Abstract:
:We present for the first time in vivo full three-dimensional (3-D) photoacoustic tomography (PAT) of the distal interphalangeal joint in a human subject. Both absorbed energy density and absorption coefficient images of the joint are quantitatively obtained using our finite-element-based photoacoustic image reconstruction algorithm coupled with the photon diffusion equation. The results show that major anatomical features in the joint along with the side arteries can be imaged with a 1-MHz transducer in a spherical scanning geometry. In addition, the cartilages associated with the joint can be quantitatively differentiated from the phalanx. This in vivo study suggests that the 3-D PAT method described has the potential to be used for early diagnosis of joint diseases such as osteoarthritis and rheumatoid arthritis.
journal_name
J Biomed Optjournal_title
Journal of biomedical opticsauthors
Sun Y,Sobel E,Jiang Hdoi
10.1117/1.3257246subject
Has Abstractpub_date
2009-11-01 00:00:00pages
064002issue
6eissn
1083-3668issn
1560-2281journal_volume
14pub_type
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