Quantitative tool for rapid disease mapping using optical coherence tomography images of azoxymethane-treated mouse colon.

abstract：:In the present study, we evaluated the applicability of ex vivo photoacoustic imaging (PAI) on small animal organs. We used photoacoustic tomography (PAT) to visualize infarcted areas within murine hearts and compared these data to other imaging techniques [magnetic resonance imaging (MRI), micro-computed tomography] ...

journal_title：Journal of biomedical optics

authors： Holotta M,Grossauer H,Kremser C,Torbica P,Völkl J,Degenhart G,Esterhammer R,Nuster R,Paltauf G,Jaschke W

更新日期：2011-03-01 00:00:00

abstract：:Discrete form sensitivity functions are derived for a number of measurement types employed in autocorrelation-based ultrasound-modulated optical tomography. The Jacobian for a particular problem is constructed from the set of such sensitivity functions arising from a raster scan of a focused ultrasound field through a...

journal_title：Journal of biomedical optics

authors： Powell S,Leung TS

更新日期：2013-12-01 00:00:00

abstract：:Cancer-related enzyme activity can be detected noninvasively using activatable fluorescent molecular probes. In contrast to "always-on" fluorescent molecular probes, activatable probes are relatively nonfluorescent at the time of administration due to intramolecular fluorescence resonance energy transfer (FRET). Enzym...

journal_title：Journal of biomedical optics

authors： Solomon M,Guo K,Sudlow GP,Berezin MY,Edwards WB,Achilefu S,Akers WJ

更新日期：2011-06-01 00:00:00

abstract：:Diffuse near-infrared tomography of tissue reveals scattering changes that originate from the submicroscopic features of the tissue; yet the existing tools to use this information to predict which features contribute to the scattering spectrum are limited by the lack of direct data quantifying the particle sizes. Brea...

journal_title：Journal of biomedical optics

authors： Bartek M,Wang X,Wells W,Paulsen KD,Pogue BW

更新日期：2006-11-01 00:00:00

abstract：:This work reviews our research during the past several years on time-resolved (TR) near-infrared diffuse optical tomography (DOT). Following an introduction of the measuring modes, two proposed schemes of image reconstruction in TR-DOT are described: one utilizes the full TR data, and the other, referred to as the mod...

journal_title：Journal of biomedical optics

authors： Zhao H,Gao F,Tanikawa Y,Yamada Y

更新日期：2007-11-01 00:00:00

abstract：:Since hyperglycaemia changes the erythrocyte cell membrane fluidity and impairs cell deformity, our goal was to characterize hemoglobin and red blood cell (RBC) light refractive property changes in diabetic patients. Microscopic investigation was carried out on intact and fixed RBCs. To determine the refractive index ...

journal_title：Journal of biomedical optics

authors： Mazarevica G,Freivalds T,Jurka A

更新日期：2002-04-01 00:00:00

abstract：:Fluorescence molecular tomography (FMT) is an important in vivo imaging modality to visualize physiological and pathological processes in small animals. However, FMT reconstruction is ill-posed and ill-conditioned due to strong optical scattering in deep tissues, which results in poor spatial resolution. It is well kn...

journal_title：Journal of biomedical optics

authors： Baikejiang R,Zhao Y,Fite BZ,Ferrara KW,Li C

更新日期：2017-05-01 00:00:00

abstract：:A simple empirical method is presented to determine the scattering coefficient mu' s from backscattered polarized images of turbid media. It uses the ratio, pixel by pixel, of two images that are the second and the first backscattered Stokes parameter images Q and I, respectively. Taking this image ratio, then integra...

journal_title：Journal of biomedical optics

authors： Jaillon F,Saint-Jalmes H

更新日期：2005-05-01 00:00:00

abstract：:We demonstrate that using time-resolved two-photon excitation endogenous fluorescence microscopy, the cadmium (Cd)-induced cellular toxic level can be assessed by the free-to protein-bound reduced nicotinamide adenine dinucleotide (free/bound NADH) ratio in a living cell. NADH fluorescence excited at 730 nm is capture...

journal_title：Journal of biomedical optics

authors： Li D,Yang MS,Lin T,Zheng W,Qu JY

更新日期：2009-09-01 00:00:00

abstract：:Optical coherence microscopy (OCM) combines confocal microscopy and optical coherence tomography (OCT) to improve imaging depth and contrast, enabling cellular imaging in human tissues. We aim to investigate OCM for ex vivo imaging of upper and lower gastrointestinal tract tissues, to establish correlations between OC...

journal_title：Journal of biomedical optics

authors： Aguirre AD,Chen Y,Bryan B,Mashimo H,Huang Q,Connolly JL,Fujimoto JG

更新日期：2010-01-01 00:00:00

abstract：:Probing tissue with near-infrared radiation (NIR) simultaneously produces remitted fluorescence and Raman scattering (IE) plus Rayleigh∕Mie light scattering (EE) that noninvasively give chemical and physical information about the materials and objects within. We model tissue as a three-phase system: plasma and red blo...

journal_title：Journal of biomedical optics

authors： Chaiken J,Deng B,Goodisman J,Shaheen G,Bussjager RJ

更新日期：2011-09-01 00:00:00

abstract：:To evaluate retinal perfusion in the human eye, a dual-wavelength confocal scanning laser ophthalmoscope (cSLO) was developed that provides spectral imaging of the fundus using a combination of red (670 nm) and near-infrared (810 nm) wavelengths. The image of the ocular fundus was analyzed to find out if quantitative ...

journal_title：Journal of biomedical optics

authors： Rasta SH,Manivannan A,Sharp PF

更新日期：2012-11-01 00:00:00

abstract：:A need exists for the continued development of diagnostic tools and methods capable of distinguishing and characterizing slight differences in the optical properties of tissues. We present a method to estimate the scattering coefficient contribution as a function of particle size in complex mixtures of polystyrene sph...

journal_title：Journal of biomedical optics

authors： Cameron BD,Li Y,Nezhuvingal A

更新日期：2006-09-01 00:00:00

abstract：:Common methods to characterize treatment efficacy based on morphological imaging may misrepresent outcomes and exclude effective therapies. Using a three-dimensional model of ovarian cancer, two functional treatment response metrics are used to evaluate photodynamic therapy (PDT) efficacy: total volume, calculated fro...

journal_title：Journal of biomedical optics

authors： Anbil S,Rizvi I,Celli JP,Alagic N,Pogue BW,Hasan T

更新日期：2013-09-01 00:00:00

abstract：:Traditional phase-resolved Doppler optical coherence tomography (DOCT) has been reported to have potential for characterizing local fluid flow within a microporous scaffold. In this work, we apply Doppler optical microangiography (DOMAG), a new imaging technique developed by combining optical microangiography (OMAG) w...

journal_title：Journal of biomedical optics

authors： Jia Y,An L,Wang RK

更新日期：2009-09-01 00:00:00

abstract：:Radiotherapy is one of the main methods to treat cancer. However, due to the propagation pattern of high-energy photons in tissue and their inability to discriminate between healthy and malignant tissues, healthy tissues may also be damaged, causing undesired side effects. A possible method for internal electron thera...

journal_title：Journal of biomedical optics

authors： Tepper M,Barkai U,Gannot I

更新日期：2015-05-01 00:00:00

abstract：:The formation of kidney stones is a common and highly studied disease, which causes intense pain and presents a high recidivism. In order to find the causes of this problem, the characterization of the main compounds is of great importance. In this sense, the analysis of the composition and structure of the stone can ...

journal_title：Journal of biomedical optics

authors： Blanco F,López-Mesas M,Serranti S,Bonifazi G,Havel J,Valiente M

更新日期：2012-07-01 00:00:00

abstract：:Subsurface fluorescence molecular tomography (FMT) has promising potential for noninvasive characterization of molecular and cellular activities in small animals by tomographic means in reflectance geometry. In this work, subsurface FMT is employed to monitor the therapeutic response of cisplatin in tumor-bearing mice...

journal_title：Journal of biomedical optics

authors： Liu F,Cao X,He W,Song J,Dai Z,Zhang B,Luo J,Li Y,Bai J

更新日期：2012-04-01 00:00:00

abstract：:We fabricate scaffolds with a fine linear grating (periodicity of 1 to 8 microm and height of 1 microm) on a glass substrate for controlling cardiomyocyte orientation. The fabrication is done by the solidification of a liquid photopolymerizable material using two laser beam interference. As the photopolymerizable mate...

journal_title：Journal of biomedical optics

authors： Fujita A,Fujita K,Nakamura O,Matsuda T,Kawata S

更新日期：2006-03-01 00:00:00

abstract：:Three-dimensional (3-D) tissue imaging offers substantial benefits to a wide range of biomedical investigations from cardiovascular biology, diabetes, Alzheimer's disease to cancer. Two-photon tissue cytometry is a novel technique based on high-speed multiphoton microscopy coupled with automated histological sectionin...

journal_title：Journal of biomedical optics

authors： Ragan T,Sylvan JD,Kim KH,Huang H,Bahlmann K,Lee RT,So PT

更新日期：2007-01-01 00:00:00

abstract：:We measure the tumor vascular response to varying irradiance rates during photodynamic therapy (PDT) in a Dunning rat prostate model with interstitial Doppler optical coherence tomography (IS-DOCT). Rats are given a photosensitizer drug, Photofrin, and the tumors are exposed to light (635 nm) with irradiance rates ran...

journal_title：Journal of biomedical optics

authors： Standish BA,Jin X,Smolen J,Mariampillai A,Munce NR,Wilson BC,Vitkin IA,Yang VX

更新日期：2007-05-01 00:00:00

abstract：:Pedicle screw (PS) fixation has been widely used for spine diseases. Scientists and clinicians employ several approaches to navigate PS during operation. We have demonstrated the feasibility of monitoring the reduced scattering coefficient (μ's) on the trajectory of PS using near-infrared spectroscopy (NIRS). To perfo...

journal_title：Journal of biomedical optics

authors： Liu Y,Wang Y,Qian Z,Zhao J,Cao X,Li W

更新日期：2014-01-01 00:00:00

abstract：:We present functional imaging of the concentration of a photodynamic therapy (PDT)-related dye in scattering tissue phantoms based on spatially resolved measurements of optical properties through spectroscopic optical coherence tomography (OCT). Expressions for the OCT signal are developed, enabling estimation of dept...

journal_title：Journal of biomedical optics

authors： Støren T,Røyset A,Svaasand LO,Lindmo T

更新日期：2005-03-01 00:00:00

abstract：:The effect of silica/gold nanoshells and titanium dioxide nanoparticles on the optical properties of skin is studied. By implementing in vivo measurements and Monte Carlo simulations, we analyze the efficiency of using these nanoparticles as contrasting agents for optical coherence tomography (OCT) imaging of skin. In...

journal_title：Journal of biomedical optics

authors： Kirillin M,Shirmanova M,Sirotkina M,Bugrova M,Khlebtsov B,Zagaynova E

更新日期：2009-03-01 00:00:00

abstract：:We present a novel fluorescence imaging system developed for real-time interventional imaging applications. The system implements a correction scheme that improves the accuracy of epi-illumination fluorescence images for light intensity variation in tissues. The implementation is based on the use of three cameras oper...

journal_title：Journal of biomedical optics

authors： Themelis G,Yoo JS,Soh KS,Schulz R,Ntziachristos V

更新日期：2009-11-01 00:00:00

abstract：:We introduce the design and theoretical analysis of a fiber-optic architecture for neural recording without contrast agents, which transduces neural electrical signals into a multiplexed optical readout. Our sensor design is inspired by electro-optic modulators, which modulate the refractive index of a waveguide by ap...

journal_title：Journal of biomedical optics

authors： Rodriques SG,Marblestone AH,Scholvin J,Dapello J,Sarkar D,Mankin M,Gao R,Wood L,Boyden ES

更新日期：2016-05-01 00:00:00

abstract：:Magnetomotive optical coherence tomography (MM-OCT) can be utilized to spatially localize the presence of magnetic particles within tissues or organs. These magnetic particle-containing regions are detected by using the capability of OCT to measure small-scale displacements induced by the activation of an external ele...

journal_title：Journal of biomedical optics

authors： Ahmad A,Kim J,Shemonski ND,Marjanovic M,Boppart SA

更新日期：2014-12-01 00:00:00

abstract：:Dental erosion starts with a chemical attack on dental tissue causing tooth demineralization, altering the tooth structure and making it more sensitive to mechanical erosion. Medical diagnosis of dental erosion is commonly achieved through a visual inspection by the dentist during dental checkups and is therefore high...

journal_title：Journal of biomedical optics

authors： Abou Nader C,Pellen F,Loutfi H,Mansour R,Le Jeune B,Le Brun G,Abboud M

更新日期：2016-07-01 00:00:00

abstract：:High-speed (video-rate) fluorescence lifetime imaging (FLIM) through a flexible endoscope is reported based on gated optical image intensifier technology. The optimization and potential application of FLIM to tissue autofluorescence for clinical applications are discussed. ...

journal_title：Journal of biomedical optics

authors： Munro I,McGinty J,Galletly N,Requejo-Isidro J,Lanigan PM,Elson DS,Dunsby C,Neil MA,Lever MJ,Stamp GW,French PM

更新日期：2005-09-01 00:00:00

abstract：:We describe the protocol for an inexpensive and nondestructive optical reflectance assay for the measurement of biofilm formation. Reflectance data are obtained using an Ocean Optics (Dunedin, Florida) USB 2000 spectrometer with a polychromatic light source. A fiber optic cable is used both for illumination and collec...

journal_title：Journal of biomedical optics

authors： Broschat SL,Loge FJ,Peppin JD,White D,Call DR,Kuhn E

更新日期：2005-07-01 00:00:00