Abstract:
:The objective was to present naturalistic 1-year follow-up information of 96 child and adolescent outpatients with major depressive disorder who had been randomized in an 8-week double-blind, placebo-controlled trial of fluoxetine. Subjects were children and adolescents, ages 8-18 years, who were entered in a randomized clinical trial of fluoxetine. Following the acute treatment trial, treatment was not controlled. At 6 months and 1 year, the subjects and parents were interviewed using the Kiddie Longitudinal Interval Follow-up Evaluation (K-LIFE) for course of depression. Eighty-seven of the 96 subjects were followed for 1 year. Of these, 74 (85%) recovered from the depressive episode during that time (47 on fluoxetine, 22 on no medication, and 5 on other antidepressants or lithium). Twenty-nine of the subjects (39%) who recovered had a recurrence of depression during the 1-year follow-up, with 55% of these occurring within 6 months. Results of this study are similar to adult studies, with respect to response and recovery of depressive episodes. Most patients (85%) recover from the episode within 1 year, but approximately 40% have a recurrence within 12 months, which is a higher recurrence rate than in adults. Recovery was associated with younger age, lower severity of depressive symptoms, higher family functioning, and fewer comorbid diagnoses. Recurrence, which occurs both on and off medication, was difficult to predict, as there was little clinical data associated with recurrence in this population.
journal_name
Depress Anxietyjournal_title
Depression and anxietyauthors
Emslie GJ,Rush AJ,Weinberg WA,Kowatch RA,Carmody T,Mayes TLdoi
10.1002/(sici)1520-6394(1998)7:1<32::aid-da4>3.0.csubject
Has Abstractpub_date
1998-01-01 00:00:00pages
32-9issue
1eissn
1091-4269issn
1520-6394pii
10.1002/(SICI)1520-6394(1998)7:1<32::AID-DA4>3.0.Cjournal_volume
7pub_type
临床试验,杂志文章,随机对照试验abstract:BACKGROUND:Hypothalamic-pituitary-adrenal (HPA) axis functioning has been implicated in the development of stress-related psychiatric diagnoses and response to adverse life experiences. This study aimed to investigate the association between genetic and epigenetics in HPA axis and response to cognitive behavior therapy...
journal_title:Depression and anxiety
pub_type: 杂志文章,多中心研究
doi:10.1002/da.22430
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Patients with obsessive-compulsive disorder (OCD) experience abnormally high levels of uncertainty, and unpredictability is evaluated negatively and not well tolerated. The current study examined neural correlates of attentional processing in response to experimentally induced uncertainty in OCD. METHODS:Tw...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22655
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:To examine the potential mediating role of parenting behaviors in the longitudinal, bidirectional relationships between maternal depression and child internalizing symptoms (i.e. depression and anxiety). METHODS:We analyzed data from 4,581 mother-child dyads from the Fragile Families and Child Wellbeing Stu...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22688
更新日期:2018-01-01 00:00:00
abstract::The superior temporal gyrus (STG) may be involved in the pathophysiology of obsessive-compulsive disorder (OCD). Moreover, the anterior STG has rich interconnections with the orbitofrontal cortex and the amygdala, and plays a role in visuospatial processing, which is impaired in patients with OCD. This study was desig...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20171
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Although numerous studies have examined the role of latent predispositions to internalizing and externalizing disorders in the structure of comorbidity among common mental disorders, none examined latent predispositions in predicting development of comorbidity. METHODS:A novel method was used to study the r...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20760
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:A few studies have examined the durability of transcranial magnetic stimulation (TMS) antidepressant benefit once patients remitted. This study examined the long-term durability of clinical benefit from TMS using a protocol-specified TMS taper and either continuation pharmacotherapy or naturalistic follow-up...
journal_title:Depression and anxiety
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/da.21967
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:To determine the factors, which are associated with suicidal ideation and ideas of self-harm in patients with congestive heart failure (CHF). METHODS:We examined 294 patients with documented CHF, New York Heart Association (NYHA) functional class II-IV, in a cross sectional study at three cardiac outpatient ...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20587
更新日期:2009-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22485
更新日期:2016-06-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20231
更新日期:2007-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20718
更新日期:2010-07-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.10015
更新日期:2002-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章,评审
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更新日期:2013-12-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22342
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Previous work on gene-environment (GxE) interplay concerning anxiety has focused on the interaction of 5-HTTLPR with childhood adversities or traumatic events whereas the impact of recent stressors is understudied, as is the integration of resilience. The current study aimed to investigate the interactive ef...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.23101
更新日期:2020-10-14 00:00:00
abstract:BACKGROUND:To elucidate mechanisms related to remission in winter seasonal affective disorder (SAD), we explored the course of individual depressive symptom offset across two distinct treatment modalities that show comparable outcomes at treatment endpoint: cognitive-behavioral therapy for SAD (CBT-SAD) and light thera...
journal_title:Depression and anxiety
pub_type: 杂志文章,随机对照试验
doi:10.1002/da.22739
更新日期:2018-05-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/(SICI)1520-6394(1996)4:3<120::AID-DA4>3.0.
更新日期:1996-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.20488
更新日期:2008-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.20022
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Oligodendrocyte transcription factor 2 (OLIG2) is primarily concentrated in the brain and spinal cord ventricular zone, where this protein stimulates oligodendrocytes and specific neurons, determines motor neuron and oligodendrocyte differentiation, and sustains replication in early development. Recent studi...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22394
更新日期:2015-10-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22995
更新日期:2020-05-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.10024
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Adolescent depression may increase risk for poor mental health outcomes in adulthood. The objective of this study was to systematically review the literature on the association between adolescent depression and adult anxiety and depressive disorders as well as suicidality. METHODS:EMBASE, MEDLINE, and PSYCi...
journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.22777
更新日期:2018-08-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22557
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Increased psychophysiological reactivity is a hallmark intermediate phenotype of posttraumatic stress disorder (PTSD). Individuals with PTSD exhibit greater skin conductance (SC) responses to trauma scripts than trauma survivors without PTSD. However, trauma scripts require time for development and cannot be...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22610
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Comorbid psychiatric disorders, cardiovascular disease, chronic hypertension, diabetes, and musculoskeletal disorders are highly prevalent in depression. However, the extent to which these conditions affect the recurrence of depression-related work disability is unknown. The specific aims of the study were t...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22286
更新日期:2014-09-01 00:00:00
abstract::Research has shown that obsessive compulsive disorder (OCD) is related to structural and functional abnormalities in the brain, and several authors have organized these findings into theories of OCD neuropsychiatric dysfunction. In this paper, these theories were used to develop a neural network model of OCD. OCD symp...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/(sici)1520-6394(1998)8:3<91::aid-da1>3.0.c
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Despite its popularity, little is known about the measurement invariance of the Patient Health Questionnaire-9 (PHQ-9) across U.S. sociodemographic groups. Use of a screener shown not to possess measurement invariance could result in under/over-detection of depression, potentially exacerbating sociodemograph...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22940
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Although losses are important consequences of disasters, few epidemiological studies of disasters have assessed complicated grief (CG) and none assessed CG associated with losses other than death of loved one. METHODS:Data come from the baseline survey of the Hurricane Katrina Community Advisory Group, a re...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20865
更新日期:2011-08-01 00:00:00
abstract::The increased risk of physical health problems in adult depressed patients has been shown in numerous studies. A recent study of the offspring of depressed parents found similar associations. The purpose of this study is to examine the strength and specificity of the association between depression and physical health ...
journal_title:Depression and anxiety
pub_type: 临床试验,杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::There is abundant evidence for abnormalities of the norepinephrine (NE) and serotonin (5HT) neurotransmitter systems in depression and anxiety disorders. The majority of evidence supports underactivation of serotonergic function and complex dysregulation of noradrenergic function, most consistent with overactivation o...
journal_title:Depression and anxiety
pub_type: 杂志文章,评审
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更新日期:2000-01-01 00:00:00