Abstract:
:The measurement of changes in blood volume in tissue is important for monitoring the effects of a wide range of therapeutic interventions, from radiation therapy to skin-flap transplants. Many systems available for purchase are either expensive or difficult to use, limiting their utility in the clinical setting. A low-cost system, capable of measuring changes in tissue blood volume via diffuse reflectance spectroscopy is presented. The system consists of an integrating sphere coupled via optical fibers to a broadband light source and a spectrometer. Validation data are presented to illustrate the accuracy and reproducibility of the system. The validity and utility of this in vivo system were demonstrated in a skin blanching/reddening experiment using epinephrine and lidocaine, and in a study measuring the severity of radiation-induced erythema during radiation therapy.
journal_name
J Biomed Optjournal_title
Journal of biomedical opticsauthors
Glennie DL,Hayward JE,McKee DE,Farrell TJdoi
10.1117/1.JBO.19.10.105005subject
Has Abstractpub_date
2014-01-01 00:00:00pages
105005issue
10eissn
1083-3668issn
1560-2281pii
1915674journal_volume
19pub_type
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