Monitoring of tumor response to cisplatin by subsurface fluorescence molecular tomography.

abstract：:Oxygen plays a very important role in living cells. The intracellular level of oxygen is under tight control, as even a small deviation from normal oxygen level affects major cellular metabolic processes and is likely to result in cellular damage or cell death. This paper describes the use of the oxygen sensitive fluo...

journal_title：Journal of biomedical optics

authors： Asiedu JK,Ji J,Nguyen M,Rosenzweig N,Rosenzweig Z

更新日期：2001-04-01 00:00:00

abstract：:Parametric and nonparametric data processing schemes for analyzing translating laser speckle data used to investigate the mechanical behavior of biological tissues are examined. Cross-correlation, minimum mean square estimator, maximum likelihood, and maximum entropy approaches are discussed and compared on speckle da...

journal_title：Journal of biomedical optics

authors： Duncan DD,Kirkpatrick SJ

更新日期：2001-10-01 00:00:00

abstract：:It is widely known that not all of the treated cells survive after introduction of exogenous molecules via any physical method. Therefore, it is important to develop methods that would allow simultaneous evaluation of both molecular delivery efficiency and cell viability. This study presents Förster resonance energy t...

journal_title：Journal of biomedical optics

authors： Ruzgys P,Tamošiūnas M,Lukinsone V,Šatkauskas S

更新日期：2017-09-01 00:00:00

abstract：:The specificity of molecular and functional photoacoustic (PA) images depends on the accuracy of the photoacoustic absorption spectroscopy. The PA signal is proportional to the product of the optical absorption coefficient and local light fluence; quantitative PA measurements of the optical absorption coefficient ther...

journal_title：Journal of biomedical optics

authors： Bauer AQ,Nothdurft RE,Erpelding TN,Wang LV,Culver JP

更新日期：2011-09-01 00:00:00

abstract：:We investigate the statistical polarization parameters of biological tissue histological section images with different morphological structure. First we outline the results of polarization coordinate mapping and analysis of the statistics of the first to fourth orders of biological tissue image polarization azimuth an...

journal_title：Journal of biomedical optics

authors： Angelsky OV,Ushenko AG,Ushenko YA,Ushenko YG,Tomka YY,Pishak VP

更新日期：2005-11-01 00:00:00

abstract：:The spatiotemporal characteristics of changes in cerebral blood volume associated with neuronal activity were investigated in the hindlimb somatosensory cortex of alpha-chloralose-urethane anesthetized rats (n=10) with optical imaging at 570 nm through a thinned skull. Activation of the cortex was carried out by elect...

journal_title：Journal of biomedical optics

authors： Li P,Luo Q,Luo W,Chen S,Cheng H,Zeng S

更新日期：2003-10-01 00:00:00

abstract：:Biological systems with intrinsic luminescent properties serve as powerful and noninvasive bioreporters for real-time and label-free monitoring of cell physiology. This study employs the bioluminescent marine bacterium Vibrio fischeri to investigate the effects of separated microwave electric (E) and magnetic (H) fiel...

journal_title：Journal of biomedical optics

authors： Williams CF,Geroni GM,Lloyd D,Choi H,Clark N,Pirog A,Lees J,Porch A

更新日期：2019-02-01 00:00:00

abstract：:We report on wide-field imaging of pulsatile motion induced by blood flow using heterodyne holographic interferometry on the thumb of a healthy volunteer, in real time. Optical Doppler images were measured with green laser light by a frequency-shifted Mach-Zehnder interferometer in off-axis configuration. The recorded...

journal_title：Journal of biomedical optics

authors： Bencteux J,Pagnoux P,Kostas T,Bayat S,Atlan M

更新日期：2015-06-01 00:00:00

abstract：:Three major analytical tools in imaging science are summarized and demonstrated relative to optical imaging in vivo. Standard resolution testing is optimal when infinite contrast is used and hardware evaluation is the goal. However, deep tissue imaging of absorption or fluorescent contrast agents in vivo often present...

journal_title：Journal of biomedical optics

authors： Pogue BW,Davis SC,Song X,Brooksby BA,Dehghani H,Paulsen KD

更新日期：2006-05-01 00:00:00

abstract：:Measuring the elasticity distribution inside the human body is of great interest because elastic abnormalities can serve as indicators of several diseases. We present a method for mapping elasticity inside soft tissues by imaging surface acoustic waves (SAWs) with digital holographic interferometry. With this method, ...

journal_title：Journal of biomedical optics

authors： Li S,Mohan KD,Sanders WW,Oldenburg AL

更新日期：2011-11-01 00:00:00

abstract：:Fluorescence diagnostic techniques are notable amongst many other optical methods because they offer high sensitivity and noninvasive measurement of tissue properties. However, a combination of multiple scattering and physical heterogeneity of biological tissues hampers interpretation of the fluorescence measurements....

journal_title：Journal of biomedical optics

authors： Churmakov DY,Meglinski IV,Greenhalgh DA

更新日期：2004-03-01 00:00:00

abstract：:Traditional white-light and fluorescent imaging techniques provide powerful methods to extract high-resolution information from two-dimensional (2-D) sections, but to retrieve information from a three-dimensional (3-D) volume they require relatively slow scanning methods that result in increased acquisition time. Usin...

journal_title：Journal of biomedical optics

authors： Duocastella M,Sun B,Arnold CB

更新日期：2012-05-01 00:00:00

abstract：:Dental erosion starts with a chemical attack on dental tissue causing tooth demineralization, altering the tooth structure and making it more sensitive to mechanical erosion. Medical diagnosis of dental erosion is commonly achieved through a visual inspection by the dentist during dental checkups and is therefore high...

journal_title：Journal of biomedical optics

authors： Abou Nader C,Pellen F,Loutfi H,Mansour R,Le Jeune B,Le Brun G,Abboud M

更新日期：2016-07-01 00:00:00

abstract：:Quantitative spectroscopy has recently been extended from a contact-probe to wide-area spectroscopic imaging to enable mapping of optical properties across a wide area of tissue. We train quantitative spectroscopic imaging (QSI) to identify cervical high-grade squamous intraepithelial lesions (HSILs) in 34 subjects un...

journal_title：Journal of biomedical optics

authors： Lau C,Mirkovic J,Yu CC,O'Donoghue GP,Galindo L,Dasari R,de las Morenas A,Feld M,Stier E

更新日期：2013-07-01 00:00:00

abstract：:The present work describes the fabrication and characterization of an optical fiber pH sensor using a sol–gel technique. The sensing head configuration is incorporated using a short section of no-core fiber, coated with tetraethyl orthosilicate and spliced at the end of a single mode fiber with a bulge. Different type...

journal_title：Journal of biomedical optics

authors： Bhardwaj V,Pathak AK,Singh VK

更新日期：2017-05-01 00:00:00

abstract：:We address the automatic differentiation of human tissue using multispectral imaging with promising potential for automatic visualization during surgery. Currently, tissue types have to be continuously differentiated based on the surgeon's knowledge only. Further, automatic methods based on optical in vivo properties ...

journal_title：Journal of biomedical optics

authors： Wisotzky EL,Uecker FC,Arens P,Dommerich S,Hilsmann A,Eisert P

更新日期：2018-05-01 00:00:00

abstract：:Vascular leakage is an important feature of various disease conditions. In vivo optical imaging provides a great opportunity for the evaluation of this phenomenon. In the present study, we focus on the development and validation of a near-infrared (NIR) imaging formula to allow reliable, cost-efficient evaluation of v...

journal_title：Journal of biomedical optics

authors： Botz B,Bölcskei K,Kemény Á,Sándor Z,Tékus V,Sétáló G Jr,Csepregi J,Mócsai A,Pintér E,Kollár L,Helyes Z

更新日期：2015-01-01 00:00:00

abstract：:Near-infrared diffuse optical tomography (DOT), one of the most sophisticated optical imaging techniques for observations through biological tissue, allows 3-D quantitative imaging of optical properties, which include functional and anatomical information. With DOT, it is expected to be possible to overcome the limita...

journal_title：Journal of biomedical optics

authors： Hoshi Y,Yamada Y

更新日期：2016-09-01 00:00:00

abstract：:Cortical spreading depression (CSD) is a slowly propagating wave of depolarization of neurons and glia and has a less characterized vascular component. CSD is a commonly used phenomenon to test new methods of live brain imaging. Application of a blood pulsations imaging (BPI) technique to study of CSD induced with hig...

journal_title：Journal of biomedical optics

authors： Teplov V,Shatillo A,Nippolainen E,Gröhn O,Giniatullin R,Kamshilin AA

更新日期：2014-04-01 00:00:00

abstract：:Surfactant stabilized microbubbles are widely used clinical contrast agents for ultrasound imaging. In this work, the light propagation through a turbid medium in the presence of microbubbles has been investigated. Through a series of experiments, it has been found that the optical attenuation is increased when the mi...

journal_title：Journal of biomedical optics

authors： Leung TS,Honeysett JE,Stride E,Deng J

更新日期：2013-01-01 00:00:00

abstract：:Planar glass waveguides with a specific number of modes were fabricated by Ag(+)-Na(+) exchange in Schott SG11 glass. The effective refractive indices were determined using m-line spectroscopy in both s- and p-polarization. By using the reversed Wentzel-Kramers-Brillouin approximation, the index profiles were describe...

journal_title：Journal of biomedical optics

authors： Hassanzadeh A,Nitsche M,Armstrong S,Nabavi N,Harrison R,Dixon SJ,Langbein U,Mittler S

更新日期：2010-05-01 00:00:00

abstract：:Lumpectomy coupled with radiation therapy and/or chemotherapy is commonly used to treat breast cancer patients. We are developing an enhanced thermal IR imaging technique that has the potential to provide real-time imaging to guide tissue excision during a lumpectomy by delineating tumor margins. This enhanced thermal...

journal_title：Journal of biomedical optics

authors： Case JR,Young MA,Dréau D,Trammell SR

更新日期：2015-11-01 00:00:00

abstract：:We fabricate scaffolds with a fine linear grating (periodicity of 1 to 8 microm and height of 1 microm) on a glass substrate for controlling cardiomyocyte orientation. The fabrication is done by the solidification of a liquid photopolymerizable material using two laser beam interference. As the photopolymerizable mate...

journal_title：Journal of biomedical optics

authors： Fujita A,Fujita K,Nakamura O,Matsuda T,Kawata S

更新日期：2006-03-01 00:00:00

abstract：:The Nikon C1 confocal laser scanning microscope is a relatively inexpensive and user-friendly instrument. We describe a straightforward method to convert the C1 for multiphoton microscopy utilizing direct coupling of a femtosecond near-infrared laser into the scan head and fiber optic transmission of emission light to...

journal_title：Journal of biomedical optics

authors： Mancuso JJ,Larson AM,Wensel TG,Saggau P

更新日期：2009-05-01 00:00:00

abstract：:Intracellular oxygen concentration is of primary importance in determining numerous physiological and pathological processes in biological systems. In this paper, we describe the application of the oxygen sensing indicator, ruthenium dibipyridine 4-(1"-pyrenyl)-2,2'-bipyridine chloride [Ru(bpy-pyr)(bpy)(2)], for molec...

journal_title：Journal of biomedical optics

authors： Ji J,Rosenzweig N,Jones I,Rosenzweig Z

更新日期：2002-07-01 00:00:00

abstract：:We report a new two-channel fluorescence microscopy technique for surface-generated fluorescence. The realized fluorescence microscope allows high resolution imaging of aqueous samples. The core element of the instrument is a parabolic mirror objective that is used to collect the fluorescence at large surface angles a...

journal_title：Journal of biomedical optics

authors： Verdes D,Ruckstuhl T,Seeger S

更新日期：2007-05-01 00:00:00

abstract：:We present the first experimental result of direct delineation of the nuclei of living rat bladder epithelium with ultrahigh-resolution optical coherence tomography (uOCT). We demonstrate that the cellular details embedded in the speckle noise in a uOCT image can be uncovered by time-lapse frame averaging that takes a...

journal_title：Journal of biomedical optics

authors： Pan YT,Wu ZL,Yuan ZJ,Wang ZG,Du CW

更新日期：2007-09-01 00:00:00

abstract：:Blood smear analysis has remained a crucial diagnostic tool for pathologists despite the advent of automatic analyzers such as flow cytometers and impedance counters. Though these current methods have proven to be indispensible tools for physicians and researchers alike, they provide limited information on the detaile...

journal_title：Journal of biomedical optics

authors： Mir M,Ding H,Wang Z,Reedy J,Tangella K,Popescu G

更新日期：2010-03-01 00:00:00

abstract：:Virus inactivation in red blood cell concentrates (RBCC) is being studied in order to increase the safety of the blood supply. For this purpose we have been studying the silicon phthalocyanine (Pc 4), a photosensitizer activated with red light. Two approaches were used to achieve enhanced selectivity of Pc 4 for virus...

journal_title：Journal of biomedical optics

authors： Ben-Hur E,Zuk MM,Oetjen J,Chan WS,Lenny L,Horowitz B

更新日期：1999-07-01 00:00:00

abstract：:Obstruction in the upper airway can often cause reductions in breathing or gas exchange efficiency and lead to rest disorders such as sleep apnea. Imaging diagnosis of the obstruction region has been accomplished using computed tomography (CT) and magnetic resonance imaging (MRI). However CT requires the use of ionizi...

journal_title：Journal of biomedical optics

authors： Jing J,Zhang J,Loy AC,Wong BJ,Chen Z

更新日期：2012-11-01 00:00:00