Atypical depression, atypical temperament and a differential antidepressant response to fluoxetine and nortriptyline.

Abstract:

:We examined the personality characteristics of depressed patients with and without atypical depression. Of 195 depressed outpatients in a randomized treatment trial of fluoxetine or nortriptyline, 16 met DSM-IV criteria for atypical depression. We compared the personality traits and disorders in those with and without atypical depression. In atypical depression, fluoxetine was superior to nortriptyline. On the Temperament and Character Inventory, those with atypical depression had high attachment, low persistence, and high anticipatory anxiety. A temperament construct of these dimensions was associated with a differential antidepressant response, regardless of other atypical features. A temperament derived measure of "rejection sensitivity" defines a group of depressed patients with a differential antidepressant response, regardless of reversed vegetative symptoms.

journal_name

Depress Anxiety

journal_title

Depression and anxiety

authors

Joyce PR,Mulder RT,McKenzie JM,Luty SE,Cloninger CR

doi

10.1002/da.20001

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

180-6

issue

3

eissn

1091-4269

issn

1520-6394

journal_volume

19

pub_type

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