Dual closed-loop, optoelectronic, auto-oscillatory detection circuit for monitoring fluorescence lifetime-based chemical sensors and biosensors.

abstract：:Optical technologies may be applied to multiple facets of spinal surgery from diagnostics to intraoperative image guidance to therapeutics. In diagnostics, the current standard remains cross-sectional static imaging. Optical surface scanning tools may have an important role; however, significant work is required to cl...

journal_title：Journal of biomedical optics

authors： Guha D,Yang VXD

更新日期：2018-06-01 00:00:00

abstract：:According to the valence asymmetry hypothesis, the left/right asymmetry of prefrontal cortex (PFC) activity is correlated with specific emotional responses to mental stress and personality traits. Here, we evaluated the relation between emotional state and asymmetry in PFC activity at rest by using near-infrared spect...

journal_title：Journal of biomedical optics

authors： Ishikawa W,Sato M,Fukuda Y,Matsumoto T,Takemura N,Sakatani K

更新日期：2014-02-01 00:00:00

abstract：SIGNIFICANCE:Our study introduces an application of deep learning to virtually generate fluorescence images to reduce the burdens of cost and time from considerable effort in sample preparation related to chemical fixation and staining. AIM:The objective of our work was to determine how successfully deep learning meth...

journal_title：Journal of biomedical optics

authors： Nguyen T,Bui V,Thai A,Lam V,Raub C,Chang LC,Nehmetallah G

更新日期：2020-09-01 00:00:00

abstract：:Cellular therapies hold promise to replace the implantation of whole organs in the treatment of disease. For most cell types, in vivo viability depends on oxygen delivery to avoid the toxic effects of hypoxia. A promising approach is the in situ vascularization of implantable devices which can mediate hypoxia and impr...

journal_title：Journal of biomedical optics

authors： Weidling J,Sameni S,Lakey JR,Botvinick E

更新日期：2014-08-01 00:00:00

abstract：:We report the design of a novel laser line-triangulation laryngoscope for the quantitative visualization of the three-dimensional movements of human vocal folds during phonation. This is the first successful in vivo recording of the three-dimensional movements of human vocal folds in absolute values. Triangulation ima...

journal_title：Journal of biomedical optics

authors： George NA,de Mul FF,Qiu Q,Rakhorst G,Schutte HK

更新日期：2008-11-01 00:00:00

abstract：PURPOSE:Investigations of foveal aberrations assume circular pupils. However, the pupil becomes increasingly elliptical with increase in visual field eccentricity. We address this and other issues concerning peripheral aberration specification. METHODS:One approach uses an elliptical pupil similar to the actual pupil ...

journal_title：Journal of biomedical optics

authors： Charman WN,Mathur A,Scott DH,Hartwig A,Atchison DA

更新日期：2012-02-01 00:00:00

abstract：:The erratum concerns amendment of Section 2.5 of the published article. ...

journal_title：Journal of biomedical optics

authors： Hu XS,Arredondo MM,Gomba M,Confer N,DaSilva AF,Johnson TD,Shalinsky M,Kovelman I

更新日期：2020-05-01 00:00:00

abstract：:We introduce the concept of deliberate placement of absorbers to alter the average path of photons through tissue for a biomedical optical device. By changing the reflectivity of a needle that separates a source and detector, the average photon path through a turbid medium can be changed. Totally reflective needles ha...

journal_title：Journal of biomedical optics

authors： Simonson P,D'Amico E,Gratton E

更新日期：2006-01-01 00:00:00

abstract：:It is widely known that not all of the treated cells survive after introduction of exogenous molecules via any physical method. Therefore, it is important to develop methods that would allow simultaneous evaluation of both molecular delivery efficiency and cell viability. This study presents Förster resonance energy t...

journal_title：Journal of biomedical optics

authors： Ruzgys P,Tamošiūnas M,Lukinsone V,Šatkauskas S

更新日期：2017-09-01 00:00:00

abstract：:The analysis of biological systems by spectroscopic techniques involves the evaluation of hundreds to thousands of variables. Hence, different statistical approaches are used to elucidate regions that discriminate classes of samples and to propose new vibrational markers for explaining various phenomena like disease m...

journal_title：Journal of biomedical optics

authors： Oliveira Mendes Td,Pinto LP,Santos LD,Tippavajhala VK,Téllez Soto CA,Martin AA

更新日期：2016-07-01 00:00:00

abstract：:Intraoperative applications of near-infrared (NIR) fluorescent contrast agents can be aided by instrumentation capable of merging the view of surgical field with that of NIR fluorescence. We demonstrate augmented microscopy, an intraoperative imaging technique in which bright-field (real) and electronically processed ...

journal_title：Journal of biomedical optics

authors： Watson JR,Gainer CF,Martirosyan N,Skoch J,Lemole GM Jr,Anton R,Romanowski M

更新日期：2015-10-01 00:00:00

abstract：:Clustering analysis (CA) and principal component analysis (PCA) were applied to dynamic Cerenkov luminescence images (dCLI). In order to investigate the performances of the proposed approaches, two distinct dynamic data sets obtained by injecting mice with (32)P-ATP and (18)F-FDG were acquired using the IVIS 200 optic...

journal_title：Journal of biomedical optics

authors： Spinelli AE,Boschi F

更新日期：2011-12-01 00:00:00

abstract：:Spatially resolved spectroscopy (SRS) allows the estimation of absolute tissue oxygen saturation, the ratio of oxygenated to total hemoglobin concentration, which may facilitate the comparison of results among patients. Eighty-two premature infants were included over two years. The cerebral tissue oxygenation index (c...

journal_title：Journal of biomedical optics

authors： Sorensen LC,Leung TS,Greisen G

更新日期：2008-11-01 00:00:00

abstract：:This work reports a miniaturized laparoscopic zoom camera that can significantly improve vision for minimally invasive surgery (MIS), also known as laparoscopic surgery. The laparoscopic zoom camera contains bioinspired fluidic lenses that can change curvature and focal length in a manner similar to the crystalline le...

journal_title：Journal of biomedical optics

authors： Tsai FS,Johnson D,Francis CS,Cho SH,Qiao W,Arianpour A,Mintz Y,Horgan S,Talamini M,Lo YH

更新日期：2010-05-01 00:00:00

abstract：:High-speed (video-rate) fluorescence lifetime imaging (FLIM) through a flexible endoscope is reported based on gated optical image intensifier technology. The optimization and potential application of FLIM to tissue autofluorescence for clinical applications are discussed. ...

journal_title：Journal of biomedical optics

authors： Munro I,McGinty J,Galletly N,Requejo-Isidro J,Lanigan PM,Elson DS,Dunsby C,Neil MA,Lever MJ,Stamp GW,French PM

更新日期：2005-09-01 00:00:00

abstract：:Noninvasive diagnostic tools, such as Trichoscan®, reflectance confocal microscopy (RCM), and optical coherence tomography (OCT), are efficient methods of hair shaft and growth evaluation. The aim of this study was to carry out a comparative assessment of these three medical procedures by measuring the hair shaft and ...

journal_title：Journal of biomedical optics

authors： Kuck M,Schanzer S,Ulrich M,Garcia Bartels N,Meinke MC,Fluhr J,Krah M,Blume-Peytavi U,Stockfleth E,Lademann J

更新日期：2012-10-01 00:00:00

abstract：:We present in vivo human total retinal blood flow measurements using Doppler Fourier domain optical coherence tomography (OCT). The scan pattern consisted of two concentric circles around the optic nerve head, transecting all retinal branch arteries and veins. The relative positions of each blood vessel in the two OCT...

journal_title：Journal of biomedical optics

authors： Wang Y,Bower BA,Izatt JA,Tan O,Huang D

更新日期：2008-11-01 00:00:00

abstract：:Fluorescence diagnostic techniques are notable amongst many other optical methods because they offer high sensitivity and noninvasive measurement of tissue properties. However, a combination of multiple scattering and physical heterogeneity of biological tissues hampers interpretation of the fluorescence measurements....

journal_title：Journal of biomedical optics

authors： Churmakov DY,Meglinski IV,Greenhalgh DA

更新日期：2004-03-01 00:00:00

abstract：:We present a hybrid method that combines a multilayered scaling method and a perturbation method to speed up the Monte Carlo simulation of diffuse reflectance from a multilayered tissue model with finite-size tumor-like heterogeneities. The proposed method consists of two steps. In the first step, a set of photon traj...

journal_title：Journal of biomedical optics

authors： Zhu C,Liu Q

更新日期：2012-01-01 00:00:00

abstract：:Field carcinogenesis is the initial stage of cancer progression. Understanding field carcinogenesis is valuable for both cancer biology and clinical medicine. Here, we used inverse spectroscopic optical coherence tomography to study colorectal cancer (CRC) and pancreatic cancer (PC) field carcinogenesis. Depth-resolve...

journal_title：Journal of biomedical optics

authors： Yi J,Radosevich AJ,Stypula-Cyrus Y,Mutyal NN,Azarin SM,Horcher E,Goldberg MJ,Bianchi LK,Bajaj S,Roy HK,Backman V

更新日期：2014-03-01 00:00:00

abstract：:In part I of the study, two attachment systems [O-ring; bar-clip (BC)] were used, and the system with three individualized O-rings provided the lowest stress on the implants and the support tissues. Therefore, the aim of this study was to assess the stress distribution, through the photoelastic method, on implant-reta...

journal_title：Journal of biomedical optics

authors： Pesqueira AA,Goiato MC,da Silva EV,Haddad MF,Moreno A,Zahoui A,dos Santos DM

更新日期：2014-06-01 00:00:00

abstract：SIGNIFICANCE:Photothermal optical coherence tomography (PT-OCT) has the promise to offer structural images coregistered with chemical composition information, which can offer a significant impact in early detection of diseases such as atherosclerosis. AIM:We take the first step in understanding the relation between PT...

journal_title：Journal of biomedical optics

authors： Salimi M,Villiger M,Tabatabaei N

更新日期：2020-12-01 00:00:00

abstract：:We present the first experimental result of direct delineation of the nuclei of living rat bladder epithelium with ultrahigh-resolution optical coherence tomography (uOCT). We demonstrate that the cellular details embedded in the speckle noise in a uOCT image can be uncovered by time-lapse frame averaging that takes a...

journal_title：Journal of biomedical optics

authors： Pan YT,Wu ZL,Yuan ZJ,Wang ZG,Du CW

更新日期：2007-09-01 00:00:00

abstract：:We present a multimodal optical microscope that incorporates six imaging modalities on one common platform. The imaging modalities include three staring modes, optical quadrature microscopy (OQM), differential interference contrast (DIC) microscopy, and epi-fluorescence microscopy, and three scanning modes, confocal r...

journal_title：Journal of biomedical optics

authors： Warger WC 2nd,Laevsky GS,Townsend DJ,Rajadhyaksha M,DiMarzio CA

更新日期：2007-07-01 00:00:00

abstract：:A wide variety of ocular diseases are associated with abnormalities in ocular circulation. As such, there is considerable interest in techniques for quantifying retinal blood flow, among which Doppler optical coherence tomography (OCT) may be the most promising. We present an approach to measure retinal blood flow in ...

journal_title：Journal of biomedical optics

authors： Werkmeister RM,Vietauer M,Knopf C,Fürnsinn C,Leitgeb RA,Reitsamer H,Gröschl M,Garhöfer G,Vilser W,Schmetterer L

更新日期：2014-01-01 00:00:00

abstract：:Abdominal surgeries carry considerable risk of gastrointestinal and intra-abdominal hemorrhage, which could possibly cause patient death. Photoacoustic imaging is one solution to overcome this challenge by providing visualization of major blood vessels during surgery. We investigate the feasibility of in vivo blood ve...

journal_title：Journal of biomedical optics

authors： Kempski KM,Wiacek A,Graham M,González E,Goodson B,Allman D,Palmer J,Hou H,Beck S,He J,Bell MAL

更新日期：2019-08-01 00:00:00

abstract：:Endoscopic ultrasound-guided fine needle aspirations (EUS-FNA) of pancreatic masses suffer from sample errors and low-negative predictive values. Fiber-optic spectroscopy in the visible to near-infrared wavelength spectrum can noninvasively extract physiological parameters from tissue and has the potential to guide th...

journal_title：Journal of biomedical optics

authors： Stegehuis PL,Boogerd LS,Inderson A,Veenendaal RA,van Gerven P,Bonsing BA,Sven Mieog J,Amelink A,Veselic M,Morreau H,van de Velde CJ,Lelieveldt BP,Dijkstra J,Robinson DJ,Vahrmeijer AL

更新日期：2017-02-01 00:00:00

abstract：:Deep anterior lamellar keratoplasty (DALK) is an emerging surgical technique for the restoration of corneal clarity and vision acuity. The big-bubble technique in DALK surgery is the most essential procedure that includes the air injection through a thin syringe needle to separate the dysfunctional region of the corne...

journal_title：Journal of biomedical optics

authors： Shin S,Bae JK,Ahn Y,Kim H,Choi G,Yoo YS,Joo CK,Moon S,Jung W

更新日期：2017-12-01 00:00:00

abstract：:Extension of optical monitoring of intact tissues from the visible and ultraviolet to the near-infrared (NIR) range (700-1300 nm) was first undertaken in 1977 for the purpose of monitoring the redox behavior of Cytochrome c oxidase (cyt c ox) in vivo. Soon it became evident that the much greater NIR translucency of sk...

journal_title：Journal of biomedical optics

authors： Jo Bsis-Vandervliet FF

更新日期：1999-10-01 00:00:00

abstract：:Autofluorescence, the endogenous fluorescence present in cells and tissues, has historically been considered a nuisance in biomedical imaging. Many endogenous fluorophores, specifically, collagen, elastin, nicotinamide adenine dinucleotide, and flavin adenine dinucleotide (FAD), are found throughout the human body. In...

journal_title：Journal of biomedical optics

authors： Deal J,Mayes S,Browning C,Hill S,Rider P,Boudreaux C,Rich TC,Leavesley SJ

更新日期：2018-12-01 00:00:00