Abstract:
BACKGROUND:Major depressive disorder (MDD) has been associated with changes in mean telomere length and mitochondrial DNA (mtDNA) copy number. This study investigates if clinical features of MDD differentially impact these molecular markers. METHODS:Data from a large, clinically ascertained sample of Han Chinese women with recurrent MDD were used to examine whether symptom presentation, severity, and comorbidity were related to salivary telomere length and/or mtDNA copy number (maximum N = 5,284 for both molecular and phenotypic data). RESULTS:Structural equation modeling revealed that duration of longest episode was positively associated with mtDNA copy number, while earlier age of onset of most severe episode and a history of dysthymia were associated with shorter telomeres. Other factors, such as symptom presentation, family history of depression, and other comorbid internalizing disorders, were not associated with these molecular markers. CONCLUSIONS:Chronicity of depressive symptoms is related to more pronounced telomere shortening and increased mtDNA copy number among individuals with a history of recurrent MDD. As these molecular markers have previously been implicated in physiological aging and morbidity, individuals who experience prolonged depressive symptoms are potentially at greater risk of adverse medical outcomes.
journal_name
Depress Anxietyjournal_title
Depression and anxietyauthors
Edwards AC,Aggen SH,Cai N,Bigdeli TB,Peterson RE,Docherty AR,Webb BT,Bacanu SA,Flint J,Kendler KSdoi
10.1002/da.22517subject
Has Abstractpub_date
2016-11-01 00:00:00pages
1048-1054issue
11eissn
1091-4269issn
1520-6394journal_volume
33pub_type
杂志文章abstract::Age at onset is an important dimension in the classification of mood disorders. Recent findings on early-onset (EO) versus late-onset (LO) unipolar chronic depressions support this subtyping. The aim of the present study was to determine clinical differences between EO and LO bipolar II chronic depression and to suppo...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/1520-6394(2001)13:1<45::aid-da7>3.0.co;2-4
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Understanding cognitive and biological mechanisms of PTSD treatment can help refine treatments and increase rates of response. METHODS:Thirty-six veterans with PTSD were randomly assigned to receive Prolonged exposure therapy (PE) or Present-Centered therapy (PCT). We examined symptoms, trauma-related cogni...
journal_title:Depression and anxiety
pub_type: 杂志文章,随机对照试验
doi:10.1002/da.22331
更新日期:2015-03-01 00:00:00
abstract::The objective was to present naturalistic 1-year follow-up information of 96 child and adolescent outpatients with major depressive disorder who had been randomized in an 8-week double-blind, placebo-controlled trial of fluoxetine. Subjects were children and adolescents, ages 8-18 years, who were entered in a randomiz...
journal_title:Depression and anxiety
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/(sici)1520-6394(1998)7:1<32::aid-da4>3.0.c
更新日期:1998-01-01 00:00:00
abstract::The diagnosis of anxiety disorders and major depression can be reliably made based on signs and symptoms. However there are significant limitations to the current system of classification including overlapping criteria, high comorbidity, and the issue of subthreshold syndromes. The literature on treatment response doc...
journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.1049
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abstract:BACKGROUND:Metacognitive therapy (MCT) is a relatively new approach to treating mental disorders. The aim of the current meta-analysis was to examine the efficacy of MCT in patients with mental disorders. METHOD:A comprehensive literature search revealed 16 published as well as unpublished studies on the efficacy of M...
journal_title:Depression and anxiety
pub_type: 杂志文章,meta分析
doi:10.1002/da.22273
更新日期:2014-05-01 00:00:00
abstract::Pediatric psychopharmacology is hindered by the relative lack of controlled, empirical clinical trials [Shatzberg and Nemeroff, 1998: Washington, D.C.: The American Psychiatric Press, Inc. p 301-306]. Psychiatric disorders in children and adolescents carry considerable morbidity, impede development, and carry a signif...
journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/1520-6394(2000)12:1+<85::AID-DA12>3.0.CO;2
更新日期:2000-01-01 00:00:00
abstract::The purpose of this study was to correlate subjective sleep characteristics based on questionnaire response, and objective sleep EEG features based on polysomnography, in 52 patients with major depressive disorders (MDD) and 49 healthy controls. With the exception of the number of awakenings, subjective and objective ...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/(sici)1520-6394(1997)5:2<97::aid-da6>3.0.c
更新日期:1997-01-01 00:00:00
abstract::Reports on the severity and reversibility of cognitive disturbances in major depression in the literature diverge due to methodological biases. The present study, using a precise methodology, examined attention and executive functions in 20 relatively young, depressed patients presenting a first or second episode of u...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20060
更新日期:2005-01-01 00:00:00
abstract::Despite emotion regulation being altered in patients with obsessive-compulsive disorder (OCD), no studies have investigated its relation to multimodal amygdala connectivity. We compared corticolimbic functional and structural connectivity between OCD patients and healthy controls (HCs), and correlated this with the di...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22845
更新日期:2019-02-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20231
更新日期:2007-01-01 00:00:00
abstract::This review examines the question of whether there should be a cluster of disorders, including the adjustment disorders (ADs), acute stress disorder (ASD), posttraumatic stress disorder (PTSD), and the dissociative disorders (DDs), in a section devoted to abnormal responses to stress and trauma in the DSM-5. Environme...
journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.20845
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Social anxiety disorder (SAD) is an incapacitating disorder running in families. Previous work associated social fearfulness with a failure to habituate, but the habituation response to neutral faces has, as of yet, not been investigated in patients with SAD and their family members concurrently. Here, we ex...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22962
更新日期:2019-12-01 00:00:00
abstract::Increasing attention has been paid to the role of inflammation in a host of illnesses including neuropsychiatric disorders such as depression and anxiety. Activation of the inflammatory response leads to release of inflammatory cytokines and mobilization of immune cells both of which have been shown to access the brai...
journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.22084
更新日期:2013-04-01 00:00:00
abstract::The use of a placebo run-in phase, in which placebo responders are withdrawn from a study before random assignment to treatment condition, has been criticized as favoring the active treatment in clinical trials. We compared the effect size of randomized, placebo-controlled clinical trials (in the treatment of depressi...
journal_title:Depression and anxiety
pub_type: 杂志文章,meta分析
doi:10.1002/da.10134
更新日期:2004-01-01 00:00:00
abstract::A reclassification of obsessive-compulsive disorder (OCD) into a new diagnostic category spectrum of "obsessive-compulsive spectrum disorders" (OCSDs) has recently been proposed, with considerable debate, for the forthcoming Diagnostic and Statistical Manual-Fifth Edition (DSM-V). This paper provides a critical analys...
journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.20488
更新日期:2008-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22145
更新日期:2014-07-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 临床试验,杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) has shown safety and efficacy for treatment-resistant depression, but requires daily treatment for 4-6 weeks. Accelerated TMS, with all treatments delivered over a few days, would have significant advantages in terms of access and patient acceptance. METHO...
journal_title:Depression and anxiety
pub_type: 临床试验,杂志文章
doi:10.1002/da.20731
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:Many patients with major depressive disorder (MDD) have been found to have psychotic symptoms. However, few studies have reported the prevalence of comorbid psychotic symptoms in first-episode drug naïve (FEDN) MDD patients. This study was to investigate the prevalence of psychotic symptoms and related risk ...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.23026
更新日期:2020-08-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.21960
更新日期:2012-07-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.23101
更新日期:2020-10-14 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.22167
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Major depressive disorder (MDD) and smoking are major public health problems and epidemiologically strongly associated. However, the relationship between smoking and depression and whether this is influenced by common confounding factors remain unclear, in part due to limited longitudinal data on covariation...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22108
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Treatment utilization/costs and work performance for persons with major depressive disorder (MDD) by severity of illness is not well documented. METHODS:Using National Comorbidity Survey-Replication (2001-2002) data, US workforce respondents (n=4,465) were classified by clinical severity (not clinically dep...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20580
更新日期:2010-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20649
更新日期:2010-03-01 00:00:00
abstract::Acute grief is emotionally intense, cognitively preoccupying, and disruptive, but grief is not an illness; major depression and anxiety disorders are. Grief and mourning have a purpose. They provide an intense, focused opportunity to reregulate emotion and to engage in a learning process that is aimed at reconfiguring...
journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.21963
更新日期:2012-06-01 00:00:00
abstract::It is well known that insomnia is more frequent in women than in men throughout all age groups. In this respect insomnia resembles other psychiatric disorders that occur more frequently in women such as anxiety and depressive disorders. Since insomnia is frequently a symptom of anxiety and depression, it remains an op...
journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.10101
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Although several studies have documented a higher prevalence of psychiatric disorders in children of depressed than nondepressed parents, previous research was conducted in predominantly White, middle, or upper-middle class populations. Only limited information is available on psychiatric disorders and psych...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20522
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Recent evidence shows that screen time may be an important risk factor for mental health. The aim of this study was to examine the association of computer/mobile devices (CMD) use and TV watching separately with depressive symptoms in a large representative sample of Chinese adults. METHODS:A sample of 18,9...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22932
更新日期:2019-09-01 00:00:00
abstract::Disrupted sensory filtering, or problems with suppressing irrelevant environmental sensory stimuli, has been reported in individuals with posttraumatic stress disorder (PTSD). However, the relationship of sensory filtering deficits to specific PTSD symptoms versus an association with general trauma exposure is unclear...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20255
更新日期:2008-01-01 00:00:00