Abstract:
:We demonstrate dynamic in vivo imaging using a low-cost portable pulsed laser diode (PLD)-based photoacoustic tomography system. The system takes advantage of an 803-nm PLD having high-repetition rate ∼7000 Hz combined with a fast-scanning single-element ultrasound transducer leading to a 5 s cross-sectional imaging. Cortical vasculature is imaged in scan time of 5 s with high signal-to-noise ratio ∼48. To examine the ability for dynamic imaging, we monitored the fast uptake and clearance process of indocyanine green in the rat brain. The system will find applications to study neurofunctional activities, characterization of pharmacokinetic, and biodistribution profiles in the development process of drugs or imaging agents.
journal_name
J Biomed Optjournal_title
Journal of biomedical opticsauthors
Upputuri PK,Pramanik Mdoi
10.1117/1.JBO.22.9.090501subject
Has Abstractpub_date
2017-09-01 00:00:00pages
1-4issue
9eissn
1083-3668issn
1560-2281pii
JBO-170391LRjournal_volume
22pub_type
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