EFFECTIVENESS OF INTERNET-DELIVERED COGNITIVE BEHAVIORAL THERAPY FOR POSTTRAUMATIC STRESS DISORDER: A SYSTEMATIC REVIEW AND META-ANALYSIS.

Abstract:

BACKGROUND:Internet-delivered cognitive behavioral therapy (iCBT) is a relatively novel treatment method that may improve the accessibility of mental health care for individuals with posttraumatic stress disorder (PTSD). The aim of this meta-analysis was to evaluate the effectiveness of iCBT compared to inactive (waitlist control and treatment-as-usual (TAU)) and active other interventions in reducing PTSD symptoms. METHODS:A meta-analysis of 12 randomized controlled trials (14 comparisons) and 1,306 participants was conducted. RESULTS:The pooled effect size of the 11 comparisons (10 studies, 1,139 participants) that compared iCBT to waitlist and TAU control was moderate (g = 0.71, 95% CI [0.49-0.93], P < .001), and showed moderate heterogeneity. The pooled effect size of the three studies (three comparisons) comparing iCBT to other interventions was small (g = 0.28, 95% CI [-0.00 to 0.56], P = .05), with low heterogeneity. CONCLUSION:The findings of this systematic review and meta-analysis show that iCBT is an effective treatment for individuals with PTSD and comorbid depressive symptoms. However, further research is needed for effective dissemination of iCBT in clinical practice.

journal_name

Depress Anxiety

journal_title

Depression and anxiety

authors

Sijbrandij M,Kunovski I,Cuijpers P

doi

10.1002/da.22533

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

783-91

issue

9

eissn

1091-4269

issn

1520-6394

journal_volume

33

pub_type

杂志文章,meta分析,评审
  • Developing biomarkers in mood disorders research through the use of rapid-acting antidepressants.

    abstract::An impediment to progress in mood disorders research is the lack of analytically valid and qualified diagnostic and treatment biomarkers. Consistent with the National Institute of Mental Health (NIMH)'s Research Domain Criteria (RDoC) initiative, the lack of diagnostic biomarkers has precluded us from moving away from...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,评审

    doi:10.1002/da.22224

    authors: Niciu MJ,Mathews DC,Nugent AC,Ionescu DF,Furey ML,Richards EM,Machado-Vieira R,Zarate CA Jr

    更新日期:2014-04-01 00:00:00

  • Sleep, circadian rhythm, and physical activity patterns in depressive and anxiety disorders: A 2-week ambulatory assessment study.

    abstract:BACKGROUND:Actigraphy may provide a more valid assessment of sleep, circadian rhythm (CR), and physical activity (PA) than self-reported questionnaires, but has not been used widely to study the association with depression/anxiety and their clinical characteristics. METHODS:Fourteen-day actigraphy data of 359 particip...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22949

    authors: Difrancesco S,Lamers F,Riese H,Merikangas KR,Beekman ATF,van Hemert AM,Schoevers RA,Penninx BWJH

    更新日期:2019-10-01 00:00:00

  • Changes in reported physical health symptoms and social function with prolonged exposure therapy for chronic posttraumatic stress disorder.

    abstract:BACKGROUND:Posttraumatic stress disorder (PTSD) is associated with significant health risk, illness, and functional impairment, e.g., Green and Kimerling [2004: Physical Health Consequences of Exposure to Extreme Stress. Washington, DC: American Psychological Association] Kimerling et al. [2000: Trauma and Health: J Tr...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20518

    authors: Rauch SA,Grunfeld TE,Yadin E,Cahill SP,Hembree E,Foa EB

    更新日期:2009-01-01 00:00:00

  • Managing rapid metabolizers of antidepressants.

    abstract::Depressed patients who rapidly metabolize antidepressants may be common, and may not respond to even high doses of antidepressants if subtherapeutic plasma levels are produced. Rapid metabolizers (RMs) are identifiable if patients are on tricyclic antidepressants (TCAs), and TCA plasma levels (commonly available) are ...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/(SICI)1520-6394(1996)4:6<320::AID-DA8>3.0.

    authors: Kraus RP,Diaz P,McEachran A

    更新日期:1996-01-01 00:00:00

  • Duration of last depressive episode may influence serum BDNF levels in remitted patients with major depression.

    abstract:BACKGROUND:Brain-derived neurotrophic factor (BDNF) may have an important role in the pathophysiology of depression. Previous studies indicate that serum BDNF levels were lower in patients with depression and increased after treatment with antidepressants. However, results of studies on serum BDNF levels in remitted pa...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.21933

    authors: Takebayashi N,Maeshima H,Baba H,Nakano Y,Satomura E,Kita Y,Namekawa Y,Nomoto H,Suzuki T,Arai H

    更新日期:2012-09-01 00:00:00

  • Generalized social phobia and avoidant personality disorder: meaningful distinction or useless duplication?

    abstract::Participants with generalized social phobia (GSP) with (n=36) and without (n=19) avoidant personality disorder (AVPD) were compared via contrasts of group means and classification analysis on purported core features of AVPD. GSP-AVPD participants proved to be more severely impaired or distressed on some group contrast...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20266

    authors: Chambless DL,Fydrich T,Rodebaugh TL

    更新日期:2008-01-01 00:00:00

  • Employer burden of mild, moderate, and severe major depressive disorder: mental health services utilization and costs, and work performance.

    abstract:BACKGROUND:Treatment utilization/costs and work performance for persons with major depressive disorder (MDD) by severity of illness is not well documented. METHODS:Using National Comorbidity Survey-Replication (2001-2002) data, US workforce respondents (n=4,465) were classified by clinical severity (not clinically dep...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20580

    authors: Birnbaum HG,Kessler RC,Kelley D,Ben-Hamadi R,Joish VN,Greenberg PE

    更新日期:2010-01-01 00:00:00

  • Exposure-based therapy changes amygdala and hippocampus resting-state functional connectivity in patients with posttraumatic stress disorder.

    abstract:BACKGROUND:Recent research suggests that posttraumatic stress disorder (PTSD) is associated with altered amygdala and hippocampal resting-state functional connectivity (rsFC). However, less research has examined whether Prolonged Exposure (PE), a first line exposure-based treatment for PTSD, has the potential to alter ...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22816

    authors: Zhu X,Suarez-Jimenez B,Lazarov A,Helpman L,Papini S,Lowell A,Durosky A,Lindquist MA,Markowitz JC,Schneier F,Wager TD,Neria Y

    更新日期:2018-10-01 00:00:00

  • Physical health problems in depressed and nondepressed children and adolescents of parents with opiate dependence.

    abstract::The increased risk of physical health problems in adult depressed patients has been shown in numerous studies. A recent study of the offspring of depressed parents found similar associations. The purpose of this study is to examine the strength and specificity of the association between depression and physical health ...

    journal_title:Depression and anxiety

    pub_type: 临床试验,杂志文章

    doi:

    authors: McAvay G,Nunes EV,Zaider TI,Goldstein RB,Weissman MM

    更新日期:1999-01-01 00:00:00

  • Parental predictors of pediatric panic disorder/agoraphobia: a controlled study in high-risk offspring.

    abstract::Our objective was to evaluate parental risk factors for pediatric-onset panic disorder/agoraphobia (PD/AG) in offspring at high risk for PD/AG. Comparisons were made between parents with PD who had a child with PD or AG (N = 27) and parents with PD without children with PD or AG (N = 79). Comparisons were also made be...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20122

    authors: Biederman J,Petty C,Faraone SV,Hirshfeld-Becker DR,Henin A,Dougherty M,Lebel TJ,Pollack M,Rosenbaum JF

    更新日期:2005-01-01 00:00:00

  • Resilience: research evidence and conceptual considerations for posttraumatic stress disorder.

    abstract::The growing recognition and occurrence of traumatic exposure in the general population has given increased salience to the need to understand the concept of resilience. More than just the "flip side" of a risk factor, the notion of resilience encompasses psychological and biological characteristics, intrinsic to an in...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,评审

    doi:10.1002/da.20175

    authors: Hoge EA,Austin ED,Pollack MH

    更新日期:2007-01-01 00:00:00

  • Adult mental health outcomes of adolescent depression: A systematic review.

    abstract:BACKGROUND:Adolescent depression may increase risk for poor mental health outcomes in adulthood. The objective of this study was to systematically review the literature on the association between adolescent depression and adult anxiety and depressive disorders as well as suicidality. METHODS:EMBASE, MEDLINE, and PSYCi...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,评审

    doi:10.1002/da.22777

    authors: Johnson D,Dupuis G,Piche J,Clayborne Z,Colman I

    更新日期:2018-08-01 00:00:00

  • Getting straight about grief.

    abstract::Acute grief is emotionally intense, cognitively preoccupying, and disruptive, but grief is not an illness; major depression and anxiety disorders are. Grief and mourning have a purpose. They provide an intense, focused opportunity to reregulate emotion and to engage in a learning process that is aimed at reconfiguring...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,评审

    doi:10.1002/da.21963

    authors: Shear MK

    更新日期:2012-06-01 00:00:00

  • Biological and symptom changes in posttraumatic stress disorder treatment: a randomized clinical trial.

    abstract:BACKGROUND:Understanding cognitive and biological mechanisms of PTSD treatment can help refine treatments and increase rates of response. METHODS:Thirty-six veterans with PTSD were randomly assigned to receive Prolonged exposure therapy (PE) or Present-Centered therapy (PCT). We examined symptoms, trauma-related cogni...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/da.22331

    authors: Rauch SA,King AP,Abelson J,Tuerk PW,Smith E,Rothbaum BO,Clifton E,Defever A,Liberzon I

    更新日期:2015-03-01 00:00:00

  • Leveraging social media to explore the barriers to treatment among individuals with depressive symptoms.

    abstract:BACKGROUND:Individuals with depression may not seek treatment for their symptoms due to several types of barriers to treatment. In support of the growing research on mental health care access and the role of social media, this study aimed to increase knowledge of these barriers among social media users. METHODS:Partic...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22990

    authors: Szlyk H,Deng J,Xu C,Krauss MJ,Cavazos-Rehg PA

    更新日期:2020-05-01 00:00:00

  • Re-examining the differential familial liability of agoraphobia and panic disorder.

    abstract:BACKGROUND:Controversy surrounds the question of whether agoraphobia (AG) exists as an independent diagnostic entity apart from panic. In favor of this position, AG without panic disorder (PD) in parents was found being unrelated to offsprings' risk for AG or PD, albeit it may enhance the familial transmission of PD (N...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.21975

    authors: Knappe S,Beesdo-Baum K,Nocon A,Wittchen HU

    更新日期:2012-11-01 00:00:00

  • Competitive memory training (COMET) for treating low self-esteem in patients with depressive disorders: a randomized clinical trial.

    abstract:BACKGROUND:Self-esteem is a major concern in mood disorders. Low self-esteem is a symptom of depressive disorders and is considered by some to be a predictor for relapse, whereas high self-esteem seems to buffer against depression. Recently, Competitive Memory Training (COMET) has shown to be effective for the enhancem...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/da.20921

    authors: Korrelboom K,Maarsingh M,Huijbrechts I

    更新日期:2012-02-01 00:00:00

  • Prevalence and risk factors for posttraumatic stress disorder: a cross-sectional study among survivors of the Wenchuan 2008 earthquake in China.

    abstract:BACKGROUND:The impact of the May 2008 Wenchuan earthquake, measuring a massive 8.0 on the surface wave magnitude scale, on public health in China has been significant and multifaceted. In light of extant data on prevalence and risk factors for posttraumatic stress disorder (PTSD) after other natural diasters, we collec...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20612

    authors: Kun P,Han S,Chen X,Yao L

    更新日期:2009-01-01 00:00:00

  • Extended release quetiapine fumarate in major depressive disorder: analysis in patients with anxious depression.

    abstract:BACKGROUND:A pooled analysis was performed on data from two studies evaluating the efficacy of once-daily extended-release quetiapine fumarate (quetiapine XR) monotherapy for patients with major depressive disorder. Through these analyses (based on Hamilton Rating Scale for Depression (HAM-D) and Hamilton Rating Scale ...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/da.21970

    authors: Thase ME,Demyttenaere K,Earley WR,Gustafsson U,Udd M,Eriksson H

    更新日期:2012-07-01 00:00:00

  • Attention bias to threat faces in severe mood dysregulation.

    abstract:BACKGROUND:We used a dot-probe paradigm to examine attention bias toward threat (i.e., angry) and happy face stimuli in severe mood dysregulation (SMD) versus healthy comparison (HC) youth. The tendency to allocate attention to threat is well established in anxiety and other disorders of negative affect. SMD is charact...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22145

    authors: Hommer RE,Meyer A,Stoddard J,Connolly ME,Mogg K,Bradley BP,Pine DS,Leibenluft E,Brotman MA

    更新日期:2014-07-01 00:00:00

  • Obsessive-compulsive disorder in youth with and without a chronic tic disorder.

    abstract::The goal of this study was to discriminate subtypes of pediatric obsessive-compulsive disorder (OCD) among youth with and without a comorbid tic disorder. Seventy-four youth (M(age)=9.7+/-2.3 years) with a principal diagnosis of OCD, with (n=46) or without (n=28) a comorbid tic disorder, were assessed with a semi-stru...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20304

    authors: Storch EA,Stigge-Kaufman D,Marien WE,Sajid M,Jacob ML,Geffken GR,Goodman WK,Murphy TK

    更新日期:2008-01-01 00:00:00

  • Early-onset versus late-onset bipolar II chronic depression.

    abstract::Age at onset is an important dimension in the classification of mood disorders. Recent findings on early-onset (EO) versus late-onset (LO) unipolar chronic depressions support this subtyping. The aim of the present study was to determine clinical differences between EO and LO bipolar II chronic depression and to suppo...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/1520-6394(2001)13:1<45::aid-da7>3.0.co;2-4

    authors: Benazzi F

    更新日期:2001-01-01 00:00:00

  • Portuguese version of Corah's Dental Anxiety Scale: transcultural adaptation and reliability analysis.

    abstract::This study explores the psychometric properties of the Portuguese version of Corah's Dental Anxiety Scale (DAS), an instrument designed to assess the manifestations of dental anxiety. The DAS has been translated into several languages, but no adaptation and reliability analysis of the Portuguese version of the scale h...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20258

    authors: Hu LW,Gorenstein C,Fuentes D

    更新日期:2007-01-01 00:00:00

  • Reduced sensory gating of the P1 potential in rape victims and combat veterans with posttraumatic stress disorder.

    abstract::The P1 midlatency auditory evoked potential was studied in female rape victims with Posttraumatic Stress Disorder (PTSD) and compared to an age-matched female control group; and in male combat veterans with PTSD and compared to three groups of age-matched male control subjects. Sensory gating of the P1 potential was d...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/(sici)1520-6394(1999)9:3<122::aid-da4>3.0.

    authors: Skinner RD,Rasco LM,Fitzgerald J,Karson CN,Matthew M,Williams DK,Garcia-Rill E

    更新日期:1999-01-01 00:00:00

  • Measurement invariance of the patient health questionnaire-9 (PHQ-9) depression screener in U.S. adults across sex, race/ethnicity, and education level: NHANES 2005-2016.

    abstract:BACKGROUND:Despite its popularity, little is known about the measurement invariance of the Patient Health Questionnaire-9 (PHQ-9) across U.S. sociodemographic groups. Use of a screener shown not to possess measurement invariance could result in under/over-detection of depression, potentially exacerbating sociodemograph...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22940

    authors: Patel JS,Oh Y,Rand KL,Wu W,Cyders MA,Kroenke K,Stewart JC

    更新日期:2019-09-01 00:00:00

  • The role of psychiatric, cardiometabolic, and musculoskeletal comorbidity in the recurrence of depression-related work disability.

    abstract:BACKGROUND:Comorbid psychiatric disorders, cardiovascular disease, chronic hypertension, diabetes, and musculoskeletal disorders are highly prevalent in depression. However, the extent to which these conditions affect the recurrence of depression-related work disability is unknown. The specific aims of the study were t...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22286

    authors: Ervasti J,Vahtera J,Pentti J,Oksanen T,Ahola K,Kivekäs T,Kivimäki M,Virtanen M

    更新日期:2014-09-01 00:00:00

  • Fluvoxamine treatment in veterans with combat-related post-traumatic stress disorder.

    abstract::This study was designed to investigate the efficacy of the antidepressant fluvoxamine in the treatment of combat-related post-traumatic stress disorder (PTSD). Fifteen veterans with combat-related PTSD and no other psychiatric diagnosis except depression were recruited to participate in a 14-week open-label study of f...

    journal_title:Depression and anxiety

    pub_type: 临床试验,杂志文章

    doi:10.1002/da.1082

    authors: Escalona R,Canive JM,Calais LA,Davidson JR

    更新日期:2002-01-01 00:00:00

  • LETHAL MEANS ACCESS AND ASSESSMENT AMONG SUICIDAL EMERGENCY DEPARTMENT PATIENTS.

    abstract:BACKGROUND:Reducing access to lethal means (especially firearms) might prevent suicide, but counseling of at-risk individuals about this strategy may not be routine. Among emergency department (ED) patients with suicidal ideation or attempts (SI/SA), we sought to describe home firearm access and examine ED provider ass...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22486

    authors: Betz ME,Miller M,Barber C,Beaty B,Miller I,Camargo CA Jr,Boudreaux ED

    更新日期:2016-06-01 00:00:00

  • RGS2 and generalized anxiety disorder in an epidemiologic sample of hurricane-exposed adults.

    abstract:BACKGROUND:Generalized anxiety disorder (GAD) is a common and sometimes disabling condition often associated with stressful life events that involve significant loss or danger. The disorder appears moderately heritable. Polymorphisms in the RGS2 (regulator of G-protein signaling 2) gene were recently associated with an...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20528

    authors: Koenen KC,Amstadter AB,Ruggiero KJ,Acierno R,Galea S,Kilpatrick DG,Gelernter J

    更新日期:2009-01-01 00:00:00

  • Endogenous oxytocin is associated with the experience of compassion and recalled upbringing in Borderline Personality Disorder.

    abstract:BACKGROUND/OBJECTIVE:The role of the neuropeptide oxytocin (OT) in Borderline Personality Disorder (BPD) is poorly understood. It is particularly unknown how early experiences with caregivers moderate the action of OT in BPD. Here, we examined the association of plasma OT levels in BPD patients with the experience of c...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22683

    authors: Ebert A,Edel MA,Gilbert P,Brüne M

    更新日期:2018-01-01 00:00:00