Abstract:
:Placebo-controlled trials have evaluated the efficacy of several medications in the treatment of social anxiety disorder but information regarding their relative efficacy is lacking. We compared the efficacy of medications systematically studied for the treatment of social anxiety disorder using meta-analytic techniques. The methodology included a database search of articles published between January 1980 and June 2001 and manual searches of bibliographies in published manuscripts. Trials were included if they reported outcome data on the Liebowitz Social Anxiety Scale (LSAS) or a categorical measure of responder status. Data were extracted independently by two authors. The Q statistic was used to assess homogeneity across trials. All analyses were conducted using intent-to-treat data. There was substantial heterogeneity across trials. The medications with largest effect sizes were phenelzine [effect size, 1.02; 95% Confidence Interval (CI), 0.52-1.52], clonazepam (effect size, 0.97; 95% CI, 0.49-1.45), gabapentin (effect size, 0.78; 95% CI, 0.29-1.27), brofaromine (effect size, 0.66; 95% CI, 0.38-0.94), and the selective serotonin reuptake inhibitors (SSRIs; effect size, 0.65; 95% CI, 0.50-0.81). There were no statistically significant differences between medications or medication groups. However, formal methods of interim monitoring adapted for meta-analyses suggested strongest evidence of efficacy for SSRIs and brofaromine. Several medications are efficacious for the treatment of social anxiety disorder. The stability of the SSRI effect size estimate in conjunction with other evidence for safety and tolerability and their ability to treat comorbid conditions supports the use of SSRIs as the first-line treatment. Direct comparisons of SSRIs vs. other promising medications deserve consideration.
journal_name
Depress Anxietyjournal_title
Depression and anxietyauthors
Blanco C,Schneier FR,Schmidt A,Blanco-Jerez CR,Marshall RD,Sánchez-Lacay A,Liebowitz MRdoi
10.1002/da.10096subject
Has Abstractpub_date
2003-01-01 00:00:00pages
29-40issue
1eissn
1091-4269issn
1520-6394journal_volume
18pub_type
杂志文章,meta分析abstract:BACKGROUND:Posttraumatic stress disorder (PTSD) is associated with significant health risk, illness, and functional impairment, e.g., Green and Kimerling [2004: Physical Health Consequences of Exposure to Extreme Stress. Washington, DC: American Psychological Association] Kimerling et al. [2000: Trauma and Health: J Tr...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20518
更新日期:2009-01-01 00:00:00
abstract::It is well known that insomnia is more frequent in women than in men throughout all age groups. In this respect insomnia resembles other psychiatric disorders that occur more frequently in women such as anxiety and depressive disorders. Since insomnia is frequently a symptom of anxiety and depression, it remains an op...
journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.10101
更新日期:2003-01-01 00:00:00
abstract::Pramipexole, a dopamine D2 receptor agonist, was tested in 174 patients with major depression, with or without melancholia and without psychotic features. Three daily dose levels (0.375 mg, 1.0 mg, and 5.0 mg) were compared to fluoxetine (Prozac) at 20 mg and placebo in a randomized, double-blind, parallel-group study...
journal_title:Depression and anxiety
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/(sici)1520-6394(2000)11:2<58::aid-da2>3.0.
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Although a large body of empirical research has examined negative psychological outcomes in older veterans, relatively little is known about the prevalence and determinants of psychological resilience in this population. METHODS:A nationally representative sample of 2,025 U.S. veterans aged 60 and older (me...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22083
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Amygdala-prefrontal cortex (PFC) functional connectivity may be influenced by anxiety and development. A prior study on anxiety found age-specific dysfunction in the ventromedial PFC (vmPFC), but not amygdala, associated with threat-safety discrimination during extinction recall (Britton et al.). However, tr...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22470
更新日期:2016-10-01 00:00:00
abstract::Acute grief is emotionally intense, cognitively preoccupying, and disruptive, but grief is not an illness; major depression and anxiety disorders are. Grief and mourning have a purpose. They provide an intense, focused opportunity to reregulate emotion and to engage in a learning process that is aimed at reconfiguring...
journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.21963
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Accumulating evidence suggests that posttraumatic stress disorder (PTSD) is associated with disrupted default mode network (DMN) connectivity, but findings across studies have not been uniform. Individual differences in relevant genes may account for some of the reported variability in the relationship betwe...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22633
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Obsessive-compulsive disorder (OCD) is a heterogeneous condition, which can be expressed as various potentially overlapping symptom dimensions. In clinical samples, some of these dimensions are associated with increased familial risk for OCD and appear to be familial (intercorrelated within pairs of affected...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20606
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Preliminary evidence suggests intravenous ketamine has rapid effects on suicidal cognition, making it an attractive candidate for depressed patients at imminent risk of suicide. In the first randomized controlled trial of ketamine using an anesthetic control condition, we tested ketamine's acute effects on e...
journal_title:Depression and anxiety
pub_type: 杂志文章,随机对照试验
doi:10.1002/da.22253
更新日期:2014-04-01 00:00:00
abstract::This study examined sex differences in the use of coping strategies and their relationship to depression and anxiety-related psychopathology. Responses on measures of coping strategies, depression, and anxiety were obtained from a carefully screened nonclinical sample (N = 107). The results demonstrated that women who...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20341
更新日期:2008-01-01 00:00:00
abstract::The psychometric properties of the Social Phobia Anxiety Inventory (SPAI) were assessed in a sample of participants who either had a primary diagnosis of social phobia or were normal volunteers. Positive evidence was obtained on the SPAI's concurrent and predictive convergent validity: it was significantly correlated ...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Exposure therapy, a gold-standard treatment for anxiety disorders, is assumed to work via extinction learning, but this has never been tested. Anxious individuals demonstrate extinction learning deficits, likely related to less ventromedial prefrontal cortex (vmPFC) and more amygdala activation, but the rela...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22583
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Little is known regarding changes in the hypothalamic-pituitary-adrenal axis (HPA axis) of adolescent girls with and without posttraumatic stress disorder (PTSD) who have recently experienced sexual abuse. Therefore, in this pilot study, we utilized non-stressed home saliva collection three times a day for t...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22154
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:There is evidence that negative affect (NA) and anxiety sensitivity (AS) predict the development of anxiety disorders, particularly panic disorder (PD). The main purpose of this study was to examine whether NA and AS will also predict the clinical course of PD. METHODS:Participants were 136 individuals with...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20423
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:To examine (1) clinically relevant anxiety with comorbid depression in an older population, and the presentation of subthreshold symptoms; (2) to assess anxiety and levels of comorbid depression associated with migration, religion, loneliness and long-term illness. METHODS:Analysis of Wave 1 of The Irish Lon...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22893
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:There is a growing body of literature suggesting that panic attacks without panic disorder are associated with increases in a wide range of psychopathology and impairment. However, the majority of the literature to date has been cross-sectional. Some longitudinal research supports the view that panic attacks...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20809
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:Depression and substance use disorders (SUDs) commonly co-occur, which presents diagnostic challenges in classifying independent major depressive disorder (MDD) versus substance-induced depressive disorder (SIDD). It remains unclear if distinct characteristics and/or patterns in temporal course distinguish M...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22122
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:The impact of childhood adversity persists across the life course. This study aimed to investigate the associations of childhood adversity with the course, suicidality, and treatment outcomes of depressive disorders. METHOD:A total of 919 people with depressive disorders were recruited. Childhood adversities...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22088
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:The clinical presentation of panic disorder (PD) is known to be highly heterogeneous, complicating research on its etiology, neurobiological pathways, and treatment. None of the attempts to identify PD subtypes have been independently reproduced, rendering the current literature inconclusive. METHODS:Using ...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22379
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Although numerous studies have examined the role of latent predispositions to internalizing and externalizing disorders in the structure of comorbidity among common mental disorders, none examined latent predispositions in predicting development of comorbidity. METHODS:A novel method was used to study the r...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20760
更新日期:2011-01-01 00:00:00
abstract::Participants with generalized social phobia (GSP) with (n=36) and without (n=19) avoidant personality disorder (AVPD) were compared via contrasts of group means and classification analysis on purported core features of AVPD. GSP-AVPD participants proved to be more severely impaired or distressed on some group contrast...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20266
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Collectively, functional neuroimaging studies implicate frontal-limbic dysfunction in the pathophysiology of posttraumatic stress disorder (PTSD), as reflected by altered amygdala reactivity and deficient prefrontal responses. These neural patterns are often elicited by social signals of threat (fearful/angr...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22243
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Women are at an increased risk of depression and other mental health problems following rape. Various etiological factors for depression, including predisposing genetic factors, have been identified. Telomeres are repetitive nucleoprotein structures located at chromosomal ends that protect them from prematur...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20903
更新日期:2011-12-21 00:00:00
abstract:BACKGROUND:Anticipatory anxiety can be described as a conditioned response with a defensive posture of freezing and autonomic activation. The purpose of this study was to assess the postural control analysis and autonomic activation in panic disorder (PD) patients presented with visual stimuli. METHODS:PD patients (n=...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20593
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Socioeconomic deprivation is associated with higher prevalence of mental health problems; however, the influence of socioeconomic status (SES) on psychological therapy outcomes is as yet unclear. AIM:To review published evidence on the association between indicators of SES (income, education, employment, ne...
journal_title:Depression and anxiety
pub_type: 杂志文章,meta分析,评审
doi:10.1002/da.22765
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:To determine the factors, which are associated with suicidal ideation and ideas of self-harm in patients with congestive heart failure (CHF). METHODS:We examined 294 patients with documented CHF, New York Heart Association (NYHA) functional class II-IV, in a cross sectional study at three cardiac outpatient ...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20587
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Dimensional assessments are planned to be included as supplements to categorical diagnoses in DSM-V. The aim of this study was to examine the unidimensionality, reliability, validity, and clinical sensitivity of brief self-rated scales for specific anxiety disorders in an unselected German sample of consecut...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.21994
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Psychosocial factors, including religious coping, consistently have been implicated in the expression of anxiety disorders. This study sought to investigate the relationship between religious coping on anxiety symptoms among a nonclinical sample of African American and European American young adults. METHOD...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20510
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Understanding cognitive and biological mechanisms of PTSD treatment can help refine treatments and increase rates of response. METHODS:Thirty-six veterans with PTSD were randomly assigned to receive Prolonged exposure therapy (PE) or Present-Centered therapy (PCT). We examined symptoms, trauma-related cogni...
journal_title:Depression and anxiety
pub_type: 杂志文章,随机对照试验
doi:10.1002/da.22331
更新日期:2015-03-01 00:00:00
abstract::The increased risk of physical health problems in adult depressed patients has been shown in numerous studies. A recent study of the offspring of depressed parents found similar associations. The purpose of this study is to examine the strength and specificity of the association between depression and physical health ...
journal_title:Depression and anxiety
pub_type: 临床试验,杂志文章
doi:
更新日期:1999-01-01 00:00:00