Abstract:
BACKGROUND:Posttraumatic stress disorder (PTSD) is associated with significant health risk, illness, and functional impairment, e.g., Green and Kimerling [2004: Physical Health Consequences of Exposure to Extreme Stress. Washington, DC: American Psychological Association] Kimerling et al. [2000: Trauma and Health: J Trauma Stress 13:115-128]. METHODS:These analyses examined whether negative health perceptions and general social functioning change with treatment of chronic PTSD among women from a randomized controlled study comparing prolonged exposure (PE; n=48) or PE combined with cognitive restructuring (PE/CR; n=40) to waitlist (n=19; Foa et al., 2005: J Consult Clin Psychol 73:953-964]. RESULTS:Self- reported physical health difficulties were significantly reduced in the PE and PE/CR conditions compared to the waitlist condition. These reductions did not demonstrate significant change during the 12 month follow-up period. Self-reported discomfort associated with physical health difficulties did not demonstrate significant change over treatment. No difference was detected between the active treatment and waitlist conditions. Both the PE and PE/CR groups reported improved social functioning at post treatment compared to the waitlist. Additional improvement in general social functioning was found between 3 and 12 month follow-up assessments. Changes in PTSD and depressive symptoms over treatment accounted for 29% of the variance in reduction of reported health problems and 30% of the variance in improvement of general social functioning. Importantly, only changes in PTSD symptoms significantly contribute to the model predicting change in physical health problems with depression associated only at a trend level. However, collinearity between PTSD and depression makes interpretation difficult. CONCLUSIONS:Negative health perceptions and general social function improve with PE. Changes in depression and PTSD with treatment are related to these changes.
journal_name
Depress Anxietyjournal_title
Depression and anxietyauthors
Rauch SA,Grunfeld TE,Yadin E,Cahill SP,Hembree E,Foa EBdoi
10.1002/da.20518subject
Has Abstractpub_date
2009-01-01 00:00:00pages
732-8issue
8eissn
1091-4269issn
1520-6394journal_volume
26pub_type
杂志文章abstract::There is abundant evidence for abnormalities of the norepinephrine (NE) and serotonin (5HT) neurotransmitter systems in depression and anxiety disorders. The majority of evidence supports underactivation of serotonergic function and complex dysregulation of noradrenergic function, most consistent with overactivation o...
journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/1520-6394(2000)12:1+<2::AID-DA2>3.0.CO;2-4
更新日期:2000-01-01 00:00:00
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journal_title:Depression and anxiety
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abstract:OBJECTIVE:To examine (1) clinically relevant anxiety with comorbid depression in an older population, and the presentation of subthreshold symptoms; (2) to assess anxiety and levels of comorbid depression associated with migration, religion, loneliness and long-term illness. METHODS:Analysis of Wave 1 of The Irish Lon...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22893
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abstract::The P1 midlatency auditory evoked potential was studied in female rape victims with Posttraumatic Stress Disorder (PTSD) and compared to an age-matched female control group; and in male combat veterans with PTSD and compared to three groups of age-matched male control subjects. Sensory gating of the P1 potential was d...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/(sici)1520-6394(1999)9:3<122::aid-da4>3.0.
更新日期:1999-01-01 00:00:00
abstract::The use of a placebo run-in phase, in which placebo responders are withdrawn from a study before random assignment to treatment condition, has been criticized as favoring the active treatment in clinical trials. We compared the effect size of randomized, placebo-controlled clinical trials (in the treatment of depressi...
journal_title:Depression and anxiety
pub_type: 杂志文章,meta分析
doi:10.1002/da.10134
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pub_type: 杂志文章,随机对照试验
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journal_title:Depression and anxiety
pub_type: 杂志文章,多中心研究
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journal_title:Depression and anxiety
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doi:10.1002/da.10096
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22804
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20715
更新日期:2010-08-01 00:00:00
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journal_title:Depression and anxiety
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20489
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Many individuals with obsessive-compulsive disorder (OCD) do not receive professional treatment due to various idiosyncratic barriers. Internet-based cognitive-behavioral therapy (iCBT) is increasingly used to narrow treatment gaps, but the efficacy of such interventions without guidance of therapists has no...
journal_title:Depression and anxiety
pub_type: 杂志文章,随机对照试验
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更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Panic disorder (PD) is highly comorbid with major depressive disorder (MDD) with potential impact on patient-reported outcomes of quality of life (QOL), functioning, and depressive symptom severity. METHODS:Using data from the sequenced treatment alternatives to relieve depression (STAR*D) trial, we compare...
journal_title:Depression and anxiety
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/da.22152
更新日期:2014-08-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.22167
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Recent studies suggest that mindfulness may be an effective component for posttraumatic stress disorder (PTSD) treatment. Mindfulness involves practice in volitional shifting of attention from "mind wandering" to present-moment attention to sensations, and cultivating acceptance. We examined potential neural...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22481
更新日期:2016-04-01 00:00:00
abstract::Reports on the severity and reversibility of cognitive disturbances in major depression in the literature diverge due to methodological biases. The present study, using a precise methodology, examined attention and executive functions in 20 relatively young, depressed patients presenting a first or second episode of u...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20060
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doi:10.1002/da.22379
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pub_type: 杂志文章
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abstract::This study was designed to investigate the efficacy of the antidepressant fluvoxamine in the treatment of combat-related post-traumatic stress disorder (PTSD). Fifteen veterans with combat-related PTSD and no other psychiatric diagnosis except depression were recruited to participate in a 14-week open-label study of f...
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pub_type: 临床试验,杂志文章
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/(SICI)1520-6394(1996)4:6<320::AID-DA8>3.0.
更新日期:1996-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
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更新日期:2012-07-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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abstract::Age at onset is an important dimension in the classification of mood disorders. Recent findings on early-onset (EO) versus late-onset (LO) unipolar chronic depressions support this subtyping. The aim of the present study was to determine clinical differences between EO and LO bipolar II chronic depression and to suppo...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/1520-6394(2001)13:1<45::aid-da7>3.0.co;2-4
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journal_title:Depression and anxiety
pub_type: 杂志文章,评审
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更新日期:2001-01-01 00:00:00
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abstract:BACKGROUND:Controversy surrounds the question of whether agoraphobia (AG) exists as an independent diagnostic entity apart from panic. In favor of this position, AG without panic disorder (PD) in parents was found being unrelated to offsprings' risk for AG or PD, albeit it may enhance the familial transmission of PD (N...
journal_title:Depression and anxiety
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更新日期:2012-11-01 00:00:00