Early detection of high-grade squamous intraepithelial lesions in the cervix with quantitative spectroscopic imaging.

abstract：:Current diagnostic capabilities and limitations of fluorescence endomicroscopy in the cervix are assessed by qualitative and quantitative image analysis. Four cervical tissue types are investigated: normal columnar epithelium, normal and precancerous squamous epithelium, and stromal tissue. This study focuses on the p...

journal_title：Journal of biomedical optics

authors： Schlosser C,Bodenschatz N,Lam S,Lee M,McAlpine JN,Miller DM,Van Niekerk DJ,Follen M,Guillaud M,MacAulay CE,Lane PM

更新日期：2016-12-01 00:00:00

abstract：:Guest editors introduce contributors to the Special Section Celebrating the Exponential Growth of Optoacoustic/Photoacoustic Imaging. ...

journal_title：Journal of biomedical optics

authors： Beard P,Anastasio M,Oraevsky AA,Wang LV

更新日期：2019-12-01 00:00:00

abstract：:The composition of cartilage is predictive of its in vivo performance. Therefore, the ability to assess its primary macromolecular components, proteoglycan (PG) and collagen, is of great importance. In the current study, we hypothesized that PG content and distribution in tissue engineered cartilage could be determine...

journal_title：Journal of biomedical optics

authors： Kim M,Bi X,Horton WE,Spencer RG,Camacho NP

更新日期：2005-05-01 00:00:00

abstract：:We quantitatively investigated the measurement sensitivity of spatially resolved spectroscopy (SRS) across six tissue models: cerebral tissue, a small animal brain, the forehead of a fetus, an adult brain, forearm muscle, and thigh muscle. The optical path length in the voxel of the model was analyzed using Monte Carl...

journal_title：Journal of biomedical optics

authors： Niwayama M

更新日期：2018-03-01 00:00:00

abstract：:Higher-order optical errors of the human eye are often responsible for reduced visual acuity in spite of an optimal spherical or cylindrical refraction. These optical aberrations are of natural origin or can result from operations in the eye that involve optical structures. The ocular aberrometer presented is based on...

journal_title：Journal of biomedical optics

authors： Mierdel P,Kaemmerer M,Mrochen M,Krinke HE,Seiler T

更新日期：2001-04-01 00:00:00

abstract：:Computational modeling of arterial mechanics continues to progress, even to the point of allowing the study of complex regions such as the aortic arch. Nevertheless, most prior studies assign homogeneous and isotropic material properties and constant wall thickness even when implementing patient-specific luminal geome...

journal_title：Journal of biomedical optics

authors： Genovese K,Humphrey JD

更新日期：2015-04-01 00:00:00

abstract：:The laser ablation rate of subgingival dental calculus irradiated at a 400-nm-wavelength, 7.4-mJ pulse energy, and 85- and 20-deg irradiation angles is measured using laser triangulation. Three-dimensional images taken before and after irradiation create a removal map with 6-μm axial resolution. Fifteen human teeth wi...

journal_title：Journal of biomedical optics

authors： Schoenly JE,Seka WD,Rechmann P

更新日期：2011-07-01 00:00:00

abstract：:We present a novel fluorescence imaging system developed for real-time interventional imaging applications. The system implements a correction scheme that improves the accuracy of epi-illumination fluorescence images for light intensity variation in tissues. The implementation is based on the use of three cameras oper...

journal_title：Journal of biomedical optics

authors： Themelis G,Yoo JS,Soh KS,Schulz R,Ntziachristos V

更新日期：2009-11-01 00:00:00

abstract：:Metal nanoparticles can be functionalized with biomolecules to selectively localize in precancerous tissues and can act as optical contrast enhancers for reflectance-based diagnosis of epithelial precancer. We carry out Monte Carlo (MC) simulations to analyze photon propagation through nanoparticle-labeled tissues and...

journal_title：Journal of biomedical optics

authors： Cihan C,Arifler D

更新日期：2011-08-01 00:00:00

abstract：SIGNIFICANCE:Photothermal optical coherence tomography (PT-OCT) has the promise to offer structural images coregistered with chemical composition information, which can offer a significant impact in early detection of diseases such as atherosclerosis. AIM:We take the first step in understanding the relation between PT...

journal_title：Journal of biomedical optics

authors： Salimi M,Villiger M,Tabatabaei N

更新日期：2020-12-01 00:00:00

abstract：:Artificial neural stimulation is widely used in clinic, rehabilitation, and research. One of the limitations of electrical stimulation is the current spread in tissue. Recently, pulsed mid-infrared laser stimulation of nerves has been investigated as an alternative stimulation method. The likely benefits of infrared n...

journal_title：Journal of biomedical optics

authors： Matic AI,Walsh JT Jr,Richter CP

更新日期：2011-11-01 00:00:00

abstract：:The efficacy of existing therapies and the discovery of innovative treatments for central nervous system (CNS) diseases have been limited by the lack of appropriate methods to investigate complex molecular processes at the synaptic level. To improve our capability to investigate complex mechanisms of synaptic signalin...

journal_title：Journal of biomedical optics

authors： Labrecque S,Sylvestre JP,Marcet S,Mangiarini F,Bourgoin B,Verhaegen M,Blais-Ouellette S,De Koninck P

更新日期：2016-04-30 00:00:00

abstract：:Reactive oxygen species (ROS) produced by photodynamic therapy (PDT) is recorded in vivo using a chemiluminescence (CL)-based gated optical system. A novel approach is developed to utilize the fluorescence (FL) of the CL probe as an internal fluorescence to calibrate the observed CL on pharmacokinetics of the probe in...

journal_title：Journal of biomedical optics

authors： Wei Y,Xing D,Luo S,Yang L,Chen Q

更新日期：2010-03-01 00:00:00

abstract：:We introduce the application of functional data analysis (fDA) on functional near-infrared spectroscopy (fNIRS) signals for the development of an accurate and clinically practical assessment method of pain perception. We used the cold pressor test to induce different levels of pain in healthy subjects while the fNIRS ...

journal_title：Journal of biomedical optics

authors： Pourshoghi A,Zakeri I,Pourrezaei K

更新日期：2016-10-01 00:00:00

abstract：:Blood smear analysis has remained a crucial diagnostic tool for pathologists despite the advent of automatic analyzers such as flow cytometers and impedance counters. Though these current methods have proven to be indispensible tools for physicians and researchers alike, they provide limited information on the detaile...

journal_title：Journal of biomedical optics

authors： Mir M,Ding H,Wang Z,Reedy J,Tangella K,Popescu G

更新日期：2010-03-01 00:00:00

abstract：:Mueller polarimetry is applied to study the samples of nails: natural (or reference) and irradiated to 2 Gy ionizing radiation dose. We measure the whole Mueller matrices of the samples as a function of the scattering angle at a wavelength of 632.8 nm. We apply depolarization analysis to measured Mueller matrices by c...

journal_title：Journal of biomedical optics

authors： Savenkov S,Priezzhev A,Oberemok Y,Sholom S,Kolomiets I,Chunikhina K

更新日期：2016-07-01 00:00:00

abstract：:Three-dimensional (3-D) tissue imaging offers substantial benefits to a wide range of biomedical investigations from cardiovascular biology, diabetes, Alzheimer's disease to cancer. Two-photon tissue cytometry is a novel technique based on high-speed multiphoton microscopy coupled with automated histological sectionin...

journal_title：Journal of biomedical optics

authors： Ragan T,Sylvan JD,Kim KH,Huang H,Bahlmann K,Lee RT,So PT

更新日期：2007-01-01 00:00:00

abstract：:The essential feature of the confocal laser scanning microscope (cLSM) is the generation of optical sections by the removal of out-of-focus light. About ten years ago, structured illumination microscopy (SIM) was introduced as an alternative method for obtaining optical sections from biological specimens. Here we comp...

journal_title：Journal of biomedical optics

authors： Weigel A,Schild D,Zeug A

更新日期：2009-01-01 00:00:00

abstract：:The results of an experimental study of the possibilities of monitoring erbium yttrium aluminum garnet laser-mediated ablation of human epidermis with the use of Fourier transform infrared (FTIR) spectroscopy and spectral polarization techniques are presented. The attenuated total reflection (ATR) method was used for ...

journal_title：Journal of biomedical optics

authors： Sviridov AP,Zimnyakov DA,Sinichkin YP,Butvina LN,Omelchenko AJ,Shakh GS,Bagratashvili VN

更新日期：2004-07-01 00:00:00

abstract：:The damage mechanism for near-infrared radiation (IRR) induced cataract is unclear. Both a photochemical and a thermal mechanism were suggested. The current paper aims to elucidate a photochemical effect based on investigation of irradiance-exposure time reciprocity. Groups of 20 rats were unilaterally exposed to 96-W...

journal_title：Journal of biomedical optics

authors： Yu Z,Schulmeister K,Talebizadeh N,Kronschläger M,Söderberg P

更新日期：2015-01-01 00:00:00

abstract：:We have applied wide-field digital interferometry (WFDI) to examine the morphology and dynamics of live red blood cells (RBCs) from individuals who suffer from sickle cell anemia (SCA), a genetic disorder that affects the structure and mechanical properties of RBCs. WFDI is a noncontact, label-free optical microscopy ...

journal_title：Journal of biomedical optics

authors： Shaked NT,Satterwhite LL,Telen MJ,Truskey GA,Wax A

更新日期：2011-03-01 00:00:00

abstract：:Selective laser targeting of the retinal pigment epithelium (RPE) is an attractive method for treating RPE-associated disorders. We are developing a method for optically detecting intracellular microcavitation that can potentially serve as an immediate feedback of the treatment outcome. Thermal denaturation or intrace...

journal_title：Journal of biomedical optics

authors： Lee H,Alt C,Pitsillides CM,Lin CP

更新日期：2007-11-01 00:00:00

abstract：:Optical clearing is a well-known phenomenon. It is based on the matching of refractive indices of a bulk material and scattering particles. The same principle is also used in scattering-based optical measurements of different constituents, such as glucose. By registering changes in scattering, it is possible to evalua...

journal_title：Journal of biomedical optics

authors： Kinnunen M,Myllylä R,Vainio S

更新日期：2008-03-01 00:00:00

abstract：:We describe a systematic approach to image, track, and quantify the movements of HIV viruses embedded in human cervical mucus. The underlying motivation for this study is that, in HIV-infected adults, women account for more than half of all new cases and most of these women acquire the infection through heterosexual c...

journal_title：Journal of biomedical optics

authors： Boukari F,Makrogiannis S,Nossal R,Boukari H

更新日期：2016-09-01 00:00:00

abstract：:Fourier domain (FD) techniques have increasingly gained attention in optical coherence tomography (OCT). This is primarily due to their demonstrated sensitivity of two to three orders of magnitude over conventional time-domain techniques. FDOCT images are subject to two primary sources of artifacts. First, a complex c...

journal_title：Journal of biomedical optics

authors： Davis AM,Choma MA,Izatt JA

更新日期：2005-11-01 00:00:00

abstract：:Cardiac architecture is inherently three-dimensional, yet most characterizations rely on two-dimensional histological slices or dissociated cells, which remove the native geometry of the heart. We previously developed a method for labeling intact heart sections without dissociation and imaging large volumes while pres...

journal_title：Journal of biomedical optics

authors： Huang H,Macgillivray C,Kwon HS,Lammerding J,Robbins J,Lee RT,So P

更新日期：2009-07-01 00:00:00

abstract：:An approach to an established technique that is potentially applicable for a more comprehensive understanding of the electrical properties of red blood cells (RBCs) is presented. Using a high-intensity gradient laser trap, RBCs can be singly trapped and consequentially ionized. The subsequent dynamics of the ionized c...

journal_title：Journal of biomedical optics

authors： Kelley M,Cooper J,Devito D,Mushi R,Aguinaga MDP,Erenso DB

更新日期：2018-05-01 00:00:00

abstract：:Fluorescence image-guided surgery (FIGS) is an emerging technique in oncology, neurology, and cardiology. To adapt intraoperative imaging for various surgical applications, increasingly flexible and compact FIGS instruments are necessary. We present a compact, portable FIGS system and demonstrate its use in cardiovasc...

journal_title：Journal of biomedical optics

authors： Wang X,Bhaumik S,Li Q,Staudinger VP,Yazdanfar S

更新日期：2010-03-01 00:00:00

abstract：SIGNIFICANCE:In multiphoton microscopy, two-photon excited fluorescence (TPEF) spectra carry valuable information on morphological and functional biological features. For measuring these biomarkers, separation of different parts of the fluorescence spectrum into channels is typically achieved by the use of optical band...

journal_title：Journal of biomedical optics

authors： Meyer BO,Stella MPJ,Holst B,Nielsen BS,Holmstrøm K,Andersen PE,Marti D

更新日期：2020-07-01 00:00:00

abstract：:We present a novel Fourier-domain angle-resolved low-coherence interferometry (a /LCI) fiber probe designed for in vivo clinical application in gastrointestinal endoscopy. The a/LCI technique measures the depth-resolved angular scattering distribution to determine the size distribution and optical density of cell nucl...

journal_title：Journal of biomedical optics

authors： Zhu Y,Terry NG,Woosley JT,Shaheen NJ,Wax A

更新日期：2011-01-01 00:00:00