Photochemical effects and hypericin photosensitized processes in collagen.

abstract：:Photodynamic therapy (PDT) is reviewed using the treatment of skin tumors as an example of superficial lesions and prostate cancer as an example of deep-lying lesions requiring interstitial intervention. These two applications are among the most commonly studied in oncological PDT, and illustrate well the different ch...

journal_title：Journal of biomedical optics

authors： Svanberg K,Bendsoe N,Axelsson J,Andersson-Engels S,Svanberg S

更新日期：2010-07-01 00:00:00

abstract：:Hemorrhagic hypovolemia and inotropic agent administration were used to manipulate cardiac output (CO) and oxygen delivery in rabbits to investigate the correlation between noninvasive frequency domain photon migration (FDPM) spectroscopy and invasive hemodynamic monitoring parameters. Frequency-domain photon migratio...

journal_title：Journal of biomedical optics

authors： Pham TH,Hornung R,Ha HP,Burney T,Serna D,Powell L,Brenner M,Tromberg BJ

更新日期：2002-01-01 00:00:00

abstract：:The Nikon C1 confocal laser scanning microscope is a relatively inexpensive and user-friendly instrument. We describe a straightforward method to convert the C1 for multiphoton microscopy utilizing direct coupling of a femtosecond near-infrared laser into the scan head and fiber optic transmission of emission light to...

journal_title：Journal of biomedical optics

authors： Mancuso JJ,Larson AM,Wensel TG,Saggau P

更新日期：2009-05-01 00:00:00

abstract：:Functional near-infrared spectroscopy (fNIRS) is being increasingly applied to affective and social neuroscience research; however, the reliability of this method is still unclear. This study aimed to evaluate the test–retest reliability of the fNIRS-based prefrontal response to emotional stimuli. Twenty-six participa...

journal_title：Journal of biomedical optics

authors： Huang Y,Mao M,Zhang Z,Zhou H,Zhao Y,Duan L,Kreplin U,Xiao X,Zhu C

更新日期：2017-01-01 00:00:00

abstract：:Endoscopic ultrasound-guided fine needle aspirations (EUS-FNA) of pancreatic masses suffer from sample errors and low-negative predictive values. Fiber-optic spectroscopy in the visible to near-infrared wavelength spectrum can noninvasively extract physiological parameters from tissue and has the potential to guide th...

journal_title：Journal of biomedical optics

authors： Stegehuis PL,Boogerd LS,Inderson A,Veenendaal RA,van Gerven P,Bonsing BA,Sven Mieog J,Amelink A,Veselic M,Morreau H,van de Velde CJ,Lelieveldt BP,Dijkstra J,Robinson DJ,Vahrmeijer AL

更新日期：2017-02-01 00:00:00

abstract：:The tissue metabolic rate of oxygen consumption (tMRO2) is a clinically relevant marker for a number of pathologies including cancer and arterial occlusive disease. We present and validate a noncontact method for quantitatively mapping tMRO2 over a wide, scalable field of view at 16  frames  /  s. We achieve this by d...

journal_title：Journal of biomedical optics

authors： Ghijsen M,Lentsch GR,Gioux S,Brenner M,Durkin AJ,Choi B,Tromberg BJ

更新日期：2018-03-01 00:00:00

abstract：:Doxorubicin is a commonly used chemotherapeutic employed to treat multiple human cancers, including numerous sarcomas and carcinomas. Furthermore, doxorubicin possesses strong fluorescent properties that make it an ideal reagent for modeling drug delivery by examining its distribution in cells and tissues. However, wh...

journal_title：Journal of biomedical optics

authors： Carlson M,Watson AL,Anderson L,Largaespada DA,Provenzano PP

更新日期：2017-11-01 00:00:00

abstract：:Fourier transform infrared (FTIR) spectroscopic imaging has been used to probe the biochemical composition of human renal tumor tissue and adjacent normal tissue. Freshly resected renal tumor tissue from surgery was prepared as a thin cryosection and examined by FTIR spectroscopic imaging. Tissue types could be discri...

journal_title：Journal of biomedical optics

authors： Sablinskas V,Urboniene V,Ceponkus J,Laurinavicius A,Dasevicius D,Jankevicius F,Hendrixson V,Koch E,Steiner G

更新日期：2011-09-01 00:00:00

abstract：:The application of near-infrared spectroscopy (NIRS) to assess microvascular function has shown promising results. An important limitation when using a single source-detector pair, however, is the lack of depth sensitivity. Diffuse optical tomography (DOT) overcomes this limitation using an array of sources and detect...

journal_title：Journal of biomedical optics

authors： Vidal-Rosas EE,Billings SA,Chico T,Coca D

更新日期：2016-06-01 00:00:00

abstract：:Blood pulse wave velocity (PWV) is an important physiological parameter that characterizes vascular stiffness. In this letter, we present electrocardiogram-synchronized, photoacoustic microscopy for noninvasive quantification of the PWV in the peripheral vessels of living mice. Interestingly, blood pulse wave-induced ...

journal_title：Journal of biomedical optics

authors： Yeh C,Hu S,Maslov K,Wang LV

更新日期：2012-07-01 00:00:00

abstract：:In order to evaluate the impact of anatomy on the spectral properties of oral tissue, we used reflectance and fluorescence spectroscopy to characterize nine different anatomic sites. All spectra were collected in vivo from healthy oral mucosa. We analyzed 710 spectra collected from the oral cavity of 79 healthy volunt...

journal_title：Journal of biomedical optics

authors： McGee S,Mirkovic J,Mardirossian V,Elackattu A,Yu CC,Kabani S,Gallagher G,Pistey R,Galindo L,Badizadegan K,Wang Z,Dasari R,Feld MS,Grillone G

更新日期：2008-11-01 00:00:00

abstract：:Flow imaging is an important technique in a range of disease areas, but estimating low flow speeds, especially near the walls of blood vessels, remains challenging. Pulsed photoacoustic flow imaging can be an alternative since there is little signal contamination from background tissue with photoacoustic imaging. We p...

journal_title：Journal of biomedical optics

authors： van den Berg PJ,Daoudi K,Steenbergen W

更新日期：2016-02-01 00:00:00

abstract：:We quantitatively investigated the measurement sensitivity of spatially resolved spectroscopy (SRS) across six tissue models: cerebral tissue, a small animal brain, the forehead of a fetus, an adult brain, forearm muscle, and thigh muscle. The optical path length in the voxel of the model was analyzed using Monte Carl...

journal_title：Journal of biomedical optics

authors： Niwayama M

更新日期：2018-03-01 00:00:00

abstract：:Quantification of nicotinamide adenine dinucleotide (NADH) changes during functional brain activation and pathological conditions provides critical insight into brain metabolism. Of the different imaging modalities, two-photon laser scanning microscopy (TPLSM) is becoming an important tool for cellular-resolution meas...

journal_title：Journal of biomedical optics

authors： Baraghis E,Devor A,Fang Q,Srinivasan VJ,Wu W,Lesage F,Ayata C,Kasischke KA,Boas DA,Sakadzić S

更新日期：2011-10-01 00:00:00

abstract：:Our current research in the framework of an interdisciplinary project focuses on modelling the dynamics of the hemoglobin reoxygenation process in post-mortem human skin by reflectance spectrometry. The observations of reoxygenation of hemoglobin in livores after postmortem exposure to a cold environment relate the re...

journal_title：Journal of biomedical optics

authors： Belenki L,Sterzik V,Schulz K,Bohnert M

更新日期：2013-01-01 00:00:00

abstract：:In the last 25 years, optical coherence tomography (OCT) has advanced to be one of the most innovative and most successful translational optical imaging techniques, achieving substantial economic impact as well as clinical acceptance. This is largely owing to the resolution improvements by a factor of 10 to the submic...

journal_title：Journal of biomedical optics

authors： Drexler W,Liu M,Kumar A,Kamali T,Unterhuber A,Leitgeb RA

更新日期：2014-01-01 00:00:00

abstract：:Diffusion of two model drugs-benzyl nicotinate and ibuprofen-and the plasma macromolecule albumin across atherosclerotic rabbit aorta was studied ex vivo by attenuated total reflection-Fourier transform infrared (ATR-FTIR) imaging. Solutions of these molecules were applied to the endothelial surface of histological se...

journal_title：Journal of biomedical optics

authors： Palombo F,Danoux CB,Weinberg PD,Kazarian SG

更新日期：2009-07-01 00:00:00

abstract：:Fluorescent proteins and dyes are routine tools for biological research to describe the behavior of genes, proteins, and cells, as well as more complex physiological dynamics such as vessel permeability and pharmacokinetics. The use of these probes in whole body in vivo imaging would allow extending the range and scop...

journal_title：Journal of biomedical optics

authors： Favicchio R,Psycharakis S,Schönig K,Bartsch D,Mamalaki C,Papamatheakis J,Ripoll J,Zacharakis G

更新日期：2016-02-01 00:00:00

abstract：:Autofluorescence-based imaging techniques have become very important in the ophthalmological field. Being noninvasive and very sensitive, they are broadly used in clinical routines. Conventional autofluorescence intensity imaging is largely influenced by the strong fluorescence of lipofuscin, a fluorophore that can be...

journal_title：Journal of biomedical optics

authors： Sauer L,Andersen KM,Dysli C,Zinkernagel MS,Bernstein PS,Hammer M

更新日期：2018-09-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) in tumor cells was found to play an important role in maintaining the malignant phenotype. Using laser scanning confocal fluorescence microscopy (LSCFM) in a recent work, we reported a variable fluorescence intensity of ethidium bromide (EB) in mitochondria nucleoids of living carcinoma cells...

journal_title：Journal of biomedical optics

authors： Villa AM,Fusi P,Pastori V,Amicarelli G,Pozzi C,Adlerstein D,Doglia SM

更新日期：2012-04-01 00:00:00

abstract：:The objective of the study is the quantitative analysis of the dose-time dependences of changes occurring in collagen of bladder and rectum after gamma-irradiation using optical methods [nonlinear microscopy in a second harmonic generation (SHG) detection regime and cross-polarization optical coherence tomography (CP ...

journal_title：Journal of biomedical optics

authors： Kochueva M,Dudenkova V,Kuznetsov S,Varlamova A,Sergeeva E,Kiseleva E,Maslennikova A

更新日期：2018-08-01 00:00:00

abstract：:Stenosis and occlusion of the superficial femoral artery (SFA) are most common in arterial occlusive disease. There are numerous interventional, surgical, and combined approaches to reconstitute maximum blood supply to the lower limb; however, despite intense clinical research, the long-term success rates are still po...

journal_title：Journal of biomedical optics

authors： Heneweer C,Siggelkow M,Helle M,Petzina R,Wulff A,Schaefer JP,Berndt R,Rusch R,Wedel T,Klaws G,Müller-Gerbl M,Röcken C,Jansen O,Lutter G,Cremer J,Groß J

更新日期：2015-02-01 00:00:00

abstract：:We demonstrate that doubly-resonant coherent anti-Stokes Raman scattering can provide enhanced and highly specific contrast for molecules containing unique Raman-active small molecular groups. This combination provides contrast for molecules that can otherwise be difficult to discriminate by Raman spectroscopy. Here, ...

journal_title：Journal of biomedical optics

authors： Weeks T,Schie I,den Hartigh LJ,Rutledge JC,Huser T

更新日期：2011-02-01 00:00:00

abstract：:Clustering analysis (CA) and principal component analysis (PCA) were applied to dynamic Cerenkov luminescence images (dCLI). In order to investigate the performances of the proposed approaches, two distinct dynamic data sets obtained by injecting mice with (32)P-ATP and (18)F-FDG were acquired using the IVIS 200 optic...

journal_title：Journal of biomedical optics

authors： Spinelli AE,Boschi F

更新日期：2011-12-01 00:00:00

abstract：:This work reports a miniaturized laparoscopic zoom camera that can significantly improve vision for minimally invasive surgery (MIS), also known as laparoscopic surgery. The laparoscopic zoom camera contains bioinspired fluidic lenses that can change curvature and focal length in a manner similar to the crystalline le...

journal_title：Journal of biomedical optics

authors： Tsai FS,Johnson D,Francis CS,Cho SH,Qiao W,Arianpour A,Mintz Y,Horgan S,Talamini M,Lo YH

更新日期：2010-05-01 00:00:00

abstract：:We demonstrate the first application of Raman spectroscopy in diagnosing nonmalignant, premalignant, malignant, and metastatic stages of breast cancer in a three-dimensional (3-D) cell culture model that closely mimics an in vivo environment. Comprehensive study comparing classification in two-dimensional (2-D) and 3-...

journal_title：Journal of biomedical optics

authors： Damayanti NP,Fang Y,Parikh MR,Craig AP,Kirshner J,Irudayaraj J

更新日期：2013-11-01 00:00:00

abstract：:Colorectal cancer is one of the most aggressive cancers usually occurring in people above the age of 50 years. In the United States, colorectal cancer is the third most diagnosed cancer. The American Cancer Society has estimated 96,830 new cases of colon cancer and 40,000 new cases of rectal cancer in 2014 in the Unit...

journal_title：Journal of biomedical optics

authors： Salman A,Sebbag G,Argov S,Mordechai S,Sahu RK

更新日期：2015-07-01 00:00:00

abstract：:Dynamic analyses of vibrational motion in cell membranes provide a lot of information on the complex dynamic motilities of a red blood cell (RBC). Here, we present the correlation properties of membrane fluctuation in discocyte and spherocyte RBCs by using quantitative phase microscopy (QPM). Since QPM can provide nan...

journal_title：Journal of biomedical optics

authors： Lee S,Lee JY,Park CS,Kim DY

更新日期：2011-07-01 00:00:00

abstract：:Reactive oxygen species (ROS) produced by photodynamic therapy (PDT) is recorded in vivo using a chemiluminescence (CL)-based gated optical system. A novel approach is developed to utilize the fluorescence (FL) of the CL probe as an internal fluorescence to calibrate the observed CL on pharmacokinetics of the probe in...

journal_title：Journal of biomedical optics

authors： Wei Y,Xing D,Luo S,Yang L,Chen Q

更新日期：2010-03-01 00:00:00

abstract：:Optical-resolution photoacoustic microscopy (ORPAM) in theory provides lateral resolution equivalent to the optical diffraction limit. Scattering media, such as biological turbid media, attenuates the optical signal and also alters the diffraction-limited spot size of the focused beam. The ORPAM signal is generated on...

journal_title：Journal of biomedical optics

authors： U-Thainual P,Kim DH

更新日期：2015-12-01 00:00:00