Impaired neural habituation to neutral faces in families genetically enriched for social anxiety disorder.

Abstract:

BACKGROUND:Social anxiety disorder (SAD) is an incapacitating disorder running in families. Previous work associated social fearfulness with a failure to habituate, but the habituation response to neutral faces has, as of yet, not been investigated in patients with SAD and their family members concurrently. Here, we examined whether impaired habituation to neutral faces is a putative neurobiological endophenotype of SAD by using data from the multiplex and multigenerational Leiden Family Lab study on SAD. METHODS:Participants (n = 110; age, 9.2 - 61.5 years) performed a habituation paradigm involving neutral faces, as these are strong social stimuli with an ambiguous meaning. We used functional magnetic resonance imaging data to investigate whether brain activation related to habituation was associated with the level of social anxiety within the families. Furthermore, the heritability of the neural habituation response was estimated. RESULTS:Our data revealed a relationship between impaired habituation to neutral faces and social anxiety in the right hippocampus and right amygdala. In addition, our data indicated that this habituation response displayed moderate - to-moderately high heritability in the right hippocampus. CONCLUSION:The present results provide support for altered habituation as a candidate SAD endophenotype; impaired neural habitation cosegregrated with the disorder within families and was heritable. These findings shed light on the genetic susceptibility to SAD.

journal_name

Depress Anxiety

journal_title

Depression and anxiety

authors

Bas-Hoogendam JM,van Steenbergen H,Blackford JU,Tissier RLM,van der Wee NJA,Westenberg PM

doi

10.1002/da.22962

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

1143-1153

issue

12

eissn

1091-4269

issn

1520-6394

journal_volume

36

pub_type

杂志文章
  • Parental Bonding Instrument and the Inventory to Diagnose Depression Lifetime version in a volunteer sample of Japanese workers.

    abstract::This study replicated the factor structure of the Parental Bonding Instrument (PBI), and explored the relationships of PBI scores to demographic variables. We investigated the association between parental bonding in the parents measured by the PBI, and lifetime history of depression in their children assessed by the I...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/(sici)1520-6394(1998)8:2<65::aid-da4>3.0.c

    authors: Uehara T,Sato T,Sakado K,Someya T

    更新日期:1998-01-01 00:00:00

  • Psychological resilience in older U.S. veterans: results from the national health and resilience in veterans study.

    abstract:BACKGROUND:Although a large body of empirical research has examined negative psychological outcomes in older veterans, relatively little is known about the prevalence and determinants of psychological resilience in this population. METHODS:A nationally representative sample of 2,025 U.S. veterans aged 60 and older (me...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22083

    authors: Pietrzak RH,Cook JM

    更新日期:2013-05-01 00:00:00

  • Where does obsessive-compulsive disorder belong in DSM-V?

    abstract::A reclassification of obsessive-compulsive disorder (OCD) into a new diagnostic category spectrum of "obsessive-compulsive spectrum disorders" (OCSDs) has recently been proposed, with considerable debate, for the forthcoming Diagnostic and Statistical Manual-Fifth Edition (DSM-V). This paper provides a critical analys...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,评审

    doi:10.1002/da.20488

    authors: Storch EA,Abramowitz J,Goodman WK

    更新日期:2008-01-01 00:00:00

  • Millon multiaxial personality patterns differentiate depressed and anxious outpatients.

    abstract::Ninety-three patients, including 47 patients with Generalized Anxiety Disorder (GAD) and 46 patients with Major Depression (MD), were entered into recent clinical trials. Clinicians acknowledge that during the initial screening process, clear separation between depressed and anxious patients may be difficult. By using...

    journal_title:Depression and anxiety

    pub_type: 临床试验,杂志文章

    doi:

    authors: Freeman AM 3rd,Kablinger AS,Rolland PD,Brannon GE

    更新日期:1999-01-01 00:00:00

  • Sedentary behaviors, physical activity, and changes in depression and psychological distress symptoms in older adults.

    abstract:BACKGROUND:Television (TV) viewing and computer use have been associated with higher risk of depression, but studies specifically assessing the impact of these and other types of sedentary behaviors (SBs) on the mental health of older adults are scarce and their results are inconclusive. Similarly, the association betw...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22804

    authors: Andrade-Gómez E,Martínez-Gómez D,Rodríguez-Artalejo F,García-Esquinas E

    更新日期:2018-09-01 00:00:00

  • Endogenous oxytocin is associated with the experience of compassion and recalled upbringing in Borderline Personality Disorder.

    abstract:BACKGROUND/OBJECTIVE:The role of the neuropeptide oxytocin (OT) in Borderline Personality Disorder (BPD) is poorly understood. It is particularly unknown how early experiences with caregivers moderate the action of OT in BPD. Here, we examined the association of plasma OT levels in BPD patients with the experience of c...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22683

    authors: Ebert A,Edel MA,Gilbert P,Brüne M

    更新日期:2018-01-01 00:00:00

  • Biological and symptom changes in posttraumatic stress disorder treatment: a randomized clinical trial.

    abstract:BACKGROUND:Understanding cognitive and biological mechanisms of PTSD treatment can help refine treatments and increase rates of response. METHODS:Thirty-six veterans with PTSD were randomly assigned to receive Prolonged exposure therapy (PE) or Present-Centered therapy (PCT). We examined symptoms, trauma-related cogni...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/da.22331

    authors: Rauch SA,King AP,Abelson J,Tuerk PW,Smith E,Rothbaum BO,Clifton E,Defever A,Liberzon I

    更新日期:2015-03-01 00:00:00

  • Freezing reaction in panic disorder patients associated with anticipatory anxiety.

    abstract:BACKGROUND:Anticipatory anxiety can be described as a conditioned response with a defensive posture of freezing and autonomic activation. The purpose of this study was to assess the postural control analysis and autonomic activation in panic disorder (PD) patients presented with visual stimuli. METHODS:PD patients (n=...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20593

    authors: Lopes FL,Azevedo TM,Imbiriba LA,Freire RC,Valença AM,Caldirola D,Perna G,Volchan E,Nardi AE

    更新日期:2009-01-01 00:00:00

  • Internet psychotherapy and the future of personalized treatment.

    abstract::Internet-delivered cognitive behavioral therapy (iCBT) was developed to overcome some of the barriers in accessing best practice face-to-face CBT. iCBT affords many benefits, such as high fidelity, greater accessibility, convenience, and reduced cost to patients and health-care systems. Recent meta-analyses of iCBT fo...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22302

    authors: Andrews G,Williams AD

    更新日期:2014-11-01 00:00:00

  • Evidence-based psychotherapy trends among posttraumatic stress disorder patients in a national healthcare system, 2001-2014.

    abstract:BACKGROUND:Although evidence-based psychotherapies (EBPs) for posttraumatic stress disorder (PTSD) were implemented starting in 2005 in the veterans health administration (VHA), the largest national healthcare system in the U.S., the rate of initiation (uptake) and prevalence of these treatments in each calendar year h...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22983

    authors: Maguen S,Holder N,Madden E,Li Y,Seal KH,Neylan TC,Lujan C,Patterson OV,DuVall SL,Shiner B

    更新日期:2020-04-01 00:00:00

  • Stability of chronotype over a 7-year follow-up period and its association with severity of depressive and anxiety symptoms.

    abstract:BACKGROUND:Chronotype is an individual's preferred timing of sleep and activity, and is often referred to as a later chronotype (or evening-type) or an earlier chronotype (or morning-type). Having an evening chronotype is associated with more severe depressive and anxiety symptoms. Based on these findings it is has bee...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22995

    authors: Druiven SJM,Hovenkamp-Hermelink JHM,Knapen SE,Kamphuis J,Haarman BCM,Penninx BWJH,Antypa N,Meesters Y,Schoevers RA,Riese H

    更新日期:2020-05-01 00:00:00

  • Effects of ketamine on explicit and implicit suicidal cognition: a randomized controlled trial in treatment-resistant depression.

    abstract:BACKGROUND:Preliminary evidence suggests intravenous ketamine has rapid effects on suicidal cognition, making it an attractive candidate for depressed patients at imminent risk of suicide. In the first randomized controlled trial of ketamine using an anesthetic control condition, we tested ketamine's acute effects on e...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/da.22253

    authors: Price RB,Iosifescu DV,Murrough JW,Chang LC,Al Jurdi RK,Iqbal SZ,Soleimani L,Charney DS,Foulkes AL,Mathew SJ

    更新日期:2014-04-01 00:00:00

  • Extended release quetiapine fumarate in major depressive disorder: analysis in patients with anxious depression.

    abstract:BACKGROUND:A pooled analysis was performed on data from two studies evaluating the efficacy of once-daily extended-release quetiapine fumarate (quetiapine XR) monotherapy for patients with major depressive disorder. Through these analyses (based on Hamilton Rating Scale for Depression (HAM-D) and Hamilton Rating Scale ...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/da.21970

    authors: Thase ME,Demyttenaere K,Earley WR,Gustafsson U,Udd M,Eriksson H

    更新日期:2012-07-01 00:00:00

  • IDENTIFYING PANIC DISORDER SUBTYPES USING FACTOR MIXTURE MODELING.

    abstract:BACKGROUND:The clinical presentation of panic disorder (PD) is known to be highly heterogeneous, complicating research on its etiology, neurobiological pathways, and treatment. None of the attempts to identify PD subtypes have been independently reproduced, rendering the current literature inconclusive. METHODS:Using ...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22379

    authors: Pattyn T,Van Den Eede F,Lamers F,Veltman D,Sabbe BG,Penninx BW

    更新日期:2015-07-01 00:00:00

  • Relationship between ADIS clinician's severity rating and self-report measures among social phobics.

    abstract::Although global clinical rating scales have been a mainstay of clinical research, little is known about the relationship between these measures and other assessment modalities. The present study examined the Clinician's Severity Rating (CSR) from the Anxiety Disorders Interview Schedule in a sample of 186 social phobi...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/(SICI)1520-6394(1996)4:3<120::AID-DA4>3.0.

    authors: Hope DA,Laguna LB,Heimberg RG,Barlow DH

    更新日期:1996-01-01 00:00:00

  • Reduced sensory gating of the P1 potential in rape victims and combat veterans with posttraumatic stress disorder.

    abstract::The P1 midlatency auditory evoked potential was studied in female rape victims with Posttraumatic Stress Disorder (PTSD) and compared to an age-matched female control group; and in male combat veterans with PTSD and compared to three groups of age-matched male control subjects. Sensory gating of the P1 potential was d...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/(sici)1520-6394(1999)9:3<122::aid-da4>3.0.

    authors: Skinner RD,Rasco LM,Fitzgerald J,Karson CN,Matthew M,Williams DK,Garcia-Rill E

    更新日期:1999-01-01 00:00:00

  • Symptom profiles of late-life anxiety and depression: The influence of migration, religion and loneliness.

    abstract:OBJECTIVE:To examine (1) clinically relevant anxiety with comorbid depression in an older population, and the presentation of subthreshold symptoms; (2) to assess anxiety and levels of comorbid depression associated with migration, religion, loneliness and long-term illness. METHODS:Analysis of Wave 1 of The Irish Lon...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22893

    authors: Curran E,Rosato M,Cooper J,Mc Garrigle CA,Leavey G

    更新日期:2019-09-01 00:00:00

  • Exposure-based therapy changes amygdala and hippocampus resting-state functional connectivity in patients with posttraumatic stress disorder.

    abstract:BACKGROUND:Recent research suggests that posttraumatic stress disorder (PTSD) is associated with altered amygdala and hippocampal resting-state functional connectivity (rsFC). However, less research has examined whether Prolonged Exposure (PE), a first line exposure-based treatment for PTSD, has the potential to alter ...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22816

    authors: Zhu X,Suarez-Jimenez B,Lazarov A,Helpman L,Papini S,Lowell A,Durosky A,Lindquist MA,Markowitz JC,Schneier F,Wager TD,Neria Y

    更新日期:2018-10-01 00:00:00

  • Effects of sertraline on depressive symptoms and attentional and executive functions in major depression.

    abstract::Reports on the severity and reversibility of cognitive disturbances in major depression in the literature diverge due to methodological biases. The present study, using a precise methodology, examined attention and executive functions in 20 relatively young, depressed patients presenting a first or second episode of u...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20060

    authors: Constant EL,Adam S,Gillain B,Seron X,Bruyer R,Seghers A

    更新日期:2005-01-01 00:00:00

  • Changes in reported physical health symptoms and social function with prolonged exposure therapy for chronic posttraumatic stress disorder.

    abstract:BACKGROUND:Posttraumatic stress disorder (PTSD) is associated with significant health risk, illness, and functional impairment, e.g., Green and Kimerling [2004: Physical Health Consequences of Exposure to Extreme Stress. Washington, DC: American Psychological Association] Kimerling et al. [2000: Trauma and Health: J Tr...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20518

    authors: Rauch SA,Grunfeld TE,Yadin E,Cahill SP,Hembree E,Foa EB

    更新日期:2009-01-01 00:00:00

  • Long-term effectiveness of cognitive therapy in major depressive disorder.

    abstract::Cognitive therapy of depression, based on the cognitive theory of depression, is an established treatment for major depressive disorder. Although few clinicians expect acute treatment of depression with antidepressant medication to prevent long-term relapse of the illness, some practitioners of cognitive therapy repor...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,评审

    doi:10.1002/da.20022

    authors: Hensley PL,Nadiga D,Uhlenhuth EH

    更新日期:2004-01-01 00:00:00

  • Protein synthesis inhibition before or after stress exposure results in divergent endocrine and BDNF responses disassociated from behavioral responses.

    abstract::This study aimed to assess the effects of anisomycin, a protein synthesis inhibitor, on behavioral responses, brain-derived neurotrophic factor (BDNF) and TrkB mRNA levels, and circulating corticosterone in rats-when administered before or after initial exposure to a predator scent stress stimulus. Magnitude of change...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20366

    authors: Kozlovsky N,Kaplan Z,Zohar J,Matar MA,Shimon H,Cohen H

    更新日期:2008-01-01 00:00:00

  • Regional differences of the prefrontal cortex in pediatric PTSD: an MRI study.

    abstract::Previous studies have revealed altered structural development of the frontal lobes and prefrontal cortex (PFC) in children with symptoms of posttraumatic stress disorder (PTSD). This study is the first to provide a detailed structural analysis of the PFC in children with and without PTSD symptoms. We compared gray and...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20131

    authors: Richert KA,Carrion VG,Karchemskiy A,Reiss AL

    更新日期:2006-01-01 00:00:00

  • Early-onset versus late-onset bipolar II chronic depression.

    abstract::Age at onset is an important dimension in the classification of mood disorders. Recent findings on early-onset (EO) versus late-onset (LO) unipolar chronic depressions support this subtyping. The aim of the present study was to determine clinical differences between EO and LO bipolar II chronic depression and to suppo...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/1520-6394(2001)13:1<45::aid-da7>3.0.co;2-4

    authors: Benazzi F

    更新日期:2001-01-01 00:00:00

  • Patterns of depressive symptom remission during the treatment of seasonal affective disorder with cognitive-behavioral therapy or light therapy.

    abstract:BACKGROUND:To elucidate mechanisms related to remission in winter seasonal affective disorder (SAD), we explored the course of individual depressive symptom offset across two distinct treatment modalities that show comparable outcomes at treatment endpoint: cognitive-behavioral therapy for SAD (CBT-SAD) and light thera...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/da.22739

    authors: Meyerhoff J,Young MA,Rohan KJ

    更新日期:2018-05-01 00:00:00

  • EEG effects of ECT: implications for rTMS.

    abstract::Electroconvulsive therapy (ECT) involves the use of electrical stimulation to elicit a series of generalized tonic-clonic seizures for therapeutic purposes and is the most effective treatment known for major depression. These treatments have significant neurophysiologic effects, many of which are manifest in the elect...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,评审

    doi:10.1002/1520-6394(2000)12:3<157::AID-DA7>3.0.CO;2-

    authors: Krystal AD,West M,Prado R,Greenside H,Zoldi S,Weiner RD

    更新日期:2000-01-01 00:00:00

  • Prevalence and risk factors for posttraumatic stress disorder: a cross-sectional study among survivors of the Wenchuan 2008 earthquake in China.

    abstract:BACKGROUND:The impact of the May 2008 Wenchuan earthquake, measuring a massive 8.0 on the surface wave magnitude scale, on public health in China has been significant and multifaceted. In light of extant data on prevalence and risk factors for posttraumatic stress disorder (PTSD) after other natural diasters, we collec...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20612

    authors: Kun P,Han S,Chen X,Yao L

    更新日期:2009-01-01 00:00:00

  • Future orientation moderates the relationship between functional status and suicide ideation in depressed adults.

    abstract::Functional impairment might amplify suicide risk in later life. A positive view of the future may reduce this risk. We tested the hypothesis that hopelessness and positive future orientation moderate the association between functional status and suicide ideation in a sample of 136 patients, 55 years of age or older, i...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20224

    authors: Hirsch JK,Duberstein PR,Conner KR,Heisel MJ,Beckman A,Franus N,Conwell Y

    更新日期:2007-01-01 00:00:00

  • Computer-assisted delivery of cognitive behavioral therapy for anxiety disorders in primary-care settings.

    abstract:OBJECTIVES:This article describes a computer-assisted cognitive behavioral therapy (CBT) program designed to support the delivery of evidenced-based CBT for the four most commonly occurring anxiety disorders (panic disorder, posttraumatic stress disorder, generalized anxiety disorder, and social anxiety disorder) in pr...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20542

    authors: Craske MG,Rose RD,Lang A,Welch SS,Campbell-Sills L,Sullivan G,Sherbourne C,Bystritsky A,Stein MB,Roy-Byrne PP

    更新日期:2009-01-01 00:00:00

  • Predictors of post-traumatic stress disorder following severe injury.

    abstract::The chronicity and morbidity of established post-traumatic stress disorder (PTSD) has stimulated interest in recognizing and understanding the early development of the disorder. Acute stress disorder, a new diagnosis intended to facilitate early case detection, rests on the occurrence of dissociative reactions. It rem...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.1071

    authors: Mellman TA,David D,Bustamante V,Fins AI,Esposito K

    更新日期:2001-01-01 00:00:00