analysis in classification and clustering of functional near-infrared spectroscopy signal in response to noxious stimuli.

abstract：:There are several pathologies whose study and diagnosis is impaired by a relatively small number of documented cases. A practical approach to overcome this obstacle and advance the research in this area consists in employing computer simulations to perform controlled in silico experiments. The results of these experim...

journal_title：Journal of biomedical optics

authors： Baranoski GV,Chen TF,Kimmel BW,Miranda E,Yim D

更新日期：2012-09-01 00:00:00

abstract：:The development of methods that allow microscale studies of complex biomaterials based on their molecular composition is of great interest to a wide range of research fields. We show that stimulated Raman scattering (SRS) microscopy is an excellent analytical tool to study distributions of different biomolecules in mu...

journal_title：Journal of biomedical optics

authors： Roeffaers MB,Zhang X,Freudiger CW,Saar BG,van Ruijven M,van Dalen G,Xiao C,Xie XS

更新日期：2010-11-01 00:00:00

abstract：:We present in vivo human total retinal blood flow measurements using Doppler Fourier domain optical coherence tomography (OCT). The scan pattern consisted of two concentric circles around the optic nerve head, transecting all retinal branch arteries and veins. The relative positions of each blood vessel in the two OCT...

journal_title：Journal of biomedical optics

authors： Wang Y,Bower BA,Izatt JA,Tan O,Huang D

更新日期：2008-11-01 00:00:00

abstract：:Laser welding has the potential to become an effective method for wound closure and healing without sutures. Closure of skin incisions by laser welding with a combination of two near-infrared lasers (980 and 1064 nm), was performed for the first time in this study. One centimeter long, full-thickness incisions were ma...

journal_title：Journal of biomedical optics

authors： Hu L,Lu Z,Wang B,Cao J,Ma X,Tian Z,Gao Z,Qin L,Wu X,Liu Y,Wang L

更新日期：2011-03-01 00:00:00

abstract：SIGNIFICANCE:Melanoma is a deadly cancer that physicians struggle to diagnose early because they lack the knowledge to differentiate benign from malignant lesions. Deep machine learning approaches to image analysis offer promise but lack the transparency to be widely adopted as stand-alone diagnostics. AIM:We aimed to...

journal_title：Journal of biomedical optics

authors： Gareau DS,Browning J,Correa Da Rosa J,Suarez-Farinas M,Lish S,Zong AM,Firester B,Vrattos C,Renert-Yuval Y,Gamboa M,Vallone MG,Barragán-Estudillo ZF,Tamez-Peña AL,Montoya J,Jesús-Silva MA,Carrera C,Malvehy J,Puig S,Mar

更新日期：2020-11-01 00:00:00

abstract：:We report that the pathologic components present within the atheromatous plaques of ApoE knock-out mice can reflect significant amounts of mid-infrared (mid-IR) light. Furthermore, the reflected light spectra contained the unique signatures of a variety of biologic features including those found in unstable or "vulner...

journal_title：Journal of biomedical optics

authors： Holman HY,Bjornstad KA,Martin MC,McKinney WR,Blakely EA,Blankenberg FG

更新日期：2008-05-01 00:00:00

abstract：:In order to understand the relationship between accommodation and vision quality, a custom-built ultra-long scan depth spectral domain optical coherence tomography (UL-SDOCT) and a Shack-Hartmann wavefront sensor (HSWFS) were combined. The resolution and scan depth of UL-SDOCT are 6 μm and 15.6 mm, respectively, which...

journal_title：Journal of biomedical optics

authors： Shi G,Wang Y,Yuan Y,Wei L,Lv F,Zhang Y

更新日期：2012-12-01 00:00:00

abstract：:Peripheral nerve injury in vivo promotes a regenerative growth in vitro characterized by an improved neurite regrowth. Knowledge of the conditioning injury effects on both morphology and mechanical properties of live sensory neurons could be instrumental to understand the cellular and molecular mechanisms leading to t...

journal_title：Journal of biomedical optics

authors： Benzina O,Szabo V,Lucas O,Saab MB,Cloitre T,Scamps F,Gergely C,Martin M

更新日期：2013-10-01 00:00:00

abstract：:A main field in biomedical optics research is diffuse optical tomography, where intensity variations of the transmitted light traversing through tissue are detected. Mathematical models and reconstruction algorithms based on finite element methods and Monte Carlo simulations describe the light transport inside the tis...

journal_title：Journal of biomedical optics

authors： Baum K,Hartmann R,Bischoff T,Oelerich JO,Finkensieper S,Heverhagen JT

更新日期：2012-12-01 00:00:00

abstract：:Probing tissue with near-infrared radiation (NIR) simultaneously produces remitted fluorescence and Raman scattering (IE) plus Rayleigh∕Mie light scattering (EE) that noninvasively give chemical and physical information about the materials and objects within. We model tissue as a three-phase system: plasma and red blo...

journal_title：Journal of biomedical optics

authors： Chaiken J,Deng B,Goodisman J,Shaheen G,Bussjager RJ

更新日期：2011-09-01 00:00:00

abstract：:The ability to noninvasively image embryonic vascular anatomy in mouse models is an important requirement for characterizing the development of the normal cardiovascular system and malformations in the heart and vascular supply. Photoacoustic imaging, which can provide high resolution non invasive images of the vascul...

journal_title：Journal of biomedical optics

authors： Laufer J,Norris F,Cleary J,Zhang E,Treeby B,Cox B,Johnson P,Scambler P,Lythgoe M,Beard P

更新日期：2012-06-01 00:00:00

abstract：:As the most abundant cell type in the central nervous system, astrocyte has been one of main research topics in neuroscience. Although various tools have been developed, at present, there is no tool that allows noninvasive activation of astrocyte in vivo without genetic or pharmacological perturbation. Here we report ...

journal_title：Journal of biomedical optics

authors： Choi M,Yoon J,Ku T,Choi K,Choi C

更新日期：2011-07-01 00:00:00

abstract：:A model that describes the concentration of photothermal (light-to-heat converters) compounds as a function of depth in a turbid medium is developed. The system consists of a pump laser (808 nm modulated at 400 Hz), which heats a photothermal compound, and a phase sensitive spectral domain optical coherence tomography...

journal_title：Journal of biomedical optics

authors： Guan G,Reif R,Huang Z,Wang RK

更新日期：2011-12-01 00:00:00

abstract：:We present a quantitative analysis of dynamic diffuse optical measurements to obtain oxygen saturation of hemoglobin in volume oscillating compartments. We used a phasor representation of oscillatory hemodynamics at the heart rate and respiration frequency to separate the oscillations of tissue concentrations of oxyhe...

journal_title：Journal of biomedical optics

authors： Kainerstorfer JM,Sassaroli A,Fantini S

更新日期：2016-10-01 00:00:00

abstract：:Intraoperative fluorescence molecular imaging based on targeted fluorescence agents is an emerging approach to improve surgical and endoscopic imaging and guidance. Short exposure times per frame and implementation at video rates are necessary to provide continuous feedback to the physician and avoid motion artifacts....

journal_title：Journal of biomedical optics

authors： Koch M,Glatz J,Ermolayev V,de Vries EG,van Dam GM,Englmeier KH,Ntziachristos V

更新日期：2014-04-01 00:00:00

abstract：:An autofluorescence lifetime wide-field imaging system that can generate contrast in underlying tissue structures of normal and malignant brain tissue samples with video rate acquisition and processing time is presented. Images of the investigated tissues were acquired with high resolution (∼35 μm) using an algorithm ...

journal_title：Journal of biomedical optics

authors： Papour A,Taylor Z,Sherman A,Sanchez D,Lucey G,Liau L,Stafsudd O,Yong W,Grundfest W

更新日期：2013-06-01 00:00:00

abstract：:We present a multimodal optical microscope that incorporates six imaging modalities on one common platform. The imaging modalities include three staring modes, optical quadrature microscopy (OQM), differential interference contrast (DIC) microscopy, and epi-fluorescence microscopy, and three scanning modes, confocal r...

journal_title：Journal of biomedical optics

authors： Warger WC 2nd,Laevsky GS,Townsend DJ,Rajadhyaksha M,DiMarzio CA

更新日期：2007-07-01 00:00:00

abstract：:In the search for improved imaging modalities for detection and diagnosis of breast cancer, a high negative prediction value is also important. Photoacoustic (optoacoustic) imaging is a relatively new technique that has high potential for visualizing breast malignancies, but little is known about the photoacoustic app...

journal_title：Journal of biomedical optics

authors： Heijblom M,Piras D,Maartens E,Huisman EJ,van den Engh FM,Klaase JM,Steenbergen W,Manohar S

更新日期：2013-12-01 00:00:00

abstract：:Mid-IR semiconductor lasers of two wavelength bands, 5.4 and 9.6 microm, are applied to measure aqueous glucose concentration ranging from 0 to 500 mgdL with Intralipid emulsion (0 to 8%) added as a fat simulator. The absorption coefficient micro(a) is found linear with respect to glucose and Intralipid concentrations...

journal_title：Journal of biomedical optics

authors： Guo B,Wang Y,Wang Y,Le HQ

更新日期：2007-03-01 00:00:00

abstract：:Smart toilets could be used to monitor different components of urine in daily life for early detection of lifestyle-related diseases and prompt provision of treatment. For analysis of biological samples such as urine by midinfrared spectroscopy, thin-film samples like liquid cells are needed because of the strong abso...

journal_title：Journal of biomedical optics

authors： Yamamoto N,Kawashima N,Kitazaki T,Mori K,Kang H,Nishiyama A,Wada K,Ishimaru I

更新日期：2018-05-01 00:00:00

abstract：:We assess the properties of contact pressure applied by manually operated fiber-optic probes as a function of the operator, probe contact area, and sample stiffness. First, the mechanical properties of human skin sites with different skin structures, thicknesses, and underlying tissues were studied by in vivo indentat...

journal_title：Journal of biomedical optics

authors： Bregar M,Cugmas B,Naglic P,Hartmann D,Pernuš F,Likar B,Bürmen M

更新日期：2015-01-01 00:00:00

abstract：SIGNIFICANCE:Although the clinical potential for Raman spectroscopy (RS) has been anticipated for decades, it has only recently been used in neurosurgery. Still, few devices have succeeded in making their way into the operating room. With recent technological advancements, however, vibrational sensing is poised to be a...

journal_title：Journal of biomedical optics

authors： DePaoli D,Lemoine É,Ember K,Parent M,Prud'homme M,Cantin L,Petrecca K,Leblond F,Côté DC

更新日期：2020-05-01 00:00:00

abstract：:This paper presents a fiber Bragg grating (FBG)-instrumented prosthetic silicone liner that provides cushioning for the residual limb and can successfully measure interface pressures inside prosthetic sockets of lower-limb amputees in a simple and practical means of sensing. The liner is made of two silicone layers be...

journal_title：Journal of biomedical optics

authors： Al-Fakih E,Arifin N,Pirouzi G,Mahamd Adikan FR,Shasmin HN,Abu Osman NA

更新日期：2017-08-01 00:00:00

abstract：:A primary focus of neurointensive care is monitoring the injured brain to detect harmful events that can impair cerebral blood flow (CBF), resulting in further injury. Since current noninvasive methods used in the clinic can only assess blood flow indirectly, the goal of this research is to develop an optical techniqu...

journal_title：Journal of biomedical optics

authors： Diop M,Tichauer KM,Elliott JT,Migueis M,Lee TY,St Lawrence K

更新日期：2010-09-01 00:00:00

abstract：:Coherent anti-Stokes Raman scattering (CARS) microscopy is used to determine the distribution and concentration of selected compounds in intact human hair. By generating images based on ratiometric CARS contrast, quantitative concentration maps of both water and externally applied d-glycine are produced in the cortex ...

journal_title：Journal of biomedical optics

authors： Zimmerley M,Lin CY,Oertel DC,Marsh JM,Ward JL,Potma EO

更新日期：2009-07-01 00:00:00

abstract：:Our long-term goal was to investigate the potential of incorporating redox imaging technique as a breast cancer (BC) diagnosis component to increase the positive predictive value of suspicious imaging finding and to reduce unnecessary biopsies and overdiagnosis. We previously found that precancer and cancer tissues in...

journal_title：Journal of biomedical optics

authors： Xu HN,Tchou J,Feng M,Zhao H,Li LZ

更新日期：2016-11-01 00:00:00

abstract：:Spatially resolved diffuse reflectance spectroscopy (srDRS) is a well-established technique for noninvasive, in vivo characterization of tissue optical properties toward diagnostic applications. srDRS has a potential for depth-resolved analysis of tissue, which is desired in various clinical situations. However, curre...

journal_title：Journal of biomedical optics

authors： Petitdidier N,Koenig A,Gerbelot R,Grateau H,Gioux S,Jallon P

更新日期：2018-11-01 00:00:00

abstract：:We investigate a technology to create a high temperature heat source on the tip surface of the glass fiber proposed for medical surgery applications. Using 4 to 6 W power level semiconductor lasers at a wavelength of 980 nm, a laser coupled fiber tip was preprocessed to contain a certain amount of titanium oxide powde...

journal_title：Journal of biomedical optics

authors： Fujimoto T,Imai Y,Tei K,Ito S,Kanazawa H,Yamaguchi S

更新日期：2014-01-01 00:00:00

abstract：:An integrated miniature multi-modal microscope (4M device) for microendoscopy was built and tested. Imaging performance is evaluated and imaging results are presented for both fluorescence and reflectance samples. Images of biological samples show successful imaging of both thin layers of fixed cells prepared on a sli...

journal_title：Journal of biomedical optics

authors： Rogers JD,Landau S,Tkaczyk TS,Descour MR,Rahman MS,Richards-Kortum R,Kärkäinen AH,Christenson T

更新日期：2008-09-01 00:00:00

abstract：:We propose an algorithm to compensate for the refractive index error in the optical coherence tomography (OCT) images of multilayer tissues, such as skin. The performance of the proposed method has been evaluated on one- and two-layer solid phantoms, as well as the skin of rat paw. ...

journal_title：Journal of biomedical optics

authors： Turani Z,Fatemizadeh E,Xu Q,Daveluy S,Mehregan D,Nasiri Avanaki MR

更新日期：2018-07-01 00:00:00