Abstract:
:We present the application of a microfluidic optical cell stretcher to measure the elasticity of malaria-infected red blood cells. The measurements confirm an increase in host cell rigidity during the maturation of the parasite Plasmodium falciparum. The device combines the selectivity and sensitivity of single-cell elasticity measurements with a throughput that is higher than conventional single-cell techniques. The method has potential to detect early stages of infection with excellent sensitivity and high speed.
journal_name
J Biomed Optjournal_title
Journal of biomedical opticsauthors
Mauritz JM,Tiffert T,Seear R,Lautenschläger F,Esposito A,Lew VL,Guck J,Kaminski CFdoi
10.1117/1.3458919subject
Has Abstractpub_date
2010-05-01 00:00:00pages
030517issue
3eissn
1083-3668issn
1560-2281journal_volume
15pub_type
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journal_title:Journal of biomedical optics
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abstract::The capabilities of micro-Raman spectroscopy for differentiating normal and malignant nasopharyngeal tissues were evaluated. Raman scattering signals were acquired from 22 normal and 52 malignant nasopharyngeal tissue samples. Distinctive spectral differences in Raman spectra between normal and malignant nasopharyngea...
journal_title:Journal of biomedical optics
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abstract::Fluorescence microscopy is commonly used to investigate disease progression in biological tissues. Biological tissues, however, are strongly scattering in the visible wavelengths, limiting the application of fluorescence microscopy to superficial (<200µm) regions. Optical clearing, which involves incubation of the tis...
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journal_title:Journal of biomedical optics
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更新日期:2007-09-01 00:00:00
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journal_title:Journal of biomedical optics
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journal_title:Journal of biomedical optics
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