Mathematical model that describes the transition from thermal to photochemical damage in retinal pigment epithelial cell culture.

Abstract:

:We propose a rate process model for describing photochemical damage to retinal cells by short wavelength laser exposures. The rate equation for photochemical damage contains a positive rate that is temperature independent, and a negative (quenching) rate that is temperature dependent. Using the traditional Arrhenius integral to describe thermal damage, we derive damage threshold doses for both thermal and photochemical mechanisms, and show that the model accounts for the sharp transition from thermal to photochemical damage thresholds that have recently been observed in an in-vitro retinal model.

journal_name

J Biomed Opt

authors

Clark CD 3rd,Denton ML,Thomas RJ

doi

10.1117/1.3544504

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

020504

issue

2

eissn

1083-3668

issn

1560-2281

journal_volume

16

pub_type

信件
  • Tool for simulating the focusing of arbitrary vector beams in free-space and stratified media.

    abstract::Vectorial models of focused beams are important to a variety of fields including microscopy, lithography, optical physics, and biomedical imaging. This has led to many models being developed, which calculate how beams of various profiles are focused both in free space and in the presence of stratified media. The major...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.23.9.090801

    authors: Munro PRT

    更新日期:2018-09-01 00:00:00

  • Antibody-based magnetic nanoparticle immunoassay for quantification of Alzheimer's disease pathogenic factor.

    abstract::Alzheimer's disease (AD) is a neurodegenerative disorder that leads to a decline in cognitive and intellectual abilities and an irreversible mental deterioration. Based on multidisciplinary AD research, the most universally accepted hypotheses on AD pathogenesis are the intracerebral aggregate formation of beta-amyloi...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.19.5.051205

    authors: Kim CB,Choi YY,Song WK,Song KB

    更新日期:2014-05-01 00:00:00

  • Imaging corneal pathology in a transgenic mouse model using nonlinear microscopy.

    abstract::A transgenic mouse model with a Clim [co-factor of LIM (a combination of first letters of Lin-11 (C. elegans), ISL1 (rat), and Mec-3 (C. elegans) gene names) domain proteins] gene partially blocked in the epithelial compartment of its tissues is used to establish the sensitivity of intrinsic reflectance nonlinear opti...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.2163254

    authors: Lyubovitsky JG,Spencer JA,Krasieva TB,Andersen B,Tromberg BJ

    更新日期:2006-01-01 00:00:00

  • Design and characterization of a handheld multimodal imaging device for the assessment of oral epithelial lesions.

    abstract::A compact handpiece combining high resolution fluorescence (HRF) imaging with optical coherence tomography (OCT) was developed to provide real-time assessment of oral lesions. This multimodal imaging device simultaneously captures coregistered en face images with subcellular detail alongside cross-sectional images of ...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.19.8.086004

    authors: Higgins LM,Pierce MC

    更新日期:2014-08-01 00:00:00

  • Temperature-modulated fluorescence tomography based on both concentration and lifetime contrast.

    abstract::It is challenging to image fluorescence objects with high spatial resolution in a highly scattering medium. Recently reported temperature-sensitive indocyanine green-loaded pluronic nanocapsules can potentially alleviate this problem. Here we demonstrate a frequency-domain temperature-modulated fluorescence tomography...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.17.5.056007

    authors: Lin Y,Kwong TC,Bolisay L,Gulsen G

    更新日期:2012-05-01 00:00:00

  • Optical fiber Bragg grating-instrumented silicone liner for interface pressure measurement within prosthetic sockets of lower-limb amputees.

    abstract::This paper presents a fiber Bragg grating (FBG)-instrumented prosthetic silicone liner that provides cushioning for the residual limb and can successfully measure interface pressures inside prosthetic sockets of lower-limb amputees in a simple and practical means of sensing. The liner is made of two silicone layers be...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.22.8.087001

    authors: Al-Fakih E,Arifin N,Pirouzi G,Mahamd Adikan FR,Shasmin HN,Abu Osman NA

    更新日期:2017-08-01 00:00:00

  • Comparative evaluation of differential laser-induced perturbation spectroscopy as a technique to discriminate emerging skin pathology.

    abstract::Fluorescence spectroscopy has been widely investigated as a technique for identifying pathological tissue; however, unrelated subject-to-subject variations in spectra complicate data analysis and interpretation. We describe and evaluate a new biosensing technique, differential laser-induced perturbation spectroscopy (...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.17.6.067002

    authors: Kozikowski RT,Smith SE,Lee JA,Castleman WL,Sorg BS,Hahn DW

    更新日期:2012-06-01 00:00:00

  • Early detection of high-grade squamous intraepithelial lesions in the cervix with quantitative spectroscopic imaging.

    abstract::Quantitative spectroscopy has recently been extended from a contact-probe to wide-area spectroscopic imaging to enable mapping of optical properties across a wide area of tissue. We train quantitative spectroscopic imaging (QSI) to identify cervical high-grade squamous intraepithelial lesions (HSILs) in 34 subjects un...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.18.7.076013

    authors: Lau C,Mirkovic J,Yu CC,O'Donoghue GP,Galindo L,Dasari R,de las Morenas A,Feld M,Stier E

    更新日期:2013-07-01 00:00:00

  • Optical properties of adenocarcinoma and squamous cell carcinoma of the gastroesophageal junction.

    abstract::Photodynamic therapy (PDT) is an alternative to radical surgical resection for T1a or nonresectable carcinomas of the gastroesophageal junction. Besides the concentration of the photosensitizer, the light distribution in tissue is responsible for tumor destruction. For this reason, knowledge about the behavior of ligh...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.2564793

    authors: Holmer C,Lehmann KS,Wanken J,Reissfelder C,Roggan A,Mueller G,Buhr HJ,Ritz JP

    更新日期:2007-01-01 00:00:00

  • Effect of motion artifacts and their correction on near-infrared spectroscopy oscillation data: a study in healthy subjects and stroke patients.

    abstract::Functional near-infrared spectroscopy is prone to contamination by motion artifacts (MAs). Motion correction algorithms have previously been proposed and their respective performance compared for evoked rain activation studies. We study instead the effect of MAs on "oscillation" data which is at the basis of functiona...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.20.5.056011

    authors: Selb J,Yücel MA,Phillip D,Schytz HW,Iversen HK,Vangel M,Ashina M,Boas DA

    更新日期:2015-05-01 00:00:00

  • Unsupervised analysis of small animal dynamic Cerenkov luminescence imaging.

    abstract::Clustering analysis (CA) and principal component analysis (PCA) were applied to dynamic Cerenkov luminescence images (dCLI). In order to investigate the performances of the proposed approaches, two distinct dynamic data sets obtained by injecting mice with (32)P-ATP and (18)F-FDG were acquired using the IVIS 200 optic...

    journal_title:Journal of biomedical optics

    pub_type: 信件

    doi:10.1117/1.3663442

    authors: Spinelli AE,Boschi F

    更新日期:2011-12-01 00:00:00

  • Temperature changes on the root surfaces of mandibular incisors after an 810-nm high-intensity intracanal diode laser irradiation.

    abstract:UNLABELLED:Temperature changes caused by laser irradiation can promote damage to the surrounding dental tissues. In this study, we evaluated the temperature changes of recently extracted human mandibular incisors during intracanal irradiation with an 810-nm diode laser at different settings. Fifty mandibular incisors w...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.17.1.015006

    authors: da Fonseca Alvarez A,Moura-Netto C,Daliberto Frugoli A,Fernando C,Aranha AC,Davidowicz H

    更新日期:2012-01-01 00:00:00

  • Photoacoustic tomography of ex vivo mouse hearts with myocardial infarction.

    abstract::In the present study, we evaluated the applicability of ex vivo photoacoustic imaging (PAI) on small animal organs. We used photoacoustic tomography (PAT) to visualize infarcted areas within murine hearts and compared these data to other imaging techniques [magnetic resonance imaging (MRI), micro-computed tomography] ...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.3556720

    authors: Holotta M,Grossauer H,Kremser C,Torbica P,Völkl J,Degenhart G,Esterhammer R,Nuster R,Paltauf G,Jaschke W

    更新日期:2011-03-01 00:00:00

  • Mapping cisplatin-induced viscosity alterations in cancer cells using molecular rotor and fluorescence lifetime imaging microscopy.

    abstract:SIGNIFICANCE:Despite the importance of the cell membrane in regulation of drug activity, the influence of drug treatments on its physical properties is still poorly understood. The combination of fluorescence lifetime imaging microscopy (FLIM) with specific viscosity-sensitive fluorescent molecular rotors allows the qu...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.25.12.126004

    authors: Shimolina LE,Gulin AA,Paez-Perez M,López-Duarte I,Druzhkova IN,Lukina MM,Gubina MV,Brooks NJ,Zagaynova EV,Kuimova MK,Shirmanova MV

    更新日期:2020-12-01 00:00:00

  • Correlation between asymmetry of spontaneous oscillation of hemodynamic changes in the prefrontal cortex and anxiety levels: a near-infrared spectroscopy study.

    abstract::According to the valence asymmetry hypothesis, the left/right asymmetry of prefrontal cortex (PFC) activity is correlated with specific emotional responses to mental stress and personality traits. Here, we evaluated the relation between emotional state and asymmetry in PFC activity at rest by using near-infrared spect...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.19.2.027005

    authors: Ishikawa W,Sato M,Fukuda Y,Matsumoto T,Takemura N,Sakatani K

    更新日期:2014-02-01 00:00:00

  • Hydrophobic cyanine dye-doped micelles for optical in vivo imaging of plasma leakage and vascular disruption.

    abstract::Vascular leakage is an important feature of various disease conditions. In vivo optical imaging provides a great opportunity for the evaluation of this phenomenon. In the present study, we focus on the development and validation of a near-infrared (NIR) imaging formula to allow reliable, cost-efficient evaluation of v...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.20.1.016022

    authors: Botz B,Bölcskei K,Kemény Á,Sándor Z,Tékus V,Sétáló G Jr,Csepregi J,Mócsai A,Pintér E,Kollár L,Helyes Z

    更新日期:2015-01-01 00:00:00

  • Fluorescence polarization of tetracycline derivatives as a technique for mapping nonmelanoma skin cancers.

    abstract::Nonmelanoma skin cancer is the most common form of human cancer, often resulting in high morbidity. Low visual contrast of these tumors makes their delineation a challenging problem. Employing a linearly polarized monochromatic light source and a wide-field CCD camera, we have developed a technique for fluorescence po...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.2435710

    authors: Yaroslavsky AN,Salomatina EV,Neel V,Anderson R,Flotte T

    更新日期:2007-01-01 00:00:00

  • Change of tumor vascular reactivity during tumor growth and postchemotherapy observed by near-infrared spectroscopy.

    abstract::Breast cancer is one of the most common cancers in females. To monitor chemotherapeutic efficacy for breast cancer, medical imaging systems such as x-ray mammography, computed tomography, magnetic resonance imaging, and ultrasound imaging have been used. Currently, it can take up to 3 to 6 weeks to see the tumor respo...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.22.12.121603

    authors: Lee S,Jeong H,Seong M,Kim JG

    更新日期:2017-12-01 00:00:00

  • Application of fluorescence recovery after photobleaching to study prestin lateral mobility in the human embryonic kidney cell.

    abstract::The transmembrane protein prestin is crucial to outer hair cell (OHC) electromotility and contributes to the sensitivity and frequency selectivity of mammalian hearing. The molecular mechanisms of electromotility remain unclear, but prestin is purported to function as both a voltage sensor and a molecular motor. Under...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.2715202

    authors: Organ LE,Raphael RM

    更新日期:2007-03-01 00:00:00

  • Vector extrapolation methods for accelerating iterative reconstruction methods in limited-data photoacoustic tomography.

    abstract::As limited data photoacoustic tomographic image reconstruction problem is known to be ill-posed, the iterative reconstruction methods were proven to be effective in terms of providing good quality initial pressure distribution. Often, these iterative methods require a large number of iterations to converge to a soluti...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.23.7.071204

    authors: Awasthi N,Kalva SK,Pramanik M,Yalavarthy PK

    更新日期:2018-02-01 00:00:00

  • Quantitative photoacoustic imaging: correcting for heterogeneous light fluence distributions using diffuse optical tomography.

    abstract::The specificity of molecular and functional photoacoustic (PA) images depends on the accuracy of the photoacoustic absorption spectroscopy. The PA signal is proportional to the product of the optical absorption coefficient and local light fluence; quantitative PA measurements of the optical absorption coefficient ther...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.3626212

    authors: Bauer AQ,Nothdurft RE,Erpelding TN,Wang LV,Culver JP

    更新日期:2011-09-01 00:00:00

  • Specific absorption spectra of hemoglobin at different PO2 levels: potential noninvasive method to detect PO2 in tissues.

    abstract::Hemoglobin (Hb), as one of main components of blood, has a unique quaternary structure. Its release of oxygen is controlled by oxygen partial pressure (PO2). We investigate the specific spectroscopic changes in Hb under different PO2 levels to optimize clinical methods of measuring tissue PO2. The transmissivity of Hb...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.17.12.125002

    authors: Liu P,Zhu Z,Zeng C,Nie G

    更新日期:2012-12-01 00:00:00

  • Dual/differential coherent anti-Stokes Raman scattering module for multiphoton microscopes with a femtosecond Ti:sapphire oscillator.

    abstract::In the last decade, coherent anti-Stokes Raman scattering (CARS) microscopy has emerged as a powerful multiphoton imaging technique offering label-free chemical sensitivity and high three-dimensional resolution. However, its widespread application in the life sciences has been hampered by the use of costly pulsed lase...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.18.6.066004

    authors: Li B,Borri P,Langbein W

    更新日期:2013-06-01 00:00:00

  • Optical coherence tomography for the diagnosis of malignant skin tumors: a meta-analysis.

    abstract::Optical coherence tomography (OCT) is an emergent imaging tool used for noninvasive diagnosis of skin diseases. The present meta-analysis was carried out to assess the accuracy of OCT for the diagnosis of skin cancer. We conducted a systematic literature search though EMBASE, Medline, PubMed, the Cochrane Library, and...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章,meta分析

    doi:10.1117/1.JBO.23.2.020902

    authors: Xiong YQ,Mo Y,Wen YQ,Cheng MJ,Huo ST,Chen XJ,Chen Q

    更新日期:2018-02-01 00:00:00

  • Ambulatory diffuse optical tomography and multimodality physiological monitoring system for muscle and exercise applications.

    abstract::Ambulatory diffuse optical tomography (aDOT) is based on near-infrared spectroscopy (NIRS) and enables three-dimensional imaging of regional hemodynamics and oxygen consumption during a person’s normal activities. Although NIRS has been previously used for muscle assessment, it has been notably limited in terms of the...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.21.9.091314

    authors: Hu G,Zhang Q,Ivkovic V,Strangman GE

    更新日期:2016-09-01 00:00:00

  • Monte-Carlo-based model for the extraction of intrinsic fluorescence from turbid media.

    abstract::A Monte-Carlo-based model of fluorescence is developed that is capable of extracting the intrinsic fluorescence properties of tissue, which are independent of the absorption and scattering properties of tissue. This model is flexible in its applicability to different illumination-collection geometries and is also vali...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.2907161

    authors: Palmer GM,Ramanujam N

    更新日期:2008-03-01 00:00:00

  • Practicability and safety of laser-assisted reduction surgery.

    abstract::We have presented an innovative laser-assisted reduction surgery (LARS) based on plasma-induced ablation and photodisruption effects. In addition, we developed a laser operation system. Fetuses of mice from the Institute for Cancer Research that were immersed in physiological saline were irradiated by convergent-pulse...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.18.11.118002

    authors: Wang Y,Xiong Q,Ye Z,Ge J

    更新日期:2013-11-01 00:00:00

  • Spherical aberration correction in multiphoton fluorescence imaging using objective correction collar.

    abstract::Multiphoton microscopy has evolved into a powerful bioimaging tool in three dimensions. However, the ability to image biological specimens in-depth can be hindered by sample spherical aberration and scattering. These two phenomena can result in the degradation of image resolution and the loss of detected multiphoton s...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.1924614

    authors: Lo W,Sun Y,Lin SJ,Jee SH,Dong CY

    更新日期:2005-05-01 00:00:00

  • Infrared spectroscopic analysis of human and bovine articular cartilage proteoglycans using carbohydrate peak or its second derivative.

    abstract::Fourier transform infrared (FTIR) microspectroscopy has been used to estimate the spatial proteoglycan (PG) and collagen contents in articular cartilage (AC). However, it is not clear whether the results of FTIR analyses are consistent between different species. Our aim was to clarify how three different FTIR PG param...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.18.9.097006

    authors: Rieppo L,Närhi T,Helminen HJ,Jurvelin JS,Saarakkala S,Rieppo J

    更新日期:2013-09-01 00:00:00

  • Label-free imaging of biomolecules in food products using stimulated Raman microscopy.

    abstract::The development of methods that allow microscale studies of complex biomaterials based on their molecular composition is of great interest to a wide range of research fields. We show that stimulated Raman scattering (SRS) microscopy is an excellent analytical tool to study distributions of different biomolecules in mu...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.3516591

    authors: Roeffaers MB,Zhang X,Freudiger CW,Saar BG,van Ruijven M,van Dalen G,Xiao C,Xie XS

    更新日期:2010-11-01 00:00:00