Abstract:
:Intraoperative applications of near-infrared (NIR) fluorescent contrast agents can be aided by instrumentation capable of merging the view of surgical field with that of NIR fluorescence. We demonstrate augmented microscopy, an intraoperative imaging technique in which bright-field (real) and electronically processed NIR fluorescence (synthetic) images are merged within the optical path of a stereomicroscope. Under luminance of 100,000 lx, representing typical illumination of the surgical field, the augmented microscope detects 189 nM concentration of indocyanine green and produces a composite of the real and synthetic images within the eyepiece of the microscope at 20 fps. Augmentation described here can be implemented as an add-on module to visualize NIR contrast agents, laser beams, or various types of electronic data within the surgical microscopes commonly used in neurosurgical, cerebrovascular, otolaryngological, and ophthalmic procedures.
journal_name
J Biomed Optjournal_title
Journal of biomedical opticsauthors
Watson JR,Gainer CF,Martirosyan N,Skoch J,Lemole GM Jr,Anton R,Romanowski Mdoi
10.1117/1.JBO.20.10.106002subject
Has Abstractpub_date
2015-10-01 00:00:00pages
106002issue
10eissn
1083-3668issn
1560-2281pii
2456180journal_volume
20pub_type
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