Coregistered photoacoustic and ultrasound imaging and classification of ovarian cancer: ex vivo and in vivo studies.

abstract：:Noninvasive cardiovascular imaging could lead to the early detection and timely treatment of complex atherosclerotic lesions responsible for major cardiovascular events. Recent investigations have suggested that optical coherence tomography (OCT) is an ideal diagnostic tool due to the high resolution this technology a...

journal_title：Journal of biomedical optics

authors： Ghosn MG,Carbajal EF,Befrui NA,Tellez A,Granada JF,Larin KV

更新日期：2008-01-01 00:00:00

abstract：:Penetration profiles of topically applied drugs and cosmetic products provide important information on their efficacy. The application of tape stripping in combination with UV/VIS spectroscopy is checked to determine the local position of topically applied substances inside the stratum corneum, the penetration profile...

journal_title：Journal of biomedical optics

authors： Weigmann HJ,Jacobi U,Antoniou C,Tsikrikas GN,Wendel V,Rapp C,Gers-Barlag H,Sterry W,Lademann J

更新日期：2005-01-01 00:00:00

abstract：:Cortical spreading depression (CSD) is a slowly propagating wave of depolarization of neurons and glia and has a less characterized vascular component. CSD is a commonly used phenomenon to test new methods of live brain imaging. Application of a blood pulsations imaging (BPI) technique to study of CSD induced with hig...

journal_title：Journal of biomedical optics

authors： Teplov V,Shatillo A,Nippolainen E,Gröhn O,Giniatullin R,Kamshilin AA

更新日期：2014-04-01 00:00:00

abstract：:A clinical need exists for low-cost and noninvasive imaging tools capable of detecting inflammation in the joints of inflammatory arthritis patients. Previous studies have reported an optical contrast between inflamed and noninflamed joints resulting from distinct absorption and scattering properties. Accurate classif...

journal_title：Journal of biomedical optics

authors： Lighter D,Filer A,Dehghani H

更新日期：2019-06-01 00:00:00

abstract：:Red blood cell (RBC) anomalies are significant symptoms for identification of health disorders and several blood diseases, which involve the modification of the parameters and biophysical characteristics of such cells. The aim of this study is to measure the three-dimensional phase information of healthy RBCs and thei...

journal_title：Journal of biomedical optics

authors： Agarwal S,Kumar V,Shakher C

更新日期：2017-10-01 00:00:00

abstract：:Intraductal carcinoma is a precancerous lesion of the breast and the immediate precursor of invasive ductal carcinoma. Multiphoton microscopy (MPM) was used to monitor the progression from intraductal carcinoma to invasive ductal carcinoma, which can improve early detection of precursor lesions and halt progression to...

journal_title：Journal of biomedical optics

authors： Wu Y,Fu F,Lian Y,Nie Y,Zhuo S,Wang C,Chen J

更新日期：2015-09-01 00:00:00

abstract：:By using a novel temporal characterization technique, we determined that a threshold average laser power of 160 mW is required to drill through a 0.75-mm-thick cortical bone for a Nd:YVO(4) mode-locked laser oscillator with a peak intensity of 1.3 GWcm(2). The ablation mechanism is identified as average-power induced ...

journal_title：Journal of biomedical optics

authors： Lee YM,Tu RY,Chiang AC,Huang YC

更新日期：2007-11-01 00:00:00

abstract：:Differential phase optical coherence tomography (DPOCT) is introduced to measure optical path length changes in response to pulsed laser irradiation (585 nm). An analytical equation that includes thermoelastic surface displacement and thermorefractive index change is derived to predict optical path length change in re...

journal_title：Journal of biomedical optics

authors： Kim J,Oh J,Milner TE

更新日期：2006-07-01 00:00:00

abstract：:So far, the study of the optical clearing is almost always about healthy tissue. However, the ultimate goal is to detect diseases for clinical application. Optical clearing on diseased skins is explored. The effect is evaluated by applying a combined liquid paraffin and glycerol mixed solution on several kinds of dise...

journal_title：Journal of biomedical optics

authors： Shan H,Liang Y,Wang J,Li Y

更新日期：2012-11-01 00:00:00

abstract：:Investigating the elasticity of ocular tissue (cornea and intraocular lens) could help the understanding and management of pathologies related to biomechanical deficiency. In previous studies, we introduced a setup based on optical coherence tomography for shear wave elastography (SWE) with high resolution and high se...

journal_title：Journal of biomedical optics

authors： Nguyen TM,Arnal B,Song S,Huang Z,Wang RK,O'Donnell M

更新日期：2015-01-01 00:00:00

abstract：:The nEUROPt protocol is one of two new protocols developed within the European project nEUROPt to characterize the performances of time-domain systems for optical imaging of the brain. It was applied in joint measurement campaigns to compare the various instruments and to assess the impact of technical improvements. T...

journal_title：Journal of biomedical optics

authors： Wabnitz H,Jelzow A,Mazurenka M,Steinkellner O,Macdonald R,Milej D,Żołek N,Kacprzak M,Sawosz P,Maniewski R,Liebert A,Magazov S,Hebden J,Martelli F,Di Ninni P,Zaccanti G,Torricelli A,Contini D,Re R,Zucchelli L,Spine

更新日期：2014-08-01 00:00:00

abstract：:Two pronounced absorption peaks in blue and red ranges of the chlorin-based photosensitizer (PS) absorption spectrum provide additional benefits in photodynamic therapy (PDT) performance. Differing optical properties of biological tissues in these ranges allow for both dual-wavelength diagnostics and PDT performance. ...

journal_title：Journal of biomedical optics

authors： Kurakina D,Khilov A,Shakhova M,Orlinskaya N,Sergeeva E,Meller A,Turchin I,Kirillin M

更新日期：2019-12-01 00:00:00

abstract：:We demonstrate dynamic in vivo imaging using a low-cost portable pulsed laser diode (PLD)-based photoacoustic tomography system. The system takes advantage of an 803-nm PLD having high-repetition rate ∼7000  Hz combined with a fast-scanning single-element ultrasound transducer leading to a 5 s cross-sectional imaging....

journal_title：Journal of biomedical optics

authors： Upputuri PK,Pramanik M

更新日期：2017-09-01 00:00:00

abstract：:New diagnostic tools are needed for the characterization of dental caries in the early stages of development. If carious lesions are detected early enough, they can be arrested without the need for surgical intervention. The objective of this study was to demonstrate that polarization sensitive optical coherence tomog...

journal_title：Journal of biomedical optics

authors： Fried D,Xie J,Shafi S,Featherstone JD,Breunig TM,Le C

更新日期：2002-10-01 00:00:00

abstract：:Characterization and three-dimensional (3-D) localization of human cancerous prostate tissue embedded in normal prostate tissue were demonstrated using backscattering scanning polarization imaging and an inverse imaging reconstruction algorithm, optical tomography using independent component analysis (OPTICA). Two-dim...

journal_title：Journal of biomedical optics

authors： Pu Y,Wang W,Xu M,Eastham JA,Tang G,Alfano RR

更新日期：2012-08-01 00:00:00

abstract：:We have applied wide-field digital interferometry (WFDI) to examine the morphology and dynamics of live red blood cells (RBCs) from individuals who suffer from sickle cell anemia (SCA), a genetic disorder that affects the structure and mechanical properties of RBCs. WFDI is a noncontact, label-free optical microscopy ...

journal_title：Journal of biomedical optics

authors： Shaked NT,Satterwhite LL,Telen MJ,Truskey GA,Wax A

更新日期：2011-03-01 00:00:00

abstract：:We present unsupervised clustering methods for automatic grouping of human red blood cells (RBCs) extracted from RBC quantitative phase images obtained by digital holographic microscopy into three RBC clusters with regular shapes, including biconcave, stomatocyte, and sphero-echinocyte. We select some good features re...

journal_title：Journal of biomedical optics

authors： Ahmadzadeh E,Jaferzadeh K,Lee J,Moon I

更新日期：2017-07-01 00:00:00

abstract：:Cellular therapies hold promise to replace the implantation of whole organs in the treatment of disease. For most cell types, in vivo viability depends on oxygen delivery to avoid the toxic effects of hypoxia. A promising approach is the in situ vascularization of implantable devices which can mediate hypoxia and impr...

journal_title：Journal of biomedical optics

authors： Weidling J,Sameni S,Lakey JR,Botvinick E

更新日期：2014-08-01 00:00:00

abstract：:We compared light-induced fluorescence (LIF) to nominal injected drug dose for predicting the depth of necrosis response to photodynamic therapy (PDT) in a murine tumor model. Mice were implanted with radiation-induced fibrosarcoma (RIF) and were injected with 0, 5, or 10 mg/kg Photofrin. 630-nm light (30 J/cm(2), 75 ...

journal_title：Journal of biomedical optics

authors： Cheung R,Solonenko M,Busch TM,Del Piero F,Putt ME,Hahn SM,Yodh AG

更新日期：2003-04-01 00:00:00

abstract：:The capabilities of micro-Raman spectroscopy for differentiating normal and malignant nasopharyngeal tissues were evaluated. Raman scattering signals were acquired from 22 normal and 52 malignant nasopharyngeal tissue samples. Distinctive spectral differences in Raman spectra between normal and malignant nasopharyngea...

journal_title：Journal of biomedical optics

authors： Li Y,Pan J,Chen G,Li C,Lin S,Shao Y,Feng S,Huang Z,Xie S,Zeng H,Chen R

更新日期：2013-02-01 00:00:00

abstract：:The laser ablation rate of subgingival dental calculus irradiated at a 400-nm-wavelength, 7.4-mJ pulse energy, and 85- and 20-deg irradiation angles is measured using laser triangulation. Three-dimensional images taken before and after irradiation create a removal map with 6-μm axial resolution. Fifteen human teeth wi...

journal_title：Journal of biomedical optics

authors： Schoenly JE,Seka WD,Rechmann P

更新日期：2011-07-01 00:00:00

abstract：:Mid-IR semiconductor lasers of two wavelength bands, 5.4 and 9.6 microm, are applied to measure aqueous glucose concentration ranging from 0 to 500 mgdL with Intralipid emulsion (0 to 8%) added as a fat simulator. The absorption coefficient micro(a) is found linear with respect to glucose and Intralipid concentrations...

journal_title：Journal of biomedical optics

authors： Guo B,Wang Y,Wang Y,Le HQ

更新日期：2007-03-01 00:00:00

abstract：:Virus inactivation in red blood cell concentrates (RBCC) is being studied in order to increase the safety of the blood supply. For this purpose we have been studying the silicon phthalocyanine (Pc 4), a photosensitizer activated with red light. Two approaches were used to achieve enhanced selectivity of Pc 4 for virus...

journal_title：Journal of biomedical optics

authors： Ben-Hur E,Zuk MM,Oetjen J,Chan WS,Lenny L,Horowitz B

更新日期：1999-07-01 00:00:00

abstract：:We address the automatic differentiation of human tissue using multispectral imaging with promising potential for automatic visualization during surgery. Currently, tissue types have to be continuously differentiated based on the surgeon's knowledge only. Further, automatic methods based on optical in vivo properties ...

journal_title：Journal of biomedical optics

authors： Wisotzky EL,Uecker FC,Arens P,Dommerich S,Hilsmann A,Eisert P

更新日期：2018-05-01 00:00:00

abstract：:The fibrillar collagen network in tumor and normal tissues is different due to remodeling of the extracellular matrix during the malignant process. Collagen type I fibers have the crystalline and noncentrosymmetric properties required for generating the second-harmonic signal. The content and structure of collagen wer...

journal_title：Journal of biomedical optics

authors： Hompland T,Erikson A,Lindgren M,Lindmo T,de Lange Davies C

更新日期：2008-09-01 00:00:00

abstract：:We have developed a novel parallel-plate diffuse optical tomography (DOT) system for three-dimensional in vivo imaging of human breast tumor based on large optical data sets. Images of oxy-, deoxy-, and total hemoglobin concentration as well as blood oxygen saturation and tissue scattering were reconstructed. Tumor ma...

journal_title：Journal of biomedical optics

authors： Choe R,Konecky SD,Corlu A,Lee K,Durduran T,Busch DR,Pathak S,Czerniecki BJ,Tchou J,Fraker DL,Demichele A,Chance B,Arridge SR,Schweiger M,Culver JP,Schnall MD,Putt ME,Rosen MA,Yodh AG

更新日期：2009-03-01 00:00:00

abstract：:Hyperspectral reflectance imaging technique has been used for in vivo detection of cervical intraepithelial neoplasia. However, the clinical outcome of this technique is suboptimal owing to multiple limitations such as nonuniform illumination, high-cost and bulky setup, and time-consuming data acquisition and processi...

journal_title：Journal of biomedical optics

authors： Zheng W,Wang C,Chang S,Zhang S,Xu RX

更新日期：2015-12-01 00:00:00

abstract：:We present the design and experimental results of a new MEMS-based endoscopic optical coherence tomography (OCT) probe. The uniqueness of this miniature OCT imaging probe is a two-axis MEMS mirror with through-silicon vias (TSVs) for interconnecting. The TSV interconnection enables ultracompact probe design, successfu...

journal_title：Journal of biomedical optics

authors： Liu L,Wu L,Sun J,Lin E,Xie H

更新日期：2011-02-01 00:00:00

abstract：:We report the design, integration, and validation of a fluorescence microscopy system for imaging of electroperturbation--the effects of nanosecond, megavolt-per-meter pulsed electric fields on biological cells and tissues. Such effects have potential applications in cancer therapy, gene regulation, and biophysical re...

journal_title：Journal of biomedical optics

authors： Sun Y,Vernier PT,Behrend M,Wang J,Thu MM,Gundersen M,Marcu L

更新日期：2006-03-01 00:00:00

abstract：:A Fourier transform spectrometer is used to simultaneously measure distance, dispersion and spectrum. It is shown that short coherence interferometry has the potential to measure the three-dimensional distribution of the spatial structure of a sample with a resolution determined by the coherence length of the light so...

journal_title：Journal of biomedical optics

authors： Hellmuth T,Welle M

更新日期：1998-01-01 00:00:00