Abstract:
:Temperature distribution is a crucial factor in determining the outcome of laser phototherapy in cancer treatment. Magnetic resonance imaging (MRI) is an ideal method for 3-D noninvasive temperature measurement. A 7.1-T MRI was used to determine laser-induced high thermal gradient temperature distribution of target tissue with high spatial resolution. Using a proton density phase shift method, thermal mapping is validated for in vivo thermal measurement with light-absorbing enhancement dye. Tissue-simulating phantom gels, biological tissues, and tumor-bearing animals were used in the experiments. An 805-nm laser was used to irradiate the samples, with laser power in the range of 1 to 3 W. A clear temperature distribution matrix within the target and surrounding tissue was obtained with a specially developed processing algorithm. The temperature mapping showed that the selective laser photothermal effect could result in temperature elevation in a range of 10 to 45 degrees C. The temperature resolution of the measurement was about 0.37 degrees C with 0.4-mm spatial resolution. The results of this study provide in vivo thermal information and future reference for optimizing laser dosage and dye concentration in cancer treatment.
journal_name
J Biomed Optjournal_title
Journal of biomedical opticsauthors
Chen Y,Gnyawali SC,Wu F,Liu H,Tesiram YA,Abbott A,Towner RA,Chen WRdoi
10.1117/1.2960020subject
Has Abstractpub_date
2008-07-01 00:00:00pages
044033issue
4eissn
1083-3668issn
1560-2281journal_volume
13pub_type
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