Optical coherence tomography today: speed, contrast, and multimodality.

abstract：:We report the design of a novel laser line-triangulation laryngoscope for the quantitative visualization of the three-dimensional movements of human vocal folds during phonation. This is the first successful in vivo recording of the three-dimensional movements of human vocal folds in absolute values. Triangulation ima...

journal_title：Journal of biomedical optics

authors： George NA,de Mul FF,Qiu Q,Rakhorst G,Schutte HK

更新日期：2008-11-01 00:00:00

abstract：:Photodynamic therapy (PDT) is reviewed using the treatment of skin tumors as an example of superficial lesions and prostate cancer as an example of deep-lying lesions requiring interstitial intervention. These two applications are among the most commonly studied in oncological PDT, and illustrate well the different ch...

journal_title：Journal of biomedical optics

authors： Svanberg K,Bendsoe N,Axelsson J,Andersson-Engels S,Svanberg S

更新日期：2010-07-01 00:00:00

abstract：:The effect of glucose on fluorescence of synthesized ZnCdS nanoparticles in the presence of glucose oxidase or in a mixture of glucose oxidase and peroxidase has been investigated. Behavior of fluorescence characteristics of ZnCdS nanoparticles with nonstabilized surface and coated with polymer shell is compared. It h...

journal_title：Journal of biomedical optics

authors： Kochubey VI,Volkova EK,Konyukhova JG

更新日期：2014-01-01 00:00:00

abstract：:Using the multiresolution ability of wavelets and effectiveness of singular value decomposition (SVD) to identify statistically robust parameters, we find a number of local and global features, capturing spectral correlations in the co- and cross-polarized channels, at different scales (of human breast tissues). The c...

journal_title：Journal of biomedical optics

authors： Gharekhan AH,Arora S,Oza AN,Sureshkumar MB,Pradhan A,Panigrahi PK

更新日期：2011-08-01 00:00:00

abstract：:Environmental metastability of zirconia (ZrO2) ceramic in the human body [represented by a tetragonal-to-monoclinic (t→m) phase transformation] takes place on the surface of the artificial joint and proceeds with time toward its interior. Its quantitative characterization is mandatory for the safety of joint implants ...

journal_title：Journal of biomedical optics

authors： Zhu W,Sugano N,Pezzotti G

更新日期：2013-12-01 00:00:00

abstract：:Smart toilets could be used to monitor different components of urine in daily life for early detection of lifestyle-related diseases and prompt provision of treatment. For analysis of biological samples such as urine by midinfrared spectroscopy, thin-film samples like liquid cells are needed because of the strong abso...

journal_title：Journal of biomedical optics

authors： Yamamoto N,Kawashima N,Kitazaki T,Mori K,Kang H,Nishiyama A,Wada K,Ishimaru I

更新日期：2018-05-01 00:00:00

abstract：:A swept source (SS)-based circular-state (CS) polarization-sensitive optical coherence tomography (PS-OCT) constructed entirely with polarization-maintaining fiber optics components is proposed with the experimental verification. By means of the proposed calibration scheme, bulk quarter-wave plates can be replaced by ...

journal_title：Journal of biomedical optics

authors： Lin H,Kao MC,Lai CM,Huang JC,Kuo WC

更新日期：2014-02-01 00:00:00

abstract：:We quantitatively investigated the measurement sensitivity of spatially resolved spectroscopy (SRS) across six tissue models: cerebral tissue, a small animal brain, the forehead of a fetus, an adult brain, forearm muscle, and thigh muscle. The optical path length in the voxel of the model was analyzed using Monte Carl...

journal_title：Journal of biomedical optics

authors： Niwayama M

更新日期：2018-03-01 00:00:00

abstract：:The study presents comparison of near-infrared light propagation and near-infrared backscattered radiation power, as simulated with numerical modeling and measured live in a patient in clinical conditions with the use of the near-infrared transillumination-backscattering sounding (NIR-TBSS) technique. A unique chance ...

journal_title：Journal of biomedical optics

authors： Frydrychowski AF,Pluciński J

更新日期：2007-07-01 00:00:00

abstract：:Spatially resolved spectroscopy (SRS) allows the estimation of absolute tissue oxygen saturation, the ratio of oxygenated to total hemoglobin concentration, which may facilitate the comparison of results among patients. Eighty-two premature infants were included over two years. The cerebral tissue oxygenation index (c...

journal_title：Journal of biomedical optics

authors： Sorensen LC,Leung TS,Greisen G

更新日期：2008-11-01 00:00:00

abstract：:Spatially resolved diffuse reflectance spectroscopy (srDRS) is a well-established technique for noninvasive, in vivo characterization of tissue optical properties toward diagnostic applications. srDRS has a potential for depth-resolved analysis of tissue, which is desired in various clinical situations. However, curre...

journal_title：Journal of biomedical optics

authors： Petitdidier N,Koenig A,Gerbelot R,Grateau H,Gioux S,Jallon P

更新日期：2018-11-01 00:00:00

abstract：:The objective is to characterize the impact of different ablation parameters on the thermal load during corneal refractive surgery by means of excimer laser ablation on porcine eyes. One hundred eleven ablations were performed in 105 porcine eyes. Each ablation was recorded using infrared thermography and analyzed mai...

journal_title：Journal of biomedical optics

authors： Arba Mosquera S,Verma S

更新日期：2015-07-01 00:00:00

abstract：:In the last decade, coherent anti-Stokes Raman scattering (CARS) microscopy has emerged as a powerful multiphoton imaging technique offering label-free chemical sensitivity and high three-dimensional resolution. However, its widespread application in the life sciences has been hampered by the use of costly pulsed lase...

journal_title：Journal of biomedical optics

authors： Li B,Borri P,Langbein W

更新日期：2013-06-01 00:00:00

abstract：:Subsurface fluorescence molecular tomography (FMT) has promising potential for noninvasive characterization of molecular and cellular activities in small animals by tomographic means in reflectance geometry. In this work, subsurface FMT is employed to monitor the therapeutic response of cisplatin in tumor-bearing mice...

journal_title：Journal of biomedical optics

authors： Liu F,Cao X,He W,Song J,Dai Z,Zhang B,Luo J,Li Y,Bai J

更新日期：2012-04-01 00:00:00

abstract：:We present in vivo human total retinal blood flow measurements using Doppler Fourier domain optical coherence tomography (OCT). The scan pattern consisted of two concentric circles around the optic nerve head, transecting all retinal branch arteries and veins. The relative positions of each blood vessel in the two OCT...

journal_title：Journal of biomedical optics

authors： Wang Y,Bower BA,Izatt JA,Tan O,Huang D

更新日期：2008-11-01 00:00:00

abstract：:An autofluorescence lifetime wide-field imaging system that can generate contrast in underlying tissue structures of normal and malignant brain tissue samples with video rate acquisition and processing time is presented. Images of the investigated tissues were acquired with high resolution (∼35 μm) using an algorithm ...

journal_title：Journal of biomedical optics

authors： Papour A,Taylor Z,Sherman A,Sanchez D,Lucey G,Liau L,Stafsudd O,Yong W,Grundfest W

更新日期：2013-06-01 00:00:00

abstract：:We propose a useful method to boost the imaging speed for spectral domain optical coherence tomography (SDOCT) by multiplying a number of high-speed spectrometers used in the system with selective precise control of data-recording and data-reading phases for spectral cameras employed in each spectrometer. To demonstra...

journal_title：Journal of biomedical optics

authors： An L,Guan G,Wang RK

更新日期：2011-06-01 00:00:00

abstract：:Pedicle screw (PS) fixation has been widely used for spine diseases. Scientists and clinicians employ several approaches to navigate PS during operation. We have demonstrated the feasibility of monitoring the reduced scattering coefficient (μ's) on the trajectory of PS using near-infrared spectroscopy (NIRS). To perfo...

journal_title：Journal of biomedical optics

authors： Liu Y,Wang Y,Qian Z,Zhao J,Cao X,Li W

更新日期：2014-01-01 00:00:00

abstract：:We used two-photon laser scanning microscopy (TPLSM) to demonstrate for the first time its potential in studying relational details at the cellular level of atherogenesis in intact, viable mouse carotid arteries. Isolated and mounted arteries of ApoE-/-mice, aged 15 or 21 weeks (7 and 13 weeks on western diet), were i...

journal_title：Journal of biomedical optics

authors： Megens RT,oude Egbrink MG,Merkx M,Slaaf DW,van Zandvoort MA

更新日期：2008-07-01 00:00:00

abstract：:Two pronounced absorption peaks in blue and red ranges of the chlorin-based photosensitizer (PS) absorption spectrum provide additional benefits in photodynamic therapy (PDT) performance. Differing optical properties of biological tissues in these ranges allow for both dual-wavelength diagnostics and PDT performance. ...

journal_title：Journal of biomedical optics

authors： Kurakina D,Khilov A,Shakhova M,Orlinskaya N,Sergeeva E,Meller A,Turchin I,Kirillin M

更新日期：2019-12-01 00:00:00

abstract：:The attenuation of near-infrared (NIR) light intensity as it propagates in a turbid medium like biological tissue is described by modified the Beer–Lambert law (MBLL). The MBLL is generally used to quantify the changes in tissue chromophore concentrations for NIR spectroscopic data analysis. Even though MBLL is effect...

journal_title：Journal of biomedical optics

authors： Bhatt M,Ayyalasomayajula KR,Yalavarthy PK

更新日期：2016-07-01 00:00:00

abstract：:Photoacoustic imaging has become an emerging tool for theranostic applications. Not only does it help in

journal_title：Journal of biomedical optics

authors： Sivasubramanian K,Mathiyazhakan M,Wiraja C,Upputuri PK,Xu C,Pramanik M

更新日期：2017-04-01 00:00:00

abstract：:Selective retina treatment (SRT) is a novel short pulsed laser therapy of several retinal diseases associated with a decreased metabolism at the retinal pigment epithelium (RPE). The range of laser pulse energies is small, in which the desired selective RPE disintegration is achieved without adverse effects to the neu...

journal_title：Journal of biomedical optics

authors： Neumann J,Brinkmann R

更新日期：2006-07-01 00:00:00

abstract：:We examine the morphological and chemical changes in the pulp chamber dentin after using endodontic agents by scanning electron microscopy (SEM), Fourier transform Raman spectroscopy (FT-Raman), and micro energy-dispersive x-ray fluorescence spectrometry (μEDXRF). Thirty teeth were sectioned exposing the pulp chamber ...

journal_title：Journal of biomedical optics

authors： Pascon FM,Kantovitz KR,Soares LE,Santo AM,Martin AA,Puppin-Rontani RM

更新日期：2012-07-01 00:00:00

abstract：:Immersion optical clearing makes it possible to use transmission polarized-light microscopy for characterization of thick (200 to 2000  μm) layers of biological tissues. We discuss polarization properties of thick samples in the context of the problem of characterization of collagen fiber alignment in connective tissu...

journal_title：Journal of biomedical optics

authors： Yakovlev DD,Shvachkina ME,Sherman MM,Spivak AV,Pravdin AB,Yakovlev DA

更新日期：2016-07-01 00:00:00

abstract：:The atrial pacemaker complex is responsible for the initiation and early propagation of cardiac impulses. Optical coherence tomography (OCT), a nondestructive imaging modality with spatial resolutions of ∼1 to 15 μm, can be used to identify unique fiber orientation patterns in this region of the heart. Functionally ch...

journal_title：Journal of biomedical optics

authors： Ambrosi CM,Fedorov VV,Schuessler RB,Rollins AM,Efimov IR

更新日期：2012-07-01 00:00:00

abstract：:Angle-resolved optical scattering properties of ovarian tissue, on different optical coherence tomography (OCT) imaging planes, were quantitatively measured by fitting the compounded OCT A-lines into a single scattering model. Higher cross correlation value of angle-resolved scattering coefficients between different O...

journal_title：Journal of biomedical optics

authors： Yang Y,Wang T,Brewer M,Zhu Q

更新日期：2012-09-01 00:00:00

abstract：:The cyclic peptide, cyclopentapeptide cyclo(lys-Arg-Gly-Asp-phe) (c(KRGDf)), which is known to target alpha(v)beta3 integrin, is dual-labeled with a radiotracer, (111)indium, for gamma scintigraphy as well as with a near-infrared dye, IRDye800, for continuous-wave (cw) imaging of alpha(v)beta3 positive human M21 melan...

journal_title：Journal of biomedical optics

authors： Houston JP,Ke S,Wang W,Li C,Sevick-Muraca EM

更新日期：2005-09-01 00:00:00

abstract：:This study aimed to evaluate the concept of using high-resolution optical coherence tomography (OCT) imaging to rapidly assess surgical specimens and determine if cancer positive margins were left behind in the surgical bed. A mouse model of breast cancer was used in this study. Surgical specimens from 30 animals were...

journal_title：Journal of biomedical optics

authors： Savastru D,Chang EW,Miclos S,Pitman MB,Patel A,Iftimia N

更新日期：2014-05-01 00:00:00

abstract：:A transgenic mouse model with a Clim [co-factor of LIM (a combination of first letters of Lin-11 (C. elegans), ISL1 (rat), and Mec-3 (C. elegans) gene names) domain proteins] gene partially blocked in the epithelial compartment of its tissues is used to establish the sensitivity of intrinsic reflectance nonlinear opti...

journal_title：Journal of biomedical optics

authors： Lyubovitsky JG,Spencer JA,Krasieva TB,Andersen B,Tromberg BJ

更新日期：2006-01-01 00:00:00