Accelerated repetitive transcranial magnetic stimulation for treatment-resistant depression.

Abstract:

BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) has shown safety and efficacy for treatment-resistant depression, but requires daily treatment for 4-6 weeks. Accelerated TMS, with all treatments delivered over a few days, would have significant advantages in terms of access and patient acceptance. METHODS:Open-label accelerated TMS (aTMS), consisting of 15 rTMS sessions administered over 2 days, was tested in 14 depressed patients not responding to at least one antidepressant medication. Effects on depression, anxiety, and cognition were assessed the day following treatment, then after 3 and 6 weeks. RESULTS:No seizure activity was observed and only one patient had a serious adverse event (increased suicidal ideation). Two patients failed to complete a full course of aTMS treatments, and 36% did not complete all study visits. Depression and anxiety significantly decreased following aTMS treatments and improvements persisted 3 and 6 weeks later. Response rates immediately following treatment and at 3 and 6 weeks were 43, 36, and 36%, respectively. Remission rates at the same timepoints were 29, 36, and 29%. CONCLUSIONS:Accelerated TMS demonstrated an excellent safety profile with efficacy comparable to that achieved in daily rTMS in other trials. Limitations primarily include open-label treatment and a small sample size.

journal_name

Depress Anxiety

journal_title

Depression and anxiety

authors

Holtzheimer PE 3rd,McDonald WM,Mufti M,Kelley ME,Quinn S,Corso G,Epstein CM

doi

10.1002/da.20731

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

960-3

issue

10

eissn

1091-4269

issn

1520-6394

journal_volume

27

pub_type

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