A preliminary study of the neural mechanisms of frustration in pediatric bipolar disorder using magnetoencephalography.

Abstract:

BACKGROUND:Irritability is prevalent and impairing in pediatric bipolar disorder (BD) but has been minimally studied using neuroimaging techniques. We used magnetoencephalography (MEG) to study theta band oscillations in the anterior cingulate cortex (ACC) during frustration in BD youth. ACC theta power is associated with attention to emotional stimuli, and the ACC may mediate responses to frustrating stimuli. METHODS:We used the affective Posner task, an attention paradigm that uses rigged feedback to induce frustration, to compare 20 medicated BD youth (14.9+/-2.0 years; 45% male) and 20 healthy controls (14.7+/-1.7 years; 45% male). MEG measured neuronal activity after negative and positive feedback; we also compared groups on reaction time, response accuracy, and self-reported affect. Patients met strict DSM-IV BD criteria and were euthymic. Controls had no psychiatric history. RESULTS:BD youth reported more negative affective responses than controls. After negative feedback, BD subjects, relative to controls, displayed greater theta power in the right ACC and bilateral parietal lobe. After positive feedback, BD subjects displayed lower theta power in the left ACC than did controls. Correlations between MEG, behavior, and affect were nonsignificant. CONCLUSION:In this first MEG study of BD youth, BD youth displayed patterns of theta oscillations in the ACC and parietal lobe in response to frustration-inducing negative feedback that differed from healthy controls. These data suggest that BD youth may display heightened processing of negative feedback and exaggerated self-monitoring after frustrating emotional stimuli. Future studies are needed with unmedicated bipolar youth, and comparison ADHD and anxiety groups.

journal_name

Depress Anxiety

journal_title

Depression and anxiety

authors

Rich BA,Holroyd T,Carver FW,Onelio LM,Mendoza JK,Cornwell BR,Fox NA,Pine DS,Coppola R,Leibenluft E

doi

10.1002/da.20649

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

276-86

issue

3

eissn

1091-4269

issn

1520-6394

journal_volume

27

pub_type

杂志文章
  • Acute stress disorder versus chronic posttraumatic stress disorder: inhibition of fear as a function of time since trauma.

    abstract:BACKGROUND:Previous work has shown that inhibition of fear is impaired in posttraumatic stress disorder (PTSD) resulting from both civilian and combat trauma. The purpose of the present study was to investigate the inhibition of learned fear in traumatized individuals diagnosed with either acute stress disorder (ASD) o...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.21991

    authors: Jovanovic T,Sakoman AJ,Kozarić-Kovačić D,Meštrović AH,Duncan EJ,Davis M,Norrholm SD

    更新日期:2013-03-01 00:00:00

  • Psychological resilience in older U.S. veterans: results from the national health and resilience in veterans study.

    abstract:BACKGROUND:Although a large body of empirical research has examined negative psychological outcomes in older veterans, relatively little is known about the prevalence and determinants of psychological resilience in this population. METHODS:A nationally representative sample of 2,025 U.S. veterans aged 60 and older (me...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22083

    authors: Pietrzak RH,Cook JM

    更新日期:2013-05-01 00:00:00

  • Brain activation during fear extinction predicts exposure success.

    abstract:BACKGROUND:Exposure therapy, a gold-standard treatment for anxiety disorders, is assumed to work via extinction learning, but this has never been tested. Anxious individuals demonstrate extinction learning deficits, likely related to less ventromedial prefrontal cortex (vmPFC) and more amygdala activation, but the rela...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22583

    authors: Ball TM,Knapp SE,Paulus MP,Stein MB

    更新日期:2017-03-01 00:00:00

  • Predictors of post-traumatic stress disorder following severe injury.

    abstract::The chronicity and morbidity of established post-traumatic stress disorder (PTSD) has stimulated interest in recognizing and understanding the early development of the disorder. Acute stress disorder, a new diagnosis intended to facilitate early case detection, rests on the occurrence of dissociative reactions. It rem...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.1071

    authors: Mellman TA,David D,Bustamante V,Fins AI,Esposito K

    更新日期:2001-01-01 00:00:00

  • Developing biomarkers in mood disorders research through the use of rapid-acting antidepressants.

    abstract::An impediment to progress in mood disorders research is the lack of analytically valid and qualified diagnostic and treatment biomarkers. Consistent with the National Institute of Mental Health (NIMH)'s Research Domain Criteria (RDoC) initiative, the lack of diagnostic biomarkers has precluded us from moving away from...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,评审

    doi:10.1002/da.22224

    authors: Niciu MJ,Mathews DC,Nugent AC,Ionescu DF,Furey ML,Richards EM,Machado-Vieira R,Zarate CA Jr

    更新日期:2014-04-01 00:00:00

  • Are SSRIs better than TCAs? Comparison of SSRIs and TCAs: a meta-analysis.

    abstract::In this analysis we examined studies of tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs) to compare efficacy and drop-out rates. Frequency of reported side effects was also studied. Using Medline, we located 36 clinical trials of TCAs and SSRIs in a double-blind comparison. We perfo...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,meta分析

    doi:10.1002/(sici)1520-6394(1997)6:1<10::aid-da2>3.0.c

    authors: Steffens DC,Krishnan KR,Helms MJ

    更新日期:1997-01-01 00:00:00

  • Cortisol awakening response in adolescents with acute sexual abuse related posttraumatic stress disorder.

    abstract:BACKGROUND:Little is known regarding changes in the hypothalamic-pituitary-adrenal axis (HPA axis) of adolescent girls with and without posttraumatic stress disorder (PTSD) who have recently experienced sexual abuse. Therefore, in this pilot study, we utilized non-stressed home saliva collection three times a day for t...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22154

    authors: Keeshin BR,Strawn JR,Out D,Granger DA,Putnam FW

    更新日期:2014-02-01 00:00:00

  • Are there gender differences in objective and subjective sleep measures? A study of insomniacs and healthy controls.

    abstract::It is well known that insomnia is more frequent in women than in men throughout all age groups. In this respect insomnia resembles other psychiatric disorders that occur more frequently in women such as anxiety and depressive disorders. Since insomnia is frequently a symptom of anxiety and depression, it remains an op...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,评审

    doi:10.1002/da.10101

    authors: Voderholzer U,Al-Shajlawi A,Weske G,Feige B,Riemann D

    更新日期:2003-01-01 00:00:00

  • Periloss dissociation, symptom severity, and treatment response in complicated grief.

    abstract:BACKGROUND:Complicated grief (CG) is a bereavement-specific syndrome characterized by traumatic and separation distress lasting over 6 months. Little is known about the role of dissociation experienced during or immediately after the loss of a loved one (i.e., periloss dissociation [PLD]) in CG. The present study aimed...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/da.22029

    authors: Bui E,Simon NM,Robinaugh DJ,Leblanc NJ,Wang Y,Skritskaya NA,Mauro C,Shear MK

    更新日期:2013-02-01 00:00:00

  • Face-to-face versus remote administration of the Montgomery-Asberg Depression Rating Scale using videoconference and telephone.

    abstract::Although the use of telemedicine in psychiatry has a long history in providing clinical care to patients, its use in clinical trials research has not yet been commonly employed. Telemedicine allows for the remote assessment of study patients, which could be done by a centralized, highly calibrated, and impartial cohor...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20392

    authors: Kobak KA,Williams JB,Jeglic E,Salvucci D,Sharp IR

    更新日期:2008-01-01 00:00:00

  • Does elimination of placebo responders in a placebo run-in increase the treatment effect in randomized clinical trials? A meta-analytic evaluation.

    abstract::The use of a placebo run-in phase, in which placebo responders are withdrawn from a study before random assignment to treatment condition, has been criticized as favoring the active treatment in clinical trials. We compared the effect size of randomized, placebo-controlled clinical trials (in the treatment of depressi...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,meta分析

    doi:10.1002/da.10134

    authors: Lee S,Walker JR,Jakul L,Sexton K

    更新日期:2004-01-01 00:00:00

  • Nonverbal memory dysfunction in obsessive-compulsive disorder patients with checking compulsions.

    abstract::Obsessive-compulsive disorder (OCD) is a clinically heterogeneous disorder; nonetheless, most of the previous neuropsychological studies for assessing the involvement of memory dysfunction grouped together patients with different symptoms, thereby potentially accounting for the inconsistencies of results. The goals of...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20377

    authors: Cha KR,Koo MS,Kim CH,Kim JW,Oh WJ,Suh HS,Lee HS

    更新日期:2008-01-01 00:00:00

  • Depression and Parkinson's disease: a new look at an old problem.

    abstract::A National Institutes of Health (National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Institute on Aging) working group meeting focused on the non-motor aspects of Parkinson's disease (PD). Below is the summary of the meeting presentations and recommendations for a res...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.10057

    authors: Edwards E,Kitt C,Oliver E,Finkelstein J,Wagster M,McDonald WM

    更新日期:2002-01-01 00:00:00

  • Sex differences in DNA methylation may contribute to risk of PTSD and depression: a review of existing evidence.

    abstract::There are well-established sex differences in the prevalence of certain mental disorders. Work in animal models has provided us with an emerging understanding of the role that epigenetic factors play in establishing sex differences in the brain during development. Similarly, work in animal models, and a more limited b...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,评审

    doi:10.1002/da.22167

    authors: Uddin M,Sipahi L,Li J,Koenen KC

    更新日期:2013-12-01 00:00:00

  • Relationship between objective and subjective sleep measures in depressed patients and healthy controls.

    abstract::The purpose of this study was to correlate subjective sleep characteristics based on questionnaire response, and objective sleep EEG features based on polysomnography, in 52 patients with major depressive disorders (MDD) and 49 healthy controls. With the exception of the number of awakenings, subjective and objective ...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/(sici)1520-6394(1997)5:2<97::aid-da6>3.0.c

    authors: Armitage R,Trivedi M,Hoffmann R,Rush AJ

    更新日期:1997-01-01 00:00:00

  • Fluoxetine in child and adolescent depression: acute and maintenance treatment.

    abstract::The objective was to present naturalistic 1-year follow-up information of 96 child and adolescent outpatients with major depressive disorder who had been randomized in an 8-week double-blind, placebo-controlled trial of fluoxetine. Subjects were children and adolescents, ages 8-18 years, who were entered in a randomiz...

    journal_title:Depression and anxiety

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/(sici)1520-6394(1998)7:1<32::aid-da4>3.0.c

    authors: Emslie GJ,Rush AJ,Weinberg WA,Kowatch RA,Carmody T,Mayes TL

    更新日期:1998-01-01 00:00:00

  • Use of venlafaxine in children and adolescents: a review of current literature.

    abstract::Pediatric psychopharmacology is hindered by the relative lack of controlled, empirical clinical trials [Shatzberg and Nemeroff, 1998: Washington, D.C.: The American Psychiatric Press, Inc. p 301-306]. Psychiatric disorders in children and adolescents carry considerable morbidity, impede development, and carry a signif...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,评审

    doi:10.1002/1520-6394(2000)12:1+<85::AID-DA12>3.0.CO;2

    authors: Weller EB,Weller RA,Davis GP

    更新日期:2000-01-01 00:00:00

  • Classification of trauma and stressor-related disorders in DSM-5.

    abstract::This review examines the question of whether there should be a cluster of disorders, including the adjustment disorders (ADs), acute stress disorder (ASD), posttraumatic stress disorder (PTSD), and the dissociative disorders (DDs), in a section devoted to abnormal responses to stress and trauma in the DSM-5. Environme...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,评审

    doi:10.1002/da.20845

    authors: Friedman MJ,Resick PA,Bryant RA,Strain J,Horowitz M,Spiegel D

    更新日期:2011-09-01 00:00:00

  • Resilience: research evidence and conceptual considerations for posttraumatic stress disorder.

    abstract::The growing recognition and occurrence of traumatic exposure in the general population has given increased salience to the need to understand the concept of resilience. More than just the "flip side" of a risk factor, the notion of resilience encompasses psychological and biological characteristics, intrinsic to an in...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,评审

    doi:10.1002/da.20175

    authors: Hoge EA,Austin ED,Pollack MH

    更新日期:2007-01-01 00:00:00

  • Quality of web-based information on social phobia: a cross-sectional study.

    abstract::The objective of the study is to evaluate the quality of web-based information on social phobia and to investigate particular quality indicators. Two keywords, "Social phobia" and "Social Anxiety Disorder", were entered into five popular World Wide Web search engines. Websites were assessed with a standardized proform...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20381

    authors: Khazaal Y,Fernandez S,Cochand S,Reboh I,Zullino D

    更新日期:2008-01-01 00:00:00

  • Protein synthesis inhibition before or after stress exposure results in divergent endocrine and BDNF responses disassociated from behavioral responses.

    abstract::This study aimed to assess the effects of anisomycin, a protein synthesis inhibitor, on behavioral responses, brain-derived neurotrophic factor (BDNF) and TrkB mRNA levels, and circulating corticosterone in rats-when administered before or after initial exposure to a predator scent stress stimulus. Magnitude of change...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20366

    authors: Kozlovsky N,Kaplan Z,Zohar J,Matar MA,Shimon H,Cohen H

    更新日期:2008-01-01 00:00:00

  • Evidence-based psychotherapy trends among posttraumatic stress disorder patients in a national healthcare system, 2001-2014.

    abstract:BACKGROUND:Although evidence-based psychotherapies (EBPs) for posttraumatic stress disorder (PTSD) were implemented starting in 2005 in the veterans health administration (VHA), the largest national healthcare system in the U.S., the rate of initiation (uptake) and prevalence of these treatments in each calendar year h...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22983

    authors: Maguen S,Holder N,Madden E,Li Y,Seal KH,Neylan TC,Lujan C,Patterson OV,DuVall SL,Shiner B

    更新日期:2020-04-01 00:00:00

  • Future orientation moderates the relationship between functional status and suicide ideation in depressed adults.

    abstract::Functional impairment might amplify suicide risk in later life. A positive view of the future may reduce this risk. We tested the hypothesis that hopelessness and positive future orientation moderate the association between functional status and suicide ideation in a sample of 136 patients, 55 years of age or older, i...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20224

    authors: Hirsch JK,Duberstein PR,Conner KR,Heisel MJ,Beckman A,Franus N,Conwell Y

    更新日期:2007-01-01 00:00:00

  • Accelerated repetitive transcranial magnetic stimulation for treatment-resistant depression.

    abstract:BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) has shown safety and efficacy for treatment-resistant depression, but requires daily treatment for 4-6 weeks. Accelerated TMS, with all treatments delivered over a few days, would have significant advantages in terms of access and patient acceptance. METHO...

    journal_title:Depression and anxiety

    pub_type: 临床试验,杂志文章

    doi:10.1002/da.20731

    authors: Holtzheimer PE 3rd,McDonald WM,Mufti M,Kelley ME,Quinn S,Corso G,Epstein CM

    更新日期:2010-10-01 00:00:00

  • APPROXIMATING A DSM-5 DIAGNOSIS OF PTSD USING DSM-IV CRITERIA.

    abstract:BACKGROUND:Diagnostic criteria for DSM-5 posttraumatic stress disorder (PTSD) are in many ways similar to DSM-IV criteria, raising the possibility that it might be possible to closely approximate DSM-5 diagnoses using DSM-IV symptoms. If so, the resulting transformation rules could be used to pool research data based o...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22364

    authors: Rosellini AJ,Stein MB,Colpe LJ,Heeringa SG,Petukhova MV,Sampson NA,Schoenbaum M,Ursano RJ,Kessler RC,Army STARRS Collaborators.

    更新日期:2015-07-01 00:00:00

  • Do anxiety and depression cluster into distinct groups?: a test of tripartite model predictions in a community sample of youth.

    abstract::Because of their high comorbidity and strong associations, the distinctiveness of anxiety and depression in youth continues to be debated. In this study we used cluster analysis in a community sample (n=225) of youth to test tripartite model predictions regarding the grouping of individuals based on their levels of an...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20215

    authors: Cannon MF,Weems CF

    更新日期:2006-01-01 00:00:00

  • Morphometric alterations of anterior superior temporal cortex in obsessive-compulsive disorder.

    abstract::The superior temporal gyrus (STG) may be involved in the pathophysiology of obsessive-compulsive disorder (OCD). Moreover, the anterior STG has rich interconnections with the orbitofrontal cortex and the amygdala, and plays a role in visuospatial processing, which is impaired in patients with OCD. This study was desig...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20171

    authors: Choi JS,Kim HS,Yoo SY,Ha TH,Chang JH,Kim YY,Shin YW,Kwon JS

    更新日期:2006-01-01 00:00:00

  • Distinct electrocortical and behavioral evidence for increased attention to threat in generalized anxiety disorder.

    abstract:BACKGROUND:Neural activity is increasingly used in addition to behavioral measures to study anxiety and attentional biases toward threatening stimuli. Event-related potentials (ERPs) might be particularly useful because of their excellent temporal resolution. In particular, the late positive potential (LPP) reflects in...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20679

    authors: MacNamara A,Hajcak G

    更新日期:2010-03-01 00:00:00

  • Patient-reported outcomes of quality of life, functioning, and depressive symptom severity in major depressive disorder comorbid with panic disorder before and after SSRI treatment in the star*d trial.

    abstract:BACKGROUND:Panic disorder (PD) is highly comorbid with major depressive disorder (MDD) with potential impact on patient-reported outcomes of quality of life (QOL), functioning, and depressive symptom severity. METHODS:Using data from the sequenced treatment alternatives to relieve depression (STAR*D) trial, we compare...

    journal_title:Depression and anxiety

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1002/da.22152

    authors: IsHak WW,Mirocha J,Christensen S,Wu F,Kwock R,Behjat J,Pi S,Akopyan A,Peselow ED,Cohen RM,Elashoff D

    更新日期:2014-08-01 00:00:00

  • Measurement invariance of the patient health questionnaire-9 (PHQ-9) depression screener in U.S. adults across sex, race/ethnicity, and education level: NHANES 2005-2016.

    abstract:BACKGROUND:Despite its popularity, little is known about the measurement invariance of the Patient Health Questionnaire-9 (PHQ-9) across U.S. sociodemographic groups. Use of a screener shown not to possess measurement invariance could result in under/over-detection of depression, potentially exacerbating sociodemograph...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22940

    authors: Patel JS,Oh Y,Rand KL,Wu W,Cyders MA,Kroenke K,Stewart JC

    更新日期:2019-09-01 00:00:00