Correlation between asymmetry of spontaneous oscillation of hemodynamic changes in the prefrontal cortex and anxiety levels: a near-infrared spectroscopy study.

abstract：:The refractive index of blood is a key biophysical parameter, which can reflect the physiological state. We measured the refractive index of whole blood and other components, such as serum, plasma, and hemoglobin, based on internal reflection by using a homemade apparatus in the spectral range of 400 to 750 nm. In add...

journal_title：Journal of biomedical optics

authors： Liu S,Deng Z,Li J,Wang J,Huang N,Cui R,Zhang Q,Mei J,Zhou W,Zhang C,Ye Q,Tian J

更新日期：2019-03-01 00:00:00

abstract：:Cerenkov light is created in clinical applications involving high-energy radiation such as in radiation therapy. There is considerable interest in using Cerenkov light as a means to perform in vivo dosimetry during radiation therapy; however, a better understanding of the light-to-dose relationship is needed. One such...

journal_title：Journal of biomedical optics

authors： Brost E,Watanabe Y

更新日期：2018-10-01 00:00:00

abstract：:We describe the use of a biochip based on complementary metal oxide semiconductor (CMOS) technology for detection of specific genetic sequences using molecular beacons (MB) immobilized on solid surfaces as probes. The applicability of this miniature detection system for screening for the BRCA1 gene is evaluated using ...

journal_title：Journal of biomedical optics

authors： Culha M,Stokes DL,Griffin GD,Vo-Dinh T

更新日期：2004-05-01 00:00:00

abstract：:We report the design, integration, and validation of a fluorescence microscopy system for imaging of electroperturbation--the effects of nanosecond, megavolt-per-meter pulsed electric fields on biological cells and tissues. Such effects have potential applications in cancer therapy, gene regulation, and biophysical re...

journal_title：Journal of biomedical optics

authors： Sun Y,Vernier PT,Behrend M,Wang J,Thu MM,Gundersen M,Marcu L

更新日期：2006-03-01 00:00:00

abstract：:We theoretically investigate the effect of noise on frequency-domain heterodyne and/or homodyne measurements of intensity-modulated beams propagating through diffusive media, such as a photon density wave. We assumed that the attenuated amplitude and delayed phase are estimated by taking the Fourier transform of the n...

journal_title：Journal of biomedical optics

authors： Kang D,Kupinski MA

更新日期：2012-01-01 00:00:00

abstract：:Colorectal surgery is the standard treatment for patients with colorectal cancer. To overcome two of the main challenges, the circumferential resection margin and postoperative complications, real-time tissue assessment could be of great benefit during surgery. In this ex vivo study, diffuse reflectance spectroscopy (...

journal_title：Journal of biomedical optics

authors： Baltussen EJM,Snaebjornsson P,de Koning SGB,Sterenborg HJCM,Aalbers AGJ,Kok N,Beets GL,Hendriks BHW,Kuhlmann KFD,Ruers TJM

更新日期：2017-10-01 00:00:00

abstract：:Using commercially available organic fluorophores, the current applications of Förster (fluorescence) resonance energy transfer (FRET) are limited to about 80 Å. However, many essential activities in cells are spatially and/or temporally dependent on the assembly/disassembly of transient complexes consisting of large-...

journal_title：Journal of biomedical optics

authors： Maliwal BP,Raut S,Fudala R,D'Auria S,Marzullo VM,Luini A,Gryczynski I,Gryczynski Z

更新日期：2012-01-01 00:00:00

abstract：:To evaluate retinal perfusion in the human eye, a dual-wavelength confocal scanning laser ophthalmoscope (cSLO) was developed that provides spectral imaging of the fundus using a combination of red (670 nm) and near-infrared (810 nm) wavelengths. The image of the ocular fundus was analyzed to find out if quantitative ...

journal_title：Journal of biomedical optics

authors： Rasta SH,Manivannan A,Sharp PF

更新日期：2012-11-01 00:00:00

abstract：:A simultaneous multispectral fluorescence imaging system incorporating multiplexed volume holographic grating (VHG) is developed to acquire multispectral images of an object in one shot. With the multiplexed VHG, the imaging system can provide the distribution and spectral characteristics of multiple fluorophores in t...

journal_title：Journal of biomedical optics

authors： Lv Y,Zhang J,Zhang D,Cai W,Chen N,Luo J

更新日期：2016-06-01 00:00:00

abstract：:Early detection of tissue hypoxia in the intensive care unit is essential for effective treatment. Reduced nicotinamide adenine dinucleotide (NADH) has been suggested to be the most sensitive indicator of tissue oxygenation at the mitochondrial level. However, no experimental evidence comparing the kinetics of changes...

journal_title：Journal of biomedical optics

authors： Shi H,Sun N,Mayevsky A,Zhang Z,Luo Q

更新日期：2014-01-01 00:00:00

abstract：:Surgical resection of pancreatic cancer represents the only chance of cure and long-term survival in this common disease. Unfortunately, determination of a cancer-free margin at surgery is based on one or two tiny frozen section biopsies, which is far from ideal. Not surprisingly, cancer is usually left behind and is ...

journal_title：Journal of biomedical optics

authors： Cromey B,McDaniel A,Matsunaga T,Vagner J,Kieu KQ,Banerjee B

更新日期：2018-04-01 00:00:00

abstract：:Breast cancer is one of the most common cancers in females. To monitor chemotherapeutic efficacy for breast cancer, medical imaging systems such as x-ray mammography, computed tomography, magnetic resonance imaging, and ultrasound imaging have been used. Currently, it can take up to 3 to 6 weeks to see the tumor respo...

journal_title：Journal of biomedical optics

authors： Lee S,Jeong H,Seong M,Kim JG

更新日期：2017-12-01 00:00:00

abstract：:Laser photocoagulation is an established treatment for a variety of retinal diseases. However, when using the same irradiation parameter, the size and strength of the lesions are unpredictable due to unknown inter- and intraindividual optical properties of the fundus layers. The aim of this work is to investigate a fe...

journal_title：Journal of biomedical optics

authors： Schlott K,Koinzer S,Baade A,Birngruber R,Roider J,Brinkmann R

更新日期：2016-09-01 00:00:00

abstract：:When irradiated with nanosecond laser pulses, gold nanoparticles allow for manipulation or destruction of cells and proteins with high spatial and temporal precision. Gold nanorods are especially attractive, because they have an up-to-20-fold stronger absorption than a sphere of equal volume, which is shifted to the o...

journal_title：Journal of biomedical optics

authors： Rudnitzki F,Bever M,Rahmanzadeh R,Brieger K,Endl E,Groll J,Hüttmann G

更新日期：2012-05-01 00:00:00

abstract：:Fluorescence spectroscopy has been widely investigated as a technique for identifying pathological tissue; however, unrelated subject-to-subject variations in spectra complicate data analysis and interpretation. We describe and evaluate a new biosensing technique, differential laser-induced perturbation spectroscopy (...

journal_title：Journal of biomedical optics

authors： Kozikowski RT,Smith SE,Lee JA,Castleman WL,Sorg BS,Hahn DW

更新日期：2012-06-01 00:00:00

abstract：:Optically derived tissue properties across a range of breast densities and the effects of breast compression on estimates of hemoglobin, oxygen metabolism, and water and lipid concentrations were obtained from a coregistered imaging system that integrates near-infrared spectral tomography (NIRST) with digital breast t...

journal_title：Journal of biomedical optics

authors： Michaelsen KE,Krishnaswamy V,Shi L,Vedantham S,Karellas A,Pogue BW,Paulsen KD,Poplack SP

更新日期：2016-09-01 00:00:00

abstract：:Optical microanglography (OMAG) is a recently developed imaging modality capable of volumetric imaging of dynamic blood perfusion, down to capillary level resolution, with an imaging depth up to 2.00 mm beneath the tissue surface. We report the use of OMAG to monitor the cerebral blood flow (CBF) over the cortex of mo...

journal_title：Journal of biomedical optics

authors： Jia Y,Alkayed N,Wang RK

更新日期：2009-07-01 00:00:00

abstract：:Shallow lesions less than 1.5-cm deep are frequently seen in breast patients when they are scanned in reflection geometry. Two boundary conditions are compared for imaging shallow lesions, and a new probe design is introduced. A partial reflection boundary condition is suitable for imaging shallow lesions less than 1....

journal_title：Journal of biomedical optics

authors： Xu C,Yuan B,Zhu Q

更新日期：2008-07-01 00:00:00

abstract：:We investigate the statistical polarization parameters of biological tissue histological section images with different morphological structure. First we outline the results of polarization coordinate mapping and analysis of the statistics of the first to fourth orders of biological tissue image polarization azimuth an...

journal_title：Journal of biomedical optics

authors： Angelsky OV,Ushenko AG,Ushenko YA,Ushenko YG,Tomka YY,Pishak VP

更新日期：2005-11-01 00:00:00

abstract：:Computational modeling of arterial mechanics continues to progress, even to the point of allowing the study of complex regions such as the aortic arch. Nevertheless, most prior studies assign homogeneous and isotropic material properties and constant wall thickness even when implementing patient-specific luminal geome...

journal_title：Journal of biomedical optics

authors： Genovese K,Humphrey JD

更新日期：2015-04-01 00:00:00

abstract：:Clinical imaging techniques for the anterior segment of the eye provide excellent anatomical information, but molecular imaging techniques are lacking. Molecular photoacoustic imaging is one option to address this need, but implementation requires use of contrast agents to distinguish molecular targets from background...

journal_title：Journal of biomedical optics

authors： Kubelick KP,Snider EJ,Ethier CR,Emelianov S

更新日期：2019-05-01 00:00:00

abstract：:We present a method for tissue fluorescence quantification in situ using a handheld fiber optic probe that measures both the fluorescence and diffuse reflectance spectra. A simplified method to decouple the fluorescence spectrum from distorting effects of the tissue optical absorption and scattering is developed, with...

journal_title：Journal of biomedical optics

authors： Kim A,Khurana M,Moriyama Y,Wilson BC

更新日期：2010-11-01 00:00:00

abstract：:An algorithm was developed to obtain depth-resolved local optical axis in birefringent samples by using conventional polarization-sensitive optical coherence tomography (PSOCT) that uses a single circularly polarized incident light. The round-trip sample Jones matrices were first constructed from the cumulative PSOCT ...

journal_title：Journal of biomedical optics

authors： Fan C,Yao G

更新日期：2012-11-01 00:00:00

abstract：SIGNIFICANCE:Although the clinical potential for Raman spectroscopy (RS) has been anticipated for decades, it has only recently been used in neurosurgery. Still, few devices have succeeded in making their way into the operating room. With recent technological advancements, however, vibrational sensing is poised to be a...

journal_title：Journal of biomedical optics

authors： DePaoli D,Lemoine É,Ember K,Parent M,Prud'homme M,Cantin L,Petrecca K,Leblond F,Côté DC

更新日期：2020-05-01 00:00:00

abstract：:Raman spectroscopy (RS) has demonstrated great potential for in vivo cancer screening; however, the biophysical changes that occur for specific diagnoses remain unclear. We recently developed an inverse biophysical skin cancer model to address this issue. Here, we presented the first demonstration of in vivo melanoma ...

journal_title：Journal of biomedical optics

authors： Feng X,Moy AJ,Nguyen HTM,Zhang Y,Zhang J,Fox MC,Sebastian KR,Reichenberg JS,Markey MK,Tunnell JW

更新日期：2018-05-01 00:00:00

abstract：:We experimentally compare the performance and image contrast of spontaneous Raman and coherent Stokes Raman scattering microscopy. We demonstrate the differences between these techniques on a series of geometry-controlled samples that range in complexity from a point (array of tips) to one-dimensional (line grating) a...

journal_title：Journal of biomedical optics

authors： Kim H,Michaels CA,Bryant GW,Stranick SJ

更新日期：2011-02-01 00:00:00

abstract：:Fluorescence Talbot microscope is a scalable field-of-view (FOV) imaging platform, which takes advantage of the phase sensitivity of the self-image of a periodic structure. Such a system can maintain the microscopic resolution and extend the FOV for the whole slide (15  mm×15  mm) scanning. Previously reported Talbot ...

journal_title：Journal of biomedical optics

authors： Sun Y,Pang S

更新日期：2016-08-01 00:00:00

abstract：:Predicting the distribution of light inside any turbid media, such as biological tissue, requires detailed information about the optical properties of the medium, including the absorption and scattering coefficients and the anisotropy factor. Particularly, in biophotonic applications where photons directly interact wi...

journal_title：Journal of biomedical optics

authors： Azimipour M,Baumgartner R,Liu Y,Jacques SL,Eliceiri K,Pashaie R

更新日期：2014-01-01 00:00:00

abstract：:Fluorescence microscopy is commonly used to investigate disease progression in biological tissues. Biological tissues, however, are strongly scattering in the visible wavelengths, limiting the application of fluorescence microscopy to superficial (<200µm) regions. Optical clearing, which involves incubation of the tis...

journal_title：Journal of biomedical optics

authors： Moy AJ,Capulong BV,Saager RB,Wiersma MP,Lo PC,Durkin AJ,Choi B

更新日期：2015-01-01 00:00:00

abstract：:Angle-resolved signals of polarized light scattered by biological cells provide rich information on cell morphology. Quantitative study of these signals can lead to new methods to develop and improve high-throughput instrumentation for cell probing such as scattering-based flow cytometry. We employ a goniometer system...

journal_title：Journal of biomedical optics

authors： Ding H,Lu JQ,Brock RS,McConnell TJ,Ojeda JF,Jacobs KM,Hu XH

更新日期：2007-05-01 00:00:00