Variations in the endogenous fluorescence of rabbit corneas after mechanical property alterations.

abstract：:Optoacoustic (photoacoustic) diagnostic modality is a technique that combines high optical contrast and ultrasound spatial resolution. We proposed using the optoacoustic technique for a number of applications, including cancer detection, monitoring of thermotherapy (hyperthermia, coagulation, and freezing), monitoring...

journal_title：Journal of biomedical optics

authors： Esenaliev RO

更新日期：2017-09-01 00:00:00

abstract：:We report on wide-field imaging of pulsatile motion induced by blood flow using heterodyne holographic interferometry on the thumb of a healthy volunteer, in real time. Optical Doppler images were measured with green laser light by a frequency-shifted Mach-Zehnder interferometer in off-axis configuration. The recorded...

journal_title：Journal of biomedical optics

authors： Bencteux J,Pagnoux P,Kostas T,Bayat S,Atlan M

更新日期：2015-06-01 00:00:00

abstract：:The transmembrane protein prestin is crucial to outer hair cell (OHC) electromotility and contributes to the sensitivity and frequency selectivity of mammalian hearing. The molecular mechanisms of electromotility remain unclear, but prestin is purported to function as both a voltage sensor and a molecular motor. Under...

journal_title：Journal of biomedical optics

authors： Organ LE,Raphael RM

更新日期：2007-03-01 00:00:00

abstract：:Spatially resolved spectroscopy (SRS) allows the estimation of absolute tissue oxygen saturation, the ratio of oxygenated to total hemoglobin concentration, which may facilitate the comparison of results among patients. Eighty-two premature infants were included over two years. The cerebral tissue oxygenation index (c...

journal_title：Journal of biomedical optics

authors： Sorensen LC,Leung TS,Greisen G

更新日期：2008-11-01 00:00:00

abstract：:Reactive oxygen species (ROS) produced by photodynamic therapy (PDT) is recorded in vivo using a chemiluminescence (CL)-based gated optical system. A novel approach is developed to utilize the fluorescence (FL) of the CL probe as an internal fluorescence to calibrate the observed CL on pharmacokinetics of the probe in...

journal_title：Journal of biomedical optics

authors： Wei Y,Xing D,Luo S,Yang L,Chen Q

更新日期：2010-03-01 00:00:00

abstract：:Two pronounced absorption peaks in blue and red ranges of the chlorin-based photosensitizer (PS) absorption spectrum provide additional benefits in photodynamic therapy (PDT) performance. Differing optical properties of biological tissues in these ranges allow for both dual-wavelength diagnostics and PDT performance. ...

journal_title：Journal of biomedical optics

authors： Kurakina D,Khilov A,Shakhova M,Orlinskaya N,Sergeeva E,Meller A,Turchin I,Kirillin M

更新日期：2019-12-01 00:00:00

abstract：:Optical coherence tomography (OCT) can provide new insight into disease progression and therapy by enabling nondestructive, serial imaging of in vivo cancer models. In previous studies, we have shown the utility of endoscopic OCT for identifying adenomas in the azoxymethane-treated mouse model of colorectal cancer and...

journal_title：Journal of biomedical optics

authors： Winkler AM,Rice PF,Drezek RA,Barton JK

更新日期：2010-07-01 00:00:00

abstract：:Optical technique based on diffuse reflectance measurement combined with indocyanine green (ICG) bolus tracking is extensively tested as a method for clinical assessment of brain perfusion in adults at the bedside. Methodology of multiwavelength and time-resolved detection of fluorescence light excited in the ICG is p...

journal_title：Journal of biomedical optics

authors： Gerega A,Milej D,Weigl W,Botwicz M,Zolek N,Kacprzak M,Wierzejski W,Toczylowska B,Mayzner-Zawadzka E,Maniewski R,Liebert A

更新日期：2012-08-01 00:00:00

abstract：:In a previous study, we investigated physical methods to reduce whole-body, diet-related autofluorescence interference in several mouse strains through changes in animal diet. Measurements of mice with an in vivo multispectral imaging system over a 21-day period allowed for the quantification of concentration changes ...

journal_title：Journal of biomedical optics

authors： Bouchard MB,MacLaurin SA,Dwyer PJ,Mansfield J,Levenson R,Krucker T

更新日期：2007-09-01 00:00:00

abstract：:Quantitative spectroscopy has recently been extended from a contact-probe to wide-area spectroscopic imaging to enable mapping of optical properties across a wide area of tissue. We train quantitative spectroscopic imaging (QSI) to identify cervical high-grade squamous intraepithelial lesions (HSILs) in 34 subjects un...

journal_title：Journal of biomedical optics

authors： Lau C,Mirkovic J,Yu CC,O'Donoghue GP,Galindo L,Dasari R,de las Morenas A,Feld M,Stier E

更新日期：2013-07-01 00:00:00

abstract：UNLABELLED:Temperature changes caused by laser irradiation can promote damage to the surrounding dental tissues. In this study, we evaluated the temperature changes of recently extracted human mandibular incisors during intracanal irradiation with an 810-nm diode laser at different settings. Fifty mandibular incisors w...

journal_title：Journal of biomedical optics

authors： da Fonseca Alvarez A,Moura-Netto C,Daliberto Frugoli A,Fernando C,Aranha AC,Davidowicz H

更新日期：2012-01-01 00:00:00

abstract：:Optical imaging using voltage-sensitive dyes has become an important tool for studying vortex-like electrical waves in the heart. Such waves, known as spiral or scroll waves, can spontaneously form in pathological ventricular myocardium, causing ventricular fibrillation and sudden death. Until recently, observations o...

journal_title：Journal of biomedical optics

authors： Bernus O,Mukund KS,Pertsov AM

更新日期：2007-01-01 00:00:00

abstract：:UV-induced collagen cross-linking is a promising treatment for keratoconus that stiffens corneal tissue and prevents further degeneration. Since keratoconus is generally localized, the efficacy of collagen cross-linking (CXL) treatments could be improved by stiffening only the weakened parts of the cornea. Here, we de...

journal_title：Journal of biomedical optics

authors： Singh M,Li J,Vantipalli S,Han Z,Larin KV,Twa MD

更新日期：2017-09-01 00:00:00

abstract：:Gap junction-mediated intercellular communication influences a variety of cellular activities. In tendons, gap junctions modulate collagen production, are involved in strain-induced cell death, and are involved in the response to mechanical stimulation. The aim of the present study was to investigate gap junction-medi...

journal_title：Journal of biomedical optics

authors： Kuzma-Kuzniarska M,Yapp C,Pearson-Jones TW,Jones AK,Hulley PA

更新日期：2014-01-01 00:00:00

abstract：:Anastomotic complication is a major morbidity associated with esophagectomy. Gastric ischemia after conduit creation contributes to anastomotic complications, but a reliable method to assess oxygenation in the gastric conduit is lacking. We hypothesize that fiber optic spectroscopy can reliably assess conduit oxygenat...

journal_title：Journal of biomedical optics

authors： Gareau DS,Truffer F,Perry KA,Pham TH,Enestvedt CK,Dolan JP,Hunter JG,Jacques SL

更新日期：2010-11-01 00:00:00

abstract：:Selective laser targeting of the retinal pigment epithelium (RPE) is an attractive method for treating RPE-associated disorders. We are developing a method for optically detecting intracellular microcavitation that can potentially serve as an immediate feedback of the treatment outcome. Thermal denaturation or intrace...

journal_title：Journal of biomedical optics

authors： Lee H,Alt C,Pitsillides CM,Lin CP

更新日期：2007-11-01 00:00:00

abstract：:Different colors of visible light penetrate to varying depths in tissue due to the wavelength dependence of tissue optical absorption and elastic scattering. We exploit this to map the contour of the closest surface of a buried fluorescent object. This uses a novel algorithm based on the diffusion theory description o...

journal_title：Journal of biomedical optics

authors： Kim A,Roy M,Dadani FN,Wilson BC

更新日期：2010-11-01 00:00:00

abstract：:Photodynamic therapy (PDT) is reviewed using the treatment of skin tumors as an example of superficial lesions and prostate cancer as an example of deep-lying lesions requiring interstitial intervention. These two applications are among the most commonly studied in oncological PDT, and illustrate well the different ch...

journal_title：Journal of biomedical optics

authors： Svanberg K,Bendsoe N,Axelsson J,Andersson-Engels S,Svanberg S

更新日期：2010-07-01 00:00:00

abstract：:Cochlear implantation offers the potential to restore sensitive hearing in patients with severe to profound deafness. However, surgical placement of the electrode array within the cochlea can produce trauma to sensorineural components, particularly if the initial turn of the cochlea is not successfully navigated as th...

journal_title：Journal of biomedical optics

authors： Gurbani SS,Wilkening P,Zhao M,Gonenc B,Cheon GW,Iordachita II,Chien W,Taylor RH,Niparko JK,Kang JU

更新日期：2014-05-01 00:00:00

abstract：:In order to monitor dynamic physiological events in near-real time, a variety of photoacoustic computed tomography (PACT) systems have been developed that can rapidly acquire data. Previously reported studies of dynamic PACT have employed conventional static methods to reconstruct a temporally ordered sequence of imag...

journal_title：Journal of biomedical optics

authors： Wang K,Xia J,Li C,Wang LV,Anastasio MA

更新日期：2014-05-01 00:00:00

abstract：:Predicting the distribution of light inside any turbid media, such as biological tissue, requires detailed information about the optical properties of the medium, including the absorption and scattering coefficients and the anisotropy factor. Particularly, in biophotonic applications where photons directly interact wi...

journal_title：Journal of biomedical optics

authors： Azimipour M,Baumgartner R,Liu Y,Jacques SL,Eliceiri K,Pashaie R

更新日期：2014-01-01 00:00:00

abstract：:Differential phase optical coherence tomography (DPOCT) is introduced to measure optical path length changes in response to pulsed laser irradiation (585 nm). An analytical equation that includes thermoelastic surface displacement and thermorefractive index change is derived to predict optical path length change in re...

journal_title：Journal of biomedical optics

authors： Kim J,Oh J,Milner TE

更新日期：2006-07-01 00:00:00

abstract：:Blood pulse wave velocity (PWV) is an important physiological parameter that characterizes vascular stiffness. In this letter, we present electrocardiogram-synchronized, photoacoustic microscopy for noninvasive quantification of the PWV in the peripheral vessels of living mice. Interestingly, blood pulse wave-induced ...

journal_title：Journal of biomedical optics

authors： Yeh C,Hu S,Maslov K,Wang LV

更新日期：2012-07-01 00:00:00

abstract：:As the most abundant cell type in the central nervous system, astrocyte has been one of main research topics in neuroscience. Although various tools have been developed, at present, there is no tool that allows noninvasive activation of astrocyte in vivo without genetic or pharmacological perturbation. Here we report ...

journal_title：Journal of biomedical optics

authors： Choi M,Yoon J,Ku T,Choi K,Choi C

更新日期：2011-07-01 00:00:00

abstract：SIGNIFICANCE:In breast-preserving tumor surgery, the inspection of the excised tissue boundaries for tumor residue is too slow to provide feedback during the surgery. The discovery of positive margins requires a new surgery which is difficult and associated with low success. If the re-excision could be done immediately...

journal_title：Journal of biomedical optics

authors： Beletkaia E,Dashtbozorg B,Jansen RG,Ruers TJM,Offerhaus HL

更新日期：2020-09-01 00:00:00

abstract：:A multifunctional line scanning ophthalmoscope (mLSO) was designed, constructed, and tested on human subjects. The mLSO could sequentially acquire wide-field, confocal, near-infrared reflectance, fluorescein angiography (FA), and indocyanine green angiography (ICGA) retinal images. The system also included a retinal t...

journal_title：Journal of biomedical optics

authors： Hammer DX,Ferguson RD,Patel AH,Vazquez V,Husain D

更新日期：2012-02-01 00:00:00

abstract：:Diffusion of therapeutic macromolecules through the extracellular matrix of tumor tissue is a crucial step in drug delivery. We use fluorescence correlation spectroscopy (FCS) to measure diffusion of IgG (150 kDa) and dextrans (155 kDa and 2 MDa) in solution, 5% gelatin hydrogel, and multicellular spheroids. Gel and s...

journal_title：Journal of biomedical optics

authors： Reitan NK,Juthajan A,Lindmo T,de Lange Davies C

更新日期：2008-09-01 00:00:00

abstract：:A method for the prediction of the average photon pathlength in turbid media has been developed. The method is based on spatially resolved diffuse reflectance with discrete source detector distances up to 2 mm. Light reflectance was simulated using a Monte Carlo technique with a one-layer model utilizing a wide range ...

journal_title：Journal of biomedical optics

authors： Nilsson H,Larsson M,Nilsson GE,Strömberg T

更新日期：2002-07-01 00:00:00

abstract：:A new skin-imaging method, which was developed recently, gives an informative image data about skin moles by collecting scattered polarized light reflected from their tissue area at different wavelengths and polarizations. This method is called as optical rotational spectropolarimetric imaging (ORSI), which scans the ...

journal_title：Journal of biomedical optics

authors： Graham L,Yitzhaky Y,Abdulhalim I

更新日期：2013-11-01 00:00:00

abstract：:The attenuation of near-infrared (NIR) light intensity as it propagates in a turbid medium like biological tissue is described by modified the Beer–Lambert law (MBLL). The MBLL is generally used to quantify the changes in tissue chromophore concentrations for NIR spectroscopic data analysis. Even though MBLL is effect...

journal_title：Journal of biomedical optics

authors： Bhatt M,Ayyalasomayajula KR,Yalavarthy PK

更新日期：2016-07-01 00:00:00