Abstract:
:Fourier transform infrared (FTIR) spectroscopic imaging has been used to probe the biochemical composition of human renal tumor tissue and adjacent normal tissue. Freshly resected renal tumor tissue from surgery was prepared as a thin cryosection and examined by FTIR spectroscopic imaging. Tissue types could be discriminated by utilizing a combination of fuzzy k-means cluster analysis and a supervised classification algorithm based on a linear discriminant analysis. The spectral classification is compared and contrasted with the histological stained image. It is further shown that renal tumor cells have spread in adjacent normal tissue. This study demonstrates that FTIR spectroscopic imaging can potentially serve as a fast and objective approach for discrimination of renal tumor tissue from normal tissue and even in the detection of tumor infiltration in adjacent tissue.
journal_name
J Biomed Optjournal_title
Journal of biomedical opticsauthors
Sablinskas V,Urboniene V,Ceponkus J,Laurinavicius A,Dasevicius D,Jankevicius F,Hendrixson V,Koch E,Steiner Gdoi
10.1117/1.3622292subject
Has Abstractpub_date
2011-09-01 00:00:00pages
096006issue
9eissn
1083-3668issn
1560-2281journal_volume
16pub_type
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