Abstract:
:Sensitization of stress-responsive neurobiological systems as a possible consequence of early adverse experience has been implicated in the pathophysiology of mood and anxiety disorders. In addition to early adversities, adulthood stressors are also known to precipitate the manifestation of these disorders. The present study sought to evaluate the relative role of early adverse experience vs. stress experiences in adulthood in the prediction of neuroendocrine stress reactivity in women. A total of 49 women (normal volunteers, depressed patients, and women with a history of early abuse) underwent a battery of interviews and completed dimensional rating scales on stress experiences and psychopathology, and were subsequently exposed to a standardized psychosocial laboratory stressor. Outcome measures were plasma adrenocorticotropin (ACTH) and cortisol responses to the stress test. Multiple linear regression analyses were performed to identify the impact of demographic variables, childhood abuse, adulthood trauma, major life events in the past year, and daily hassles in the past month, as well as psychopathology on hormonal stress responsiveness. Peak ACTH responses to psychosocial stress were predicted by a history of childhood abuse, the number of separate abuse events, the number of adulthood traumas, and the severity of depression. Similar predictors were identified for peak cortisol responses. Although abused women reported more severe negative life events in adulthood than controls, life events did not affect neuroendocrine reactivity. The regression model explained 35% of the variance of ACTH responses. The interaction of childhood abuse and adulthood trauma was the most powerful predictor of ACTH responsiveness. Our findings suggest that a history of childhood abuse per se is related to increased neuroendocrine stress reactivity, which is further enhanced when additional trauma is experienced in adulthood.
journal_name
Depress Anxietyjournal_title
Depression and anxietyauthors
Heim C,Newport DJ,Wagner D,Wilcox MM,Miller AH,Nemeroff CBdoi
10.1002/da.10015subject
Has Abstractpub_date
2002-01-01 00:00:00pages
117-25issue
3eissn
1091-4269issn
1520-6394journal_volume
15pub_type
杂志文章abstract:BACKGROUND:Recent evidence shows that screen time may be an important risk factor for mental health. The aim of this study was to examine the association of computer/mobile devices (CMD) use and TV watching separately with depressive symptoms in a large representative sample of Chinese adults. METHODS:A sample of 18,9...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22932
更新日期:2019-09-01 00:00:00
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doi:10.1002/da.20522
更新日期:2009-01-01 00:00:00
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journal_title:Depression and anxiety
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20224
更新日期:2007-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20171
更新日期:2006-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.10101
更新日期:2003-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:Depression and anxiety
pub_type: 杂志文章
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journal_title:Depression and anxiety
pub_type: 杂志文章,meta分析
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20377
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journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.20175
更新日期:2007-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20679
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Internet-delivered cognitive behavioral therapy (iCBT) is a relatively novel treatment method that may improve the accessibility of mental health care for individuals with posttraumatic stress disorder (PTSD). The aim of this meta-analysis was to evaluate the effectiveness of iCBT compared to inactive (waitl...
journal_title:Depression and anxiety
pub_type: 杂志文章,meta分析,评审
doi:10.1002/da.22533
更新日期:2016-09-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1002/da.22897
更新日期:2019-07-01 00:00:00
abstract::This study sought to describe clinical and demographic characteristics differentiating patients with DSM-III-R simple phobias comorbid with one or more of five DSM-III-R index anxiety disorders as compared with those with the index diagnoses alone. From 711 subjects participating in a multicenter, longitudinal, natura...
journal_title:Depression and anxiety
pub_type: 临床试验,杂志文章,多中心研究
doi:
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Many patients with major depressive disorder (MDD) have been found to have psychotic symptoms. However, few studies have reported the prevalence of comorbid psychotic symptoms in first-episode drug naïve (FEDN) MDD patients. This study was to investigate the prevalence of psychotic symptoms and related risk ...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.23026
更新日期:2020-08-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.21960
更新日期:2012-07-01 00:00:00
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doi:10.1002/da.20649
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journal_title:Depression and anxiety
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journal_title:Depression and anxiety
pub_type: 杂志文章
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journal_title:Depression and anxiety
pub_type: 杂志文章,评审
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更新日期:2016-08-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章,评审
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更新日期:2010-06-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2015-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/da.20268
更新日期:2008-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.21933
更新日期:2012-09-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章,meta分析
doi:10.1002/(sici)1520-6394(1997)6:1<10::aid-da2>3.0.c
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Recent studies suggest that mindfulness may be an effective component for posttraumatic stress disorder (PTSD) treatment. Mindfulness involves practice in volitional shifting of attention from "mind wandering" to present-moment attention to sensations, and cultivating acceptance. We examined potential neural...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22481
更新日期:2016-04-01 00:00:00