Abstract:
:We investigate optoelectronic properties of integrated structures comprising semiconductor light-emitting materials for optical probes of microscopic biological systems. Compound semiconductors are nearly ideal light emitters for probing cells and other microorganisms because of their spectral match to the transparency wavelengths of biomolecules. Unfortunately, the chemical composition of these materials is incompatible with the biochemistry of cells and related biofluids. To overcome these limitations, we investigate functionalized semiconductor surfaces and structures to simultaneously enhance light emission and the flow of biological fluids in semiconductor microcavities. We have identified several important materials problems associated with the semiconductor/biosystem interface. One is the biofluid degradation of electroluminescence by ionic diffusion into compound semiconductors. Ions that diffuse into the active region of a semiconductor light emitter can create point defects that degrade the quantum efficiency of the radiative recombination process. In this paper we discuss ways of mitigating these problems using materials design and surface chemistry, and suggest future applications for these materials.
journal_name
J Biomed Optjournal_title
Journal of biomedical opticsauthors
Gourley PL,Copeland RG,Cox JD,Hendricks JK,McDonald AE,Peterson SL,Sasaki DYdoi
10.1117/1.1506931subject
Has Abstractpub_date
2002-10-01 00:00:00pages
546-54issue
4eissn
1083-3668issn
1560-2281journal_volume
7pub_type
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