Evaluating the use of optical coherence tomography for the detection of epithelial cancers in vitro.

abstract：:We present the first experimental result of direct delineation of the nuclei of living rat bladder epithelium with ultrahigh-resolution optical coherence tomography (uOCT). We demonstrate that the cellular details embedded in the speckle noise in a uOCT image can be uncovered by time-lapse frame averaging that takes a...

journal_title：Journal of biomedical optics

authors： Pan YT,Wu ZL,Yuan ZJ,Wang ZG,Du CW

更新日期：2007-09-01 00:00:00

abstract：:A promising method to achieve rapid convergence for image reconstruction is introduced for the continuous-wave near-infrared (NIR) diffuse optical tomography (DOT). Tomographic techniques are usually implemented off line and are time consuming to realize image reconstruction, especially for NIR DOT. Therefore, it is e...

journal_title：Journal of biomedical optics

authors： Pan MC,Pan MC

更新日期：2010-01-01 00:00:00

abstract：:Confocal micro-Raman spectroscopy--a valuable analytical tool in biological and medical field of research-allows probing molecular vibrations of samples without external labels or extensive preparation. We employ confocal micro-Raman spectroscopy to characterize renal tumors and normal tissue. Results show that Raman ...

journal_title：Journal of biomedical optics

authors： Zhuang Z,Li N,Guo Z,Zhu M,Xiong K,Chen S

更新日期：2013-03-01 00:00:00

abstract：:We describe the use of a Teflon-AF liquid core optical fiber (LCOF) geometry to enhance the collection of Raman scattering from the biochemical creatinine, dissolved in water and in urine. At short integration times, where shot noise is most troublesome, the enhanced signal leads to greater accuracy in estimating the ...

journal_title：Journal of biomedical optics

authors： Qi D,Berger AJ

更新日期：2005-05-01 00:00:00

abstract：:In the last 25 years, optical coherence tomography (OCT) has advanced to be one of the most innovative and most successful translational optical imaging techniques, achieving substantial economic impact as well as clinical acceptance. This is largely owing to the resolution improvements by a factor of 10 to the submic...

journal_title：Journal of biomedical optics

authors： Drexler W,Liu M,Kumar A,Kamali T,Unterhuber A,Leitgeb RA

更新日期：2014-01-01 00:00:00

abstract：:We report an accurate optical differentiation technique between healthy and malaria-infected erythrocytes by quasi-simultaneous measurements of transmittance, reflectance, and scattering properties of unstained blood smears using a multispectral and multimode light-emitting diode microscope. We propose a technique for...

journal_title：Journal of biomedical optics

authors： Merdasa A,Brydegaard M,Svanberg S,Zoueu JT

更新日期：2013-03-01 00:00:00

abstract：:The objective of this work was to compare the accuracy of analyte concentration estimation when using transmission versus diffuse reflectance spectroscopy of a scattering medium. Monte Carlo ray tracing of light through the medium was used in conjunction with pure component absorption spectra and Beer-Lambert absorpti...

journal_title：Journal of biomedical optics

authors： Gardner CM

更新日期：2018-01-01 00:00:00

abstract：:The objective is to characterize the impact of different ablation parameters on the thermal load during corneal refractive surgery by means of excimer laser ablation on porcine eyes. One hundred eleven ablations were performed in 105 porcine eyes. Each ablation was recorded using infrared thermography and analyzed mai...

journal_title：Journal of biomedical optics

authors： Arba Mosquera S,Verma S

更新日期：2015-07-01 00:00:00

abstract：:Using the multiresolution ability of wavelets and effectiveness of singular value decomposition (SVD) to identify statistically robust parameters, we find a number of local and global features, capturing spectral correlations in the co- and cross-polarized channels, at different scales (of human breast tissues). The c...

journal_title：Journal of biomedical optics

authors： Gharekhan AH,Arora S,Oza AN,Sureshkumar MB,Pradhan A,Panigrahi PK

更新日期：2011-08-01 00:00:00

abstract：:The study of red blood cell (RBC) aggregation is of great interest because of its implications for human health. Altered RBC aggregation can lead to microcirculatory problems as in vascular pathologies, such as hypertension and diabetes, due to a decrease in the erythrocyte surface electric charge and an increase in t...

journal_title：Journal of biomedical optics

authors： Toderi MA,Castellini HV,Riquelme BD

更新日期：2017-01-01 00:00:00

abstract：:Optical coherence tomography (OCT) is an emergent imaging tool used for noninvasive diagnosis of skin diseases. The present meta-analysis was carried out to assess the accuracy of OCT for the diagnosis of skin cancer. We conducted a systematic literature search though EMBASE, Medline, PubMed, the Cochrane Library, and...

journal_title：Journal of biomedical optics

authors： Xiong YQ,Mo Y,Wen YQ,Cheng MJ,Huo ST,Chen XJ,Chen Q

更新日期：2018-02-01 00:00:00

abstract：:All aberrations produced inside a biospecimen can degrade the quality of a three-dimensional image in two-photon excitation laser scanning microscopy. Previously, we developed a transmissive liquid-crystal device to correct spherical aberrations that improved the image quality of a fixed-mouse-brain slice treated with...

journal_title：Journal of biomedical optics

authors： Tanabe A,Hibi T,Ipponjima S,Matsumoto K,Yokoyama M,Kurihara M,Hashimoto N,Nemoto T

更新日期：2016-12-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) in tumor cells was found to play an important role in maintaining the malignant phenotype. Using laser scanning confocal fluorescence microscopy (LSCFM) in a recent work, we reported a variable fluorescence intensity of ethidium bromide (EB) in mitochondria nucleoids of living carcinoma cells...

journal_title：Journal of biomedical optics

authors： Villa AM,Fusi P,Pastori V,Amicarelli G,Pozzi C,Adlerstein D,Doglia SM

更新日期：2012-04-01 00:00:00

abstract：:For clinical optoacoustic imaging, linear probes are preferably used because they allow versatile imaging of the human body with real-time display and free-hand probe guidance. The two-dimensional (2-D) optoacoustic image obtained with this type of probe is generally interpreted as a 2-D cross-section of the tissue ju...

journal_title：Journal of biomedical optics

authors： Preisser S,Bush NL,Gertsch-Grover AG,Peeters S,Bailey AE,Bamber JC,Frenz M,Jaeger M

更新日期：2013-02-01 00:00:00

abstract：SIGNIFICANCE:Photothermal optical coherence tomography (PT-OCT) has the promise to offer structural images coregistered with chemical composition information, which can offer a significant impact in early detection of diseases such as atherosclerosis. AIM:We take the first step in understanding the relation between PT...

journal_title：Journal of biomedical optics

authors： Salimi M,Villiger M,Tabatabaei N

更新日期：2020-12-01 00:00:00

abstract：:Oxidative stress has become an exciting area of schizophrenia (SCZ) research, and provides ample opportunities and hope for a better understanding of its pathophysiology, which may lead to new treatment strategies. The first objective of the present study was to analyze the oxidative stress markers in breath samples o...

journal_title：Journal of biomedical optics

authors： Popa C,Petrus M,Bratu AM

更新日期：2015-05-01 00:00:00

abstract：:We present three-dimensional (3-D) high-resolution spectral-domain optical coherence microscopy (SD-OCM) by using a supercontinuum (SC) fiber laser source with 300-nm spectral bandwidth (full-width at half-maximum) in the 1700-nm spectral band. By using low-coherence interferometry with SC light and a confocal detecti...

journal_title：Journal of biomedical optics

authors： Yamanaka M,Hayakawa N,Nishizawa N

更新日期：2019-07-01 00:00:00

abstract：:We fabricate scaffolds with a fine linear grating (periodicity of 1 to 8 microm and height of 1 microm) on a glass substrate for controlling cardiomyocyte orientation. The fabrication is done by the solidification of a liquid photopolymerizable material using two laser beam interference. As the photopolymerizable mate...

journal_title：Journal of biomedical optics

authors： Fujita A,Fujita K,Nakamura O,Matsuda T,Kawata S

更新日期：2006-03-01 00:00:00

abstract：:Guest editors introduce contributors to the Special Section Celebrating the Exponential Growth of Optoacoustic/Photoacoustic Imaging. ...

journal_title：Journal of biomedical optics

authors： Beard P,Anastasio M,Oraevsky AA,Wang LV

更新日期：2019-12-01 00:00:00

abstract：:A primary focus of neurointensive care is monitoring the injured brain to detect harmful events that can impair cerebral blood flow (CBF), resulting in further injury. Since current noninvasive methods used in the clinic can only assess blood flow indirectly, the goal of this research is to develop an optical techniqu...

journal_title：Journal of biomedical optics

authors： Diop M,Tichauer KM,Elliott JT,Migueis M,Lee TY,St Lawrence K

更新日期：2010-09-01 00:00:00

abstract：:Pilot results on the application of the finite-difference time-domain (FDTD) approach for studying the implementation of the optical immersion technique for the visualization of single and multiple gold nanoparticles in biological cells are presented. We focus on two different scenarios considering single biological c...

journal_title：Journal of biomedical optics

authors： Tanev S,Tuchin VV,Paddon P

更新日期：2006-11-01 00:00:00

abstract：:The formation of kidney stones is a common and highly studied disease, which causes intense pain and presents a high recidivism. In order to find the causes of this problem, the characterization of the main compounds is of great importance. In this sense, the analysis of the composition and structure of the stone can ...

journal_title：Journal of biomedical optics

authors： Blanco F,López-Mesas M,Serranti S,Bonifazi G,Havel J,Valiente M

更新日期：2012-07-01 00:00:00

abstract：:Optical technique based on diffuse reflectance measurement combined with indocyanine green (ICG) bolus tracking is extensively tested as a method for clinical assessment of brain perfusion in adults at the bedside. Methodology of multiwavelength and time-resolved detection of fluorescence light excited in the ICG is p...

journal_title：Journal of biomedical optics

authors： Gerega A,Milej D,Weigl W,Botwicz M,Zolek N,Kacprzak M,Wierzejski W,Toczylowska B,Mayzner-Zawadzka E,Maniewski R,Liebert A

更新日期：2012-08-01 00:00:00

abstract：:Optically sectioned detection of fluorescence immunoassays using a confocal microscope enables the creation of both homo- and heterogeneous planar format assays. We report a set assays requiring optically sectioned detection using a model system and analysis procedures for separating signals of a surface layer from an...

journal_title：Journal of biomedical optics

authors： Ghafari H,Zhou Y,Ali S,Hanley QS

更新日期：2009-11-01 00:00:00

abstract：:A real-time photoacoustic imaging system is designed and built. This system is based on a commercially available ultrasound imaging system. It can achieve a frame rate of 8 frames/sec. Vasculature in the hand of a human volunteer is imaged, and the resulting photoacoustic image is combined with the ultrasound image. T...

journal_title：Journal of biomedical optics

authors： Kolkman RG,Brands PJ,Steenbergen W,van Leeuwen TG

更新日期：2008-09-01 00:00:00

abstract：:We propose a handheld projective imaging device for orthotopic projection of near-infrared fluorescence images onto target biological tissue at visible wavelengths without any additional visual aid. The device integrates a laser diode light source module, a camera module, a projector, an ultrasonic distance sensor, a ...

journal_title：Journal of biomedical optics

authors： Li C,Liu P,Shao P,Pei J,Li Y,Pawlik TM,Martin EW,Xu RX

更新日期：2019-08-01 00:00:00

abstract：:Diffusion of therapeutic macromolecules through the extracellular matrix of tumor tissue is a crucial step in drug delivery. We use fluorescence correlation spectroscopy (FCS) to measure diffusion of IgG (150 kDa) and dextrans (155 kDa and 2 MDa) in solution, 5% gelatin hydrogel, and multicellular spheroids. Gel and s...

journal_title：Journal of biomedical optics

authors： Reitan NK,Juthajan A,Lindmo T,de Lange Davies C

更新日期：2008-09-01 00:00:00

abstract：:Spectrally resolved two-photon excited autofluorescence imaging is used to distinguish different cell types and functional areas during dynamic processes in the living gut. Excitation and emission spectra of mucosal tissue and tissue components are correlated to spectra of endogenous chromophores. We show that selecti...

journal_title：Journal of biomedical optics

authors： Orzekowsky-Schroeder R,Klinger A,Martensen B,Blessenohl M,Gebert A,Vogel A,Hüttmann G

更新日期：2011-11-01 00:00:00

abstract：:A synchrotron light source dedicated to medical applications has been designed at National Institute of Radiological Sciences. The storage ring, with circumference of 80 m, is designed for acceleration of 2.3 GeV and a stored current of 420 mA. It is equipped with two multipole wigglers to produce sufficient photon fl...

journal_title：Journal of biomedical optics

authors： Torikoshi M,Tsunoo T,Endo M,Noda K,Kumada M,Yamada S,Soga F,Hyodo K

更新日期：2001-07-01 00:00:00

abstract：:We propose a rate process model for describing photochemical damage to retinal cells by short wavelength laser exposures. The rate equation for photochemical damage contains a positive rate that is temperature independent, and a negative (quenching) rate that is temperature dependent. Using the traditional Arrhenius i...

journal_title：Journal of biomedical optics

authors： Clark CD 3rd,Denton ML,Thomas RJ

更新日期：2011-02-01 00:00:00