Mathematical model that describes the transition from thermal to photochemical damage in retinal pigment epithelial cell culture.


:We propose a rate process model for describing photochemical damage to retinal cells by short wavelength laser exposures. The rate equation for photochemical damage contains a positive rate that is temperature independent, and a negative (quenching) rate that is temperature dependent. Using the traditional Arrhenius integral to describe thermal damage, we derive damage threshold doses for both thermal and photochemical mechanisms, and show that the model accounts for the sharp transition from thermal to photochemical damage thresholds that have recently been observed in an in-vitro retinal model.


J Biomed Opt


Clark CD 3rd,Denton ML,Thomas RJ




Has Abstract


2011-02-01 00:00:00












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    authors: Pham TH,Hornung R,Ha HP,Burney T,Serna D,Powell L,Brenner M,Tromberg BJ

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    abstract::Bacterial contamination of blood products is one of the most frequent infectious complications of transfusion. Since glucose levels in blood supplies decrease as bacteria proliferate, it should be possible to detect the presence of bacterial contamination by measuring the glucose concentrations in the blood components...

    journal_title:Journal of biomedical optics

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    authors: Suzuki Y,Maruo K,Zhang AW,Shimogaki K,Ogawa H,Hirayama F

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  • Multimodal optical measurement in vitro of surface deformations and wall thickness of the pressurized aortic arch.

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    journal_title:Journal of biomedical optics

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    authors: Genovese K,Humphrey JD

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  • Evaluation and quantification of spectral information in tissue by confocal microscopy.

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    authors: Maeder U,Marquardt K,Beer S,Bergmann T,Schmidts T,Heverhagen JT,Zink K,Runkel F,Fiebich M

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    journal_title:Journal of biomedical optics

    pub_type: 杂志文章


    authors: Werkmeister RM,Vietauer M,Knopf C,Fürnsinn C,Leitgeb RA,Reitsamer H,Gröschl M,Garhöfer G,Vilser W,Schmetterer L

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  • Appearance of breast cysts in planar geometry photoacoustic mammography using 1064-nm excitation.

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    authors: Heijblom M,Piras D,Maartens E,Huisman EJ,van den Engh FM,Klaase JM,Steenbergen W,Manohar S

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    authors: Lee YM,Tu RY,Chiang AC,Huang YC

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    journal_title:Journal of biomedical optics

    pub_type: 杂志文章


    authors: Elmaklizi A,Schäfer J,Kienle A

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  • Monitoring of drug and stimulation induced cerebral blood flow velocity changes in rat sensory cortex using spectral domain Doppler optical coherence tomography.

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    journal_title:Journal of biomedical optics

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    authors: Wang C,Yang Y,Ding Z,Meng J,Wang K,Yang W,Xu Y

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    authors: Angelsky OV,Ushenko AG,Ushenko YA,Ushenko YG,Tomka YY,Pishak VP

    更新日期:2005-11-01 00:00:00

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    authors: Campos-Delgado DU,Gutierrez-Navarro O,Arce-Santana ER,Skala MC,Walsh AJ,Jo JA

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    journal_title:Journal of biomedical optics

    pub_type: 杂志文章


    authors: Palmer GM,Viola RJ,Schroeder T,Yarmolenko PS,Dewhirst MW,Ramanujam N

    更新日期:2009-03-01 00:00:00

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    pub_type: 杂志文章,评审


    authors: Kirillin M,Motovilova T,Shakhova N

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    journal_title:Journal of biomedical optics

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    authors: Abookasis D,Shochat A,Mathews MS

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  • Caries detection and quantification around stained pits and fissures in occlusal tooth surfaces with fluorescence.

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    authors: Lee HS,Kim SK,Park SW,de Josselin de Jong E,Kwon HK,Jeong SH,Kim BI

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    journal_title:Journal of biomedical optics

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    authors: Kovaleva VD,Uzdensky AB

    更新日期:2016-10-01 00:00:00

  • Dynamics of retinal photocoagulation and rupture.

    abstract::In laser retinal photocoagulation, short (<20 ms) pulses have been found to reduce thermal damage to the inner retina, decrease treatment time, and minimize pain. However, the safe therapeutic window (defined as the ratio of power for producing a rupture to that of mild coagulation) decreases with shorter exposures. T...

    journal_title:Journal of biomedical optics

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    authors: Sramek C,Paulus Y,Nomoto H,Huie P,Brown J,Palanker D

    更新日期:2009-05-01 00:00:00

  • Correlation of in vivo photosensitizer fluorescence and photodynamic-therapy-induced depth of necrosis in a murine tumor model.

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    journal_title:Journal of biomedical optics

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    authors: Cheung R,Solonenko M,Busch TM,Del Piero F,Putt ME,Hahn SM,Yodh AG

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    authors: Chen TL,Lo YL,Liao CC,Phan QH

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    journal_title:Journal of biomedical optics

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    authors: Yeh C,Hu S,Maslov K,Wang LV

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    pub_type: 杂志文章


    authors: Diop M,Tichauer KM,Elliott JT,Migueis M,Lee TY,St Lawrence K

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    journal_title:Journal of biomedical optics

    pub_type: 杂志文章


    authors: Rollins AM,Yazdanfar S,Barton JK,Izatt JA

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  • Miniature endoscopic optical coherence tomography probe employing a two-axis microelectromechanical scanning mirror with through-silicon vias.

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