Abstract:
:We report a photonic approach for selective inactivation of viruses with a near-infrared subpicosecond laser. We demonstrate that this method can selectively inactivate viral particles ranging from nonpathogenic viruses such as the M13 bacteriophage and the tobacco mosaic virus to pathogenic viruses such as the human papillomavirus and the human immunodeficiency virus (HIV). At the same time, sensitive materials such as human Jurkat T cells, human red blood cells, and mouse dendritic cells remain unharmed. The laser technology targets the global mechanical properties of the viral protein shell, making it relatively insensitive to the local genetic mutation in the target viruses. As a result, the approach can inactivate both the wild and mutated strains of viruses. This intriguing advantage is particularly important in the treatment of diseases involving rapidly mutating viral species such as HIV. Our photonic approach could be used for the disinfection of viral pathogens in blood products and for the treatment of blood-borne viral diseases in the clinic.
journal_name
J Biomed Optjournal_title
Journal of biomedical opticsauthors
Tsen KT,Tsen SW,Fu Q,Lindsay SM,Kibler K,Jacobs B,Wu TC,Karanam B,Jagu S,Roden RB,Hung CF,Sankey OF,Ramakrishna B,Kiang JGdoi
10.1117/1.3275477subject
Has Abstractpub_date
2009-11-01 00:00:00pages
064042issue
6eissn
1083-3668issn
1560-2281journal_volume
14pub_type
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journal_title:Journal of biomedical optics
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