Analysis of human nails by laser-induced breakdown spectroscopy.

abstract：:Intraoperative margin assessment is imperative to cancer cure but is a continued challenge to successful surgery. Breast conserving surgery is a relevant example, where a cosmetically improved outcome is gained over mastectomy, but re-excision is required in >25  %   of cases due to positive or closely involved margin...

journal_title：Journal of biomedical optics

authors： Schaefer JM,Barth CW,Davis SC,Gibbs SL

更新日期：2019-02-01 00:00:00

abstract：:Anastomotic complication is a major morbidity associated with esophagectomy. Gastric ischemia after conduit creation contributes to anastomotic complications, but a reliable method to assess oxygenation in the gastric conduit is lacking. We hypothesize that fiber optic spectroscopy can reliably assess conduit oxygenat...

journal_title：Journal of biomedical optics

authors： Gareau DS,Truffer F,Perry KA,Pham TH,Enestvedt CK,Dolan JP,Hunter JG,Jacques SL

更新日期：2010-11-01 00:00:00

abstract：:We theoretically investigate the effect of noise on frequency-domain heterodyne and/or homodyne measurements of intensity-modulated beams propagating through diffusive media, such as a photon density wave. We assumed that the attenuated amplitude and delayed phase are estimated by taking the Fourier transform of the n...

journal_title：Journal of biomedical optics

authors： Kang D,Kupinski MA

更新日期：2012-01-01 00:00:00

abstract：:In breast surgery, a lack of knowledge about what is below the tissue surface may lead to positive tumor margins and iatrogenic damage. Diffuse reflectance spectroscopy (DRS) is a spectroscopic technique that can distinguish between healthy and tumor tissue making it a suitable technology for intraoperative guidance. ...

journal_title：Journal of biomedical optics

authors： Adank MW,Fleischer JC,Dankelman J,Hendriks BHW

更新日期：2018-11-01 00:00:00

abstract：:Optically sectioned detection of fluorescence immunoassays using a confocal microscope enables the creation of both homo- and heterogeneous planar format assays. We report a set assays requiring optically sectioned detection using a model system and analysis procedures for separating signals of a surface layer from an...

journal_title：Journal of biomedical optics

authors： Ghafari H,Zhou Y,Ali S,Hanley QS

更新日期：2009-11-01 00:00:00

abstract：:A simple empirical method is presented to determine the scattering coefficient mu' s from backscattered polarized images of turbid media. It uses the ratio, pixel by pixel, of two images that are the second and the first backscattered Stokes parameter images Q and I, respectively. Taking this image ratio, then integra...

journal_title：Journal of biomedical optics

authors： Jaillon F,Saint-Jalmes H

更新日期：2005-05-01 00:00:00

abstract：:In-vivo imaging of the vascular system can provide novel insight into the dynamics of vasoconstriction and vasodilation. Fourier domain optical coherence tomography (FD-OCT) is an optical, noncontact imaging technique based on interferometry of short-coherent near-infrared light with axial resolution of less than 10 m...

journal_title：Journal of biomedical optics

authors： Meissner S,Müller G,Walther J,Morawietz H,Koch E

更新日期：2009-05-01 00:00:00

abstract：:Time-resolved measurement of early arriving photons through diffusive media has been shown to effectively reduce the high degree of light scatter in biological tissue. However, the experimentally achievable reduction in photon scatter and the impact of time-gated detection on instrument noise performance is not well u...

journal_title：Journal of biomedical optics

authors： Valim N,Brock J,Niedre M

更新日期：2010-11-01 00:00:00

abstract：:The spectroscopy of analyte-specific molecular vibrations in tissue thin sections has opened up a path toward histopathology without the need for tissue staining. However, biomedical vibrational imaging has not yet advanced from academic research to routine histopathology due to long acquisition times for the microsco...

journal_title：Journal of biomedical optics

authors： Kröger N,Egl A,Engel M,Gretz N,Haase K,Herpich I,Kränzlin B,Neudecker S,Pucci A,Schönhals A,Vogt J,Petrich W

更新日期：2014-01-01 00:00:00

abstract：:Traditional phase-resolved Doppler optical coherence tomography (DOCT) has been reported to have potential for characterizing local fluid flow within a microporous scaffold. In this work, we apply Doppler optical microangiography (DOMAG), a new imaging technique developed by combining optical microangiography (OMAG) w...

journal_title：Journal of biomedical optics

authors： Jia Y,An L,Wang RK

更新日期：2009-09-01 00:00:00

abstract：:Measuring the elasticity distribution inside the human body is of great interest because elastic abnormalities can serve as indicators of several diseases. We present a method for mapping elasticity inside soft tissues by imaging surface acoustic waves (SAWs) with digital holographic interferometry. With this method, ...

journal_title：Journal of biomedical optics

authors： Li S,Mohan KD,Sanders WW,Oldenburg AL

更新日期：2011-11-01 00:00:00

abstract：:We present a method for lung cancer detection exploiting reflectance spectra measured in vivo during endoscopic imaging of the lung. The measured reflectance spectra were analyzed using a specially developed light-transport model to obtain quantitative information about cancer-related, physiological, and morphologic c...

journal_title：Journal of biomedical optics

authors： Fawzy YS,Petek M,Tercelj M,Zeng H

更新日期：2006-07-01 00:00:00

abstract：:Vectorial models of focused beams are important to a variety of fields including microscopy, lithography, optical physics, and biomedical imaging. This has led to many models being developed, which calculate how beams of various profiles are focused both in free space and in the presence of stratified media. The major...

journal_title：Journal of biomedical optics

authors： Munro PRT

更新日期：2018-09-01 00:00:00

abstract：:We describe the protocol for an inexpensive and nondestructive optical reflectance assay for the measurement of biofilm formation. Reflectance data are obtained using an Ocean Optics (Dunedin, Florida) USB 2000 spectrometer with a polychromatic light source. A fiber optic cable is used both for illumination and collec...

journal_title：Journal of biomedical optics

authors： Broschat SL,Loge FJ,Peppin JD,White D,Call DR,Kuhn E

更新日期：2005-07-01 00:00:00

abstract：SIGNIFICANCE:Adaptive optics optical coherence tomography (AO-OCT) technology enables non-invasive, high-resolution three-dimensional (3D) imaging of the retina and promises earlier detection of ocular disease. However, AO-OCT data are corrupted by eye-movement artifacts that must be removed in post-processing, a proce...

journal_title：Journal of biomedical optics

authors： Kurokawa K,Crowell JA,Do N,Lee JJ,Miller DT

更新日期：2021-01-01 00:00:00

abstract：:Resin embedding is widely used and facilitates microscopic imaging of biological tissues. In contrast, quenching of fluorescence during embedding process hinders the application of resin embedding for imaging of fluorescence-labeled samples. For samples expressing fluorescent proteins, it has been demonstrated that th...

journal_title：Journal of biomedical optics

authors： Li L,Rao G,Lv X,Chen R,Cheng X,Wang X,Zeng S,Liu X

更新日期：2018-02-01 00:00:00

abstract：:Optical coherence tomography (OCT) is an emerging technology for high-resolution, noncontact imaging of transparent and scattering media. Polarization-sensitive optical coherence tomography (PS-OCT) is a functional extension of OCT that can image birefringent properties of a biological sample. PS-OCT was used to measu...

journal_title：Journal of biomedical optics

authors： Götzinger E,Pircher M,Sticker M,Fercher AF,Hitzenberger CK

更新日期：2004-01-01 00:00:00

abstract：:Immersion optical clearing makes it possible to use transmission polarized-light microscopy for characterization of thick (200 to 2000  μm) layers of biological tissues. We discuss polarization properties of thick samples in the context of the problem of characterization of collagen fiber alignment in connective tissu...

journal_title：Journal of biomedical optics

authors： Yakovlev DD,Shvachkina ME,Sherman MM,Spivak AV,Pravdin AB,Yakovlev DA

更新日期：2016-07-01 00:00:00

abstract：:Motion artifacts are the most significant sources of noise in the context of pediatric brain imaging designs and data analyses, especially in applications of functional near-infrared spectroscopy (fNIRS), in which it can completely affect the quality of the data acquired. Different methods have been developed to corre...

journal_title：Journal of biomedical optics

authors： Hu XS,Arredondo MM,Gomba M,Confer N,DaSilva AF,Johnson TD,Shalinsky M,Kovelman I

更新日期：2015-01-01 00:00:00

abstract：:Our aim is the development of a simple optical method for pulse wave profile, pulse wave delay time, and blood flow measurement. The method is based on recording the Doppler frequency shift related to a moving target--blood vessel walls or small particles. The Doppler signal is detected using the self-mixing that occu...

journal_title：Journal of biomedical optics

authors： Meigas K,Hinrikus H,Kattai R,Lass J

更新日期：2003-01-01 00:00:00

abstract：:A tutorial introduction to diffuse light transport is presented. The basic analytic equations of time-resolved, steady-state and modulated light transport are introduced. The perturbation method for handling slight heterogeneities in optical properties is outlined. The treatment of boundary conditions such as an air/t...

journal_title：Journal of biomedical optics

authors： Jacques SL,Pogue BW

更新日期：2008-07-01 00:00:00

abstract：:We present the design and experimental results of a new MEMS-based endoscopic optical coherence tomography (OCT) probe. The uniqueness of this miniature OCT imaging probe is a two-axis MEMS mirror with through-silicon vias (TSVs) for interconnecting. The TSV interconnection enables ultracompact probe design, successfu...

journal_title：Journal of biomedical optics

authors： Liu L,Wu L,Sun J,Lin E,Xie H

更新日期：2011-02-01 00:00:00

abstract：:Waveguide evanescent field fluorescence (WEFF) microscopy is a new development that allows the imaging of contact regions between biological cells and their substratum, as well as imaging of ultrathin films such as monomolecular Langmuir-Blodgett (LB) films. Mixed-lipid monolayer systems mimicking lung surfactant were...

journal_title：Journal of biomedical optics

authors： Hassanzadeh A,Mittler S

更新日期：2011-04-01 00:00:00

abstract：:We report noninvasive, in vivo optical imaging deep within a mouse brain by swept-source optical coherence tomography (SS-OCT), enabled by a 1.3-μm vertical cavity surface emitting laser (VCSEL). VCSEL SS-OCT offers a constant signal sensitivity of 105 dB throughout an entire depth of 4.25 mm in air, ensuring an exten...

journal_title：Journal of biomedical optics

authors： Choi WJ,Wang RK

更新日期：2015-10-01 00:00:00

abstract：:The scattering of polarized light from a two layer scattering medium is investigated using Monte Carlo simulations. First order and normalized second order moments are used to analyze the spatial properties of the emerging light in different polarization states. Linearly and circularly polarized illumination is used t...

journal_title：Journal of biomedical optics

authors： Stockford IM,Morgan SP,Chang PC,Walker JG

更新日期：2002-07-01 00:00:00

abstract：:Oral cancer is one of the most common cancers worldwide. One-fifth of the world's oral cancer subjects are from India and other South Asian countries. The present Raman mapping study was carried out to understand biochemical variations in normal and malignant oral buccal mucosa. Data were acquired using WITec alpha 30...

journal_title：Journal of biomedical optics

authors： Behl I,Kukreja L,Deshmukh A,Singh SP,Mamgain H,Hole AR,Krishna CM

更新日期：2014-12-01 00:00:00

abstract：:Optical coherence microscopy (OCM) combines confocal microscopy and optical coherence tomography (OCT) to improve imaging depth and contrast, enabling cellular imaging in human tissues. We aim to investigate OCM for ex vivo imaging of upper and lower gastrointestinal tract tissues, to establish correlations between OC...

journal_title：Journal of biomedical optics

authors： Aguirre AD,Chen Y,Bryan B,Mashimo H,Huang Q,Connolly JL,Fujimoto JG

更新日期：2010-01-01 00:00:00

abstract：:We report the use of spectral Doppler optical coherence tomography imaging (SDOCTI) for quantitative evaluation of dynamic blood circulation before and after a localized ischemic stroke in a mouse model. Rose Bengal photodynamic therapy (PDT) is used as a noninvasive means for inducing localized ischemia in cortical m...

journal_title：Journal of biomedical optics

authors： Yu L,Nguyen E,Liu G,Choi B,Chen Z

更新日期：2010-11-01 00:00:00

abstract：:Suture ligation of blood vessels during surgery can be time-consuming and skill-intensive. Energy-based, electrosurgical, and ultrasonic devices have recently replaced the use of sutures and mechanical clips (which leave foreign objects in the body) for many surgical procedures, providing rapid hemostasis during surge...

journal_title：Journal of biomedical optics

authors： Cilip CM,Rosenbury SB,Giglio N,Hutchens TC,Schweinsberger GR,Kerr D,Latimer C,Nau WH,Fried NM

更新日期：2013-05-01 00:00:00

abstract：:Malaria parasites induce morphological, biochemical, and mechanical changes in red blood cells (RBCs). Mechanical variations are closely related to the deformability of individual RBCs. The deformation of various RBCs, including healthy and malaria-infected RBCs (iRBCs), can be directly observed through quantitative p...

journal_title：Journal of biomedical optics

authors： Byeon H,Ha YR,Lee SJ

更新日期：2015-11-01 00:00:00