Abstract:
:Extension of optical monitoring of intact tissues from the visible and ultraviolet to the near-infrared (NIR) range (700-1300 nm) was first undertaken in 1977 for the purpose of monitoring the redox behavior of Cytochrome c oxidase (cyt c ox) in vivo. Soon it became evident that the much greater NIR translucency of skin and bone made it possible to reach brain and muscle tissue without surgical intervention. The presence of hemoglobin absorption led to complications forcing the construction of algorithms to separate the signals of the two molecular entities. It was also realized, however, that the hemoglobin signals provide information regarding the source of oxygen in the tissue, while the cyt c ox signals indicate the intracellular availability of oxygen for oxidative phosphorylation. This ability of recognizing the source/sink relationship greatly enhances the value of NIR spectrophotometry (NIRS) for research and clinical purposes. © 1999 Society of Photo-Optical Instrumentation Engineers.
journal_name
J Biomed Optjournal_title
Journal of biomedical opticsauthors
Jo Bsis-Vandervliet FFdoi
10.1117/1.429952subject
Has Abstractpub_date
1999-10-01 00:00:00pages
392-6issue
4eissn
1083-3668issn
1560-2281pii
1101290journal_volume
4pub_type
杂志文章abstract::Simplified measurement of macular pigment optical density (MPOD) is important because of the ocular health benefits that are attributed to these retinal carotenoids. Here, we describe a novel instrument designed for this purpose, based on heterochromatic flicker photometry (HFP), which removes a number of difficulties...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.JBO.18.10.107003
更新日期:2013-10-01 00:00:00
abstract::Functional near-infrared spectroscopy (fNIRS) is being increasingly applied to affective and social neuroscience research; however, the reliability of this method is still unclear. This study aimed to evaluate the test–retest reliability of the fNIRS-based prefrontal response to emotional stimuli. Twenty-six participa...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.JBO.22.1.016011
更新日期:2017-01-01 00:00:00
abstract::Lumpectomy coupled with radiation therapy and/or chemotherapy is commonly used to treat breast cancer patients. We are developing an enhanced thermal IR imaging technique that has the potential to provide real-time imaging to guide tissue excision during a lumpectomy by delineating tumor margins. This enhanced thermal...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
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更新日期:2015-11-01 00:00:00
abstract::Virus inactivation in red blood cell concentrates (RBCC) is being studied in order to increase the safety of the blood supply. For this purpose we have been studying the silicon phthalocyanine (Pc 4), a photosensitizer activated with red light. Two approaches were used to achieve enhanced selectivity of Pc 4 for virus...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.429931
更新日期:1999-07-01 00:00:00
abstract::Since hyperglycaemia changes the erythrocyte cell membrane fluidity and impairs cell deformity, our goal was to characterize hemoglobin and red blood cell (RBC) light refractive property changes in diabetic patients. Microscopic investigation was carried out on intact and fixed RBCs. To determine the refractive index ...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.1463043
更新日期:2002-04-01 00:00:00
abstract::A pilot human study is conducted to evaluate the potential of using diffuse photon density wave (DPDW) methodology at near-infrared (NIR) wavelengths (685 to 830 nm) to monitor changes in tissue hemoglobin concentration in diabetic foot ulcers. Hemoglobin concentration is measured by DPDW in 12 human wounds for a peri...
journal_title:Journal of biomedical optics
pub_type: 临床试验,杂志文章
doi:10.1117/1.3275467
更新日期:2009-11-01 00:00:00
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journal_title:Journal of biomedical optics
pub_type: 杂志文章
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更新日期:2016-09-01 00:00:00
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journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.JBO.22.9.097001
更新日期:2017-09-01 00:00:00
abstract:SIGNIFICANCE:Adaptive optics optical coherence tomography (AO-OCT) technology enables non-invasive, high-resolution three-dimensional (3D) imaging of the retina and promises earlier detection of ocular disease. However, AO-OCT data are corrupted by eye-movement artifacts that must be removed in post-processing, a proce...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
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更新日期:2021-01-01 00:00:00
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journal_title:Journal of biomedical optics
pub_type: 杂志文章
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更新日期:2005-09-01 00:00:00
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journal_title:Journal of biomedical optics
pub_type: 杂志文章
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更新日期:2019-11-01 00:00:00
abstract::We present a quantitative analysis of dynamic diffuse optical measurements to obtain oxygen saturation of hemoglobin in volume oscillating compartments. We used a phasor representation of oscillatory hemodynamics at the heart rate and respiration frequency to separate the oscillations of tissue concentrations of oxyhe...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.JBO.21.10.101408
更新日期:2016-10-01 00:00:00
abstract::The acousto-optic deflector (AOD) is highly preferred in laser scanning microscopy for its fast scanning ability and random-addressing capability. However, its application in two-photon microscopy is frustrated by the dispersion of the AOD, which results in beam distortion and pulse lengthening. We report the analysis...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
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更新日期:2007-03-01 00:00:00
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journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.JBO.23.3.030503
更新日期:2018-03-01 00:00:00
abstract::We propose an algorithm to compensate for the refractive index error in the optical coherence tomography (OCT) images of multilayer tissues, such as skin. The performance of the proposed method has been evaluated on one- and two-layer solid phantoms, as well as the skin of rat paw. ...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.JBO.23.7.070501
更新日期:2018-07-01 00:00:00
abstract::Intraductal carcinoma is a precancerous lesion of the breast and the immediate precursor of invasive ductal carcinoma. Multiphoton microscopy (MPM) was used to monitor the progression from intraductal carcinoma to invasive ductal carcinoma, which can improve early detection of precursor lesions and halt progression to...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
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更新日期:2015-09-01 00:00:00
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journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.JBO.18.7.076021
更新日期:2013-07-01 00:00:00
abstract::Microvascular network of the retina plays an important role in diagnosis and monitoring of various retinal diseases. We propose a three-dimensional (3-D) segmentation method with intensity-based Doppler variance (IBDV) based on swept-source optical coherence tomography. The automatic 3-D segmentation method is used to...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.JBO.20.7.076003
更新日期:2015-07-01 00:00:00
abstract::Emission and excitation spectra of collagen were recorded in the ultraviolet and visible regions. The existence of several types of chromophores absorbing and emitting throughout these spectral regions was observed. It was shown that laser irradiation at 355 and 532 nm caused collagen fluorescence photobleaching by 30...
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pub_type: 杂志文章
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更新日期:2001-01-01 00:00:00
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journal_title:Journal of biomedical optics
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更新日期:2004-05-01 00:00:00
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journal_title:Journal of biomedical optics
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更新日期:2011-01-01 00:00:00
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journal_title:Journal of biomedical optics
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更新日期:2012-02-01 00:00:00
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journal_title:Journal of biomedical optics
pub_type: 信件
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更新日期:2011-12-01 00:00:00
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journal_title:Journal of biomedical optics
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更新日期:2010-03-01 00:00:00
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journal_title:Journal of biomedical optics
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journal_title:Journal of biomedical optics
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更新日期:2009-09-01 00:00:00
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journal_title:Journal of biomedical optics
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更新日期:2011-01-01 00:00:00
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journal_title:Journal of biomedical optics
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更新日期:2011-07-01 00:00:00
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journal_title:Journal of biomedical optics
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更新日期:2007-01-01 00:00:00
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journal_title:Journal of biomedical optics
pub_type: 杂志文章
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更新日期:2019-06-01 00:00:00