Graphics processing unit-based dispersion encoded full-range frequency-domain optical coherence tomography.

Abstract:

:Dispersion encoded full-range (DEFR) frequency-domain optical coherence tomography (FD-OCT) and its enhanced version, fast DEFR, utilize dispersion mismatch between sample and reference arm to eliminate the ambiguity in OCT signals caused by non-complex valued spectral measurement, thereby numerically doubling the usable information content. By iteratively suppressing asymmetrically dispersed complex conjugate artifacts of OCT-signal pulses the complex valued signal can be recovered without additional measurements, thus doubling the spatial signal range to cover the full positive and negative sampling range. Previously the computational complexity and low processing speed limited application of DEFR to smaller amounts of data and did not allow for interactive operation at high resolution. We report a graphics processing unit (GPU)-based implementation of fast DEFR, which significantly improves reconstruction speed by a factor of more than 90 in respect to CPU-based processing and thereby overcomes these limitations. Implemented on a commercial low-cost GPU, a display line rate of ∼21,000 depth scans/s for 2048 samples/depth scan using 10 iterations of the fast DEFR algorithm has been achieved, sufficient for real-time visualization in situ.

journal_name

J Biomed Opt

authors

Wang L,Hofer B,Guggenheim JA,Povazay B

doi

10.1117/1.JBO.17.7.077007

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

077007

issue

7

eissn

1083-3668

issn

1560-2281

journal_volume

17

pub_type

杂志文章
  • Evaluation of the contribution of the renal capsule and cortex to kidney autofluorescence intensity under ultraviolet excitation.

    abstract::The use of reduced nicotinamide adenine dinucleotide (NADH) fluorescence to gain metabolic information on kidneys in response to an alteration in oxygen availability has previously been experimentally demonstrated, but signal quantification has not, to date, been addressed. In this work the relative contribution to ra...

    journal_title:Journal of biomedical optics

    pub_type: 信件

    doi:10.1117/1.3094948

    authors: Raman RN,Pivetti CD,Rubenchik AM,Matthews DL,Troppmann C,Demos SG

    更新日期:2009-03-01 00:00:00

  • Biocompatible semiconductor optoelectronics.

    abstract::We investigate optoelectronic properties of integrated structures comprising semiconductor light-emitting materials for optical probes of microscopic biological systems. Compound semiconductors are nearly ideal light emitters for probing cells and other microorganisms because of their spectral match to the transparenc...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.1506931

    authors: Gourley PL,Copeland RG,Cox JD,Hendricks JK,McDonald AE,Peterson SL,Sasaki DY

    更新日期:2002-10-01 00:00:00

  • Measurement of the refractive index of whole blood and its components for a continuous spectral region.

    abstract::The refractive index of blood is a key biophysical parameter, which can reflect the physiological state. We measured the refractive index of whole blood and other components, such as serum, plasma, and hemoglobin, based on internal reflection by using a homemade apparatus in the spectral range of 400 to 750 nm. In add...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.24.3.035003

    authors: Liu S,Deng Z,Li J,Wang J,Huang N,Cui R,Zhang Q,Mei J,Zhou W,Zhang C,Ye Q,Tian J

    更新日期:2019-03-01 00:00:00

  • Hybrid method for fast Monte Carlo simulation of diffuse reflectance from a multilayered tissue model with tumor-like heterogeneities.

    abstract::We present a hybrid method that combines a multilayered scaling method and a perturbation method to speed up the Monte Carlo simulation of diffuse reflectance from a multilayered tissue model with finite-size tumor-like heterogeneities. The proposed method consists of two steps. In the first step, a set of photon traj...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.17.1.010501

    authors: Zhu C,Liu Q

    更新日期:2012-01-01 00:00:00

  • Tutorial on diffuse light transport.

    abstract::A tutorial introduction to diffuse light transport is presented. The basic analytic equations of time-resolved, steady-state and modulated light transport are introduced. The perturbation method for handling slight heterogeneities in optical properties is outlined. The treatment of boundary conditions such as an air/t...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.2967535

    authors: Jacques SL,Pogue BW

    更新日期:2008-07-01 00:00:00

  • Quantitative performance characterization of three-dimensional noncontact fluorescence molecular tomography.

    abstract::Fluorescent proteins and dyes are routine tools for biological research to describe the behavior of genes, proteins, and cells, as well as more complex physiological dynamics such as vessel permeability and pharmacokinetics. The use of these probes in whole body in vivo imaging would allow extending the range and scop...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.21.2.026009

    authors: Favicchio R,Psycharakis S,Schönig K,Bartsch D,Mamalaki C,Papamatheakis J,Ripoll J,Zacharakis G

    更新日期:2016-02-01 00:00:00

  • Lipid-cell interactions in human monocytes investigated by doubly-resonant coherent anti-Stokes Raman scattering microscopy.

    abstract::We demonstrate that doubly-resonant coherent anti-Stokes Raman scattering can provide enhanced and highly specific contrast for molecules containing unique Raman-active small molecular groups. This combination provides contrast for molecules that can otherwise be difficult to discriminate by Raman spectroscopy. Here, ...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.3544585

    authors: Weeks T,Schie I,den Hartigh LJ,Rutledge JC,Huser T

    更新日期:2011-02-01 00:00:00

  • Comparative analysis of single- and dual-wavelength photodynamic therapy regimes with chlorin-based photosensitizers: animal study.

    abstract::Two pronounced absorption peaks in blue and red ranges of the chlorin-based photosensitizer (PS) absorption spectrum provide additional benefits in photodynamic therapy (PDT) performance. Differing optical properties of biological tissues in these ranges allow for both dual-wavelength diagnostics and PDT performance. ...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.25.6.063804

    authors: Kurakina D,Khilov A,Shakhova M,Orlinskaya N,Sergeeva E,Meller A,Turchin I,Kirillin M

    更新日期:2019-12-01 00:00:00

  • Amending of fluorescence sensor signal localization in human skin by matching of the refractive index.

    abstract::Fluorescence diagnostic techniques are notable amongst many other optical methods because they offer high sensitivity and noninvasive measurement of tissue properties. However, a combination of multiple scattering and physical heterogeneity of biological tissues hampers interpretation of the fluorescence measurements....

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.1645796

    authors: Churmakov DY,Meglinski IV,Greenhalgh DA

    更新日期:2004-03-01 00:00:00

  • Prehistological evaluation of benign and malignant pigmented skin lesions with optical computed tomography.

    abstract::Discrimination of benign and malignant melanocytic lesions is a major issue in clinical dermatology. Assessment of the thickness of melanoma is critical for prognosis and treatment selection. We aimed to evaluate a novel optical computed tomography (optical-CT) system as a tool for three-dimensional (3-D) imaging of m...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.17.6.066004

    authors: Kokolakis A,Zacharakis G,Krasagakis K,Lasithiotakis K,Favicchio R,Spiliopoulos G,Giannikaki E,Ripoll J,Tosca A

    更新日期:2012-06-01 00:00:00

  • Computer model to investigate the effect of eye movements on retinal heating during long-duration fixation on a laser source.

    abstract::A computer simulation called RHME (Retinal Heating in Moving Eye) is developed to simulate the heating pattern that occurs in the retina during a long-duration exposure to a continuous wave laser beam. The simulation takes into account eye movements that occur during a deliberate fixation. Due to the rapid (millisecon...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.1783355

    authors: Lund BJ

    更新日期:2004-09-01 00:00:00

  • Noncontact spirometry with a webcam.

    abstract::We present an imaging-based method for noncontact spirometry. The method tracks the subtle respiratory-induced shoulder movement of a subject, builds a calibration curve, and determines the flow-volume spirometry curve and vital respiratory parameters, including forced expiratory volume in the first second, forced vit...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.22.5.057002

    authors: Liu C,Yang Y,Tsow F,Shao D,Tao N

    更新日期:2017-05-01 00:00:00

  • Pancreatic cancer cell detection by targeted lipid microbubbles and multiphoton imaging.

    abstract::Surgical resection of pancreatic cancer represents the only chance of cure and long-term survival in this common disease. Unfortunately, determination of a cancer-free margin at surgery is based on one or two tiny frozen section biopsies, which is far from ideal. Not surprisingly, cancer is usually left behind and is ...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.23.4.046501

    authors: Cromey B,McDaniel A,Matsunaga T,Vagner J,Kieu KQ,Banerjee B

    更新日期:2018-04-01 00:00:00

  • Multiwavelength time-resolved detection of fluorescence during the inflow of indocyanine green into the adult's brain.

    abstract::Optical technique based on diffuse reflectance measurement combined with indocyanine green (ICG) bolus tracking is extensively tested as a method for clinical assessment of brain perfusion in adults at the bedside. Methodology of multiwavelength and time-resolved detection of fluorescence light excited in the ICG is p...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.17.8.087001

    authors: Gerega A,Milej D,Weigl W,Botwicz M,Zolek N,Kacprzak M,Wierzejski W,Toczylowska B,Mayzner-Zawadzka E,Maniewski R,Liebert A

    更新日期:2012-08-01 00:00:00

  • Preliminary evaluation of optical glucose sensing in red cell concentrations using near-infrared diffuse-reflectance spectroscopy.

    abstract::Bacterial contamination of blood products is one of the most frequent infectious complications of transfusion. Since glucose levels in blood supplies decrease as bacteria proliferate, it should be possible to detect the presence of bacterial contamination by measuring the glucose concentrations in the blood components...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.17.1.017004

    authors: Suzuki Y,Maruo K,Zhang AW,Shimogaki K,Ogawa H,Hirayama F

    更新日期:2012-01-01 00:00:00

  • Methodology for examining polarized light interactions with tissues and tissuelike media in the exact backscattering direction.

    abstract::The properties of polarized light emerging from turbid media in the exact backscattering direction are studied by modulating the incident light polarization state and isolating the synchronous signal with lock-in amplifier detection. The results are reported for polystyrene microsphere suspensions in distilled water, ...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.430004

    authors: Studinski RC,Vitkin IA

    更新日期:2000-07-01 00:00:00

  • Image reconstruction in photoacoustic tomography with variable speed of sound using a higher-order geometrical acoustics approximation.

    abstract::Previous research correcting for variable speed of sound in photoacoustic tomography (PAT) based on a generalized radon transform (GRT) model assumes first-order geometrical acoustics (GA) approximation. In the GRT model, the pressure is related to the optical absorption, in an acoustically inhomogeneous medium, throu...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.3333550

    authors: Modgil D,Anastasio MA,La Rivière PJ

    更新日期:2010-03-01 00:00:00

  • Laser-ultraviolet-A-induced ultraweak photon emission in mammalian cells.

    abstract::Photobiological research in the last 30 yr has shown the existence of ultraweak photon emission in biological tissue, which can be detected with sophisticated photomultiplier systems. Although the emission of this ultraweak radiation, often termed biophotons, is extremely low in mammalian cells, it can be efficiently ...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.1899185

    authors: Niggli HJ,Tudisco S,Privitera G,Applegate LA,Scordino A,Musumeci F

    更新日期:2005-03-01 00:00:00

  • Detecting inflammation in rheumatoid arthritis using Fourier transform analysis of dorsal optical transmission images from a pilot study.

    abstract::A clinical need exists for low-cost and noninvasive imaging tools capable of detecting inflammation in the joints of inflammatory arthritis patients. Previous studies have reported an optical contrast between inflamed and noninflamed joints resulting from distinct absorption and scattering properties. Accurate classif...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.24.6.066008

    authors: Lighter D,Filer A,Dehghani H

    更新日期:2019-06-01 00:00:00

  • Real-time measurement of the vaginal pressure profile using an optical-fiber-based instrumented speculum.

    abstract::Pelvic organ prolapse (POP) occurs when changes to the pelvic organ support structures cause descent or herniation of the pelvic organs into the vagina. Clinical evaluation of POP is a series of manual measurements known as the pelvic organ prolapse quantification (POP-Q) score. However, it fails to identify the mecha...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.21.12.127008

    authors: Parkinson LA,Gargett CE,Young N,Rosamilia A,Vashi AV,Werkmeister JA,Papageorgiou AW,Arkwright JW

    更新日期:2016-12-01 00:00:00

  • Silver nanoparticle-induced degranulation observed with quantitative phase microscopy.

    abstract::Monitoring a degranulation process in a live mast cell is a quite important issue in immunology and pharmacology. Because the size of a granule is normally much smaller than the resolution limit of an optical microscope system, there is no direct real-time live cell imaging technique for observing degranulation proces...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.3470104

    authors: Yang W,Lee S,Lee J,Bae Y,Kim D

    更新日期:2010-07-01 00:00:00

  • Tracer-cocktail injections for combined pre- and intraoperative multimodal imaging of lymph nodes in a spontaneous mouse prostate tumor model.

    abstract::To improve surgical guidance toward prostate draining lymph nodes, we investigate the potential of intraoperative fluorescence imaging and combined pre- and intraoperative multimodality imaging approaches. Transgenic adenocarcinoma mouse prostate mice with spontaneous prostate tumors are injected intratumorally with: ...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.3528027

    authors: van Leeuwen AC,Buckle T,Bendle G,Vermeeren L,Valdés Olmos R,van de Poel HG,van Leeuwen FW

    更新日期:2011-01-01 00:00:00

  • Miniature endoscopic optical coherence tomography probe employing a two-axis microelectromechanical scanning mirror with through-silicon vias.

    abstract::We present the design and experimental results of a new MEMS-based endoscopic optical coherence tomography (OCT) probe. The uniqueness of this miniature OCT imaging probe is a two-axis MEMS mirror with through-silicon vias (TSVs) for interconnecting. The TSV interconnection enables ultracompact probe design, successfu...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.3533323

    authors: Liu L,Wu L,Sun J,Lin E,Xie H

    更新日期:2011-02-01 00:00:00

  • Three-dimensional optical method for integrated visualization of mouse islet microstructure and vascular network with subcellular-level resolution.

    abstract::Microscopic visualization of islets of Langerhans under normal and diabetic conditions is essential for understanding the pathophysiology of the disease. The intrinsic opacity of pancreata, however, limits optical accessibility for high-resolution light microscopy of islets in situ. Because the standard microtome-base...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.3470241

    authors: Fu YY,Lu CH,Lin CW,Juang JH,Enikolopov G,Sibley E,Chiang AS,Tang SC

    更新日期:2010-07-01 00:00:00

  • Quantitative real-time optical imaging of the tissue metabolic rate of oxygen consumption.

    abstract::The tissue metabolic rate of oxygen consumption (tMRO2) is a clinically relevant marker for a number of pathologies including cancer and arterial occlusive disease. We present and validate a noncontact method for quantitatively mapping tMRO2 over a wide, scalable field of view at 16  frames  /  s. We achieve this by d...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.23.3.036013

    authors: Ghijsen M,Lentsch GR,Gioux S,Brenner M,Durkin AJ,Choi B,Tromberg BJ

    更新日期:2018-03-01 00:00:00

  • Quantification of fiber orientation in the canine atrial pacemaker complex using optical coherence tomography.

    abstract::The atrial pacemaker complex is responsible for the initiation and early propagation of cardiac impulses. Optical coherence tomography (OCT), a nondestructive imaging modality with spatial resolutions of ∼1 to 15 μm, can be used to identify unique fiber orientation patterns in this region of the heart. Functionally ch...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.17.7.071309

    authors: Ambrosi CM,Fedorov VV,Schuessler RB,Rollins AM,Efimov IR

    更新日期:2012-07-01 00:00:00

  • Hyperspectral imaging based method for fast characterization of kidney stone types.

    abstract::The formation of kidney stones is a common and highly studied disease, which causes intense pain and presents a high recidivism. In order to find the causes of this problem, the characterization of the main compounds is of great importance. In this sense, the analysis of the composition and structure of the stone can ...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.17.7.076027

    authors: Blanco F,López-Mesas M,Serranti S,Bonifazi G,Havel J,Valiente M

    更新日期:2012-07-01 00:00:00

  • Use of picosecond Kerr-gated Raman spectroscopy to suppress signals from both surface and deep layers in bladder and prostate tissue.

    abstract::Raman spectroscopy is an optical technique able to interrogate biological tissues, giving us an understanding of the changes in molecular structure that are associated with disease development. The Kerr-gated Raman spectroscopy technique uses a picosecond pulsed laser as well as fast temporal gating of collected Raman...

    journal_title:Journal of biomedical optics

    pub_type: 临床试验,杂志文章

    doi:10.1117/1.1991848

    authors: Prieto MC,Matousek P,Towrie M,Parker AW,Wright M,Ritchie AW,Stone N

    更新日期:2005-07-01 00:00:00

  • Intravascular near-infrared fluorescence catheter with ultrasound guidance and blood attenuation correction.

    abstract::Intravascular near-infrared fluorescence (NIRF) imaging offers a new approach for characterizing atherosclerotic plaque, but random catheter positioning within the vessel lumen results in variable light attenuation and can yield inaccurate measurements. We hypothesized that NIRF measurements could be corrected for var...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.18.5.056009

    authors: Dixon AJ,Hossack JA

    更新日期:2013-05-01 00:00:00

  • New aspects in assessment of changes in width of subarachnoid space with near-infrared transillumination-backscattering sounding, part 2: clinical verification in the patient.

    abstract::The study presents comparison of near-infrared light propagation and near-infrared backscattered radiation power, as simulated with numerical modeling and measured live in a patient in clinical conditions with the use of the near-infrared transillumination-backscattering sounding (NIR-TBSS) technique. A unique chance ...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.2753756

    authors: Frydrychowski AF,Pluciński J

    更新日期:2007-07-01 00:00:00