Deep learning-level melanoma detection by interpretable machine learning and imaging biomarker cues.

abstract：:We investigate the relationship between the laser beam at the retina (spot size) and the extent of retinal injury from single ultrashort laser pulses. From previous studies it is believed that the retinal effect of single 3-ps laser pulses should vary in extent and location, depending on the occurrence of laser-induce...

journal_title：Journal of biomedical optics

authors： Roach WP,Cain CP,Narayan DG,Noojin GD,Boppart SA,Birngruber R,Fujimoto JG,Toth CA

更新日期：2004-11-01 00:00:00

abstract：:Computational modeling of arterial mechanics continues to progress, even to the point of allowing the study of complex regions such as the aortic arch. Nevertheless, most prior studies assign homogeneous and isotropic material properties and constant wall thickness even when implementing patient-specific luminal geome...

journal_title：Journal of biomedical optics

authors： Genovese K,Humphrey JD

更新日期：2015-04-01 00:00:00

abstract：:The effect of sampling region size and tissue heterogeneity is examined using fluorescence histogram assessment in a rat prostate tumor model with benzoporphyrin derivative fluorophore. Spatial heterogeneity in the fluorescence signal occurs on both macroscopic and microscopic scales. The periphery of the tumor is mor...

journal_title：Journal of biomedical optics

authors： Pogue BW,Chen B,Zhou X,Hoopes PJ

更新日期：2005-07-01 00:00:00

abstract：:Blood smear analysis has remained a crucial diagnostic tool for pathologists despite the advent of automatic analyzers such as flow cytometers and impedance counters. Though these current methods have proven to be indispensible tools for physicians and researchers alike, they provide limited information on the detaile...

journal_title：Journal of biomedical optics

authors： Mir M,Ding H,Wang Z,Reedy J,Tangella K,Popescu G

更新日期：2010-03-01 00:00:00

abstract：:Amblyopia is a form of visual impairment caused by ocular misalignment (strabismus) or defocus in an otherwise healthy eye. If detected early, the condition can be fully treated, yet over half of all children with amblyopia under age 5 escape detection. We developed a Pediatric Vision Screener (PVS) to detect amblyopi...

journal_title：Journal of biomedical optics

authors： Nassif DS,Piskun NV,Gramatikov BI,Guyton DL,Hunter DG

更新日期：2004-11-01 00:00:00

abstract：:In a previous study, we investigated physical methods to reduce whole-body, diet-related autofluorescence interference in several mouse strains through changes in animal diet. Measurements of mice with an in vivo multispectral imaging system over a 21-day period allowed for the quantification of concentration changes ...

journal_title：Journal of biomedical optics

authors： Bouchard MB,MacLaurin SA,Dwyer PJ,Mansfield J,Levenson R,Krucker T

更新日期：2007-09-01 00:00:00

abstract：:Toward developing a new method for restoring tissue viscoelasticity in scarred vocal folds, we previously proposed a method to localize biomaterials within subepithelial voids ablated using ultrafast laser pulses. The clinical implementation of this method necessitates the quantification of the laser parameters for ab...

journal_title：Journal of biomedical optics

authors： Yildirim M,Ferhanoglu O,Kobler J,Zeitels SM,Ben-Yakar A

更新日期：2013-11-01 00:00:00

abstract：:This study investigates the correlation of tumor blood oxygenation and tumor pO(2) with respect to carbogen inhalation. After having refined and validated the algorithms for calculating hemoglobin concentrations, we used near-infrared spectroscopy (NIRS) to measure changes of oxygenated hemoglobin concentration (delta...

journal_title：Journal of biomedical optics

authors： Kim JG,Zhao D,Song Y,Constantinescu A,Mason RP,Liu H

更新日期：2003-01-01 00:00:00

abstract：:Intravascular near-infrared fluorescence (NIRF) imaging offers a new approach for characterizing atherosclerotic plaque, but random catheter positioning within the vessel lumen results in variable light attenuation and can yield inaccurate measurements. We hypothesized that NIRF measurements could be corrected for var...

journal_title：Journal of biomedical optics

authors： Dixon AJ,Hossack JA

更新日期：2013-05-01 00:00:00

abstract：:This paper presents an effective two-step scheme for automatic object detection in computed radiography (CR) images. First, various structure elements of the morphological filters, designed by incorporating available morphological features of the objects of interest including their sizes and rough shape descriptions, ...

journal_title：Journal of biomedical optics

authors： Xuan J,Adali T,Wang Y,Siegel E

更新日期：2000-10-01 00:00:00

abstract：:We present functional imaging of the concentration of a photodynamic therapy (PDT)-related dye in scattering tissue phantoms based on spatially resolved measurements of optical properties through spectroscopic optical coherence tomography (OCT). Expressions for the OCT signal are developed, enabling estimation of dept...

journal_title：Journal of biomedical optics

authors： Støren T,Røyset A,Svaasand LO,Lindmo T

更新日期：2005-03-01 00:00:00

abstract：:Photodynamic therapy (PDT) is an alternative to radical surgical resection for T1a or nonresectable carcinomas of the gastroesophageal junction. Besides the concentration of the photosensitizer, the light distribution in tissue is responsible for tumor destruction. For this reason, knowledge about the behavior of ligh...

journal_title：Journal of biomedical optics

authors： Holmer C,Lehmann KS,Wanken J,Reissfelder C,Roggan A,Mueller G,Buhr HJ,Ritz JP

更新日期：2007-01-01 00:00:00

abstract：:Optoacoustic (photoacoustic) diagnostic modality is a technique that combines high optical contrast and ultrasound spatial resolution. We proposed using the optoacoustic technique for a number of applications, including cancer detection, monitoring of thermotherapy (hyperthermia, coagulation, and freezing), monitoring...

journal_title：Journal of biomedical optics

authors： Esenaliev RO

更新日期：2017-09-01 00:00:00

abstract：:Ex vivo human skin has been used extensively for cosmeceutical and drug delivery studies, transplantable skin allografts, or skin flaps. However, it has a half-life of a few days due to ischemic necrosis. Traditional methods of assessing viability can be time-consuming and provide limited metabolic information. Using ...

journal_title：Journal of biomedical optics

authors： Sanchez WY,Prow TW,Sanchez WH,Grice JE,Roberts MS

更新日期：2010-07-01 00:00:00

abstract：SIGNIFICANCE:The retina is critical for vision, and several diseases may alter its biomechanical properties. However, assessing the biomechanical properties of the retina nondestructively is a challenge due to its fragile nature and location within the eye globe. Advancements in Brillouin spectroscopy have provided the...

journal_title：Journal of biomedical optics

authors： Ambekar YS,Singh M,Scarcelli G,Rueda EM,Hall BM,Poché RA,Larin KV

更新日期：2020-09-01 00:00:00

abstract：:We present Monte Carlo modeling studies to provide a quantitative understanding of contrast observed in spatially resolved reflectance spectra of normal and highly dysplastic cervical tissue. Simulations have been carried out to analyze the sensitivity of spectral measurements to a range of changes in epithelial and s...

journal_title：Journal of biomedical optics

authors： Arifler D,MacAulay C,Follen M,Richards-Kortum R

更新日期：2006-11-01 00:00:00

abstract：:Near-infrared diffuse optical tomography (DOT), one of the most sophisticated optical imaging techniques for observations through biological tissue, allows 3-D quantitative imaging of optical properties, which include functional and anatomical information. With DOT, it is expected to be possible to overcome the limita...

journal_title：Journal of biomedical optics

authors： Hoshi Y,Yamada Y

更新日期：2016-09-01 00:00:00

abstract：:We describe the use of a biochip based on complementary metal oxide semiconductor (CMOS) technology for detection of specific genetic sequences using molecular beacons (MB) immobilized on solid surfaces as probes. The applicability of this miniature detection system for screening for the BRCA1 gene is evaluated using ...

journal_title：Journal of biomedical optics

authors： Culha M,Stokes DL,Griffin GD,Vo-Dinh T

更新日期：2004-05-01 00:00:00

abstract：:In part I of the study, two attachment systems [O-ring; bar-clip (BC)] were used, and the system with three individualized O-rings provided the lowest stress on the implants and the support tissues. Therefore, the aim of this study was to assess the stress distribution, through the photoelastic method, on implant-reta...

journal_title：Journal of biomedical optics

authors： Pesqueira AA,Goiato MC,da Silva EV,Haddad MF,Moreno A,Zahoui A,dos Santos DM

更新日期：2014-06-01 00:00:00

abstract：:The optical activity of glucose molecules is important for diagnosing and monitoring blood glucose of diabetes. In order to accurately detect the diabetes at an early stage, there is an urgent need to develop innovative detection methods. By use of Mueller matrix decomposition (MMD), we have studied the optical activi...

journal_title：Journal of biomedical optics

authors： Sun P,Ma Y,Liu W,Yang Q,Jia Q

更新日期：2014-04-01 00:00:00

abstract：:The thulium fiber laser (TFL) is currently being studied as an alternative to the conventional holmium:YAG (Ho:YAG) laser for lithotripsy. The diode-pumped TFL may be electronically modulated to operate with variable parameters (e.g., pulse rate, pulse duration, and duty cycle) for studying the influence of pulse trai...

journal_title：Journal of biomedical optics

authors： Blackmon RL,Irby PB,Fried NM

更新日期：2012-02-01 00:00:00

abstract：:Cortical spreading depression (CSD) is a pronounced depolarization of neurons and glia that spreads slowly across the cortex followed by a period of depressed electrophysiological activity. The vascular changes associated with CSD are a large transient increase in blood flow followed by a prolonged decrease lasting gr...

journal_title：Journal of biomedical optics

authors： Guiou M,Sheth S,Nemoto M,Walker M,Pouratian N,Ba A,Toga AW

更新日期：2005-01-01 00:00:00

abstract：:An algorithm was developed to obtain depth-resolved local optical axis in birefringent samples by using conventional polarization-sensitive optical coherence tomography (PSOCT) that uses a single circularly polarized incident light. The round-trip sample Jones matrices were first constructed from the cumulative PSOCT ...

journal_title：Journal of biomedical optics

authors： Fan C,Yao G

更新日期：2012-11-01 00:00:00

abstract：:Optical measurements of metabolism are ideally acquired in vivo; however, intravital measurements are often impractical. Accurate ex vivo assessments would greatly broaden the applicability of optical measurements of metabolism. We investigate the use of live tissue culture experiments to serve as a surrogate for in v...

journal_title：Journal of biomedical optics

authors： Walsh AJ,Poole KM,Duvall CL,Skala MC

更新日期：2012-11-01 00:00:00

abstract：:The ability to quantitatively determine tissue fluorescence is of interest for the purpose of better understanding the details of photodynamic therapy of skin cancer. In particular, we are interested in quantifying protoporphyrin IX (PpIX) in vivo. We present a method of correcting fluorescence for effects of native t...

journal_title：Journal of biomedical optics

authors： Saager RB,Cuccia DJ,Saggese S,Kelly KM,Durkin AJ

更新日期：2011-12-01 00:00:00

abstract：:A classifier capable of ranking structural alterations of the cytoskeleton is developed. Images of cytoskeletal microtubules obtained from the epifluorescence microscopy of primary culture rat hepatocytes are analyzed. Morphological descriptors are extracted by contour and mass fractal analysis, direct methods, and sp...

journal_title：Journal of biomedical optics

authors： Crosta GF,Urani C,Fumarola L

更新日期：2006-03-01 00:00:00

abstract：:We propose an offset-sparsity decomposition method for the enhancement of a color microscopic image of a stained specimen. The method decomposes vectorized spectral images into offset terms and sparse terms. A sparse term represents an enhanced image, and an offset term represents a "shadow." The related optimization ...

journal_title：Journal of biomedical optics

authors： Kopriva I,Hadžija MP,Hadžija M,Aralica G

更新日期：2015-07-01 00:00:00

abstract：:In order to evaluate the impact of anatomy on the spectral properties of oral tissue, we used reflectance and fluorescence spectroscopy to characterize nine different anatomic sites. All spectra were collected in vivo from healthy oral mucosa. We analyzed 710 spectra collected from the oral cavity of 79 healthy volunt...

journal_title：Journal of biomedical optics

authors： McGee S,Mirkovic J,Mardirossian V,Elackattu A,Yu CC,Kabani S,Gallagher G,Pistey R,Galindo L,Badizadegan K,Wang Z,Dasari R,Feld MS,Grillone G

更新日期：2008-11-01 00:00:00

abstract：:Lumpectomy coupled with radiation therapy and/or chemotherapy is commonly used to treat breast cancer patients. We are developing an enhanced thermal IR imaging technique that has the potential to provide real-time imaging to guide tissue excision during a lumpectomy by delineating tumor margins. This enhanced thermal...

journal_title：Journal of biomedical optics

authors： Case JR,Young MA,Dréau D,Trammell SR

更新日期：2015-11-01 00:00:00

abstract：:Reduction of optical scattering in turbid biological tissues using nonreactive chemical agents has potential applications for light-based diagnostics and therapeutics. Optical clearing effects by exogenous chemical agents, in particular sugars and sugar alcohols, have been found to be temporary with tissue rehydration...

journal_title：Journal of biomedical optics

authors： Yeh AT,Hirshburg J

更新日期：2006-01-01 00:00:00