Photodynamic therapy: superficial and interstitial illumination.

abstract：:Animal models are widely used to investigate the pathological mechanisms of spinal cord injury (SCI), most commonly in rats. It is well known that compromised blood flow caused by mechanical disruption of the vasculature can produce irreversible damage and cell death in hypoperfused tissue regions and spinal cord tiss...

journal_title：Journal of biomedical optics

authors： Phillips JP,Cibert-Goton V,Langford RM,Shortland PJ

更新日期：2013-03-01 00:00:00

abstract：:Fourier transform infrared (FTIR) microspectroscopy has been used to estimate the spatial proteoglycan (PG) and collagen contents in articular cartilage (AC). However, it is not clear whether the results of FTIR analyses are consistent between different species. Our aim was to clarify how three different FTIR PG param...

journal_title：Journal of biomedical optics

authors： Rieppo L,Närhi T,Helminen HJ,Jurvelin JS,Saarakkala S,Rieppo J

更新日期：2013-09-01 00:00:00

abstract：:The formation of kidney stones is a common and highly studied disease, which causes intense pain and presents a high recidivism. In order to find the causes of this problem, the characterization of the main compounds is of great importance. In this sense, the analysis of the composition and structure of the stone can ...

journal_title：Journal of biomedical optics

authors： Blanco F,López-Mesas M,Serranti S,Bonifazi G,Havel J,Valiente M

更新日期：2012-07-01 00:00:00

abstract：:The measurement of changes in blood volume in tissue is important for monitoring the effects of a wide range of therapeutic interventions, from radiation therapy to skin-flap transplants. Many systems available for purchase are either expensive or difficult to use, limiting their utility in the clinical setting. A low...

journal_title：Journal of biomedical optics

authors： Glennie DL,Hayward JE,McKee DE,Farrell TJ

更新日期：2014-01-01 00:00:00

abstract：:Endoscopic ultrasound-guided fine needle aspirations (EUS-FNA) of pancreatic masses suffer from sample errors and low-negative predictive values. Fiber-optic spectroscopy in the visible to near-infrared wavelength spectrum can noninvasively extract physiological parameters from tissue and has the potential to guide th...

journal_title：Journal of biomedical optics

authors： Stegehuis PL,Boogerd LS,Inderson A,Veenendaal RA,van Gerven P,Bonsing BA,Sven Mieog J,Amelink A,Veselic M,Morreau H,van de Velde CJ,Lelieveldt BP,Dijkstra J,Robinson DJ,Vahrmeijer AL

更新日期：2017-02-01 00:00:00

abstract：SIGNIFICANCE:Spatial frequency domain imaging (SFDI) is an imaging modality that projects spatially modulated light patterns to determine optical property maps for absorption and reduced scattering of biological tissue via a pixel-by-pixel data acquisition and analysis procedure. Compressive sensing (CS) is a signal pr...

journal_title：Journal of biomedical optics

authors： Mellors BOL,Bentley A,Spear AM,Howle CR,Dehghani H

更新日期：2020-11-01 00:00:00

abstract：:Three-dimensional (3-D) tissue imaging offers substantial benefits to a wide range of biomedical investigations from cardiovascular biology, diabetes, Alzheimer's disease to cancer. Two-photon tissue cytometry is a novel technique based on high-speed multiphoton microscopy coupled with automated histological sectionin...

journal_title：Journal of biomedical optics

authors： Ragan T,Sylvan JD,Kim KH,Huang H,Bahlmann K,Lee RT,So PT

更新日期：2007-01-01 00:00:00

abstract：:The erratum notes a correction to Fig. 5 for the published article. ...

journal_title：Journal of biomedical optics

authors： Mundo AI,Greening GJ,Fahr MJ,Hale LN,Bullard EA,Rajaram N,Muldoon TJ

更新日期：2020-04-01 00:00:00

abstract：:Current diagnostic capabilities and limitations of fluorescence endomicroscopy in the cervix are assessed by qualitative and quantitative image analysis. Four cervical tissue types are investigated: normal columnar epithelium, normal and precancerous squamous epithelium, and stromal tissue. This study focuses on the p...

journal_title：Journal of biomedical optics

authors： Schlosser C,Bodenschatz N,Lam S,Lee M,McAlpine JN,Miller DM,Van Niekerk DJ,Follen M,Guillaud M,MacAulay CE,Lane PM

更新日期：2016-12-01 00:00:00

abstract：:This work reports a miniaturized laparoscopic zoom camera that can significantly improve vision for minimally invasive surgery (MIS), also known as laparoscopic surgery. The laparoscopic zoom camera contains bioinspired fluidic lenses that can change curvature and focal length in a manner similar to the crystalline le...

journal_title：Journal of biomedical optics

authors： Tsai FS,Johnson D,Francis CS,Cho SH,Qiao W,Arianpour A,Mintz Y,Horgan S,Talamini M,Lo YH

更新日期：2010-05-01 00:00:00

abstract：:The objective of the study is the quantitative analysis of the dose-time dependences of changes occurring in collagen of bladder and rectum after gamma-irradiation using optical methods [nonlinear microscopy in a second harmonic generation (SHG) detection regime and cross-polarization optical coherence tomography (CP ...

journal_title：Journal of biomedical optics

authors： Kochueva M,Dudenkova V,Kuznetsov S,Varlamova A,Sergeeva E,Kiseleva E,Maslennikova A

更新日期：2018-08-01 00:00:00

abstract：:A real-time photoacoustic imaging system is designed and built. This system is based on a commercially available ultrasound imaging system. It can achieve a frame rate of 8 frames/sec. Vasculature in the hand of a human volunteer is imaged, and the resulting photoacoustic image is combined with the ultrasound image. T...

journal_title：Journal of biomedical optics

authors： Kolkman RG,Brands PJ,Steenbergen W,van Leeuwen TG

更新日期：2008-09-01 00:00:00

abstract：:Many optical diagnostic approaches rely on changes in scattering and absorption properties to generate optical contrast between normal and diseased tissue. Recently, there has been increasing interest in using exogenous agents to enhance this intrinsic contrast with particular emphasis on the development for targeting...

journal_title：Journal of biomedical optics

authors： Lin AW,Lewinski NA,West JL,Halas NJ,Drezek RA

更新日期：2005-11-01 00:00:00

abstract：:Our current research in the framework of an interdisciplinary project focuses on modelling the dynamics of the hemoglobin reoxygenation process in post-mortem human skin by reflectance spectrometry. The observations of reoxygenation of hemoglobin in livores after postmortem exposure to a cold environment relate the re...

journal_title：Journal of biomedical optics

authors： Belenki L,Sterzik V,Schulz K,Bohnert M

更新日期：2013-01-01 00:00:00

abstract：:Traditional phase-resolved Doppler optical coherence tomography (DOCT) has been reported to have potential for characterizing local fluid flow within a microporous scaffold. In this work, we apply Doppler optical microangiography (DOMAG), a new imaging technique developed by combining optical microangiography (OMAG) w...

journal_title：Journal of biomedical optics

authors： Jia Y,An L,Wang RK

更新日期：2009-09-01 00:00:00

abstract：:Using commercially available organic fluorophores, the current applications of Förster (fluorescence) resonance energy transfer (FRET) are limited to about 80 Å. However, many essential activities in cells are spatially and/or temporally dependent on the assembly/disassembly of transient complexes consisting of large-...

journal_title：Journal of biomedical optics

authors： Maliwal BP,Raut S,Fudala R,D'Auria S,Marzullo VM,Luini A,Gryczynski I,Gryczynski Z

更新日期：2012-01-01 00:00:00

abstract：:Time-resolved measurement of early arriving photons through diffusive media has been shown to effectively reduce the high degree of light scatter in biological tissue. However, the experimentally achievable reduction in photon scatter and the impact of time-gated detection on instrument noise performance is not well u...

journal_title：Journal of biomedical optics

authors： Valim N,Brock J,Niedre M

更新日期：2010-11-01 00:00:00

abstract：:We present a hybrid method that combines a multilayered scaling method and a perturbation method to speed up the Monte Carlo simulation of diffuse reflectance from a multilayered tissue model with finite-size tumor-like heterogeneities. The proposed method consists of two steps. In the first step, a set of photon traj...

journal_title：Journal of biomedical optics

authors： Zhu C,Liu Q

更新日期：2012-01-01 00:00:00

abstract：:Hemoglobin (Hb), as one of main components of blood, has a unique quaternary structure. Its release of oxygen is controlled by oxygen partial pressure (PO2). We investigate the specific spectroscopic changes in Hb under different PO2 levels to optimize clinical methods of measuring tissue PO2. The transmissivity of Hb...

journal_title：Journal of biomedical optics

authors： Liu P,Zhu Z,Zeng C,Nie G

更新日期：2012-12-01 00:00:00

abstract：:We present a multimodal optical microscope that incorporates six imaging modalities on one common platform. The imaging modalities include three staring modes, optical quadrature microscopy (OQM), differential interference contrast (DIC) microscopy, and epi-fluorescence microscopy, and three scanning modes, confocal r...

journal_title：Journal of biomedical optics

authors： Warger WC 2nd,Laevsky GS,Townsend DJ,Rajadhyaksha M,DiMarzio CA

更新日期：2007-07-01 00:00:00

abstract：:We interrogate the ability of free-space fluorescence tomography to image small animals in vivo using charge-coupled device (CCD) camera measurements over 360-deg noncontact projections. We demonstrate the performance of normalized dual-wavelength measurements that are essential for in-vivo use, as they account for th...

journal_title：Journal of biomedical optics

authors： Deliolanis NC,Dunham J,Wurdinger T,Figueiredo JL,Tannous BA,Ntziachristos V

更新日期：2009-05-01 00:00:00

abstract：:Skin cancer diagnosis depends not only on histopathological examination but also on visual inspection before and after the excision of suspected lesion. Neoplasm is accompanied with changes in birefringence of collagen, pleomorphicity, and hyperchromatic state of epithelial nuclei. These phenomena can be measured by s...

journal_title：Journal of biomedical optics

authors： Aharon O,Abdulhalim I,Arnon O,Rosenberg L,Dyomin V,Silberstein E

更新日期：2011-08-01 00:00:00

abstract：:We propose an algorithm to compensate for the refractive index error in the optical coherence tomography (OCT) images of multilayer tissues, such as skin. The performance of the proposed method has been evaluated on one- and two-layer solid phantoms, as well as the skin of rat paw. ...

journal_title：Journal of biomedical optics

authors： Turani Z,Fatemizadeh E,Xu Q,Daveluy S,Mehregan D,Nasiri Avanaki MR

更新日期：2018-07-01 00:00:00

abstract：SIGNIFICANCE:Despite the importance of the cell membrane in regulation of drug activity, the influence of drug treatments on its physical properties is still poorly understood. The combination of fluorescence lifetime imaging microscopy (FLIM) with specific viscosity-sensitive fluorescent molecular rotors allows the qu...

journal_title：Journal of biomedical optics

authors： Shimolina LE,Gulin AA,Paez-Perez M,López-Duarte I,Druzhkova IN,Lukina MM,Gubina MV,Brooks NJ,Zagaynova EV,Kuimova MK,Shirmanova MV

更新日期：2020-12-01 00:00:00

abstract：:Virus inactivation in red blood cell concentrates (RBCC) is being studied in order to increase the safety of the blood supply. For this purpose we have been studying the silicon phthalocyanine (Pc 4), a photosensitizer activated with red light. Two approaches were used to achieve enhanced selectivity of Pc 4 for virus...

journal_title：Journal of biomedical optics

authors： Ben-Hur E,Zuk MM,Oetjen J,Chan WS,Lenny L,Horowitz B

更新日期：1999-07-01 00:00:00

abstract：:The expensive fabrication of current opto-microfluidic sensors is a barrier to the successful adoption of these devices in point-of-care testing. This work reports a simple inexpensive opto-microfluidic device incorporating a poly(dimethylsiloxane)-glass hybrid microfluidic chip modified with gold nanoparticles and a ...

journal_title：Journal of biomedical optics

authors： Pires NM,Dong T

更新日期：2014-03-01 00:00:00

abstract：:Fluorescence cystoscopy (FC) efficiently enhances the detection and improves the therapeutic management of early bladder cancer. During an FC, about 150 ml of water is needed to inflate the bladder. The water is quickly diluted by urine which can be fluorescent. If this bladder washout fluid (BWF) becomes fluorescent,...

journal_title：Journal of biomedical optics

authors： Zellweger M,Martoccia C,Mengin M,Iselin C,van den Bergh H,Wagnières G

更新日期：2015-06-01 00:00:00

abstract：:We present a novel confocal microscope that has dual-axis architecture and biaxial postobjective scanning for the collection of fluorescence images from biological specimens. This design uses two low-numerical-aperture lenses to achieve high axial resolution and long working distance, and the scanning mirror located d...

journal_title：Journal of biomedical optics

authors： Wang TD,Contag CH,Mandella MJ,Chan NY,Kino GS

更新日期：2004-07-01 00:00:00

abstract：:Dispersion encoded full-range (DEFR) frequency-domain optical coherence tomography (FD-OCT) and its enhanced version, fast DEFR, utilize dispersion mismatch between sample and reference arm to eliminate the ambiguity in OCT signals caused by non-complex valued spectral measurement, thereby numerically doubling the usa...

journal_title：Journal of biomedical optics

authors： Wang L,Hofer B,Guggenheim JA,Povazay B

更新日期：2012-07-01 00:00:00

abstract：:Lumpectomy coupled with radiation therapy and/or chemotherapy is commonly used to treat breast cancer patients. We are developing an enhanced thermal IR imaging technique that has the potential to provide real-time imaging to guide tissue excision during a lumpectomy by delineating tumor margins. This enhanced thermal...

journal_title：Journal of biomedical optics

authors： Case JR,Young MA,Dréau D,Trammell SR

更新日期：2015-11-01 00:00:00