Abstract:
BACKGROUND:Irritability is prevalent and impairing in pediatric bipolar disorder (BD) but has been minimally studied using neuroimaging techniques. We used magnetoencephalography (MEG) to study theta band oscillations in the anterior cingulate cortex (ACC) during frustration in BD youth. ACC theta power is associated with attention to emotional stimuli, and the ACC may mediate responses to frustrating stimuli. METHODS:We used the affective Posner task, an attention paradigm that uses rigged feedback to induce frustration, to compare 20 medicated BD youth (14.9+/-2.0 years; 45% male) and 20 healthy controls (14.7+/-1.7 years; 45% male). MEG measured neuronal activity after negative and positive feedback; we also compared groups on reaction time, response accuracy, and self-reported affect. Patients met strict DSM-IV BD criteria and were euthymic. Controls had no psychiatric history. RESULTS:BD youth reported more negative affective responses than controls. After negative feedback, BD subjects, relative to controls, displayed greater theta power in the right ACC and bilateral parietal lobe. After positive feedback, BD subjects displayed lower theta power in the left ACC than did controls. Correlations between MEG, behavior, and affect were nonsignificant. CONCLUSION:In this first MEG study of BD youth, BD youth displayed patterns of theta oscillations in the ACC and parietal lobe in response to frustration-inducing negative feedback that differed from healthy controls. These data suggest that BD youth may display heightened processing of negative feedback and exaggerated self-monitoring after frustrating emotional stimuli. Future studies are needed with unmedicated bipolar youth, and comparison ADHD and anxiety groups.
journal_name
Depress Anxietyjournal_title
Depression and anxietyauthors
Rich BA,Holroyd T,Carver FW,Onelio LM,Mendoza JK,Cornwell BR,Fox NA,Pine DS,Coppola R,Leibenluft Edoi
10.1002/da.20649subject
Has Abstractpub_date
2010-03-01 00:00:00pages
276-86issue
3eissn
1091-4269issn
1520-6394journal_volume
27pub_type
杂志文章abstract:BACKGROUND:Previous work has shown that inhibition of fear is impaired in posttraumatic stress disorder (PTSD) resulting from both civilian and combat trauma. The purpose of the present study was to investigate the inhibition of learned fear in traumatized individuals diagnosed with either acute stress disorder (ASD) o...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.21991
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Although a large body of empirical research has examined negative psychological outcomes in older veterans, relatively little is known about the prevalence and determinants of psychological resilience in this population. METHODS:A nationally representative sample of 2,025 U.S. veterans aged 60 and older (me...
journal_title:Depression and anxiety
pub_type: 杂志文章
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更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Exposure therapy, a gold-standard treatment for anxiety disorders, is assumed to work via extinction learning, but this has never been tested. Anxious individuals demonstrate extinction learning deficits, likely related to less ventromedial prefrontal cortex (vmPFC) and more amygdala activation, but the rela...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22583
更新日期:2017-03-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.1071
更新日期:2001-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章,评审
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更新日期:2014-04-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章,meta分析
doi:10.1002/(sici)1520-6394(1997)6:1<10::aid-da2>3.0.c
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Little is known regarding changes in the hypothalamic-pituitary-adrenal axis (HPA axis) of adolescent girls with and without posttraumatic stress disorder (PTSD) who have recently experienced sexual abuse. Therefore, in this pilot study, we utilized non-stressed home saliva collection three times a day for t...
journal_title:Depression and anxiety
pub_type: 杂志文章
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journal_title:Depression and anxiety
pub_type: 杂志文章,评审
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journal_title:Depression and anxiety
pub_type: 杂志文章,随机对照试验
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journal_title:Depression and anxiety
pub_type: 杂志文章
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journal_title:Depression and anxiety
pub_type: 杂志文章,meta分析
doi:10.1002/da.10134
更新日期:2004-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
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abstract::A National Institutes of Health (National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Institute on Aging) working group meeting focused on the non-motor aspects of Parkinson's disease (PD). Below is the summary of the meeting presentations and recommendations for a res...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.10057
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journal_title:Depression and anxiety
pub_type: 杂志文章,评审
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更新日期:2013-12-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/(sici)1520-6394(1997)5:2<97::aid-da6>3.0.c
更新日期:1997-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1998-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/1520-6394(2000)12:1+<85::AID-DA12>3.0.CO;2
更新日期:2000-01-01 00:00:00
abstract::This review examines the question of whether there should be a cluster of disorders, including the adjustment disorders (ADs), acute stress disorder (ASD), posttraumatic stress disorder (PTSD), and the dissociative disorders (DDs), in a section devoted to abnormal responses to stress and trauma in the DSM-5. Environme...
journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.20845
更新日期:2011-09-01 00:00:00
abstract::The growing recognition and occurrence of traumatic exposure in the general population has given increased salience to the need to understand the concept of resilience. More than just the "flip side" of a risk factor, the notion of resilience encompasses psychological and biological characteristics, intrinsic to an in...
journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.20175
更新日期:2007-01-01 00:00:00
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journal_title:Depression and anxiety
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journal_title:Depression and anxiety
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pub_type: 杂志文章
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更新日期:2007-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 临床试验,杂志文章
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更新日期:2010-10-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22364
更新日期:2015-07-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20215
更新日期:2006-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20171
更新日期:2006-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20679
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Panic disorder (PD) is highly comorbid with major depressive disorder (MDD) with potential impact on patient-reported outcomes of quality of life (QOL), functioning, and depressive symptom severity. METHODS:Using data from the sequenced treatment alternatives to relieve depression (STAR*D) trial, we compare...
journal_title:Depression and anxiety
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2014-08-01 00:00:00
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