Analyzing near-infrared scattering from human skin to monitor changes in hematocrit.

Abstract:

:Probing tissue with near-infrared radiation (NIR) simultaneously produces remitted fluorescence and Raman scattering (IE) plus Rayleigh∕Mie light scattering (EE) that noninvasively give chemical and physical information about the materials and objects within. We model tissue as a three-phase system: plasma and red blood cell (RBC) phases that are mobile and a static tissue phase. In vivo, any volume of tissue naturally experiences spatial and temporal fluctuations of blood plasma and RBC content. Plasma and RBC fractions may be discriminated from each other on the basis of their physical, chemical, and optical properties. Thus, IE and EE from NIR probing yield information about these fractions. Assuming there is no void volume in viable tissue, or that void volume is constant, changes in plasma and RBC volume fractions may be calculated from simultaneous measurements of the two observables, EE and IE. In a previously published analysis we showed the underlying phenomenology but did not provide an algorithm for calculating volume fractions from experimental data. Now, we present a simple analysis that allows monitoring of fluid fraction and hematocrit (Hct) changes by measuring IE and EE, and apply it to some experimental in vivo measurements.

journal_name

J Biomed Opt

authors

Chaiken J,Deng B,Goodisman J,Shaheen G,Bussjager RJ

doi

10.1117/1.3625283

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

097005

issue

9

eissn

1083-3668

issn

1560-2281

journal_volume

16

pub_type

杂志文章
  • Laser-ultraviolet-A-induced ultraweak photon emission in mammalian cells.

    abstract::Photobiological research in the last 30 yr has shown the existence of ultraweak photon emission in biological tissue, which can be detected with sophisticated photomultiplier systems. Although the emission of this ultraweak radiation, often termed biophotons, is extremely low in mammalian cells, it can be efficiently ...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.1899185

    authors: Niggli HJ,Tudisco S,Privitera G,Applegate LA,Scordino A,Musumeci F

    更新日期:2005-03-01 00:00:00

  • Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol.

    abstract::The nEUROPt protocol is one of two new protocols developed within the European project nEUROPt to characterize the performances of time-domain systems for optical imaging of the brain. It was applied in joint measurement campaigns to compare the various instruments and to assess the impact of technical improvements. T...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.19.8.086012

    authors: Wabnitz H,Jelzow A,Mazurenka M,Steinkellner O,Macdonald R,Milej D,Żołek N,Kacprzak M,Sawosz P,Maniewski R,Liebert A,Magazov S,Hebden J,Martelli F,Di Ninni P,Zaccanti G,Torricelli A,Contini D,Re R,Zucchelli L,Spine

    更新日期:2014-08-01 00:00:00

  • Modeling optical behavior of birefringent biological tissues for evaluation of quantitative polarized light microscopy.

    abstract::Quantitative polarized light microscopy (qPLM) is a popular tool for the investigation of birefringent architectures in biological tissues. Collagen, the most abundant protein in mammals, is such a birefringent material. Interpretation of results of qPLM in terms of collagen network architecture and anisotropy is chal...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.3241986

    authors: van Turnhout MC,Kranenbarg S,van Leeuwen JL

    更新日期:2009-09-01 00:00:00

  • Quantitative diffuse reflectance and fluorescence spectroscopy: tool to monitor tumor physiology in vivo.

    abstract::This study demonstrates the use of optical spectroscopy for monitoring tumor oxygenation and metabolism in response to hyperoxic gas breathing. Hemoglobin saturation and redox ratio were quantified for a set of 14 and 9 mice, respectively, measured at baseline and during carbogen breathing (95% O(2), 5% CO(2)). In par...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.3103586

    authors: Palmer GM,Viola RJ,Schroeder T,Yarmolenko PS,Dewhirst MW,Ramanujam N

    更新日期:2009-03-01 00:00:00

  • Analysis of the change in peak corneal temperature during excimer laser ablation in porcine eyes.

    abstract::The objective is to characterize the impact of different ablation parameters on the thermal load during corneal refractive surgery by means of excimer laser ablation on porcine eyes. One hundred eleven ablations were performed in 105 porcine eyes. Each ablation was recorded using infrared thermography and analyzed mai...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.20.7.078001

    authors: Arba Mosquera S,Verma S

    更新日期:2015-07-01 00:00:00

  • Specifying peripheral aberrations in visual science.

    abstract:PURPOSE:Investigations of foveal aberrations assume circular pupils. However, the pupil becomes increasingly elliptical with increase in visual field eccentricity. We address this and other issues concerning peripheral aberration specification. METHODS:One approach uses an elliptical pupil similar to the actual pupil ...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.17.2.025004

    authors: Charman WN,Mathur A,Scott DH,Hartwig A,Atchison DA

    更新日期:2012-02-01 00:00:00

  • Enhanced thulium fiber laser lithotripsy using micro-pulse train modulation.

    abstract::The thulium fiber laser (TFL) is currently being studied as an alternative to the conventional holmium:YAG (Ho:YAG) laser for lithotripsy. The diode-pumped TFL may be electronically modulated to operate with variable parameters (e.g., pulse rate, pulse duration, and duty cycle) for studying the influence of pulse trai...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.17.2.028002

    authors: Blackmon RL,Irby PB,Fried NM

    更新日期:2012-02-01 00:00:00

  • Comparison of time-resolved and continuous-wave near-infrared techniques for measuring cerebral blood flow in piglets.

    abstract::A primary focus of neurointensive care is monitoring the injured brain to detect harmful events that can impair cerebral blood flow (CBF), resulting in further injury. Since current noninvasive methods used in the clinic can only assess blood flow indirectly, the goal of this research is to develop an optical techniqu...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.3488626

    authors: Diop M,Tichauer KM,Elliott JT,Migueis M,Lee TY,St Lawrence K

    更新日期:2010-09-01 00:00:00

  • Optical properties of mouse brain tissue after optical clearing with FocusClear™.

    abstract::Fluorescence microscopy is commonly used to investigate disease progression in biological tissues. Biological tissues, however, are strongly scattering in the visible wavelengths, limiting the application of fluorescence microscopy to superficial (<200µm) regions. Optical clearing, which involves incubation of the tis...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.20.9.095010

    authors: Moy AJ,Capulong BV,Saager RB,Wiersma MP,Lo PC,Durkin AJ,Choi B

    更新日期:2015-01-01 00:00:00

  • High-speed 1310 nm-band spectral domain optical coherence tomography at 184,000 lines per second.

    abstract::We propose a useful method to boost the imaging speed for spectral domain optical coherence tomography (SDOCT) by multiplying a number of high-speed spectrometers used in the system with selective precise control of data-recording and data-reading phases for spectral cameras employed in each spectrometer. To demonstra...

    journal_title:Journal of biomedical optics

    pub_type: 信件

    doi:10.1117/1.3592492

    authors: An L,Guan G,Wang RK

    更新日期:2011-06-01 00:00:00

  • Structured light scatteroscopy.

    abstract::A new imaging approach, structured light scatteroscopy (SLS), is demonstrated, which offers rapid wide-field imaging of microscopic morphological variations in bulk tissue surfaces. Elastic scattering of light offers exquisite sensitivity to ultrastructural changes at multiple size scales ranging from nanometers to mi...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.19.7.070504

    authors: Krishnaswamy V,Elliott JT,McClatchy DM 3rd,Barth RJ Jr,Wells WA,Pogue BW,Paulsen KD

    更新日期:2014-01-01 00:00:00

  • Ultrasonic standing wave preparation of a liquid cell for glucose measurements in urine by midinfrared spectroscopy and potential application to smart toilets.

    abstract::Smart toilets could be used to monitor different components of urine in daily life for early detection of lifestyle-related diseases and prompt provision of treatment. For analysis of biological samples such as urine by midinfrared spectroscopy, thin-film samples like liquid cells are needed because of the strong abso...

    journal_title:Journal of biomedical optics

    pub_type: 信件

    doi:10.1117/1.JBO.23.5.050503

    authors: Yamamoto N,Kawashima N,Kitazaki T,Mori K,Kang H,Nishiyama A,Wada K,Ishimaru I

    更新日期:2018-05-01 00:00:00

  • Caries detection and quantification around stained pits and fissures in occlusal tooth surfaces with fluorescence.

    abstract::Occlusal discoloration due to staining frequently occurs on the pits and fissures of teeth. Noncariogenic discoloration (non-CD) refers to the attachment of staining chromogens to sound surfaces, whereas cariogenic discoloration (CD) represents the discoloration of porous structures due to bacterial metabolites and mi...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.23.9.091402

    authors: Lee HS,Kim SK,Park SW,de Josselin de Jong E,Kwon HK,Jeong SH,Kim BI

    更新日期:2018-03-01 00:00:00

  • Holographic analysis on deformation and restoration of malaria-infected red blood cells by antimalarial drug.

    abstract::Malaria parasites induce morphological, biochemical, and mechanical changes in red blood cells (RBCs). Mechanical variations are closely related to the deformability of individual RBCs. The deformation of various RBCs, including healthy and malaria-infected RBCs (iRBCs), can be directly observed through quantitative p...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.20.11.115003

    authors: Byeon H,Ha YR,Lee SJ

    更新日期:2015-11-01 00:00:00

  • Real-time brightfield, darkfield, and phase contrast imaging in a light-emitting diode array microscope.

    abstract::We demonstrate a single-camera imaging system that can simultaneously acquire brightfield, darkfield, and phase contrast images in real time. Our method uses computational illumination via a programmable light-emitting diode (LED) array at the source plane, providing flexible patterning of illumination angles. Brightf...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.19.10.106002

    authors: Liu Z,Tian L,Liu S,Waller L

    更新日期:2014-01-01 00:00:00

  • Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography.

    abstract::We have developed a novel parallel-plate diffuse optical tomography (DOT) system for three-dimensional in vivo imaging of human breast tumor based on large optical data sets. Images of oxy-, deoxy-, and total hemoglobin concentration as well as blood oxygen saturation and tissue scattering were reconstructed. Tumor ma...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.3103325

    authors: Choe R,Konecky SD,Corlu A,Lee K,Durduran T,Busch DR,Pathak S,Czerniecki BJ,Tchou J,Fraker DL,Demichele A,Chance B,Arridge SR,Schweiger M,Culver JP,Schnall MD,Putt ME,Rosen MA,Yodh AG

    更新日期:2009-03-01 00:00:00

  • Adaptive wide-field optical tomography.

    abstract::We describe a wide-field optical tomography technique, which allows the measurement-guided optimization of illumination patterns for enhanced reconstruction performances. The iterative optimization of the excitation pattern aims at reducing the dynamic range in photons transmitted through biological tissue. It increas...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.18.3.036006

    authors: Venugopal V,Intes X

    更新日期:2013-03-01 00:00:00

  • Optical delivery of liposome encapsulated chemical stimuli to neuronal cells.

    abstract::Spatially confined and precise time delivery of neuroactive molecules is an important issue in neurophysiology. In this work we developed a technique for delivering chemical stimuli to cultured neurons consisting in encapsulating the molecules of interest in liposomes. These vectors were then loaded in reservoirs cons...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.3616133

    authors: Pinato G,Raffaelli T,D'Este E,Tavano F,Cojoc D

    更新日期:2011-09-01 00:00:00

  • High temperature heat source generation with quasi-continuous wave semiconductor lasers at power levels of 6 W for medical use.

    abstract::We investigate a technology to create a high temperature heat source on the tip surface of the glass fiber proposed for medical surgery applications. Using 4 to 6 W power level semiconductor lasers at a wavelength of 980 nm, a laser coupled fiber tip was preprocessed to contain a certain amount of titanium oxide powde...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.19.10.101502

    authors: Fujimoto T,Imai Y,Tei K,Ito S,Kanazawa H,Yamaguchi S

    更新日期:2014-01-01 00:00:00

  • Quantitative photoacoustic imaging: correcting for heterogeneous light fluence distributions using diffuse optical tomography.

    abstract::The specificity of molecular and functional photoacoustic (PA) images depends on the accuracy of the photoacoustic absorption spectroscopy. The PA signal is proportional to the product of the optical absorption coefficient and local light fluence; quantitative PA measurements of the optical absorption coefficient ther...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.3626212

    authors: Bauer AQ,Nothdurft RE,Erpelding TN,Wang LV,Culver JP

    更新日期:2011-09-01 00:00:00

  • Infrared laser thermal fusion of blood vessels: preliminary ex vivo tissue studies.

    abstract::Suture ligation of blood vessels during surgery can be time-consuming and skill-intensive. Energy-based, electrosurgical, and ultrasonic devices have recently replaced the use of sutures and mechanical clips (which leave foreign objects in the body) for many surgical procedures, providing rapid hemostasis during surge...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.18.5.058001

    authors: Cilip CM,Rosenbury SB,Giglio N,Hutchens TC,Schweinsberger GR,Kerr D,Latimer C,Nau WH,Fried NM

    更新日期:2013-05-01 00:00:00

  • Miniature endoscopic optical coherence tomography probe employing a two-axis microelectromechanical scanning mirror with through-silicon vias.

    abstract::We present the design and experimental results of a new MEMS-based endoscopic optical coherence tomography (OCT) probe. The uniqueness of this miniature OCT imaging probe is a two-axis MEMS mirror with through-silicon vias (TSVs) for interconnecting. The TSV interconnection enables ultracompact probe design, successfu...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.3533323

    authors: Liu L,Wu L,Sun J,Lin E,Xie H

    更新日期:2011-02-01 00:00:00

  • Combined ultrasound and photoacoustic imaging to detect and stage deep vein thrombosis: phantom and ex vivo studies.

    abstract::Treatment of deep venous thrombosis (DVT)--a primary cause of potentially fatal pulmonary embolism (PE)--depends on the age of the thrombus. The existing clinical imaging methods are capable of visualizing a thrombus but cannot determine the age of the blood clot. Therefore, there is a need for an imaging technique to...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.2992175

    authors: Karpiouk AB,Aglyamov SR,Mallidi S,Shah J,Scott WG,Rubin JM,Emelianov SY

    更新日期:2008-09-01 00:00:00

  • Quantitative imaging of protein-protein interactions by multiphoton fluorescence lifetime imaging microscopy using a streak camera.

    abstract::Fluorescence lifetime imaging microscopy (FLIM) using multiphoton excitation techniques is now finding an important place in quantitative imaging of protein-protein interactions and intracellular physiology. Recent developments in multiphoton FLIM methods are reviewed and a novel multiphoton FLIM system using a streak...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.1577574

    authors: Krishnan RV,Masuda A,Centonze VE,Herman B

    更新日期:2003-07-01 00:00:00

  • Needle-based fluorescence endomicroscopy via structured illumination with a plastic, achromatic objective.

    abstract::In order to diagnose cancer, a sample must be removed, prepared, and examined under a microscope, which is expensive, invasive, and time consuming. Fiber optic fluorescence endomicroscopy, where an image guide is used to obtain high-resolution images of tissue in vivo, has shown promise as an alternative to convention...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.18.9.096003

    authors: Kyrish M,Dobbs J,Jain S,Wang X,Yu D,Richards-Kortum R,Tkaczyk TS

    更新日期:2013-09-01 00:00:00

  • Change of tumor vascular reactivity during tumor growth and postchemotherapy observed by near-infrared spectroscopy.

    abstract::Breast cancer is one of the most common cancers in females. To monitor chemotherapeutic efficacy for breast cancer, medical imaging systems such as x-ray mammography, computed tomography, magnetic resonance imaging, and ultrasound imaging have been used. Currently, it can take up to 3 to 6 weeks to see the tumor respo...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.22.12.121603

    authors: Lee S,Jeong H,Seong M,Kim JG

    更新日期:2017-12-01 00:00:00

  • Nondestructive imaging of fiber structure in articular cartilage using optical polarization tractography.

    abstract::Collagen fiber orientation plays an important role in determining the structure and function of the articular cartilage. However, there is currently a lack of nondestructive means to image the fiber orientation from the cartilage surface. The purpose of this study is to investigate whether the newly developed optical ...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.21.11.116004

    authors: Yao X,Wang Y,Ravanfar M,Pfeiffer FM,Duan D,Yao G

    更新日期:2016-11-01 00:00:00

  • Modulation transfer function measurement of scanning reflectance microscopes.

    abstract::Real-time medical imaging systems such as reflectance confocal microscopes and optical coherence microscopes are being tested in multiple-patient and multiple-center clinical trials. The modulation transfer function (MTF) of these systems at any given time influences the image information content and can affect the in...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.2779352

    authors: Wang Z,Glazowski CE,Zavislan JM

    更新日期:2007-09-01 00:00:00

  • Lamellar keratoplasty using position-guided surgical needle and M-mode optical coherence tomography.

    abstract::Deep anterior lamellar keratoplasty (DALK) is an emerging surgical technique for the restoration of corneal clarity and vision acuity. The big-bubble technique in DALK surgery is the most essential procedure that includes the air injection through a thin syringe needle to separate the dysfunctional region of the corne...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.22.12.125005

    authors: Shin S,Bae JK,Ahn Y,Kim H,Choi G,Yoo YS,Joo CK,Moon S,Jung W

    更新日期:2017-12-01 00:00:00

  • Measuring contraction propagation and localizing pacemaker cells using high speed video microscopy.

    abstract::Previous studies have shown the ability of many lymphatic vessels to contract phasically to pump lymph. Every lymphangion can act like a heart with pacemaker sites that initiate the phasic contractions. The contractile wave propagates along the vessel to synchronize the contraction. However, determining the location o...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.3544512

    authors: Akl TJ,Nepiyushchikh ZV,Gashev AA,Zawieja DC,Cot GL

    更新日期:2011-02-01 00:00:00