Unguided Internet-based cognitive-behavioral therapy for obsessive-compulsive disorder: A randomized controlled trial.

Abstract:

BACKGROUND:Many individuals with obsessive-compulsive disorder (OCD) do not receive professional treatment due to various idiosyncratic barriers. Internet-based cognitive-behavioral therapy (iCBT) is increasingly used to narrow treatment gaps, but the efficacy of such interventions without guidance of therapists has not been well studied. This study evaluated the efficacy of an unguided iCBT that includes third-wave approaches for the treatment of OCD symptoms. METHODS:A total of 128 individuals with self-reported OCD symptoms were randomly allocated to either an intervention group (unguided iCBT) or to a care-as-usual (CAU) control group following an anonymous baseline assessment via an online survey. Eight weeks after inclusion, a reassessment was carried out online. The Yale-Brown Obsessive-Compulsive Scale served as the primary outcome parameter for detecting symptom changes in the per-protocol sample with at least 60 minutes utilization. RESULTS:The iCBT group showed a significantly stronger reduction of OCD symptoms with a medium effect size (η²p  = 0.06) compared with the control condition. This effect was moderated by the general frequency of Internet usage (η²p  = 0.08); the more time per day users spent online, the less they benefited from the intervention. Secondary outcomes revealed (1) a medium effect size on self-esteem (η²p  = 0.06); (2) no statistically significant effects on quality of life, depression symptoms, impulsivity, or social insecurity; and (3) good acceptability of the intervention. CONCLUSIONS:The current study provides evidence that unguided iCBT for OCD may be a viable option for individuals who experience treatment barriers. As non-compliance remains a challenge, this topic needs further research.

journal_name

Depress Anxiety

journal_title

Depression and anxiety

authors

Schröder J,Werkle N,Cludius B,Jelinek L,Moritz S,Westermann S

doi

10.1002/da.23105

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

1208-1220

issue

12

eissn

1091-4269

issn

1520-6394

journal_volume

37

pub_type

杂志文章,随机对照试验
  • Depression and smoking: a 5-year prospective study of patients with major depressive disorder.

    abstract:BACKGROUND:Major depressive disorder (MDD) and smoking are major public health problems and epidemiologically strongly associated. However, the relationship between smoking and depression and whether this is influenced by common confounding factors remain unclear, in part due to limited longitudinal data on covariation...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22108

    authors: Holma IA,Holma KM,Melartin TK,Ketokivi M,Isometsä ET

    更新日期:2013-06-01 00:00:00

  • Comparison of severe life stress in depressed mothers and non-mothers: do children matter?

    abstract::Given the high rates of maladjustment among children of depressed mothers, parenting is likely to cause significant life stress in this population, potentially worsening the course of mothers' depression. The present study is a comparison of severe life stress in 38 mothers and 62 non-mothers receiving treatment for r...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.1026

    authors: Feske U,Shear MK,Anderson B,Cyranowski J,Strassburger M,Matty M,Luther J,Frank E

    更新日期:2001-01-01 00:00:00

  • Executive control of attention in individuals with contamination-related obsessive-compulsive symptoms.

    abstract:BACKGROUND:In this study, we examined executive control of attention in individuals with contamination-related obsessive-compulsive (OC) symptoms using a modified version of the Eriksen flanker task. The task indexes one's ability to resolve attentional conflict between different responses and to ignore task distracter...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20703

    authors: Najmi S,Hindash AC,Amir N

    更新日期:2010-09-01 00:00:00

  • Successful medication withdrawal after cognitive-behavioral therapy in a treatment-resistant preadolescent male with obsessive-compulsive disorder.

    abstract::There are no reports of a child taking a selective serotonin reuptake inhibitor and an atypical anti-psychotic being successfully tapered from these medications after completion of cognitive-behavioral therapy (CBT) for obsessive-compulsive disorder. With this in mind, we report the case of an 8.5-year-old male who wa...

    journal_title:Depression and anxiety

    pub_type: 信件

    doi:10.1002/da.20448

    authors: Goldstein RB,Storch EA,Lehmkuhl H,Geffken GR,Goodman WK,Murphy TK

    更新日期:2009-01-01 00:00:00

  • A double-blind, randomized, placebo-controlled, fixed-dose phase III study of vilazodone in patients with generalized anxiety disorder.

    abstract:BACKGROUND:Vilazodone, a selective serotonin reuptake inhibitor and 5-HT1A receptor partial agonist, is approved for treating major depressive disorder in adults. This study (NCT01629966 ClinicalTrials.gov) evaluated the efficacy and safety of vilazodone in adults with generalized anxiety disorder (GAD). METHODS:A mul...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/da.22365

    authors: Gommoll C,Durgam S,Mathews M,Forero G,Nunez R,Tang X,Thase ME

    更新日期:2015-06-01 00:00:00

  • LETHAL MEANS ACCESS AND ASSESSMENT AMONG SUICIDAL EMERGENCY DEPARTMENT PATIENTS.

    abstract:BACKGROUND:Reducing access to lethal means (especially firearms) might prevent suicide, but counseling of at-risk individuals about this strategy may not be routine. Among emergency department (ED) patients with suicidal ideation or attempts (SI/SA), we sought to describe home firearm access and examine ED provider ass...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22486

    authors: Betz ME,Miller M,Barber C,Beaty B,Miller I,Camargo CA Jr,Boudreaux ED

    更新日期:2016-06-01 00:00:00

  • Exploring potential associations of suicidal ideation and ideas of self-harm in patients with congestive heart failure.

    abstract:OBJECTIVE:To determine the factors, which are associated with suicidal ideation and ideas of self-harm in patients with congestive heart failure (CHF). METHODS:We examined 294 patients with documented CHF, New York Heart Association (NYHA) functional class II-IV, in a cross sectional study at three cardiac outpatient ...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20587

    authors: Lossnitzer N,Müller-Tasch T,Löwe B,Zugck C,Nelles M,Remppis A,Haass M,Rauch B,Jünger J,Herzog W,Wild B

    更新日期:2009-01-01 00:00:00

  • Psychotic symptoms in first-episode and drug naïve patients with major depressive disorder: Prevalence and related clinical factors.

    abstract:BACKGROUND:Many patients with major depressive disorder (MDD) have been found to have psychotic symptoms. However, few studies have reported the prevalence of comorbid psychotic symptoms in first-episode drug naïve (FEDN) MDD patients. This study was to investigate the prevalence of psychotic symptoms and related risk ...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.23026

    authors: Shen Y,Wei Y,Yang XN,Zhang G,Du X,Jia Q,Zhu X,Ma Y,Lang X,Luo X,Zhang XY

    更新日期:2020-08-01 00:00:00

  • Focal and aberrant prefrontal engagement during emotion regulation in veterans with posttraumatic stress disorder.

    abstract:BACKGROUND:Collectively, functional neuroimaging studies implicate frontal-limbic dysfunction in the pathophysiology of posttraumatic stress disorder (PTSD), as reflected by altered amygdala reactivity and deficient prefrontal responses. These neural patterns are often elicited by social signals of threat (fearful/angr...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22243

    authors: Rabinak CA,MacNamara A,Kennedy AE,Angstadt M,Stein MB,Liberzon I,Phan KL

    更新日期:2014-10-01 00:00:00

  • Cortisol awakening response in adolescents with acute sexual abuse related posttraumatic stress disorder.

    abstract:BACKGROUND:Little is known regarding changes in the hypothalamic-pituitary-adrenal axis (HPA axis) of adolescent girls with and without posttraumatic stress disorder (PTSD) who have recently experienced sexual abuse. Therefore, in this pilot study, we utilized non-stressed home saliva collection three times a day for t...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22154

    authors: Keeshin BR,Strawn JR,Out D,Granger DA,Putnam FW

    更新日期:2014-02-01 00:00:00

  • Behavior and emotion modulation deficits in preschoolers at risk for bipolar disorder.

    abstract:BACKGROUND:Bipolar disorder (BD) is highly familial, but studies have yet to examine preschoolers at risk for BD using standardized, developmentally appropriate clinical assessment tools. We used such methods to test whether preschoolers at familial risk for BD have more observed difficulty modulating emotions and beha...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22342

    authors: Tseng WL,Guyer AE,Briggs-Gowan MJ,Axelson D,Birmaher B,Egger HL,Helm J,Stowe Z,Towbin KA,Wakschlag LS,Leibenluft E,Brotman MA

    更新日期:2015-05-01 00:00:00

  • Associations between systemic inflammation and somatic depressive symptoms: Findings from the Moli-sani study.

    abstract:BACKGROUND:The link between systemic inflammation and depression has been deeply investigated, but relatively few studies explored symptom-specific associations, mostly focusing on common inflammatory biomarkers like C-reactive protein (CRP) levels. METHODS:We investigated associations of low-grade inflammation with d...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.23070

    authors: Gialluisi A,Di Castelnuovo A,Bracone F,De Curtis A,Cerletti C,Donati MB,de Gaetano G,Iacoviello L

    更新日期:2020-09-01 00:00:00

  • Treatment of severe depression with the selective serotonin reuptake inhibitors.

    abstract::The selective serotonin reuptake inhibitors (SSRIs) are recognized as effective as and better tolerated than older antidepressant therapies and have become the drugs of choice in the treatment of mild to moderate depression. However, there is a clinical impression that the SSRIs are less effective than older therapies...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,评审

    doi:10.1002/(SICI)1520-6394(1996)4:4<182::AID-DA4>3.0.

    authors: Schatzberg AF

    更新日期:1996-01-01 00:00:00

  • Quality of web-based information on social phobia: a cross-sectional study.

    abstract::The objective of the study is to evaluate the quality of web-based information on social phobia and to investigate particular quality indicators. Two keywords, "Social phobia" and "Social Anxiety Disorder", were entered into five popular World Wide Web search engines. Websites were assessed with a standardized proform...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20381

    authors: Khazaal Y,Fernandez S,Cochand S,Reboh I,Zullino D

    更新日期:2008-01-01 00:00:00

  • Recurrence of major depressive episodes is strongly dependent on the number of previous episodes.

    abstract:BACKGROUND:A history of past major depressive episodes (MDEs) is known to be a risk factor for future MDEs. Additional information about the relationship between past and future episodes would be useful in clinical practice, it is therefore important to fully understand the epidemiology of major depression. We asked wh...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22173

    authors: Bulloch A,Williams J,Lavorato D,Patten S

    更新日期:2014-01-01 00:00:00

  • Acute stress disorder versus chronic posttraumatic stress disorder: inhibition of fear as a function of time since trauma.

    abstract:BACKGROUND:Previous work has shown that inhibition of fear is impaired in posttraumatic stress disorder (PTSD) resulting from both civilian and combat trauma. The purpose of the present study was to investigate the inhibition of learned fear in traumatized individuals diagnosed with either acute stress disorder (ASD) o...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.21991

    authors: Jovanovic T,Sakoman AJ,Kozarić-Kovačić D,Meštrović AH,Duncan EJ,Davis M,Norrholm SD

    更新日期:2013-03-01 00:00:00

  • Race and religion: differential prediction of anxiety symptoms by religious coping in African American and European American young adults.

    abstract:BACKGROUND:Psychosocial factors, including religious coping, consistently have been implicated in the expression of anxiety disorders. This study sought to investigate the relationship between religious coping on anxiety symptoms among a nonclinical sample of African American and European American young adults. METHOD...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20510

    authors: Chapman LK,Steger MF

    更新日期:2010-03-01 00:00:00

  • Getting straight about grief.

    abstract::Acute grief is emotionally intense, cognitively preoccupying, and disruptive, but grief is not an illness; major depression and anxiety disorders are. Grief and mourning have a purpose. They provide an intense, focused opportunity to reregulate emotion and to engage in a learning process that is aimed at reconfiguring...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,评审

    doi:10.1002/da.21963

    authors: Shear MK

    更新日期:2012-06-01 00:00:00

  • Prevalence and risk factors for posttraumatic stress disorder: a cross-sectional study among survivors of the Wenchuan 2008 earthquake in China.

    abstract:BACKGROUND:The impact of the May 2008 Wenchuan earthquake, measuring a massive 8.0 on the surface wave magnitude scale, on public health in China has been significant and multifaceted. In light of extant data on prevalence and risk factors for posttraumatic stress disorder (PTSD) after other natural diasters, we collec...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20612

    authors: Kun P,Han S,Chen X,Yao L

    更新日期:2009-01-01 00:00:00

  • RGS2 and generalized anxiety disorder in an epidemiologic sample of hurricane-exposed adults.

    abstract:BACKGROUND:Generalized anxiety disorder (GAD) is a common and sometimes disabling condition often associated with stressful life events that involve significant loss or danger. The disorder appears moderately heritable. Polymorphisms in the RGS2 (regulator of G-protein signaling 2) gene were recently associated with an...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20528

    authors: Koenen KC,Amstadter AB,Ruggiero KJ,Acierno R,Galea S,Kilpatrick DG,Gelernter J

    更新日期:2009-01-01 00:00:00

  • Symptoms of anxiety in depression: assessment of item performance of the Hamilton Anxiety Rating Scale in patients with depression.

    abstract:BACKGROUND:Although diagnostically dissociable, anxiety is strongly co-morbid with depression. To examine further the clinical symptoms of anxiety in major depressive disorder (MDD), a non-parametric item response analysis on "blinded" data from four pharmaceutical company clinical trials was performed on the Hamilton ...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20435

    authors: Vaccarino AL,Evans KR,Sills TL,Kalali AH

    更新日期:2008-01-01 00:00:00

  • Competitive memory training (COMET) for treating low self-esteem in patients with depressive disorders: a randomized clinical trial.

    abstract:BACKGROUND:Self-esteem is a major concern in mood disorders. Low self-esteem is a symptom of depressive disorders and is considered by some to be a predictor for relapse, whereas high self-esteem seems to buffer against depression. Recently, Competitive Memory Training (COMET) has shown to be effective for the enhancem...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/da.20921

    authors: Korrelboom K,Maarsingh M,Huijbrechts I

    更新日期:2012-02-01 00:00:00

  • CHRONICITY OF DEPRESSION AND MOLECULAR MARKERS IN A LARGE SAMPLE OF HAN CHINESE WOMEN.

    abstract:BACKGROUND:Major depressive disorder (MDD) has been associated with changes in mean telomere length and mitochondrial DNA (mtDNA) copy number. This study investigates if clinical features of MDD differentially impact these molecular markers. METHODS:Data from a large, clinically ascertained sample of Han Chinese women...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22517

    authors: Edwards AC,Aggen SH,Cai N,Bigdeli TB,Peterson RE,Docherty AR,Webb BT,Bacanu SA,Flint J,Kendler KS

    更新日期:2016-11-01 00:00:00

  • Predictors of PTSD 40 years after combat: Findings from the National Vietnam Veterans longitudinal study.

    abstract:BACKGROUND:Few studies have longitudinally examined predictors of posttraumatic stress disorder (PTSD) in a nationally representative sample of US veterans. We examined predictors of warzone-related PTSD over a 25-year span using data from the National Vietnam Veterans Longitudinal Study (NVVLS). METHODS:The NVVLS is ...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22628

    authors: Steenkamp MM,Schlenger WE,Corry N,Henn-Haase C,Qian M,Li M,Horesh D,Karstoft KI,Williams C,Ho CL,Shalev A,Kulka R,Marmar C

    更新日期:2017-08-01 00:00:00

  • Panic disorder: a review of DSM-IV panic disorder and proposals for DSM-V.

    abstract::This review covers the literature since the publication of DSM-IV on the diagnostic criteria for panic attacks (PAs) and panic disorder (PD). Specific recommendations are made based on the evidence available. In particular, slight changes are proposed for the wording of the diagnostic criteria for PAs to ease the diff...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,评审

    doi:10.1002/da.20654

    authors: Craske MG,Kircanski K,Epstein A,Wittchen HU,Pine DS,Lewis-Fernández R,Hinton D,DSM V Anxiety.,OC Spectrum.,Posttraumatic and Dissociative Disorder Work Group.

    更新日期:2010-02-01 00:00:00

  • Distinct associations of computer/mobile devices use and TV watching with depressive symptoms in adults: A large population study in China.

    abstract:BACKGROUND:Recent evidence shows that screen time may be an important risk factor for mental health. The aim of this study was to examine the association of computer/mobile devices (CMD) use and TV watching separately with depressive symptoms in a large representative sample of Chinese adults. METHODS:A sample of 18,9...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22932

    authors: Yu B,Gu Y,Bao X,Meng G,Wu H,Zhang Q,Liu L,Sun S,Wang X,Zhou M,Jia Q,Song K,Niu K

    更新日期:2019-09-01 00:00:00

  • Do anxiety and depression cluster into distinct groups?: a test of tripartite model predictions in a community sample of youth.

    abstract::Because of their high comorbidity and strong associations, the distinctiveness of anxiety and depression in youth continues to be debated. In this study we used cluster analysis in a community sample (n=225) of youth to test tripartite model predictions regarding the grouping of individuals based on their levels of an...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20215

    authors: Cannon MF,Weems CF

    更新日期:2006-01-01 00:00:00

  • The role of psychiatric, cardiometabolic, and musculoskeletal comorbidity in the recurrence of depression-related work disability.

    abstract:BACKGROUND:Comorbid psychiatric disorders, cardiovascular disease, chronic hypertension, diabetes, and musculoskeletal disorders are highly prevalent in depression. However, the extent to which these conditions affect the recurrence of depression-related work disability is unknown. The specific aims of the study were t...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22286

    authors: Ervasti J,Vahtera J,Pentti J,Oksanen T,Ahola K,Kivekäs T,Kivimäki M,Virtanen M

    更新日期:2014-09-01 00:00:00

  • Depression and Alzheimer's disease.

    abstract::Depressive symptoms, due either major depression or clinically significant, subsyndromal depression, occur commonly in the course of Alzheimer's disease. For a variety of clinical and methodological reasons, this remains an area that begs for new investigation. At the very least, these depressive symptoms should be vi...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,评审

    doi:

    authors: Tune LE

    更新日期:1998-01-01 00:00:00

  • The role of comorbid anxiety in exercise and depression trials: Secondary analysis of the SMILE-II randomized clinical trial.

    abstract:OBJECTIVES:To explore the anxiolytic effects of a 4-month randomized, placebo-controlled trial of exercise and antidepressant medication in patients with major depressive disorder (MDD), and to examine the potential modifying effects of anxiety in treating depressive symptoms. MATERIALS AND METHODS:In this secondary a...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.23088

    authors: Blumenthal JA,Babyak MA,Craighead WE,Davidson J,Hinderliter A,Hoffman B,Doraiswamy PM,Sherwood A

    更新日期:2020-08-12 00:00:00