Sex differences in DNA methylation may contribute to risk of PTSD and depression: a review of existing evidence.

Abstract:

:There are well-established sex differences in the prevalence of certain mental disorders. Work in animal models has provided us with an emerging understanding of the role that epigenetic factors play in establishing sex differences in the brain during development. Similarly, work in animal models, and a more limited but growing literature based on human studies, has demonstrated that DNA methylation (DNAm) changes occur in response to environmental stress, with some of these occurring in a sex-specific manner. In this review, we explore whether DNAm plays a role in contributing to the observed sex differences in prevalence of mental disorders in which stress contributes significantly to their etiologies, specifically posttraumatic stress disorder (PTSD) and depression. We propose that investigating sex differences in DNAm among genes known to influence brain development may help to shed light on the sexually dimorphic risk for, or resilience to, developing PTSD and depression.

journal_name

Depress Anxiety

journal_title

Depression and anxiety

authors

Uddin M,Sipahi L,Li J,Koenen KC

doi

10.1002/da.22167

subject

Has Abstract

pub_date

2013-12-01 00:00:00

pages

1151-60

issue

12

eissn

1091-4269

issn

1520-6394

journal_volume

30

pub_type

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