Ultrafast optical property map generation using lookup tables.

abstract：:The erratum notes a correction to Fig. 5 for the published article. ...

journal_title：Journal of biomedical optics

authors： Mundo AI,Greening GJ,Fahr MJ,Hale LN,Bullard EA,Rajaram N,Muldoon TJ

更新日期：2020-04-01 00:00:00

abstract：:We describe the implementation and use of an adaptive optics loop in the imaging path of a commercial wide field microscope. We show that it is possible to maintain the optical performances of the original microscope when imaging through aberrant biological samples. The sources used for illuminating the adaptive optic...

journal_title：Journal of biomedical optics

authors： Vermeulen P,Muro E,Pons T,Loriette V,Fragola A

更新日期：2011-07-01 00:00:00

abstract：:Different colors of visible light penetrate to varying depths in tissue due to the wavelength dependence of tissue optical absorption and elastic scattering. We exploit this to map the contour of the closest surface of a buried fluorescent object. This uses a novel algorithm based on the diffusion theory description o...

journal_title：Journal of biomedical optics

authors： Kim A,Roy M,Dadani FN,Wilson BC

更新日期：2010-11-01 00:00:00

abstract：:This work reviews our research during the past several years on time-resolved (TR) near-infrared diffuse optical tomography (DOT). Following an introduction of the measuring modes, two proposed schemes of image reconstruction in TR-DOT are described: one utilizes the full TR data, and the other, referred to as the mod...

journal_title：Journal of biomedical optics

authors： Zhao H,Gao F,Tanikawa Y,Yamada Y

更新日期：2007-11-01 00:00:00

abstract：:Predicting the distribution of light inside any turbid media, such as biological tissue, requires detailed information about the optical properties of the medium, including the absorption and scattering coefficients and the anisotropy factor. Particularly, in biophotonic applications where photons directly interact wi...

journal_title：Journal of biomedical optics

authors： Azimipour M,Baumgartner R,Liu Y,Jacques SL,Eliceiri K,Pashaie R

更新日期：2014-01-01 00:00:00

abstract：:Collagen fiber orientation plays an important role in determining the structure and function of the articular cartilage. However, there is currently a lack of nondestructive means to image the fiber orientation from the cartilage surface. The purpose of this study is to investigate whether the newly developed optical ...

journal_title：Journal of biomedical optics

authors： Yao X,Wang Y,Ravanfar M,Pfeiffer FM,Duan D,Yao G

更新日期：2016-11-01 00:00:00

abstract：:We report the design, integration, and validation of a fluorescence microscopy system for imaging of electroperturbation--the effects of nanosecond, megavolt-per-meter pulsed electric fields on biological cells and tissues. Such effects have potential applications in cancer therapy, gene regulation, and biophysical re...

journal_title：Journal of biomedical optics

authors： Sun Y,Vernier PT,Behrend M,Wang J,Thu MM,Gundersen M,Marcu L

更新日期：2006-03-01 00:00:00

abstract：:We experimentally compare the performance and image contrast of spontaneous Raman and coherent Stokes Raman scattering microscopy. We demonstrate the differences between these techniques on a series of geometry-controlled samples that range in complexity from a point (array of tips) to one-dimensional (line grating) a...

journal_title：Journal of biomedical optics

authors： Kim H,Michaels CA,Bryant GW,Stranick SJ

更新日期：2011-02-01 00:00:00

abstract：:Intracellular oxygen concentration is of primary importance in determining numerous physiological and pathological processes in biological systems. In this paper, we describe the application of the oxygen sensing indicator, ruthenium dibipyridine 4-(1"-pyrenyl)-2,2'-bipyridine chloride [Ru(bpy-pyr)(bpy)(2)], for molec...

journal_title：Journal of biomedical optics

authors： Ji J,Rosenzweig N,Jones I,Rosenzweig Z

更新日期：2002-07-01 00:00:00

abstract：:The recycling of G-protein-coupled receptors (GPCR) to the cell surface after internalization plays an important role in the regulation of overall GPCR activity. The angiotensin II type I receptor (AT1R) belongs to class B GPCRs that recycle slowly back to the cell surface. Previous studies have proposed that Rab11 co...

journal_title：Journal of biomedical optics

authors： Li H,Li HF,Felder RA,Periasamy A,Jose PA

更新日期：2008-05-01 00:00:00

abstract：:Infrared microscopic imaging has been utilized to analyze for the first time the spatial distribution of lipid structure in an ex vivo human organ culture skin wound healing model. Infrared images were collected at zero, two, four, and six days following wounding. Analysis of lipid infrared spectral properties reveale...

journal_title：Journal of biomedical optics

authors： Yu G,Stojadinovic O,Tomic-Canic M,Flach CR,Mendelsohn R

更新日期：2012-09-01 00:00:00

abstract：:The development of accurate and clinically applicable tools to assess cancer risk is essential to define candidates to undergo screening for early-stage cancers at a curable stage or provide a novel method to monitor chemoprevention treatments. With the use of our recently developed optical technology--spatial-domain ...

journal_title：Journal of biomedical optics

authors： Bista RK,Uttam S,Hartman DJ,Qiu W,Yu J,Zhang L,Brand RE,Liu Y

更新日期：2012-06-01 00:00:00

abstract：:We report on wide-field imaging of pulsatile motion induced by blood flow using heterodyne holographic interferometry on the thumb of a healthy volunteer, in real time. Optical Doppler images were measured with green laser light by a frequency-shifted Mach-Zehnder interferometer in off-axis configuration. The recorded...

journal_title：Journal of biomedical optics

authors： Bencteux J,Pagnoux P,Kostas T,Bayat S,Atlan M

更新日期：2015-06-01 00:00:00

abstract：:Anastomotic complication is a major morbidity associated with esophagectomy. Gastric ischemia after conduit creation contributes to anastomotic complications, but a reliable method to assess oxygenation in the gastric conduit is lacking. We hypothesize that fiber optic spectroscopy can reliably assess conduit oxygenat...

journal_title：Journal of biomedical optics

authors： Gareau DS,Truffer F,Perry KA,Pham TH,Enestvedt CK,Dolan JP,Hunter JG,Jacques SL

更新日期：2010-11-01 00:00:00

abstract：:We describe a computer eye model that allows for aspheric surfaces and a three-dimensional computer-based ray-tracing technique to simulate optical properties of the human eye and visual perception under various eye defects. Eye surfaces, such as the cornea, eye lens, and retina, are modeled or approximated by a set o...

journal_title：Journal of biomedical optics

authors： Fink W,Micol D

更新日期：2006-09-01 00:00:00

abstract：:We demonstrate that doubly-resonant coherent anti-Stokes Raman scattering can provide enhanced and highly specific contrast for molecules containing unique Raman-active small molecular groups. This combination provides contrast for molecules that can otherwise be difficult to discriminate by Raman spectroscopy. Here, ...

journal_title：Journal of biomedical optics

authors： Weeks T,Schie I,den Hartigh LJ,Rutledge JC,Huser T

更新日期：2011-02-01 00:00:00

abstract：:Clinical imaging techniques for the anterior segment of the eye provide excellent anatomical information, but molecular imaging techniques are lacking. Molecular photoacoustic imaging is one option to address this need, but implementation requires use of contrast agents to distinguish molecular targets from background...

journal_title：Journal of biomedical optics

authors： Kubelick KP,Snider EJ,Ethier CR,Emelianov S

更新日期：2019-05-01 00:00:00

abstract：:An autofluorescence lifetime wide-field imaging system that can generate contrast in underlying tissue structures of normal and malignant brain tissue samples with video rate acquisition and processing time is presented. Images of the investigated tissues were acquired with high resolution (∼35 μm) using an algorithm ...

journal_title：Journal of biomedical optics

authors： Papour A,Taylor Z,Sherman A,Sanchez D,Lucey G,Liau L,Stafsudd O,Yong W,Grundfest W

更新日期：2013-06-01 00:00:00

abstract：:Dispersion encoded full-range (DEFR) frequency-domain optical coherence tomography (FD-OCT) and its enhanced version, fast DEFR, utilize dispersion mismatch between sample and reference arm to eliminate the ambiguity in OCT signals caused by non-complex valued spectral measurement, thereby numerically doubling the usa...

journal_title：Journal of biomedical optics

authors： Wang L,Hofer B,Guggenheim JA,Povazay B

更新日期：2012-07-01 00:00:00

abstract：:We describe a systematic approach to image, track, and quantify the movements of HIV viruses embedded in human cervical mucus. The underlying motivation for this study is that, in HIV-infected adults, women account for more than half of all new cases and most of these women acquire the infection through heterosexual c...

journal_title：Journal of biomedical optics

authors： Boukari F,Makrogiannis S,Nossal R,Boukari H

更新日期：2016-09-01 00:00:00

abstract：:Biomedical applications of terahertz (THz) radiation are appealing because THz radiation is nonionizing and has the demonstrated ability to detect intrinsic contrasts between cancerous and normal tissue. A linear polarization-sensitive detection technique for tumor margin delineation has already been demonstrated; how...

journal_title：Journal of biomedical optics

authors： Martin JP,Joseph CS,Giles RH

更新日期：2016-07-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) in tumor cells was found to play an important role in maintaining the malignant phenotype. Using laser scanning confocal fluorescence microscopy (LSCFM) in a recent work, we reported a variable fluorescence intensity of ethidium bromide (EB) in mitochondria nucleoids of living carcinoma cells...

journal_title：Journal of biomedical optics

authors： Villa AM,Fusi P,Pastori V,Amicarelli G,Pozzi C,Adlerstein D,Doglia SM

更新日期：2012-04-01 00:00:00

abstract：:Fluorescence image-guided surgery (FIGS) is an emerging technique in oncology, neurology, and cardiology. To adapt intraoperative imaging for various surgical applications, increasingly flexible and compact FIGS instruments are necessary. We present a compact, portable FIGS system and demonstrate its use in cardiovasc...

journal_title：Journal of biomedical optics

authors： Wang X,Bhaumik S,Li Q,Staudinger VP,Yazdanfar S

更新日期：2010-03-01 00:00:00

abstract：:We present a study using a method able to assess tissue oxygenation, taking into account the absorption and the level of scattering in myocardial tissue using a calibrated fiber optic probe. With this method, interindividual comparisons of oxygenation can be made despite varying tissue optical properties during corona...

journal_title：Journal of biomedical optics

authors： Häggblad E,Lindbergh T,Karlsson MG,Casimir-Ahn H,Salerud EG,Strömberg T

更新日期：2008-09-01 00:00:00

abstract：:Breast cancer is one of the most common cancers in females. To monitor chemotherapeutic efficacy for breast cancer, medical imaging systems such as x-ray mammography, computed tomography, magnetic resonance imaging, and ultrasound imaging have been used. Currently, it can take up to 3 to 6 weeks to see the tumor respo...

journal_title：Journal of biomedical optics

authors： Lee S,Jeong H,Seong M,Kim JG

更新日期：2017-12-01 00:00:00

abstract：:The excited state lifetime of a fluorophore together with its fluorescence emission spectrum provide information that can yield valuable insights into the nature of a fluorophore and its microenvironment. However, it is difficult to obtain both channels of information in a conventional scheme as detectors are typicall...

journal_title：Journal of biomedical optics

authors： Sagar MAK,Dai B,Chacko J,Weber J,Velten A,Sanders S,White J,Eliceiri K

更新日期：2019-12-01 00:00:00

abstract：:Optical clearing is a well-known phenomenon. It is based on the matching of refractive indices of a bulk material and scattering particles. The same principle is also used in scattering-based optical measurements of different constituents, such as glucose. By registering changes in scattering, it is possible to evalua...

journal_title：Journal of biomedical optics

authors： Kinnunen M,Myllylä R,Vainio S

更新日期：2008-03-01 00:00:00

abstract：:This study introduces a single-channel optical video stereomicroscope based on a transparent rotating deflector (TRD) for high-resolution and high-magnification stereomicroscopy. The existing stereomicroscopes have some limitations, such as limited resolution and magnification, fixed optical channel, and the necessity...

journal_title：Journal of biomedical optics

authors： Radfar E,Park J,Jung B

更新日期：2016-12-01 00:00:00

abstract：:Optical coherence tomography (OCT) provides more parameters than pure morphology does. In a recent paper [A. Knuettel and M. Boehlau-Godau, J. Biomed. Opt. 5(1) 83-92 (2000)] we have shown that the refractive index (RI) can be evaluated in a localized manner in skin tissue under in vivo conditions. Based on a theory, ...

journal_title：Journal of biomedical optics

authors： Knüttel A,Bonev S,Knaak W

更新日期：2004-03-01 00:00:00

abstract：:Photodynamic therapy (PDT) is an alternative to radical surgical resection for T1a or nonresectable carcinomas of the gastroesophageal junction. Besides the concentration of the photosensitizer, the light distribution in tissue is responsible for tumor destruction. For this reason, knowledge about the behavior of ligh...

journal_title：Journal of biomedical optics

authors： Holmer C,Lehmann KS,Wanken J,Reissfelder C,Roggan A,Mueller G,Buhr HJ,Ritz JP

更新日期：2007-01-01 00:00:00