Abstract:
:We report an accurate optical differentiation technique between healthy and malaria-infected erythrocytes by quasi-simultaneous measurements of transmittance, reflectance, and scattering properties of unstained blood smears using a multispectral and multimode light-emitting diode microscope. We propose a technique for automated imaging, identification, and counting of malaria-infected erythrocytes for real-time and cost-effective parasitaemia diagnosis as an effective alternative to the manual screening of stained blood smears, now considered to be the gold standard in malaria diagnosis. We evaluate the performance of our algorithm against manual estimations of an expert and show a spectrally resolved increased scattering from malaria-infected blood cells.
journal_name
J Biomed Optjournal_title
Journal of biomedical opticsauthors
Merdasa A,Brydegaard M,Svanberg S,Zoueu JTdoi
10.1117/1.JBO.18.3.036002subject
Has Abstractpub_date
2013-03-01 00:00:00pages
036002issue
3eissn
1083-3668issn
1560-2281pii
1657397journal_volume
18pub_type
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