Mathematical model that describes the transition from thermal to photochemical damage in retinal pigment epithelial cell culture.

Abstract:

:We propose a rate process model for describing photochemical damage to retinal cells by short wavelength laser exposures. The rate equation for photochemical damage contains a positive rate that is temperature independent, and a negative (quenching) rate that is temperature dependent. Using the traditional Arrhenius integral to describe thermal damage, we derive damage threshold doses for both thermal and photochemical mechanisms, and show that the model accounts for the sharp transition from thermal to photochemical damage thresholds that have recently been observed in an in-vitro retinal model.

journal_name

J Biomed Opt

authors

Clark CD 3rd,Denton ML,Thomas RJ

doi

10.1117/1.3544504

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

020504

issue

2

eissn

1083-3668

issn

1560-2281

journal_volume

16

pub_type

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