Mathematical model that describes the transition from thermal to photochemical damage in retinal pigment epithelial cell culture.


:We propose a rate process model for describing photochemical damage to retinal cells by short wavelength laser exposures. The rate equation for photochemical damage contains a positive rate that is temperature independent, and a negative (quenching) rate that is temperature dependent. Using the traditional Arrhenius integral to describe thermal damage, we derive damage threshold doses for both thermal and photochemical mechanisms, and show that the model accounts for the sharp transition from thermal to photochemical damage thresholds that have recently been observed in an in-vitro retinal model.


J Biomed Opt


Clark CD 3rd,Denton ML,Thomas RJ




Has Abstract


2011-02-01 00:00:00












  • Tool for simulating the focusing of arbitrary vector beams in free-space and stratified media.

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  • Antibody-based magnetic nanoparticle immunoassay for quantification of Alzheimer's disease pathogenic factor.

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    journal_title:Journal of biomedical optics

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    authors: Kim CB,Choi YY,Song WK,Song KB

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  • Imaging corneal pathology in a transgenic mouse model using nonlinear microscopy.

    abstract::A transgenic mouse model with a Clim [co-factor of LIM (a combination of first letters of Lin-11 (C. elegans), ISL1 (rat), and Mec-3 (C. elegans) gene names) domain proteins] gene partially blocked in the epithelial compartment of its tissues is used to establish the sensitivity of intrinsic reflectance nonlinear opti...

    journal_title:Journal of biomedical optics

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    authors: Lyubovitsky JG,Spencer JA,Krasieva TB,Andersen B,Tromberg BJ

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  • Design and characterization of a handheld multimodal imaging device for the assessment of oral epithelial lesions.

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    journal_title:Journal of biomedical optics

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    authors: Higgins LM,Pierce MC

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    journal_title:Journal of biomedical optics

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    authors: Lin Y,Kwong TC,Bolisay L,Gulsen G

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  • Optical fiber Bragg grating-instrumented silicone liner for interface pressure measurement within prosthetic sockets of lower-limb amputees.

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    authors: Holmer C,Lehmann KS,Wanken J,Reissfelder C,Roggan A,Mueller G,Buhr HJ,Ritz JP

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    authors: Selb J,Yücel MA,Phillip D,Schytz HW,Iversen HK,Vangel M,Ashina M,Boas DA

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    journal_title:Journal of biomedical optics

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    authors: da Fonseca Alvarez A,Moura-Netto C,Daliberto Frugoli A,Fernando C,Aranha AC,Davidowicz H

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    authors: Holotta M,Grossauer H,Kremser C,Torbica P,Völkl J,Degenhart G,Esterhammer R,Nuster R,Paltauf G,Jaschke W

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  • Mapping cisplatin-induced viscosity alterations in cancer cells using molecular rotor and fluorescence lifetime imaging microscopy.

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    authors: Ishikawa W,Sato M,Fukuda Y,Matsumoto T,Takemura N,Sakatani K

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    authors: Botz B,Bölcskei K,Kemény Á,Sándor Z,Tékus V,Sétáló G Jr,Csepregi J,Mócsai A,Pintér E,Kollár L,Helyes Z

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    authors: Yaroslavsky AN,Salomatina EV,Neel V,Anderson R,Flotte T

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  • Change of tumor vascular reactivity during tumor growth and postchemotherapy observed by near-infrared spectroscopy.

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    journal_title:Journal of biomedical optics

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    authors: Lee S,Jeong H,Seong M,Kim JG

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  • Application of fluorescence recovery after photobleaching to study prestin lateral mobility in the human embryonic kidney cell.

    abstract::The transmembrane protein prestin is crucial to outer hair cell (OHC) electromotility and contributes to the sensitivity and frequency selectivity of mammalian hearing. The molecular mechanisms of electromotility remain unclear, but prestin is purported to function as both a voltage sensor and a molecular motor. Under...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章


    authors: Organ LE,Raphael RM

    更新日期:2007-03-01 00:00:00

  • Vector extrapolation methods for accelerating iterative reconstruction methods in limited-data photoacoustic tomography.

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    pub_type: 杂志文章


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    journal_title:Journal of biomedical optics

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    authors: Bauer AQ,Nothdurft RE,Erpelding TN,Wang LV,Culver JP

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  • Specific absorption spectra of hemoglobin at different PO2 levels: potential noninvasive method to detect PO2 in tissues.

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    journal_title:Journal of biomedical optics

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    authors: Li B,Borri P,Langbein W

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  • Optical coherence tomography for the diagnosis of malignant skin tumors: a meta-analysis.

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    authors: Xiong YQ,Mo Y,Wen YQ,Cheng MJ,Huo ST,Chen XJ,Chen Q

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  • Ambulatory diffuse optical tomography and multimodality physiological monitoring system for muscle and exercise applications.

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    journal_title:Journal of biomedical optics

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    authors: Hu G,Zhang Q,Ivkovic V,Strangman GE

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    journal_title:Journal of biomedical optics

    pub_type: 杂志文章


    authors: Palmer GM,Ramanujam N

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    journal_title:Journal of biomedical optics

    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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