Abstract:
BACKGROUND:Panic disorder (PD) is highly comorbid with major depressive disorder (MDD) with potential impact on patient-reported outcomes of quality of life (QOL), functioning, and depressive symptom severity. METHODS:Using data from the sequenced treatment alternatives to relieve depression (STAR*D) trial, we compared entry and post-SSRI-treatment QOL, functioning, and depressive symptom severity scores in MDD patients with comorbid PD (MDD+PD) to MDD patients without PD (MDDnoPD). We also compared pre- and posttreatment proportions of patients with severe impairments in quality of life and functioning. RESULTS:MDD+PD patients experienced significantly lower QOL and functioning and more severe depressive symptoms than MDDnoPD patients at entry. Following treatment with citalopram, both groups showed significant improvements, however, nearly 30-60% of patients still suffered from severe quality of life and functioning impairments. MDD+PD patients exited with lower QOL and functioning than MDDnoPD patients, a difference that became statistically insignificant after adjusting for baseline measures of depressive symptom severity, functioning, and QOL, comorbid anxiety disorders (PTSD, GAD, social, and specific phobias), age, and college education. CONCLUSIONS:Functional outcomes using QOL and functioning measures should be utilized in treating and researching MDD so that shortfalls in traditional treatment can be identified and additional interventions can be designed to address severe baseline QOL and functioning deficits in MDD comorbid with PD.
journal_name
Depress Anxietyjournal_title
Depression and anxietyauthors
IsHak WW,Mirocha J,Christensen S,Wu F,Kwock R,Behjat J,Pi S,Akopyan A,Peselow ED,Cohen RM,Elashoff Ddoi
10.1002/da.22152subject
Has Abstractpub_date
2014-08-01 00:00:00pages
707-16issue
8eissn
1091-4269issn
1520-6394journal_volume
31pub_type
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journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.20177
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abstract:BACKGROUND:Many patients with major depressive disorder (MDD) have been found to have psychotic symptoms. However, few studies have reported the prevalence of comorbid psychotic symptoms in first-episode drug naïve (FEDN) MDD patients. This study was to investigate the prevalence of psychotic symptoms and related risk ...
journal_title:Depression and anxiety
pub_type: 杂志文章
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journal_title:Depression and anxiety
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journal_title:Depression and anxiety
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doi:10.1002/da.20448
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journal_title:Depression and anxiety
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journal_title:Depression and anxiety
pub_type: 杂志文章
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journal_title:Depression and anxiety
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/da.22365
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journal_title:Depression and anxiety
pub_type: 杂志文章
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journal_title:Depression and anxiety
pub_type: 杂志文章
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journal_title:Depression and anxiety
pub_type: 杂志文章,多中心研究
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20001
更新日期:2004-01-01 00:00:00
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journal_title:Depression and anxiety
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20636
更新日期:2010-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22517
更新日期:2016-11-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22557
更新日期:2017-02-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22845
更新日期:2019-02-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
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journal_title:Depression and anxiety
pub_type: 杂志文章,评审
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journal_title:Depression and anxiety
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更新日期:2011-09-01 00:00:00
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journal_title:Depression and anxiety
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:
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更新日期:2009-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2019-02-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Depression and anxiety
pub_type: 杂志文章,随机对照试验
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journal_title:Depression and anxiety
pub_type: 临床试验,杂志文章
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更新日期:1999-01-01 00:00:00
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journal_title:Depression and anxiety
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journal_title:Depression and anxiety
pub_type: 临床试验,杂志文章
doi:
更新日期:1999-01-01 00:00:00