Abstract:
:Pilot results on the application of the finite-difference time-domain (FDTD) approach for studying the implementation of the optical immersion technique for the visualization of single and multiple gold nanoparticles in biological cells are presented. We focus on two different scenarios considering single biological cells containing (1) cytoplasm, nucleus, and membrane and (2) cytoplasm, nucleus, gold nanoparticles, and membrane. To the best of our knowledge, this is the first time the cell membrane thickness and gold nanoparticle effects on the forward scattered light from biological cells are discussed. The applicability and the potential of the FDTD approach for studying optical immersion technique enhanced bioimaging is demonstrated.
journal_name
J Biomed Optjournal_title
Journal of biomedical opticsauthors
Tanev S,Tuchin VV,Paddon Pdoi
10.1117/1.2400239subject
Has Abstractpub_date
2006-11-01 00:00:00pages
064037issue
6eissn
1083-3668issn
1560-2281journal_volume
11pub_type
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journal_title:Journal of biomedical optics
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