Optical imaging of acute epileptic networks in mice.

abstract：:Red blood cell (RBC) anomalies are significant symptoms for identification of health disorders and several blood diseases, which involve the modification of the parameters and biophysical characteristics of such cells. The aim of this study is to measure the three-dimensional phase information of healthy RBCs and thei...

journal_title：Journal of biomedical optics

authors： Agarwal S,Kumar V,Shakher C

更新日期：2017-10-01 00:00:00

abstract：:Differential phase optical coherence tomography (DPOCT) is introduced to measure optical path length changes in response to pulsed laser irradiation (585 nm). An analytical equation that includes thermoelastic surface displacement and thermorefractive index change is derived to predict optical path length change in re...

journal_title：Journal of biomedical optics

authors： Kim J,Oh J,Milner TE

更新日期：2006-07-01 00:00:00

abstract：:Fluorescence lifetime imaging (FLi) could potentially improve exogenous near-infrared (NIR) fluorescence imaging, because it offers the capability of discriminating a signal of interest from background, provides real-time monitoring of a chemical environment, and permits the use of several different fluorescent dyes h...

journal_title：Journal of biomedical optics

authors： Gioux S,Lomnes SJ,Choi HS,Frangioni JV

更新日期：2010-03-01 00:00:00

abstract：:Stenosis and occlusion of the superficial femoral artery (SFA) are most common in arterial occlusive disease. There are numerous interventional, surgical, and combined approaches to reconstitute maximum blood supply to the lower limb; however, despite intense clinical research, the long-term success rates are still po...

journal_title：Journal of biomedical optics

authors： Heneweer C,Siggelkow M,Helle M,Petzina R,Wulff A,Schaefer JP,Berndt R,Rusch R,Wedel T,Klaws G,Müller-Gerbl M,Röcken C,Jansen O,Lutter G,Cremer J,Groß J

更新日期：2015-02-01 00:00:00

abstract：:Autofluorescence-based imaging techniques have become very important in the ophthalmological field. Being noninvasive and very sensitive, they are broadly used in clinical routines. Conventional autofluorescence intensity imaging is largely influenced by the strong fluorescence of lipofuscin, a fluorophore that can be...

journal_title：Journal of biomedical optics

authors： Sauer L,Andersen KM,Dysli C,Zinkernagel MS,Bernstein PS,Hammer M

更新日期：2018-09-01 00:00:00

abstract：:Three-dimensional (3-D) tissue imaging offers substantial benefits to a wide range of biomedical investigations from cardiovascular biology, diabetes, Alzheimer's disease to cancer. Two-photon tissue cytometry is a novel technique based on high-speed multiphoton microscopy coupled with automated histological sectionin...

journal_title：Journal of biomedical optics

authors： Ragan T,Sylvan JD,Kim KH,Huang H,Bahlmann K,Lee RT,So PT

更新日期：2007-01-01 00:00:00

abstract：:An integrated miniature multi-modal microscope (4M device) for microendoscopy was built and tested. Imaging performance is evaluated and imaging results are presented for both fluorescence and reflectance samples. Images of biological samples show successful imaging of both thin layers of fixed cells prepared on a sli...

journal_title：Journal of biomedical optics

authors： Rogers JD,Landau S,Tkaczyk TS,Descour MR,Rahman MS,Richards-Kortum R,Kärkäinen AH,Christenson T

更新日期：2008-09-01 00:00:00

abstract：:Traditional white-light and fluorescent imaging techniques provide powerful methods to extract high-resolution information from two-dimensional (2-D) sections, but to retrieve information from a three-dimensional (3-D) volume they require relatively slow scanning methods that result in increased acquisition time. Usin...

journal_title：Journal of biomedical optics

authors： Duocastella M,Sun B,Arnold CB

更新日期：2012-05-01 00:00:00

abstract：:Studies of bioluminescence in living animals, such as cell-based biosensor applications, require measurement of light at different wavelengths, but accurate light measurement is impeded by absorption by tissues at wavelengths<600 nm. We present a novel approach to this problem--the use of a plastic window in the skin/...

journal_title：Journal of biomedical optics

authors： Huang Q,Acha V,Yow R,Schneider E,Sardar DK,Hornsby PJ

更新日期：2007-09-01 00:00:00

abstract：:In order to understand the relationship between accommodation and vision quality, a custom-built ultra-long scan depth spectral domain optical coherence tomography (UL-SDOCT) and a Shack-Hartmann wavefront sensor (HSWFS) were combined. The resolution and scan depth of UL-SDOCT are 6 μm and 15.6 mm, respectively, which...

journal_title：Journal of biomedical optics

authors： Shi G,Wang Y,Yuan Y,Wei L,Lv F,Zhang Y

更新日期：2012-12-01 00:00:00

abstract：:We introduce the concept of deliberate placement of absorbers to alter the average path of photons through tissue for a biomedical optical device. By changing the reflectivity of a needle that separates a source and detector, the average photon path through a turbid medium can be changed. Totally reflective needles ha...

journal_title：Journal of biomedical optics

authors： Simonson P,D'Amico E,Gratton E

更新日期：2006-01-01 00:00:00

abstract：:For clinical optoacoustic imaging, linear probes are preferably used because they allow versatile imaging of the human body with real-time display and free-hand probe guidance. The two-dimensional (2-D) optoacoustic image obtained with this type of probe is generally interpreted as a 2-D cross-section of the tissue ju...

journal_title：Journal of biomedical optics

authors： Preisser S,Bush NL,Gertsch-Grover AG,Peeters S,Bailey AE,Bamber JC,Frenz M,Jaeger M

更新日期：2013-02-01 00:00:00

abstract：:Fourier transform infrared (FTIR) spectroscopic imaging has been used to probe the biochemical composition of human renal tumor tissue and adjacent normal tissue. Freshly resected renal tumor tissue from surgery was prepared as a thin cryosection and examined by FTIR spectroscopic imaging. Tissue types could be discri...

journal_title：Journal of biomedical optics

authors： Sablinskas V,Urboniene V,Ceponkus J,Laurinavicius A,Dasevicius D,Jankevicius F,Hendrixson V,Koch E,Steiner G

更新日期：2011-09-01 00:00:00

abstract：:Compact optical imagers that can detect both spectral and polarization signatures are required in many biomedical applications. An acousto-optic-tunable-filter (AOTF)-based imager is ideally suited to provide both agile spectral and polarization signatures. Such an imager can be readily used for real-time in vivo medi...

journal_title：Journal of biomedical optics

authors： Gupta N

更新日期：2005-09-01 00:00:00

abstract：:Recaldent is a product of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP). The remineralizing potential of CPP-ACP per se, or when combined with 0.22% Fl gel on artificially demineralized enamel using laser florescence, is investigated. Mesial surfaces of 15 sound human molars are tested using a He-Cd lase...

journal_title：Journal of biomedical optics

authors： Elsayad I,Sakr A,Badr Y

更新日期：2009-07-01 00:00:00

abstract：:Mid-IR semiconductor lasers of two wavelength bands, 5.4 and 9.6 microm, are applied to measure aqueous glucose concentration ranging from 0 to 500 mgdL with Intralipid emulsion (0 to 8%) added as a fat simulator. The absorption coefficient micro(a) is found linear with respect to glucose and Intralipid concentrations...

journal_title：Journal of biomedical optics

authors： Guo B,Wang Y,Wang Y,Le HQ

更新日期：2007-03-01 00:00:00

abstract：:The development of methods that allow microscale studies of complex biomaterials based on their molecular composition is of great interest to a wide range of research fields. We show that stimulated Raman scattering (SRS) microscopy is an excellent analytical tool to study distributions of different biomolecules in mu...

journal_title：Journal of biomedical optics

authors： Roeffaers MB,Zhang X,Freudiger CW,Saar BG,van Ruijven M,van Dalen G,Xiao C,Xie XS

更新日期：2010-11-01 00:00:00

abstract：:Discrimination of benign and malignant melanocytic lesions is a major issue in clinical dermatology. Assessment of the thickness of melanoma is critical for prognosis and treatment selection. We aimed to evaluate a novel optical computed tomography (optical-CT) system as a tool for three-dimensional (3-D) imaging of m...

journal_title：Journal of biomedical optics

authors： Kokolakis A,Zacharakis G,Krasagakis K,Lasithiotakis K,Favicchio R,Spiliopoulos G,Giannikaki E,Ripoll J,Tosca A

更新日期：2012-06-01 00:00:00

abstract：:Near-infrared spectroscopy is a novel imaging technique potentially sensitive to both brain hemodynamics (slow signal) and neuronal activity (fast optical signal, FOS). The big challenge of measuring FOS noninvasively lies in the presumably low signal-to-noise ratio. Thus, detectability of the FOS has been controversi...

journal_title：Journal of biomedical optics

authors： Medvedev AV,Kainerstorfer JM,Borisov SV,Gandjbakhche AH,Vanmeter J

更新日期：2010-11-01 00:00:00

abstract：:Vascular leakage is an important feature of various disease conditions. In vivo optical imaging provides a great opportunity for the evaluation of this phenomenon. In the present study, we focus on the development and validation of a near-infrared (NIR) imaging formula to allow reliable, cost-efficient evaluation of v...

journal_title：Journal of biomedical optics

authors： Botz B,Bölcskei K,Kemény Á,Sándor Z,Tékus V,Sétáló G Jr,Csepregi J,Mócsai A,Pintér E,Kollár L,Helyes Z

更新日期：2015-01-01 00:00:00

abstract：:Optical coherence tomography (OCT) can provide new insight into disease progression and therapy by enabling nondestructive, serial imaging of in vivo cancer models. In previous studies, we have shown the utility of endoscopic OCT for identifying adenomas in the azoxymethane-treated mouse model of colorectal cancer and...

journal_title：Journal of biomedical optics

authors： Winkler AM,Rice PF,Drezek RA,Barton JK

更新日期：2010-07-01 00:00:00

abstract：:Cortical spreading depression (CSD) is a slowly propagating wave of depolarization of neurons and glia and has a less characterized vascular component. CSD is a commonly used phenomenon to test new methods of live brain imaging. Application of a blood pulsations imaging (BPI) technique to study of CSD induced with hig...

journal_title：Journal of biomedical optics

authors： Teplov V,Shatillo A,Nippolainen E,Gröhn O,Giniatullin R,Kamshilin AA

更新日期：2014-04-01 00:00:00

abstract：:Previous research correcting for variable speed of sound in photoacoustic tomography (PAT) based on a generalized radon transform (GRT) model assumes first-order geometrical acoustics (GA) approximation. In the GRT model, the pressure is related to the optical absorption, in an acoustically inhomogeneous medium, throu...

journal_title：Journal of biomedical optics

authors： Modgil D,Anastasio MA,La Rivière PJ

更新日期：2010-03-01 00:00:00

abstract：:Optical coherence tomography (OCT)-based elasticity imaging can map soft tissue elasticity based on speckle-tracking of elastic wave propagation using highly sensitive phase measurements of OCT signals. Using a fixed elastic wave source and moving detection, current imaging sequences have difficulty in reconstructing ...

journal_title：Journal of biomedical optics

authors： Hsieh BY,Song S,Nguyen TM,Yoon SJ,Shen TT,Wang RK,O'Donnell M

更新日期：2016-11-01 00:00:00

abstract：:Surgical resection of pancreatic cancer represents the only chance of cure and long-term survival in this common disease. Unfortunately, determination of a cancer-free margin at surgery is based on one or two tiny frozen section biopsies, which is far from ideal. Not surprisingly, cancer is usually left behind and is ...

journal_title：Journal of biomedical optics

authors： Cromey B,McDaniel A,Matsunaga T,Vagner J,Kieu KQ,Banerjee B

更新日期：2018-04-01 00:00:00

abstract：:The area of in vivo sensing using optical fibers commonly uses materials such as silica and polymethyl methacrylate, both of which possess much higher modulus than human tissue. The mechanical mismatch between materials and living tissue has been seen to cause higher levels of glial encapsulation, scarring, and inflam...

journal_title：Journal of biomedical optics

authors： McMillan S,Rader C,Jorfi M,Pickrell G,Foster EJ

更新日期：2017-02-01 00:00:00

abstract：:High resolution is important for sensitive detection of subtle distortions of retinal morphology at an early stage of eye diseases. We demonstrate virtually structured detection (VSD) as a feasible method to achieve in vivo super-resolution ophthalmoscopy. A line-scanning strategy was employed to achieve a super-resol...

journal_title：Journal of biomedical optics

authors： Liu C,Zhi Y,Wang B,Thapa D,Chen Y,Alam M,Lu Y,Yao X

更新日期：2016-12-01 00:00:00

abstract：:We describe the implementation and use of an adaptive optics loop in the imaging path of a commercial wide field microscope. We show that it is possible to maintain the optical performances of the original microscope when imaging through aberrant biological samples. The sources used for illuminating the adaptive optic...

journal_title：Journal of biomedical optics

authors： Vermeulen P,Muro E,Pons T,Loriette V,Fragola A

更新日期：2011-07-01 00:00:00

abstract：:We report an accurate optical differentiation technique between healthy and malaria-infected erythrocytes by quasi-simultaneous measurements of transmittance, reflectance, and scattering properties of unstained blood smears using a multispectral and multimode light-emitting diode microscope. We propose a technique for...

journal_title：Journal of biomedical optics

authors： Merdasa A,Brydegaard M,Svanberg S,Zoueu JT

更新日期：2013-03-01 00:00:00

abstract：:Optical coherence tomography (OCT) is a noninvasive imaging methodology that is able to image tissue to depths of over 1 mm. Many epithelial conditions, such as melanoma and oral cancers, require an invasive biopsy for diagnosis. A noninvasive, real-time, point of care method of imaging depth-resolved epithelial struc...

journal_title：Journal of biomedical optics

authors： Smith LE,Hearnden V,Lu Z,Smallwood R,Hunter KD,Matcher SJ,Thornhill MH,Murdoch C,MacNeil S

更新日期：2011-11-01 00:00:00