Abstract:
:We propose a rate process model for describing photochemical damage to retinal cells by short wavelength laser exposures. The rate equation for photochemical damage contains a positive rate that is temperature independent, and a negative (quenching) rate that is temperature dependent. Using the traditional Arrhenius integral to describe thermal damage, we derive damage threshold doses for both thermal and photochemical mechanisms, and show that the model accounts for the sharp transition from thermal to photochemical damage thresholds that have recently been observed in an in-vitro retinal model.
journal_name
J Biomed Optjournal_title
Journal of biomedical opticsauthors
Clark CD 3rd,Denton ML,Thomas RJdoi
10.1117/1.3544504subject
Has Abstractpub_date
2011-02-01 00:00:00pages
020504issue
2eissn
1083-3668issn
1560-2281journal_volume
16pub_type
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