Abstract:
BACKGROUND:Women are at an increased risk of depression and other mental health problems following rape. Various etiological factors for depression, including predisposing genetic factors, have been identified. Telomeres are repetitive nucleoprotein structures located at chromosomal ends that protect them from premature degradation. Telomeres reduce in length with each cell division, resulting in cellular senescence and apoptosis. METHODS:Relative quantification of telomeric repeats using qPCR was performed to investigate whether shorter relative leukocyte telomere length (LTL) in a cohort of 64 rape victims was associated with resilience, the development of rape trauma-related major depressive disorder (MDD) or the development of posttraumatic stress disorder (PTSD) after 3 months. RESULTS:Out of the 64 participants, 23 participants were diagnosed with MDD at baseline and 31 after 3 months. Nine participants were diagnosed with PTSD (MDD and PTSD specifically related to the trauma). No significant associations were observed between relative LTL and resilience or the development of MDD at either baseline or after 3 months in this cohort. However, a marginally significant association was evident between relative LTL and PTSD status. CONCLUSIONS:The significant association between relative LTL and PTSD suggests that shorter relative LTL might have acted as a predisposing factor in the development of PTSD after a severely traumatic event. The results of this study indicate that telomere shortening may be an important marker of PTSD risk, with implications for early intervention and timely treatment, and as such warrant replication in a larger cohort.
journal_name
Depress Anxietyjournal_title
Depression and anxietyauthors
Malan S,Hemmings S,Kidd M,Martin L,Seedat Sdoi
10.1002/da.20903subject
Has Abstractpub_date
2011-12-21 00:00:00pages
1081-5issue
12eissn
1091-4269issn
1520-6394journal_volume
28pub_type
杂志文章abstract:BACKGROUND:Amygdala-prefrontal cortex (PFC) functional connectivity may be influenced by anxiety and development. A prior study on anxiety found age-specific dysfunction in the ventromedial PFC (vmPFC), but not amygdala, associated with threat-safety discrimination during extinction recall (Britton et al.). However, tr...
journal_title:Depression and anxiety
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journal_title:Depression and anxiety
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Depression and anxiety
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journal_title:Depression and anxiety
pub_type: 杂志文章,meta分析
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journal_title:Depression and anxiety
pub_type: 杂志文章
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journal_title:Depression and anxiety
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pub_type: 杂志文章,随机对照试验
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journal_title:Depression and anxiety
pub_type: 杂志文章
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journal_title:Depression and anxiety
pub_type: 杂志文章,随机对照试验
doi:10.1002/da.20439
更新日期:2009-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20489
更新日期:2008-01-01 00:00:00
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journal_title:Depression and anxiety
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更新日期:2006-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1002/da.20635
更新日期:2009-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.21963
更新日期:2012-06-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20865
更新日期:2011-08-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20087
更新日期:2005-01-01 00:00:00
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journal_title:Depression and anxiety
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20183
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pub_type: 临床试验,杂志文章
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journal_title:Depression and anxiety
pub_type: 杂志文章
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更新日期:1998-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
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pub_type: 杂志文章,meta分析,评审
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journal_title:Depression and anxiety
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更新日期:2016-11-01 00:00:00
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