Abstract:
:We have developed a near-infrared (NIR) fluorescence goggle system based on the complementary metal-oxide-semiconductor active pixel sensor imaging and see-through display technologies. The fluorescence goggle system is a compact wearable intraoperative fluorescence imaging and display system that can guide surgery in real time. The goggle is capable of detecting fluorescence of indocyanine green solution in the picomolar range. Aided by NIR quantum dots, we successfully used the fluorescence goggle to guide sentinel lymph node mapping in a rat model. We further demonstrated the feasibility of using the fluorescence goggle in guiding surgical resection of breast cancer metastases in the liver in conjunction with NIR fluorescent probes. These results illustrate the diverse potential use of the goggle system in surgical procedures.
journal_name
J Biomed Optjournal_title
Journal of biomedical opticsauthors
Liu Y,Njuguna R,Matthews T,Akers WJ,Sudlow GP,Mondal S,Tang R,Gruev V,Achilefu Sdoi
10.1117/1.JBO.18.10.101303subject
Has Abstractpub_date
2013-10-01 00:00:00pages
101303issue
10eissn
1083-3668issn
1560-2281pii
1693259journal_volume
18pub_type
杂志文章abstract::Traditional phase-resolved Doppler optical coherence tomography (DOCT) has been reported to have potential for characterizing local fluid flow within a microporous scaffold. In this work, we apply Doppler optical microangiography (DOMAG), a new imaging technique developed by combining optical microangiography (OMAG) w...
journal_title:Journal of biomedical optics
pub_type: 信件
doi:10.1117/1.3233590
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abstract::We present a novel confocal microscope that has dual-axis architecture and biaxial postobjective scanning for the collection of fluorescence images from biological specimens. This design uses two low-numerical-aperture lenses to achieve high axial resolution and long working distance, and the scanning mirror located d...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
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abstract::Deep anterior lamellar keratoplasty (DALK) is an emerging surgical technique for the restoration of corneal clarity and vision acuity. The big-bubble technique in DALK surgery is the most essential procedure that includes the air injection through a thin syringe needle to separate the dysfunctional region of the corne...
journal_title:Journal of biomedical optics
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abstract::Image resolution and signal level in fluorescence microscopy through inhomogeneous turbid media consisting of scatterers of multiple sizes under single- (1p), two- (2p), and three-photon (3p) excitation have been investigated based on a modified Monte Carlo model. The effects of the size distribution and the concentra...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
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更新日期:2003-07-01 00:00:00
abstract::The excited state lifetime of a fluorophore together with its fluorescence emission spectrum provide information that can yield valuable insights into the nature of a fluorophore and its microenvironment. However, it is difficult to obtain both channels of information in a conventional scheme as detectors are typicall...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
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更新日期:2019-12-01 00:00:00
abstract::Characterization and three-dimensional (3-D) localization of human cancerous prostate tissue embedded in normal prostate tissue were demonstrated using backscattering scanning polarization imaging and an inverse imaging reconstruction algorithm, optical tomography using independent component analysis (OPTICA). Two-dim...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.JBO.17.8.081419
更新日期:2012-08-01 00:00:00
abstract::We propose an algorithm to compensate for the refractive index error in the optical coherence tomography (OCT) images of multilayer tissues, such as skin. The performance of the proposed method has been evaluated on one- and two-layer solid phantoms, as well as the skin of rat paw. ...
journal_title:Journal of biomedical optics
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更新日期:2018-07-01 00:00:00
abstract::The objective is to characterize the impact of different ablation parameters on the thermal load during corneal refractive surgery by means of excimer laser ablation on porcine eyes. One hundred eleven ablations were performed in 105 porcine eyes. Each ablation was recorded using infrared thermography and analyzed mai...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
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更新日期:2015-07-01 00:00:00
abstract::Shallow lesions less than 1.5-cm deep are frequently seen in breast patients when they are scanned in reflection geometry. Two boundary conditions are compared for imaging shallow lesions, and a new probe design is introduced. A partial reflection boundary condition is suitable for imaging shallow lesions less than 1....
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.2966703
更新日期:2008-07-01 00:00:00
abstract::Oral cancer is one of the most common cancers worldwide. One-fifth of the world's oral cancer subjects are from India and other South Asian countries. The present Raman mapping study was carried out to understand biochemical variations in normal and malignant oral buccal mucosa. Data were acquired using WITec alpha 30...
journal_title:Journal of biomedical optics
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更新日期:2014-12-01 00:00:00
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journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.JBO.19.4.046012
更新日期:2014-04-01 00:00:00
abstract::Gap junction-mediated intercellular communication influences a variety of cellular activities. In tendons, gap junctions modulate collagen production, are involved in strain-induced cell death, and are involved in the response to mechanical stimulation. The aim of the present study was to investigate gap junction-medi...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.JBO.19.1.015001
更新日期:2014-01-01 00:00:00
abstract::Diffuse reflectance spectroscopy, which has been demonstrated as a noninvasive diagnostic technique, relies on quantitative models for extracting optical property values from turbid media, such as biological tissues. We review and compare reflectance models that have been published, and we test similar models over a m...
journal_title:Journal of biomedical optics
pub_type: 杂志文章,评审
doi:10.1117/1.JBO.19.7.075005
更新日期:2014-01-01 00:00:00
abstract::Cellular therapies hold promise to replace the implantation of whole organs in the treatment of disease. For most cell types, in vivo viability depends on oxygen delivery to avoid the toxic effects of hypoxia. A promising approach is the in situ vascularization of implantable devices which can mediate hypoxia and impr...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.JBO.19.8.087006
更新日期:2014-08-01 00:00:00
abstract::Cell morphology is often used as a valuable indicator of the physical condition and general status of living cells. We demonstrate a noninvasive method for morphological characterization of adherent cells. We measure infrared reflectivity spectrum at oblique angle from living cells cultured on thin Au film, and utiliz...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.JBO.17.8.081409
更新日期:2012-08-01 00:00:00
abstract::SpineLab is a software tool developed for reconstructing neuronal feature skeletons from three-dimensional single- or multi-photon image stacks. These images often suffer from limited resolution and a low signal-to-noise ratio, making the extraction of morphometric information difficult. To overcome this limitation, w...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
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更新日期:2012-07-01 00:00:00
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journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.JBO.22.5.055001
更新日期:2017-05-01 00:00:00
abstract::Artificial neural stimulation is widely used in clinic, rehabilitation, and research. One of the limitations of electrical stimulation is the current spread in tissue. Recently, pulsed mid-infrared laser stimulation of nerves has been investigated as an alternative stimulation method. The likely benefits of infrared n...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3655590
更新日期:2011-11-01 00:00:00
abstract::Previous studies have shown the ability of many lymphatic vessels to contract phasically to pump lymph. Every lymphangion can act like a heart with pacemaker sites that initiate the phasic contractions. The contractile wave propagates along the vessel to synchronize the contraction. However, determining the location o...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
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更新日期:2011-02-01 00:00:00
abstract::Fluorescence-guided diagnosis of tumor tissue is in many cases insufficient, because false positive results interfere with the outcome. Improvement through observation of cell metabolism might offer the solution, but needs a detailed understanding of the origin of autofluorescence. With respect to this, spectrally res...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
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journal_title:Journal of biomedical optics
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journal_title:Journal of biomedical optics
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更新日期:2016-12-01 00:00:00
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journal_title:Journal of biomedical optics
pub_type: 杂志文章
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journal_title:Journal of biomedical optics
pub_type: 杂志文章
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更新日期:2011-11-01 00:00:00
abstract::A transgenic mouse model with a Clim [co-factor of LIM (a combination of first letters of Lin-11 (C. elegans), ISL1 (rat), and Mec-3 (C. elegans) gene names) domain proteins] gene partially blocked in the epithelial compartment of its tissues is used to establish the sensitivity of intrinsic reflectance nonlinear opti...
journal_title:Journal of biomedical optics
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更新日期:2006-01-01 00:00:00
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journal_title:Journal of biomedical optics
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journal_title:Journal of biomedical optics
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journal_title:Journal of biomedical optics
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pub_type: 信件
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