Abstract:
:Complete and continuous imaging of microvascular networks is crucial for a wide variety of biomedical applications. Photoacoustic tomography can provide high resolution microvascular imaging using hemoglobin within red blood cells (RBCs) as an endogenic contrast agent. However, intermittent RBC flow in capillaries results in discontinuous and fragmentary capillary images. To overcome this problem, we use Evans blue (EB) dye as a contrast agent for in vivo photoacoustic imaging. EB has strong optical absorption and distributes uniformly in the blood stream by chemically binding to albumin. With the help of EB, complete and continuous microvascular networks--especially capillaries--are imaged. The diffusion dynamics of EB leaving the blood stream and the clearance dynamics of the EB-albumin complex are also quantitatively investigated.
journal_name
J Biomed Optjournal_title
Journal of biomedical opticsauthors
Yao J,Maslov K,Hu S,Wang LVdoi
10.1117/1.3251044subject
Has Abstractpub_date
2009-09-01 00:00:00pages
054049issue
5eissn
1083-3668issn
1560-2281journal_volume
14pub_type
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