Experimental measurement of time-dependent photon scatter for diffuse optical tomography.

Abstract:

:Time-resolved measurement of early arriving photons through diffusive media has been shown to effectively reduce the high degree of light scatter in biological tissue. However, the experimentally achievable reduction in photon scatter and the impact of time-gated detection on instrument noise performance is not well understood. We measure time-dependent photon density sensitivity functions (PDSFs) between a pulsed laser source and a photomultiplier tube operating in time-correlated single-photon-counting mode. Our data show that with our system, measurement of early arriving photons reduces the full width half maximum of PDSFs on average by about 40 to 60% versus quasicontinuous wave photons over a range of experimental conditions similar to those encountered in small animal tomography, corresponding to a 64 to 84% reduction in PDSF volume. Factoring in noise considerations, the optimal operating point of our instrument is determined to be about the 10% point on the rising edge of the transmitted intensity curve. Time-dependent Monte Carlo simulations and the time-resolved diffusion approximation are used to model photon propagation and are evaluated for agreement with experimental data.

journal_name

J Biomed Opt

authors

Valim N,Brock J,Niedre M

doi

10.1117/1.3523371

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

065006

issue

6

eissn

1083-3668

issn

1560-2281

journal_volume

15

pub_type

杂志文章
  • Surface plasmon-based infrared spectroscopy for cell biosensing.

    abstract::Cell morphology is often used as a valuable indicator of the physical condition and general status of living cells. We demonstrate a noninvasive method for morphological characterization of adherent cells. We measure infrared reflectivity spectrum at oblique angle from living cells cultured on thin Au film, and utiliz...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.17.8.081409

    authors: Yashunsky V,Lirtsman V,Zilbershtein A,Bein A,Schwartz B,Aroeti B,Golosovsky M,Davidov D

    更新日期:2012-08-01 00:00:00

  • Optical fiber Bragg grating-instrumented silicone liner for interface pressure measurement within prosthetic sockets of lower-limb amputees.

    abstract::This paper presents a fiber Bragg grating (FBG)-instrumented prosthetic silicone liner that provides cushioning for the residual limb and can successfully measure interface pressures inside prosthetic sockets of lower-limb amputees in a simple and practical means of sensing. The liner is made of two silicone layers be...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.22.8.087001

    authors: Al-Fakih E,Arifin N,Pirouzi G,Mahamd Adikan FR,Shasmin HN,Abu Osman NA

    更新日期:2017-08-01 00:00:00

  • Analyzing reflectance spectra of human skin in legal medicine.

    abstract::Our current research in the framework of an interdisciplinary project focuses on modelling the dynamics of the hemoglobin reoxygenation process in post-mortem human skin by reflectance spectrometry. The observations of reoxygenation of hemoglobin in livores after postmortem exposure to a cold environment relate the re...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.18.1.017004

    authors: Belenki L,Sterzik V,Schulz K,Bohnert M

    更新日期:2013-01-01 00:00:00

  • Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domain.

    abstract::The ability to quantitatively determine tissue fluorescence is of interest for the purpose of better understanding the details of photodynamic therapy of skin cancer. In particular, we are interested in quantifying protoporphyrin IX (PpIX) in vivo. We present a method of correcting fluorescence for effects of native t...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.3665440

    authors: Saager RB,Cuccia DJ,Saggese S,Kelly KM,Durkin AJ

    更新日期:2011-12-01 00:00:00

  • Effect of motion artifacts and their correction on near-infrared spectroscopy oscillation data: a study in healthy subjects and stroke patients.

    abstract::Functional near-infrared spectroscopy is prone to contamination by motion artifacts (MAs). Motion correction algorithms have previously been proposed and their respective performance compared for evoked rain activation studies. We study instead the effect of MAs on "oscillation" data which is at the basis of functiona...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.20.5.056011

    authors: Selb J,Yücel MA,Phillip D,Schytz HW,Iversen HK,Vangel M,Ashina M,Boas DA

    更新日期:2015-05-01 00:00:00

  • In vivo wide-field multispectral scanning laser ophthalmoscopy-optical coherence tomography mouse retinal imager: longitudinal imaging of ganglion cells, microglia, and Müller glia, and mapping of the mouse retinal and choroidal vasculature.

    abstract::Scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) provide complementary views of the retina, with the former collecting fluorescence data with good lateral but relatively low-axial resolution, and the latter collecting label-free backscattering data with comparable lateral but much higher axia...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.20.12.126005

    authors: Zhang P,Zam A,Jian Y,Wang X,Li Y,Lam KS,Burns ME,Sarunic MV,Pugh EN Jr,Zawadzki RJ

    更新日期:2015-01-01 00:00:00

  • Distinguishing tracheal and esophageal tissues with hyperspectral imaging and fiber-optic sensing.

    abstract::During emergency medical situations, where the patient has an obstructed airway or necessitates respiratory support, endotracheal intubation (ETI) is the medical technique of placing a tube into the trachea in order to facilitate adequate ventilation of the lungs. Complications during ETI, such as repeated attempts, f...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.21.11.117004

    authors: Nawn CD,Souhan BE,Carter R 3rd,Kneapler C,Fell N,Ye JY

    更新日期:2016-11-01 00:00:00

  • Noninvasive measurements of carotenoids in bovine udder by reflection spectroscopy.

    abstract::For a long time, the antioxidative status in cattle has been discussed as an indicator for stress conditions resulting from disease or exertion. Until now, invasive approaches have been necessary to obtain blood samples or biopsy materials and gain insights into the antioxidative status of cattle. Due to these efforts...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.17.10.101514

    authors: Klein J,Darvin ME,Müller KE,Lademann J

    更新日期:2012-10-01 00:00:00

  • Quantitative photoacoustic imaging: correcting for heterogeneous light fluence distributions using diffuse optical tomography.

    abstract::The specificity of molecular and functional photoacoustic (PA) images depends on the accuracy of the photoacoustic absorption spectroscopy. The PA signal is proportional to the product of the optical absorption coefficient and local light fluence; quantitative PA measurements of the optical absorption coefficient ther...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.3626212

    authors: Bauer AQ,Nothdurft RE,Erpelding TN,Wang LV,Culver JP

    更新日期:2011-09-01 00:00:00

  • Characterization of natural and irradiated nails by means of the depolarization metrics.

    abstract::Mueller polarimetry is applied to study the samples of nails: natural (or reference) and irradiated to 2 Gy ionizing radiation dose. We measure the whole Mueller matrices of the samples as a function of the scattering angle at a wavelength of 632.8 nm. We apply depolarization analysis to measured Mueller matrices by c...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.21.7.071108

    authors: Savenkov S,Priezzhev A,Oberemok Y,Sholom S,Kolomiets I,Chunikhina K

    更新日期:2016-07-01 00:00:00

  • Modulated electron-multiplied fluorescence lifetime imaging microscope: all-solid-state camera for fluorescence lifetime imaging.

    abstract::We have built an all-solid-state camera that is directly modulated at the pixel level for frequency-domain fluorescence lifetime imaging microscopy (FLIM) measurements. This novel camera eliminates the need for an image intensifier through the use of an application-specific charge coupled device design in a frequency-...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.jbo.17.12.126020

    authors: Zhao Q,Schelen B,Schouten R,van den Oever R,Leenen R,van Kuijk H,Peters I,Polderdijk F,Bosiers J,Raspe M,Jalink K,Geert Sander de Jong J,van Geest B,Stoop K,Young IT

    更新日期:2012-12-01 00:00:00

  • In vivo near-infrared dual-axis confocal microendoscopy in the human lower gastrointestinal tract.

    abstract::Near-infrared confocal microendoscopy is a promising technique for deep in vivo imaging of tissues and can generate high-resolution cross-sectional images at the micron-scale. We demonstrate the use of a dual-axis confocal (DAC) near-infrared fluorescence microendoscope with a 5.5-mm outer diameter for obtaining clini...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.17.2.021102

    authors: Piyawattanametha W,Ra H,Qiu Z,Friedland S,Liu JT,Loewke K,Kino GS,Solgaard O,Wang TD,Mandella MJ,Contag CH

    更新日期:2012-02-01 00:00:00

  • Evans blue dye-enhanced capillary-resolution photoacoustic microscopy in vivo.

    abstract::Complete and continuous imaging of microvascular networks is crucial for a wide variety of biomedical applications. Photoacoustic tomography can provide high resolution microvascular imaging using hemoglobin within red blood cells (RBCs) as an endogenic contrast agent. However, intermittent RBC flow in capillaries res...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.3251044

    authors: Yao J,Maslov K,Hu S,Wang LV

    更新日期:2009-09-01 00:00:00

  • New method for evaluation of in vivo scattering and refractive index properties obtained with optical coherence tomography.

    abstract::Optical coherence tomography (OCT) provides more parameters than pure morphology does. In a recent paper [A. Knuettel and M. Boehlau-Godau, J. Biomed. Opt. 5(1) 83-92 (2000)] we have shown that the refractive index (RI) can be evaluated in a localized manner in skin tissue under in vivo conditions. Based on a theory, ...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.1647544

    authors: Knüttel A,Bonev S,Knaak W

    更新日期:2004-03-01 00:00:00

  • Chemical reactivation of fluorescein isothiocyanate immunofluorescence-labeled resin-embedded samples.

    abstract::Resin embedding is widely used and facilitates microscopic imaging of biological tissues. In contrast, quenching of fluorescence during embedding process hinders the application of resin embedding for imaging of fluorescence-labeled samples. For samples expressing fluorescent proteins, it has been demonstrated that th...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.23.2.020501

    authors: Li L,Rao G,Lv X,Chen R,Cheng X,Wang X,Zeng S,Liu X

    更新日期:2018-02-01 00:00:00

  • Identification of abnormal motor cortex activation patterns in children with cerebral palsy by functional near-infrared spectroscopy.

    abstract::We demonstrate the utility of functional near-infrared spectroscopy (fNIRS) as a tool for physicians to study cortical plasticity in children with cerebral palsy (CP). Motor cortex activation patterns were studied in five healthy children and five children with CP (8.4+/-2.3 years old in both groups) performing a fing...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.3432746

    authors: Khan B,Tian F,Behbehani K,Romero MI,Delgado MR,Clegg NJ,Smith L,Reid D,Liu H,Alexandrakis G

    更新日期:2010-05-01 00:00:00

  • Impact of treatment response metrics on photodynamic therapy planning and outcomes in a three-dimensional model of ovarian cancer.

    abstract::Common methods to characterize treatment efficacy based on morphological imaging may misrepresent outcomes and exclude effective therapies. Using a three-dimensional model of ovarian cancer, two functional treatment response metrics are used to evaluate photodynamic therapy (PDT) efficacy: total volume, calculated fro...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.18.9.098004

    authors: Anbil S,Rizvi I,Celli JP,Alagic N,Pogue BW,Hasan T

    更新日期:2013-09-01 00:00:00

  • Characterization and three-dimensional localization of cancerous prostate tissue using backscattering scanning polarization imaging and independent component analysis.

    abstract::Characterization and three-dimensional (3-D) localization of human cancerous prostate tissue embedded in normal prostate tissue were demonstrated using backscattering scanning polarization imaging and an inverse imaging reconstruction algorithm, optical tomography using independent component analysis (OPTICA). Two-dim...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.17.8.081419

    authors: Pu Y,Wang W,Xu M,Eastham JA,Tang G,Alfano RR

    更新日期:2012-08-01 00:00:00

  • Cellular resolution ex vivo imaging of gastrointestinal tissues with optical coherence microscopy.

    abstract::Optical coherence microscopy (OCM) combines confocal microscopy and optical coherence tomography (OCT) to improve imaging depth and contrast, enabling cellular imaging in human tissues. We aim to investigate OCM for ex vivo imaging of upper and lower gastrointestinal tract tissues, to establish correlations between OC...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.3322704

    authors: Aguirre AD,Chen Y,Bryan B,Mashimo H,Huang Q,Connolly JL,Fujimoto JG

    更新日期:2010-01-01 00:00:00

  • Optical fiber-based dispersion for spectral discrimination in fluorescence lifetime imaging systems.

    abstract::The excited state lifetime of a fluorophore together with its fluorescence emission spectrum provide information that can yield valuable insights into the nature of a fluorophore and its microenvironment. However, it is difficult to obtain both channels of information in a conventional scheme as detectors are typicall...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.25.1.014506

    authors: Sagar MAK,Dai B,Chacko J,Weber J,Velten A,Sanders S,White J,Eliceiri K

    更新日期:2019-12-01 00:00:00

  • Extraction of optical properties and prediction of light distribution in rat brain tissue.

    abstract::Predicting the distribution of light inside any turbid media, such as biological tissue, requires detailed information about the optical properties of the medium, including the absorption and scattering coefficients and the anisotropy factor. Particularly, in biophotonic applications where photons directly interact wi...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.19.7.075001

    authors: Azimipour M,Baumgartner R,Liu Y,Jacques SL,Eliceiri K,Pashaie R

    更新日期:2014-01-01 00:00:00

  • Processing algorithms for tracking speckle shifts in optical elastography of biological tissues.

    abstract::Parametric and nonparametric data processing schemes for analyzing translating laser speckle data used to investigate the mechanical behavior of biological tissues are examined. Cross-correlation, minimum mean square estimator, maximum likelihood, and maximum entropy approaches are discussed and compared on speckle da...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.1412224

    authors: Duncan DD,Kirkpatrick SJ

    更新日期:2001-10-01 00:00:00

  • Temperature-controlled in vivo ocular exposure to 1090-nm radiation suggests that near-infrared radiation cataract is thermally induced.

    abstract::The damage mechanism for near-infrared radiation (IRR) induced cataract is unclear. Both a photochemical and a thermal mechanism were suggested. The current paper aims to elucidate a photochemical effect based on investigation of irradiance-exposure time reciprocity. Groups of 20 rats were unilaterally exposed to 96-W...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.20.1.015003

    authors: Yu Z,Schulmeister K,Talebizadeh N,Kronschläger M,Söderberg P

    更新日期:2015-01-01 00:00:00

  • Design and validation of an angle-resolved low-coherence interferometry fiber probe for in vivo clinical measurements of depth-resolved nuclear morphology.

    abstract::We present a novel Fourier-domain angle-resolved low-coherence interferometry (a /LCI) fiber probe designed for in vivo clinical application in gastrointestinal endoscopy. The a/LCI technique measures the depth-resolved angular scattering distribution to determine the size distribution and optical density of cell nucl...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.3520130

    authors: Zhu Y,Terry NG,Woosley JT,Shaheen NJ,Wax A

    更新日期:2011-01-01 00:00:00

  • Automated three-dimensional morphology-based clustering of human erythrocytes with regular shapes: stomatocytes, discocytes, and echinocytes.

    abstract::We present unsupervised clustering methods for automatic grouping of human red blood cells (RBCs) extracted from RBC quantitative phase images obtained by digital holographic microscopy into three RBC clusters with regular shapes, including biconcave, stomatocyte, and sphero-echinocyte. We select some good features re...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.22.7.076015

    authors: Ahmadzadeh E,Jaferzadeh K,Lee J,Moon I

    更新日期:2017-07-01 00:00:00

  • Eigenvector-based spatial filtering for reduction of physiological interference in diffuse optical imaging.

    abstract::Diffuse optical imaging is an effective technique for noninvasive functional brain imaging. However, the measurements respond to systemic hemodynamic fluctuations caused by the cardiac cycle, respiration, and blood pressure, which may obscure or overwhelm the desired stimulus-evoked response. Previous work on this pro...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.1852552

    authors: Zhang Y,Brooks DH,Franceschini MA,Boas DA

    更新日期:2005-01-01 00:00:00

  • Closure of skin incisions by laser-welding with a combination of two near-infrared diode lasers: preliminary study for determination of optimal parameters.

    abstract::Laser welding has the potential to become an effective method for wound closure and healing without sutures. Closure of skin incisions by laser welding with a combination of two near-infrared lasers (980 and 1064 nm), was performed for the first time in this study. One centimeter long, full-thickness incisions were ma...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.3552648

    authors: Hu L,Lu Z,Wang B,Cao J,Ma X,Tian Z,Gao Z,Qin L,Wu X,Liu Y,Wang L

    更新日期:2011-03-01 00:00:00

  • Model-based spectroscopic analysis of the oral cavity: impact of anatomy.

    abstract::In order to evaluate the impact of anatomy on the spectral properties of oral tissue, we used reflectance and fluorescence spectroscopy to characterize nine different anatomic sites. All spectra were collected in vivo from healthy oral mucosa. We analyzed 710 spectra collected from the oral cavity of 79 healthy volunt...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.2992139

    authors: McGee S,Mirkovic J,Mardirossian V,Elackattu A,Yu CC,Kabani S,Gallagher G,Pistey R,Galindo L,Badizadegan K,Wang Z,Dasari R,Feld MS,Grillone G

    更新日期:2008-11-01 00:00:00

  • Statistical strategies to reveal potential vibrational markers for in vivo analysis by confocal Raman spectroscopy.

    abstract::The analysis of biological systems by spectroscopic techniques involves the evaluation of hundreds to thousands of variables. Hence, different statistical approaches are used to elucidate regions that discriminate classes of samples and to propose new vibrational markers for explaining various phenomena like disease m...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.21.7.075010

    authors: Oliveira Mendes Td,Pinto LP,Santos LD,Tippavajhala VK,Téllez Soto CA,Martin AA

    更新日期:2016-07-01 00:00:00

  • Infrared microscopic imaging of cutaneous wound healing: lipid conformation in the migrating epithelial tongue.

    abstract::Infrared microscopic imaging has been utilized to analyze for the first time the spatial distribution of lipid structure in an ex vivo human organ culture skin wound healing model. Infrared images were collected at zero, two, four, and six days following wounding. Analysis of lipid infrared spectral properties reveale...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.17.9.096009

    authors: Yu G,Stojadinovic O,Tomic-Canic M,Flach CR,Mendelsohn R

    更新日期:2012-09-01 00:00:00